LOCUS       NM_001271741            5324 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens casein kinase 1 alpha 1 (CSNK1A1), transcript variant
            3, mRNA.
ACCESSION   NM_001271741
VERSION     NM_001271741.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5324)
  AUTHORS   Pham,A.M. and Kwun,H.J.
  TITLE     Casein kinase 1alpha mediates phosphorylation of the Merkel cell
            polyomavirus large T antigen for beta-TrCP destruction complex
            interaction and subsequent degradation
  JOURNAL   mBio 15 (8), e0111724 (2024)
   PUBMED   38940554
  REMARK    GeneRIF: Casein kinase 1alpha mediates phosphorylation of the
            Merkel cell polyomavirus large T antigen for beta-TrCP destruction
            complex interaction and subsequent degradation.
REFERENCE   2  (bases 1 to 5324)
  AUTHORS   Cullati,S.N., Akizuki,K., Chen,J.S., Johnson,J.L.,
            Yaron-Barir,T.M., Cantley,L.C. and Gould,K.L.
  TITLE     Substrate displacement of CK1 C-termini regulates kinase
            specificity
  JOURNAL   Sci Adv 10 (19), eadj5185 (2024)
   PUBMED   38728403
  REMARK    GeneRIF: Substrate displacement of CK1 C-termini regulates kinase
            specificity.
REFERENCE   3  (bases 1 to 5324)
  AUTHORS   Pan,M., Hu,T., Lyu,J., Yin,Y., Sun,J., Wang,Q., Xu,L., Hu,H. and
            Wang,C.
  TITLE     CSNK1A1/CK1alpha suppresses autoimmunity by restraining the
            CGAS-STING1 signaling
  JOURNAL   Autophagy 20 (2), 311-328 (2024)
   PUBMED   37723657
  REMARK    GeneRIF: CSNK1A1/CK1alpha suppresses autoimmunity by restraining
            the CGAS-STING1 signaling.
REFERENCE   4  (bases 1 to 5324)
  AUTHORS   Nishiguchi,G., Mascibroda,L.G., Young,S.M., Caine,E.A.,
            Abdelhamed,S., Kooijman,J.J., Miller,D.J., Das,S., McGowan,K.,
            Mayasundari,A., Shi,Z., Barajas,J.M., Hiltenbrand,R., Aggarwal,A.,
            Chang,Y., Mishra,V., Narina,S., Thomas,M., Loughran,A.J.,
            Kalathur,R., Yu,K., Zhou,S., Wang,X., High,A.A., Peng,J.,
            Pruett-Miller,S.M., Daniels,D.L., Urh,M., Shelat,A.A.,
            Mullighan,C.G., Riching,K.M., Zaman,G.J.R., Fischer,M., Klco,J.M.
            and Rankovic,Z.
  TITLE     Selective CK1alpha degraders exert antiproliferative activity
            against a broad range of human cancer cell lines
  JOURNAL   Nat Commun 15 (1), 482 (2024)
   PUBMED   38228616
  REMARK    GeneRIF: Selective CK1alpha degraders exert antiproliferative
            activity against a broad range of human cancer cell lines.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5324)
  AUTHORS   Al-Attar,R., Jargstorf,J., Romagnuolo,R., Jouni,M., Alibhai,F.J.,
            Lampe,P.D., Solan,J.L. and Laflamme,M.A.
  TITLE     Casein Kinase 1 Phosphomimetic Mutations Negatively Impact
            Connexin-43 Gap Junctions in Human Pluripotent Stem Cell-Derived
            Cardiomyocytes
  JOURNAL   Biomolecules 14 (1), 61 (2024)
   PUBMED   38254663
  REMARK    GeneRIF: Casein Kinase 1 Phosphomimetic Mutations Negatively Impact
            Connexin-43 Gap Junctions in Human Pluripotent Stem Cell-Derived
            Cardiomyocytes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5324)
  AUTHORS   Beyaert,R., Vanhaesebroeck,B., Declercq,W., Van Lint,J.,
            Vandenabele,P., Agostinis,P., Vandenheede,J.R. and Fiers,W.
  TITLE     Casein kinase-1 phosphorylates the p75 tumor necrosis factor
            receptor and negatively regulates tumor necrosis factor signaling
            for apoptosis
  JOURNAL   J Biol Chem 270 (40), 23293-23299 (1995)
   PUBMED   7559483
REFERENCE   7  (bases 1 to 5324)
  AUTHORS   Gross,S.D., Hoffman,D.P., Fisette,P.L., Baas,P. and Anderson,R.A.
  TITLE     A phosphatidylinositol 4,5-bisphosphate-sensitive casein kinase I
            alpha associates with synaptic vesicles and phosphorylates a subset
            of vesicle proteins
  JOURNAL   J Cell Biol 130 (3), 711-724 (1995)
   PUBMED   7622570
REFERENCE   8  (bases 1 to 5324)
  AUTHORS   Fish,K.J., Cegielska,A., Getman,M.E., Landes,G.M. and Virshup,D.M.
  TITLE     Isolation and characterization of human casein kinase I epsilon
            (CKI), a novel member of the CKI gene family
  JOURNAL   J Biol Chem 270 (25), 14875-14883 (1995)
   PUBMED   7797465
REFERENCE   9  (bases 1 to 5324)
  AUTHORS   Tapia,C., Featherstone,T., Gomez,C., Taillon-Miller,P.,
            Allende,C.C. and Allende,J.E.
  TITLE     Cloning and chromosomal localization of the gene coding for human
            protein kinase CK1
  JOURNAL   FEBS Lett 349 (2), 307-312 (1994)
   PUBMED   8050587
REFERENCE   10 (bases 1 to 5324)
  AUTHORS   Brockman,J.L., Gross,S.D., Sussman,M.R. and Anderson,R.A.
  TITLE     Cell cycle-dependent localization of casein kinase I to mitotic
            spindles
  JOURNAL   Proc Natl Acad Sci U S A 89 (20), 9454-9458 (1992)
   PUBMED   1409656
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA144898.1, AF218004.1, BC009186.2, BC008717.2, BU618830.1 and
            AC021078.5.
            
            On Jun 2, 2019 this sequence version replaced NM_001271741.1.
            
            Transcript Variant: This variant (3) lacks an in-frame internal
            exon and uses an alternate splice site, compared to variant 1. This
            results in a shorter protein (isoform 3), compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.196450.1,
                                           SRR1803616.195679.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                DA144898.1         114-202
            90-1677             AF218004.1         1-1588
            1678-2239           BC009186.2         94-655
            2240-2322           BC008717.2         1932-2014
            2323-2412           BU618830.1         17-106              c
            2413-5324           AC021078.5         120973-123884
FEATURES             Location/Qualifiers
     source          1..5324
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q32"
     gene            1..5324
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /note="casein kinase 1 alpha 1"
                     /db_xref="GeneID:1452"
                     /db_xref="HGNC:HGNC:2451"
                     /db_xref="MIM:600505"
     exon            1..598
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /inference="alignment:Splign:2.1.0"
     CDS             476..1453
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /EC_number="2.7.11.1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     down-regulated in lung cancer; epididymis secretory sperm
                     binding protein Li 77p; CKI-alpha; clock regulator kinase"
                     /codon_start=1
                     /product="casein kinase I isoform alpha isoform 3"
                     /protein_id="NP_001258670.1"
                     /db_xref="CCDS:CCDS64291.1"
                     /db_xref="GeneID:1452"
                     /db_xref="HGNC:HGNC:2451"
                     /db_xref="MIM:600505"
                     /translation="MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVA
                     VKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFN
                     FCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGL
                     AKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTS
                     LPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMY
                     LRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGF"
     exon            599..705
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /inference="alignment:Splign:2.1.0"
     exon            706..832
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /inference="alignment:Splign:2.1.0"
     exon            833..931
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1071
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1150
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1225
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1332
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1445
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..5324
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2296..2301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /note="hexamer: ATTAAA"
     polyA_site      2313
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /note="major polyA site"
     regulatory      3946..3951
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /note="hexamer: AATAAA"
     regulatory      3956..3961
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /note="hexamer: AATATA"
     polyA_site      3967
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /note="major polyA site"
     polyA_site      3992
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
     regulatory      5304..5309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /note="hexamer: AATAAA"
     polyA_site      5324
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
ORIGIN      
        1 cccagagtgc tctgcgccgt gaagaagcgg ctcccgggga ctgggggcat tttgtgttgg
       61 ctggagctgg agtaacaaga tggcgtcgtc cgcggagtga caggggtccc tctgggccgg
      121 agccggcggc agtggtggca gcggtatcgc cgccctagct caccgcgccc cttttccagc
      181 ccgcgacgtc gccgcgcaag cgaggcagcg gcggccgccg agaaacaagt ggcccagcct
      241 ggtaaccgcc gagaagccct tcacaaactg cggcctggca aaaagaaacc tgactgagcg
      301 gcggtgatca ggttcccctc tgctgattct gggccccgaa ccccggtaaa ggcctccgtg
      361 ttccgtttcc tgccgccctc ctccgtagcc ttgcctagtg taggagcccc gaggcctccg
      421 tcctcttccc agaggtgtcg gggcttggcc ccagcctcca tcttcgtctc tcaggatggc
      481 gagtagcagc ggctccaagg ctgaattcat tgtcggaggg aaatataaac tggtacggaa
      541 gatcgggtct ggctccttcg gggacatcta tttggcgatc aacatcacca acggcgagga
      601 agtggcagtg aagctagaat ctcagaaggc caggcatccc cagttgctgt acgagagcaa
      661 gctctataag attcttcaag gtggggttgg catcccccac atacggtggt atggtcagga
      721 aaaagactac aatgtactag tcatggatct tctgggacct agcctcgaag acctcttcaa
      781 tttctgttca agaaggttca caatgaaaac tgtacttatg ttagctgacc agatgatcag
      841 tagaattgaa tatgtgcata caaagaattt tatacacaga gacattaaac cagataactt
      901 cctaatgggt attgggcgtc actgtaataa gttattcctt attgattttg gtttggccaa
      961 aaagtacaga gacaacagga caaggcaaca cataccatac agagaagata aaaacctcac
     1021 tggcactgcc cgatatgcta gcatcaatgc acatcttggt attgagcaga gtcgccgaga
     1081 tgacatggaa tcattaggat atgttttgat gtattttaat agaaccagcc tgccatggca
     1141 agggctaaag gctgcaacaa agaaacaaaa atatgaaaag attagtgaaa agaagatgtc
     1201 cacgcctgtt gaagttttat gtaaggggtt tcctgcagaa tttgcgatgt acttaaacta
     1261 ttgtcgtggg ctacgctttg aggaagcccc agattacatg tatctgaggc agctattccg
     1321 cattcttttc aggaccctga accatcaata tgactacaca tttgattgga caatgttaaa
     1381 gcagaaagca gcacagcagg cagcctcttc cagtgggcag ggtcagcagg cccaaacccc
     1441 cacaggtttc taagcatgaa ttgaggaaca gaagaagcag agcagatgat cggagcagca
     1501 tttgtttctc cccaaatcta gaaattttag ttcatatgta cactagccag tggttgtgga
     1561 caaccattta cttggtgtaa agaacttaat ttcagtataa actgactctg ggcagcattg
     1621 gtgatgctgt atcctgagtt gtagcctctg taattgtgaa tattaactga gatagtgaaa
     1681 catggtgtcc ggttttctat tgcatttttt caagtggaaa agttaactaa atggttgaca
     1741 cacaaaaatt ggtggagaaa ttgtgcatat gccaattttt tgttaaaacc ttttgttttg
     1801 aactatactg ctttgagatc tcatttcaga agaacggcat gaacagtctt cagccacagt
     1861 tgtgatggtt gttaaatgct cacaattgtg cattcttagg gtttttccat ccctggggtt
     1921 tgcaagttgt tcacttaaaa cattcttaaa atggttggct tcttgtctgc aagccagctg
     1981 atatggtagc aaccaaagat tccagtgttt gagcatatga aagactctgc ctgcttaatt
     2041 gtgctagaaa taacagcatc taaagtgaag acttaagaaa aacttagtga ctactagatt
     2101 atccttagga ctctgcatta actctataat gttcttggta ttaaaaaaaa agcatatttg
     2161 tcacagaaat ttagttaaca tcttacaact gaacatgtat gtatgttgct tagataaatg
     2221 taatcactgt aaacatctat atgatctggg attttgtttt tattttgaaa tgggagcttt
     2281 tttgtttaca agttcattaa aaactaaaaa ctgtttctgt aaggaaatga gatttttttt
     2341 aaacaacaaa aaatgccttg ctgactcact attaaataaa aatctcccca attttttgat
     2401 agactacttc aagccatttg ttacatggta ttcctttgca agtcaattta ggtttcgtgt
     2461 tataactttt cctctttttt taagaaaaat gaaaaaagta attcttttgt ctgaagggga
     2521 aaggcattct ttcatttttt tctttttttt tttttttttt tatgacttgc aggcacaata
     2581 tctagtactg caactgccag aacttggtat tgtagctgct gcccgctgac tagcagctgg
     2641 actgattttg aataaaaatg aaagcattaa agggtttccc tacaaaacat ttttctttaa
     2701 aatacttttg aaatggctat aagcagttga ctttcaccct tggagagcat cacactgtgt
     2761 gaggttcagt gattgttgac cctccccagc ccctcctgct tctttaagtt atctgtgtgc
     2821 gtgcgcttcc tctcaatctt ctttgcacgc tcatttcttt ttctctgacc catgagaaag
     2881 gaaaacttac tgatgataat ttttaaatag tgtaatttat tcatttatag catgtcagga
     2941 taaattaaaa gaacatttgt ctggaaatgc tgccgggagc ctattgtgta aatgtaggta
     3001 ttttgtaaaa taaccttgaa attgtaaatt gacacgtgtt tggtcagatt gtgtcaagtt
     3061 taatttgttt tgttttcttt tttctttttt ttatttgaaa actactttag caataattaa
     3121 ttccatgatt atcacattct gccattaagg gatattagta ccgtaatact gaagaaattt
     3181 tattaagtct gaacttctgg ggtaggcagc ttctttgttt cttttctatc cacccttgtc
     3241 ggttgaggta tttgtttctt gactaataaa ccctttgata cttttagcca gaaatcagtc
     3301 tcataaagct atttttgagt atagtttgtg taaaataaaa atgtttagct ttggtaataa
     3361 cttccaagct gaactccctc tagcaagata tttttcagtg cttttattta ctatgcactt
     3421 agactatgca ctttttctga aatatttttg taacactttt ttgtattttt gccatttgaa
     3481 aaggttgtgg tgtagttggt ctgtaattaa gttgcagatt taaaactgct gttagctttg
     3541 taaatcaaaa tataggtgtt ttttgtcctg gtatatcgtc attccatctg cagctggagc
     3601 tggaatccca ttgatcttct agctaccatt cattttcttc actgttcaca aaagaagagt
     3661 gtgaaattca gtgaatgctg ttactaatcc tgttacgaga tgaatctcat ttcaccaaaa
     3721 ttaaattatg tttttccgct aaaatgatga tacaagttga agacacatca ctctgaaatt
     3781 ggaagacctc accacttaag gctccacagt ggcttactca gctgaactct aggttactac
     3841 tctttacttt gttcacccat tggggggtgc agttttttta aaatgttggg agatggccat
     3901 tctaactact gttgaatgtc tctgttttgg gaaggtataa caagaaataa aaaagaatat
     3961 atatgaaggg agagactggt tatctcctcc catatggttg tgcttatcct cttatggctt
     4021 acaaatgaat atttggaggt ttgctttcac aatgatttcc catcaacaaa tatttttagt
     4081 aggatttttc ctgtttctgt tagtccttgc agtactcata aatgttttaa gctgagcata
     4141 ctgtaatagt cataagttta atttcattat aataaaaata atcaaacaaa aggactttag
     4201 aacccaagac aatgagctag ttttccctaa agtttgctga actattaagg aatatgttct
     4261 tatagctttt gactagaatg agtcatggga attctaagaa gggatggcct agacattttt
     4321 agctcagtta aattcagcat ttaatgcagg tgagttcctg ggtcgttttc caactagtct
     4381 ggaacagtct ggttctgact caaactggta taaagcatta ttttaggttt tctctttgcc
     4441 agtttttaag cagttataac catgtaaatc aagatgtgag gacatctata tgaagtatag
     4501 taaagaagtg gtgtcagcag atcaatatgt gtgtcctggg tgtgctgctc tcttaagtga
     4561 gactttgtga gactatactt taaatgcatt attaccattg cttacatttt gggggatttt
     4621 cttcctcctc aaaacttcca tttctattgt aatattctta atgacaatct tttttttttt
     4681 ttagcagtgt atgtttgaaa cagccaaaga tggcgatgaa ccaagtgtaa attgatctaa
     4741 gcagcccatg cagtttgtgt tgaatcaaca aacagtgtat tgttgaagtg aaattatttt
     4801 ctgaaatgac ttgttagacc agttttgagg acatactcaa aagtagagta ataatggctc
     4861 ctgggatgga gaaatatgag atgaacctgg aacattctat tatggtgcca caaaggaaat
     4921 ctaaaaaaaa aaaaaaaaaa aaaagtggtt ggctaggagc agtggcacac gcctgtgatt
     4981 ccagcacttt gggaggccga agtgggcagg agttcaagac cagcctggcc aacatagtga
     5041 aaccctgtct ctactaaaaa tacaaaaatt agccgggtgt ggtggcgggc gcctgtaatc
     5101 ccagcttttc aagaggctga ggcagaagaa tcgcttgaac ccgggagatg gaggttgcag
     5161 tgagctgaga tcgtgccact gcactccagc ctgggcgttg cagtgagact ccgtctcaac
     5221 aacaacaaaa aggtggatac atgtcaaaag ggcacaggag ccacttgaag gattatactt
     5281 gctaaatctg tgtcaattat caaaataaac tggtagcaac gtta
//
