LOCUS       NM_198123              13052 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens CUB and Sushi multiple domains 3 (CSMD3), transcript
            variant a, mRNA.
ACCESSION   NM_198123
VERSION     NM_198123.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13052)
  AUTHORS   Wang,H., St Julien,K.R., Stevenson,D.K., Hoffmann,T.J., Witte,J.S.,
            Lazzeroni,L.C., Krasnow,M.A., Quaintance,C.C., Oehlert,J.W.,
            Jelliffe-Pawlowski,L.L., Gould,J.B., Shaw,G.M. and O'Brodovich,H.M.
  TITLE     A genome-wide association study (GWAS) for bronchopulmonary
            dysplasia
  JOURNAL   Pediatrics 132 (2), 290-297 (2013)
   PUBMED   23897914
REFERENCE   2  (bases 1 to 13052)
  AUTHORS   Divaris,K., Monda,K.L., North,K.E., Olshan,A.F., Lange,E.M.,
            Moss,K., Barros,S.P., Beck,J.D. and Offenbacher,S.
  TITLE     Genome-wide association study of periodontal pathogen colonization
  JOURNAL   J Dent Res 91 (7 Suppl), 21S-28S (2012)
   PUBMED   22699663
REFERENCE   3  (bases 1 to 13052)
  AUTHORS   Service,S.K., Verweij,K.J., Lahti,J., Congdon,E., Ekelund,J.,
            Hintsanen,M., Raikkonen,K., Lehtimaki,T., Kahonen,M., Widen,E.,
            Taanila,A., Veijola,J., Heath,A.C., Madden,P.A., Montgomery,G.W.,
            Sabatti,C., Jarvelin,M.R., Palotie,A., Raitakari,O., Viikari,J.,
            Martin,N.G., Eriksson,J.G., Keltikangas-Jarvinen,L., Wray,N.R. and
            Freimer,N.B.
  TITLE     A genome-wide meta-analysis of association studies of Cloninger's
            Temperament Scales
  JOURNAL   Transl Psychiatry 2 (5), e116 (2012)
   PUBMED   22832960
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 13052)
  AUTHORS   Gylfe,A.E., Sirkia,J., Ahlsten,M., Jarvinen,H., Mecklin,J.P.,
            Karhu,A. and Aaltonen,L.A.
  TITLE     Somatic mutations and germline sequence variants in patients with
            familial colorectal cancer
  JOURNAL   Int J Cancer 127 (12), 2974-2980 (2010)
   PUBMED   21351276
  REMARK    GeneRIF: Nonsynonymous variants of CSMD3 is associated with
            familial colorectal cancer.
REFERENCE   5  (bases 1 to 13052)
  AUTHORS   Beuten,J., Gelfond,J.A., Martinez-Fierro,M.L., Weldon,K.S.,
            Crandall,A.C., Rojas-Martinez,A., Thompson,I.M. and Leach,R.J.
  TITLE     Association of chromosome 8q variants with prostate cancer risk in
            Caucasian and Hispanic men
  JOURNAL   Carcinogenesis 30 (8), 1372-1379 (2009)
   PUBMED   19528667
  REMARK    GeneRIF: Single-nucleotide polymorphisms in CSMD3 is associated
            with prostate cancer risk in hispanic men.
REFERENCE   6  (bases 1 to 13052)
  AUTHORS   Floris,C., Rassu,S., Boccone,L., Gasperini,D., Cao,A. and
            Crisponi,L.
  TITLE     Two patients with balanced translocations and autistic disorder:
            CSMD3 as a candidate gene for autism found in their common 8q23
            breakpoint area
  JOURNAL   Eur J Hum Genet 16 (6), 696-704 (2008)
   PUBMED   18270536
  REMARK    GeneRIF: Breakpoints on chromosomes 8 in both patients do not
            interrupt any known gene but both map in a region containing the
            CSMD3 gene, which thereby can be considered as a candidate for
            autistic spectrum disorders
REFERENCE   7  (bases 1 to 13052)
  AUTHORS   Riedl,S., Giedion,A., Schweitzer,K., Mullner-Eidenbock,A.,
            Grill,F., Frisch,H. and Ludecke,H.J.
  TITLE     Pronounced short stature in a girl with tricho-rhino-phalangeal
            syndrome II (TRPS II, Langer-Giedion syndrome) and growth hormone
            deficiency
  JOURNAL   Am J Med Genet A 131 (2), 200-203 (2004)
   PUBMED   15523607
  REMARK    GeneRIF: CSMD3 is deleted in a subject with combined
            tricho-rhino-phalangeal syndrome II with mental retardation and
            growth hormone deficiency.
REFERENCE   8  (bases 1 to 13052)
  AUTHORS   Shimizu,A., Asakawa,S., Sasaki,T., Yamazaki,S., Yamagata,H.,
            Kudoh,J., Minoshima,S., Kondo,I. and Shimizu,N.
  TITLE     A novel giant gene CSMD3 encoding a protein with CUB and sushi
            multiple domains: a candidate gene for benign adult familial
            myoclonic epilepsy on human chromosome 8q23.3-q24.1
  JOURNAL   Biochem Biophys Res Commun 309 (1), 143-154 (2003)
   PUBMED   12943675
  REMARK    GeneRIF: CSMD3 encodes a protein with CUB and sushi multiple
            domains and is a candidate gene for benign adult familial myoclonic
            epilepsy on human chromosome 8q23.3-q24.1
REFERENCE   9  (bases 1 to 13052)
  AUTHORS   Lau,W.L. and Scholnick,S.B.
  TITLE     Identification of two new members of the CSMD gene family
  JOURNAL   Genomics 82 (3), 412-415 (2003)
   PUBMED   12906867
  REMARK    GeneRIF: CSMD3 protein domain structure and the sequence of the
            cytoplasmic tail are highly conserved between mammals and fish.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB114604.1, AY210419.1 and AB114605.1.
            
            On Nov 23, 2018 this sequence version replaced NM_198123.1.
            
            Transcript Variant: This variant (a) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB114604.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297405.10/ ENSP00000297405.5
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10945             AB114604.1         75-11019
            10946-13048         AY210419.1         10384-12486
            13049-13052         AB114605.1         13013-13016
FEATURES             Location/Qualifiers
     source          1..13052
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q23.3"
     gene            1..13052
                     /gene="CSMD3"
                     /note="CUB and Sushi multiple domains 3"
                     /db_xref="GeneID:114788"
                     /db_xref="HGNC:HGNC:19291"
                     /db_xref="MIM:608399"
     exon            1..263
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..11209
                     /gene="CSMD3"
                     /note="isoform 1 is encoded by transcript variant a; CUB
                     and sushi domain-containing protein 3; CUB and sushi
                     multiple domains protein 3"
                     /codon_start=1
                     /product="CUB and sushi domain-containing protein 3
                     isoform 1"
                     /protein_id="NP_937756.1"
                     /db_xref="CCDS:CCDS6315.1"
                     /db_xref="GeneID:114788"
                     /db_xref="HGNC:HGNC:19291"
                     /db_xref="MIM:608399"
                     /translation="MKGIRKGESRAKESKPWEPGKRRCAKCGRLDFILMKKMGIKSGF
                     TFWNLVFLLTVSCVKGFIYTCGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNR
                     IQIVFQSFALEEEYDYLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFA
                     VSAHGFKVYYEELQSSSCGNPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTC
                     IANSVNTASWDFPVPICRAEDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPG
                     DTISLIFTDFQMEEKYDYLEIEGSEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHR
                     YRGFSAPYQGSSTLTHTTSTGELEEHNRTTTGAIAVASTPADVTVSSVTAVTIHRLSE
                     EQRVQVTSLRNSGLDPNTSKDGLSPHPADTQSTRRRPRHAEQIERTKELAVVTHRVKK
                     AIDFKSRGFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLGSTV
                     QFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPF
                     QYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGGEVGDPRTVLQVLTGS
                     FVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESCGDPGTPLYGIREGDGFSN
                     RDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEG
                     YGNNLNCIWTIISDPGSRIHLSFNDFDLESQFDFLAVKDGDSPESPILGTFTGAEVPS
                     HLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIPINARRFGDNFQLGSSI
                     SVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGY
                     YKDSLNCEWVIEAEPGHSIKITFERFQTELNYDVLEVHDGPNLLSPLLGSYNGTQVPQ
                     FLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPGIPVHGRRYGHDFSIGS
                     TVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGYPEFYP
                     NSLNCTWTVDVTHGKGVQFNFHTFHLEDHHDYLLITENGSFTQPLARLTGSDLPPTIN
                     AGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPCEDPGIPQYGSRIGFNFGIGDTL
                     TFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECGASATNNEGILLSPNYPLNYE
                     NNHECIYSIQVQAGKGINISARTFHLAQGDVLKIYDGKDKTTHLLGAFTGASMRGLTL
                     SSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSHCEDPGIPQFGYKISDQGHFAGSTII
                     YGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYPFPYD
                     NNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVWDGPPENDMLLKEISGSLIPEGI
                     HSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNGDGREPGDTVVF
                     QCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPCGGNLTGSSGFILSPNFPHPYPH
                     SRDCDWTITVNADYVISLAFISFSIEPNYDFLYIYDGPDSNSPLIGSFQDSKLPERIE
                     SSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESCFDPGNIMNGTRLGMDYKLGSTVTYY
                     CDAGYVLQGYSTLTCIMGDDGRPGWNRALPSCHAPCGSRSTGSEGTVLSPNYPKNYSV
                     GHNCVYSIAVPKEFVVFGQFVFFQTSLHDVVEVYDGPTQQSSLLSSLSGSHSGESLPL
                     SSGNQITIRFTSVGPITAKGFHFVYQAVPRTSSTQCSSVPEPRFGRRIGNEFAVGSSV
                     LFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPCGGILTKRKGTILSPGYPEP
                     YDNNLNCVWKITVPEGAGIQVQVVSFATEHNWDSLDFYDGGDNNAPRLGSYSGTTIPH
                     LLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLDSCPEPQTPSSGIKIGDRYMVGDVV
                     SFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQCGGAMSDFSGVILSPGFPGNYP
                     SSLDCTWTINLPIGFGVHLQFVNFSTETIHDYLEVRSGSSETSTVIGRLSGPQIPSSL
                     FSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSCPDPRPFRNGFVIGNDFTVGQTISF
                     ECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCGGNITAMNGTIYSPGYPDEYPNF
                     QDCFWLVRVPPGNGIYINFTVLQTEPIYDFITVWDGPDQNSPQIGQFSGNTALESVYS
                     TSNQILIKFHSDFTTSGFFVLSYHAYQLRVCQPPPPVPNAEILTEDDEFEIGDIIRYQ
                     CLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLCPANELRLDSTGVILSPGYPDSYPN
                     LQMCAWSISVEKGYNITMFVEFFQTEKEFDVLQVYDGPNIQSPVLISLSGDYSSAFNI
                     TSNGHEVFLQWSADHGNNKKGFRIRYIAFYCSTPESPPHGYIISQTGGQLNSVVRWAC
                     DRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTDYLVGTRV
                     TYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWRIVNG
                     SHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYCQIISCGELPTPPNGNK
                     IGTQTSYGSTAIFTCDLGFMLVGSAVRECLSSGLWSESETRCLAGHCGIPELIVNGQV
                     IGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRT
                     SGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKR
                     ESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECIMIDCGHPGVPP
                     NAVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHWSGSQPHCSGDATGTCGDPG
                     TPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQPECKAVQCGNPG
                     TTANGKVFRIDGTTFSSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTIISCGDP
                     GIPANGLRYGDDYVVGQNVSYMCQPGYTMELNGSRIRTCTINGTWSGVMPTCRAVTCP
                     TPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGTWSGEVPQCLPKFCG
                     DPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEPTQT
                     SCENPGVPRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTWSGIQPECIP
                     HSCKQPETPAHANVVGMDLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKVPIC
                     EAGSKILVKDPRPALGTPSPKLSVPDDVFAQNYIWKGSYNFKGRKQPMTLTVTSFNAS
                     TGRVNATLSNSNMELLLSGVYKSQEARLMLRIYLIKVPAHASVKKMKEENWAMDGFVS
                     AEPDGATYVFQGFIQGKDYGQFGLQRLGLNMSEGSNSSNQPHGTNSSSVAIAILVPFF
                     ALIFAGFGFYLYKQRTAPKTQYTGCSVHENNNGQAAFENPMYDTNAKSVEGKAVRFDP
                     NLNTVCTMV"
     exon            264..486
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            487..599
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            600..794
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            795..1002
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1115
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1427
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1505
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1593
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1718
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1840
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1944
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2057
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2240
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2567
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2762
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            2763..2901
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..3089
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            3090..3278
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            3279..3395
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            3396..3611
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            3612..3800
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            3801..3970
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            3971..4127
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            4128..4319
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            4320..4446
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            4447..4649
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            4650..4841
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            4842..4980
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            4981..5168
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            5169..5363
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            5364..5480
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            5481..5594
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            5595..5690
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            5691..5894
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            5895..6019
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            6020..6116
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            6117..6221
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            6222..6340
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            6341..6410
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            6411..6527
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            6528..6737
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            6738..6926
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            6927..7104
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            7105..7250
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            7251..7331
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            7332..7445
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            7446..7634
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            7635..7781
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            7782..7970
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            7971..8156
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            8157..8351
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            8352..8525
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            8526..8699
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            8700..8873
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            8874..9059
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            9060..9233
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            9234..9416
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            9417..9593
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            9594..9773
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            9774..9947
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            9948..10121
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            10122..10195
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            10196..10307
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            10308..10487
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            10488..10553
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            10554..10712
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            10713..10825
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            10826..10913
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            10914..11049
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     exon            11050..13052
                     /gene="CSMD3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      13024..13029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSMD3"
                     /note="hexamer: AATAAA"
     polyA_site      13052
                     /gene="CSMD3"
                     /note="major polyA site"
ORIGIN      
        1 actccgagct gtgaccgcgc accaacaaca gcaacaactc cactgcgccg ggctgaggag
       61 caggaattag gagctcgcga ataatatgaa agggatccgc aaaggggaaa gccgagcaaa
      121 ggaatccaaa ccctgggagc ctggcaagcg aagatgcgct aaatgtggcc gcctagactt
      181 catcctgatg aagaaaatgg ggattaaaag tggatttacg ttttggaacc tcgtcttttt
      241 attgacggtg tcttgtgtga aaggatttat ttatacatgt ggtggaactt taaaaggact
      301 taatggcact atagaaagcc ctggttttcc atatggatat ccaaatggtg caaactgcac
      361 atgggtaata atagcagaag aacgaaatag aatacaaatt gtttttcagt catttgctct
      421 agaagaagaa tacgactact tatcattata tgatggacat cctcatccta caaactttag
      481 gacaaggtta acaggattcc atctgccacc tccagtgaca agtaccaaat ctgtgttctc
      541 actacgtttg accagtgatt ttgcagttag tgctcatgga tttaaggtat attacgaaga
      601 attgcagagt agctcttgtg gaaatcctgg tgttccaccc aaaggtgtat tatatggcac
      661 aagattcgac gtcggggaca agatccgcta cagctgtgta actggataca tccttgatgg
      721 ccaccctcag ctcacctgca tagccaattc agttaataca gcttcgtggg attttcctgt
      781 tcctatctgt agagctgaag atgcttgtgg aggaacaatg agaggatcca gtggcatcat
      841 atccagccct agttttccta atgagtacca taacaatgct gattgcactt ggaccattgt
      901 agcagagcct ggggacacaa tttcactcat atttactgat tttcaaatgg aagagaaata
      961 tgattactta gaaatagaag gttctgagcc acctaccata tggttatctg gaatgaatat
     1021 accaccacca attatcagca acaaaaactg gctcagactg cattttgtta cagacagcaa
     1081 tcatcgatac cgtggattta gtgctcccta tcaaggttct tctacattga cccacactac
     1141 ctccactggt gagttagagg agcataacag gactaccact ggtgctattg ctgttgctag
     1201 cacacctgca gatgttactg tatccagtgt tacagctgtc accatccata gactttccga
     1261 ggaacagcga gtgcaagtta cgagtctcag aaattcaggt ctggacccca acacgtccaa
     1321 ggacgggctc tctcctcatc cagcagatac acaaagtacc aggagaagac caagacatgc
     1381 tgaacagata gaaagaacta aagagcttgc agttgttact catagagtga aaaaggccat
     1441 agattttaaa tctagaggat ttaaattgtt tccagggaaa gacaacagca acaagttttc
     1501 tatcttaaat gagggaggta ttaaaacagc ttccaattta tgcccagatc caggagaacc
     1561 agaaaatggg aagagaatcg gatcagattt tagccttgga tcaactgtgc agttctcttg
     1621 tgatgaagat tatgtcctac agggcgcaaa gagcatcacc tgtcaacgga tagctgaagt
     1681 ttttgctgct tggagtgatc acaggcctgt gtgtaaagtg aaaacgtgtg gctctaatct
     1741 tcaaggacca agtggtacct ttacatctcc caactttccg ttccagtatg acagcaatgc
     1801 acaatgtgtc tgggtcatca cagcagtgaa tacaaataag gttatccaga taaattttga
     1861 agaatttgat ctggagattg gctatgatac cttgacaatt ggcgatgggg gcgaagttgg
     1921 agatcctagg acagtgctcc aagtgctgac tggaagcttt gtaccagact tgatagtgag
     1981 catgagtagc caaatgtggc tgcaccttca aacggacgaa agtgttggat ctgttggttt
     2041 caaggttaac tacaaagaaa ttgagaaaga aagttgtggt gatcctggta cacccttata
     2101 tggaattaga gaaggcgatg gattttctaa tcgtgatgtt ttaaggtttg aatgccagtt
     2161 tgggtttgaa ttaattggag agaaatccat tgtttgtcaa gagaataacc aatggtctgc
     2221 aaacataccc atctgtatct ttccctgcct gtctaacttt actgcaccaa tgggaacagt
     2281 tctttctcct gattacccag aagggtatgg aaataattta aattgcatct ggacgataat
     2341 ctctgatcca gggagccgga tacatctttc tttcaatgac tttgacctgg aatcccagtt
     2401 tgatttcctt gctgttaaag atggtgactc tccagaatcc ccaattcttg gaacctttac
     2461 tggggctgag gtgccttccc atcttactag taatagtcac atactgcgat tggaatttca
     2521 ggctgaccac tcaatgtcag gacgtggctt taacatcact tacaacacat ttggacataa
     2581 tgaatgccct gatcctggaa taccaatcaa tgcacggcgg tttggggaca actttcaatt
     2641 aggaagttca atttcagtta tttgtgaaga aggatttatt aaaacccagg gaacagaaac
     2701 aattacatgt attcttatgg atggaaaagt aatgtggagt ggactgattc caaaatgtgg
     2761 agccccatgt ggtggccatt tttcagctcc cagtggagtg attctctcac caggatggcc
     2821 aggatactac aaagactctt tgaattgtga gtgggtgatt gaagctgaac ctggacactc
     2881 tatcaaaatt acatttgaaa gatttcagac tgaactgaat tatgatgttc tggaagttca
     2941 tgatgggcca aatcttctgt cacccttgct tggatcttac aatggcaccc aagtgcccca
     3001 gtttctattt agtagcagta attttatata ccttctattt acaacagaca acagtcgttc
     3061 caataatggt ttcaagattc attatgaaag tgttacagtg aacacgtatt cttgtttgga
     3121 ccctggcata cctgtacatg gccgtcgcta tggtcatgat ttctccattg gctctactgt
     3181 ttcatttagt tgtgattcag gatacaggtt gagtcatgaa gagccccttc tatgcgaaaa
     3241 aaaccactgg tggagtcatc cacttccaac ctgtgatgca ttatgtggag gagatgttag
     3301 agggcctagt ggaacaatct tatcacctgg ttacccggaa ttttatccaa attctctgaa
     3361 ttgtacatgg actgttgatg taacccatgg aaaaggtgtg cagttcaact tccacacttt
     3421 tcatttggaa gaccatcatg actacttact gatcacagag aatggcagtt ttacccaacc
     3481 actggcacgc ctgactggtt cagatcttcc tccaacaatc aatgctggtc tctatggaaa
     3541 tttcagggct caattgcgtt tcatttcaga tttttcaata tcatatgaag gatttaacat
     3601 aacattctct gaatataacc ttgaaccttg tgaagatcct ggcattcctc aatatggtag
     3661 tcgaatcggg ttcaactttg ggattggtga cactctgacc ttctcatgct cttcgggtta
     3721 tcgactggaa ggaacatcag agatcatctg tcttggtggt ggccgacgag tgtggagtgc
     3781 acctctgcca aggtgtgtgg ctgaatgtgg tgcatctgca acgaataatg aaggaatttt
     3841 gctgtctcca aattatccac tcaactatga aaacaaccat gaatgcattt atagtattca
     3901 ggttcaagca ggaaagggaa tcaatatttc agccagaaca tttcatttag cacaaggaga
     3961 tgttcttaag atttatgatg gaaaagataa aacgactcat ctactaggtg cttttactgg
     4021 tgcatctatg cgcggactga cacttagtag tacttcaaat caactctggc tagaatttaa
     4081 ttccgatact gaagggacag atgaaggctt tcaacttgtg tataccagtt ttgaactctc
     4141 acactgtgaa gatcctggca ttccacaatt tggatacaag atcagtgacc aaggccactt
     4201 tgctggtagc accatcattt atggatgcaa tccaggctac actctccacg gaagtagcct
     4261 tctcaagtgc atgacagggg agagaagggc atgggactat cctctgcctt cctgtattgc
     4321 tgaatgtgga ggtcgtttta aaggagaatc atcaggaaga atcttatctc ctggctatcc
     4381 ttttccatat gacaataacc tgcgttgcat gtggatgatt gaggtagatc ctggaaatat
     4441 tgtcagcttg cagtttcttg cttttgatac ggaagcatca catgatatac tccgagtctg
     4501 ggacggtcca ccagaaaatg atatgctttt aaaggaaatt agtggatctc ttattcctga
     4561 aggaattcat agcaccctca atatagtaac catccagttt gacacggatt tttatattag
     4621 caaatctgga tttgcaattc agttttcaag ttctgttgcc actgcgtgtc gtgacccagg
     4681 ggtccccatg aatgggactc gaaatgggga tggaagagaa cctggggaca ctgttgtttt
     4741 tcaatgtgac ccaggatatg aacttcaagg agaggaaaga ataacctgca ttcaggtaga
     4801 aaatcggtac ttctggcagc ccagcccacc agtctgtata gcaccctgtg gaggcaattt
     4861 aacaggatct tcaggcttta ttctttcacc aaacttccct catccatatc cgcatagcag
     4921 agactgtgac tggactatca ccgtcaatgc agactatgtt atctccttgg cgttcatcag
     4981 ttttagcata gaaccaaact atgacttcct ctatatctat gatggaccag acagtaatag
     5041 cccactgatt ggaagttttc aagacagcaa gttaccagag agaatagaaa gcagctcaaa
     5101 tacaatgcat ttggcttttc ggagtgatgg atctgttagt tacactggat ttcatctaga
     5161 atacaaagca aaactgcgag agtcctgctt tgatccaggc aatataatga atggcaccag
     5221 acttggaatg gattataaat tagggtcaac agtcacctat tactgtgatg ctggttatgt
     5281 tcttcaaggt tattcaacac tcacctgtat catgggagat gatggaagac ctggatggaa
     5341 tagagccttg ccaagttgtc atgcgccctg tggaagtcgt tcaacaggtt cagaaggcac
     5401 tgttctatca ccaaactatc caaaaaatta cagtgtggga cataattgtg tttattctat
     5461 agcagttcca aaggagtttg tggtgtttgg ccagtttgta tttttccaga catcactcca
     5521 cgatgttgtt gaggtgtatg atgggccaac tcagcaatct tctctgttat cttccctctc
     5581 aggatcccat tcaggagaat cacttccact gagttcaggt aatcagatca caattcgatt
     5641 tacttcagtt ggaccaataa cagctaaggg atttcacttt gtttaccaag ctgttcctag
     5701 aacaagttct acacaatgca gttctgtgcc tgaaccaaga ttcggaagaa gaattggcaa
     5761 tgaatttgca gtcggttcat cggttctttt tgattgtaat ccaggatata ttctccatgg
     5821 atccatagca attaggtgtg aaacagtgcc caattctttg gcccagtgga atgattcctt
     5881 acctacttgt attgtgccct gtggtggaat tttaactaag cgcaaaggga ctattttgtc
     5941 acctggatac cctgagcctt atgacaacaa tctgaattgt gtgtggaaga tcacagtgcc
     6001 agagggagct ggcattcaag tgcaagttgt tagctttgct acagaacata attgggattc
     6061 tctggacttt tatgatgggg gagacaacaa tgctccaaga cttggaagct attcaggaac
     6121 aacaataccc catcttttga atagtacgtc taataatctg tatctaaatt ttcaatcaga
     6181 catcagtgtt tctgctgcag gatttcatct tgaatacaca gcaattggtt tggattcctg
     6241 tcctgaacca caaactccta gcagtggaat taaaattgga gacagatata tggttggaga
     6301 tgtagtatcc tttcagtgtg atcaaggata ttctcttcag ggtcactctc acattacatg
     6361 tatgccagga cctgtaagaa gatggaatta tccaatccca atttgtttag ctcagtgtgg
     6421 tggtgctatg tcagacttca gtggtgtgat cctcagtcct gggtttcctg gaaactatcc
     6481 cagcagttta gattgcacat ggacaataaa tctacccata ggttttggtg tacatctcca
     6541 gtttgtaaat ttttctacag aaaccataca tgattatttg gaagtacgaa gtggatcctc
     6601 agaaactagt actgttattg gccggcttag tggtcctcaa ataccatctt ccttattcag
     6661 caccacccat gaaaccagct tatattttca cagtgactat tcacaaaaca aacaagggtt
     6721 tcatattgta taccaagcct atcagttgca aagctgtcct gatccacgcc cgtttcgaaa
     6781 tggttttgta attggtaatg attttactgt gggtcaaacc atttcatttg aatgtttccc
     6841 aggatacaca ttaattggaa attcagctct cacatgcctt cacggagtca gtcgtaattg
     6901 gaatcatcca cttccaaggt gtgaagctct ttgtggtggg aatataactg caatgaatgg
     6961 caccatttat tctcctgggt atcctgatga atatccaaac tttcaagatt gtttttggct
     7021 tgtaagagta ccccctggga atggcatcta catcaatttt actgtccttc aaacagaacc
     7081 aatatatgat ttcattactg tatgggatgg accagaccaa aattcacctc agatcggtca
     7141 gttcagtggc aataccgctt tggaatcagt ctacagtact tcaaatcaga ttctaatcaa
     7201 attccacagt gatttcacaa caagtggctt ttttgtgctc agttatcacg cctatcaact
     7261 aagggtgtgc caacctccac cacctgtgcc caatgctgaa attttgacgg aagatgatga
     7321 atttgaaata ggtgatatta ttaggtatca gtgtcttcca ggatttactt tagttggtaa
     7381 tgcaattctg acgtgcagat taggagaacg actgcagatg gatggagcac ctccagtttg
     7441 tcaagtgctc tgtcctgcca atgaattacg gctagattct actggagtca tattgagccc
     7501 tggatatcct gacagttacc caaatcttca aatgtgtgca tggagcattt cagtggaaaa
     7561 gggttataat atcaccatgt ttgtagaatt cttccagaca gaaaaggaat ttgatgttct
     7621 tcaggtgtat gatggaccaa atattcaaag tccagtgctt atttccctca gtggggatta
     7681 ttcatctgct tttaatataa caagcaatgg tcatgaagta tttcttcagt ggtcagcaga
     7741 tcatggcaat aacaaaaaag gcttccggat aagatatata gctttctact gtagtacacc
     7801 agaatcccca cctcatggat atattatcag tcagacaggt gggcagctta acagtgtggt
     7861 ccgttgggcc tgtgatcgag gattccgact tgttggaaaa agcagtgctg tgtgcagaaa
     7921 gtcttcctat gggtatcatg catgggatgc gccagtccct gcctgtcaag caatttcctg
     7981 tgggattcct aaagctccaa caaatggagg aatactaaca acagactatt tggtaggaac
     8041 gcgagttacc tatttttgta atgatggata tcgattgtca tccaaagaac tcactacagc
     8101 tgtatgccaa tcagatggaa catggagcaa tcataacaag acccctcgct gtgttgttgt
     8161 tacatgtcca agcatcaatt cctttatctt ggaacatgga agatggcgaa ttgtgaatgg
     8221 ctcccattat gaatacaaaa ccaaagtagt tttcagctgt gaccctggtt atcatggact
     8281 aggtcctgcc tccatcgaat gtcttcctaa tggtacttgg agttggagaa atgaaagacc
     8341 atattgccaa attatttcct gtggagaact acctacacct ccaaatggaa ataagattgg
     8401 aactcaaact tcatatggct caacagctat ctttacctgc gacttgggat tcatgcttgt
     8461 gggctctgct gtaagggaat gcctttcctc aggtctttgg agtgaatctg aaaccagatg
     8521 cctagcgggt cattgtggaa ttccagaact gattgtgaat ggtcaagtca ttggagaaaa
     8581 ttatggatat agagacacag ttgtatatca atgtaatcct ggttttcgat tgattggttc
     8641 ttcagtgagg atatgtcaac aggatcacaa ttggtctggt cagctcccat cctgtgtgcc
     8701 tgttagctgt ggtcaccctg gtagtccaat ttatggaaga acaagtggaa atgggttcaa
     8761 ctttaatgat gtggtaacat tctcatgcaa tattgggtat cttatgcaag ggccaacaaa
     8821 ggcacagtgc caggccaaca gacagtggag ccatcctcca cctatgtgca aagtggtcaa
     8881 ctgttctgat cctggaattc cagccaattc taaaagagaa agtaaaatag aacatggaaa
     8941 ttttacttac ggcactgtgg tattctatga ctgcaatcct ggatattttt tatttggatc
     9001 ttcagttttg atatgtcaac caaatggaca atgggacaaa cctttaccag aatgtatcat
     9061 gattgactgt ggacaccctg gcgttcctcc taatgcagtc ctgtctggcg agaagtatac
     9121 ttttgggtct actgttcact attcctgcac aggaaagcgt tcccttttag gccagtcatc
     9181 aagaacctgc caattgaatg gccattggag tggatcacaa cctcattgtt caggtgatgc
     9241 tactgggaca tgtggcgatc caggtactcc cggccatggc tctagacagg aaagcaattt
     9301 cagaactaaa agtactgtac gttatgcttg tgatactggt tacatccttc atggctcaga
     9361 agaaagaaca tgtttagcta atggcagttg gaccggaagg cagccagagt gcaaagctgt
     9421 gcagtgtggt aacccaggaa ccacagccaa tgggaaagtc ttccgaattg atggcacaac
     9481 attttctagt tcagtcattt attcctgcat ggagggatac atcctttctg gaccttcagt
     9541 tagacagtgc acagccaatg gaacatggtc tggaacttta cctaactgta caataatcag
     9601 ttgtggagac ccaggtatac cagccaatgg actgagatat ggagatgatt atgtggttgg
     9661 acaaaatgtt tcttacatgt gccagccagg ctacacgatg gaattgaatg gctccagaat
     9721 caggacttgt acaattaatg gcacatggag tggagtaatg ccaacttgta gagctgttac
     9781 ctgcccaact cctccccaga tctctaatgg aaggctggaa ggaacaaatt tcgactgggg
     9841 ctttagtatt agctacatct gttctccagg ctatgagcta tccttccctg ctgttttgac
     9901 ctgtgtaggg aatggtacct ggagtggtga agtaccgcag tgcttaccaa agttttgtgg
     9961 tgaccctggt atacctgccc aaggaaaaag agaaggcaaa agctttatat accagtcaga
    10021 ggtttcattc agctgcaatt ttcctttcat attagtggga tcaagcacca gaatatgtca
    10081 agcagatggc acttggagtg gttcatcacc tcactgcata gagcctaccc aaacctcttg
    10141 tgaaaaccca ggtgtgcctc ggcatggatc tcagaacaat acattcggat ttcaagtagg
    10201 aagtgttgta cagttccatt gcaaaaaagg acaccttctc caagggtcta caacacgcac
    10261 ctgcctccct gatcttacgt ggagtgggat tcagcctgaa tgcatacccc acagctgtaa
    10321 acagccagaa actcctgctc atgcaaatgt cgtagggatg gaccttccat ctcatgggta
    10381 tacactgatt tatacctgtc agcctggctt cttcttagca ggtggaacag aacatagagt
    10441 gtgtagatcc gataacacct ggactggaaa agttcccatt tgtgaagctg gttctaaaat
    10501 attggtgaaa gatcctagac ctgcactggg aacacccagc ccaaagctaa gtgttcctga
    10561 tgatgtattt gcccaaaatt atatatggaa aggctcttac aatttcaaag gaaggaaaca
    10621 acccatgacc ttaacagtta ctagtttcaa tgcttccact gggagagtta acgcaacact
    10681 gagcaatagc aacatggagc tgctactttc aggggtatat aaaagccagg aagctcgcct
    10741 aatgttacgc atatatctta ttaaagtacc tgctcatgct tctgtgaaga aaatgaagga
    10801 agaaaattgg gcaatggatg gctttgtttc tgctgagcct gatggagcta cttatgtatt
    10861 tcaaggattt attcaaggca aagattatgg acaatttggc ctacaaagac tgggactgaa
    10921 tatgtcagaa ggttcaaatt cttcaaatca acctcatggt acaaatagta gttctgtagc
    10981 cattgctatt cttgtgcctt tttttgcact tatatttgca ggatttggat tttatcttta
    11041 taaacaaagg actgcaccta aaacacagta tacaggatgt tcagttcatg aaaataacaa
    11101 tggccaagca gcttttgaaa atcccatgta tgacaccaac gcaaagtcag tggaagggaa
    11161 ggcggtacga tttgatccca acttgaacac ggtttgcaca atggtataac gaggcaacct
    11221 ttgccttctt cagaagcttg gaaatcgaca cacaaaacag tgcacattta gttcactgct
    11281 aaacaaatta aagcacactt ttcaggactt gctgggtcac cttttcctga ggaatgatac
    11341 agaagagtgt tttttcataa actggaccat aattcttcat gtttaccatg gagagtttta
    11401 cagaaatttg gctgcactct gagagtgctt actcacagtt tatttgcttt ttttaaaaag
    11461 gagattattc taaaatataa acttatttgc atatattgga ggagcatcca ctatcagtat
    11521 ttctgtgctt tataaactat attagaggga ctgggtttaa aaaaaaagat atagggtaga
    11581 aataagagct atacttacaa gagtcaatag atcactgact tctctttaac tgtcctgagc
    11641 tacatcacgc ccacaaatct gtctttcata ccactctatc tgccattcat tcttgttaaa
    11701 tgaggcattg ttttctttat ttaagattga gttatgactt taaatgttta tgagctagtt
    11761 tatgcctcgg aagacataag gtttcccatt ccaatttgaa tctttctatt tctttagcat
    11821 catattgctc ttcttctttt agactggttg tcatagtttc tgcaaagggc aagttcattg
    11881 tgctaccctc ccaattcccc cattatggag taaccagtat tattcagtga gctatggggt
    11941 agtgtttcac tccttgcttc aatatggttt tttcctattt atttttatta ttttttaatc
    12001 ccaaatgtga tagtagcttc agtatgtttc ctcacccaaa aaccatttgg ctggcagaaa
    12061 ttatctagaa aaattattat tttgcagtta tctgagacac caaacttacc atcctttatt
    12121 ttacaatatt tttgatcgac caaataaaat gtcctaataa tctactctat ttatatctac
    12181 atttccttcc agctgagtct tcaaatttag cattattttg acacttttaa ttttcattta
    12241 acaatggatt agaaaaatat tttggtctag ccactaaaca taatgactga aaaaaattat
    12301 tattataaat caccaatata aatttattgc ctacaattgt ggacttatca tatttttata
    12361 tatttttaaa tttctgtacc tttattgtta aacaccaagt ttcacataca agaggtttct
    12421 ttcattgtca aattaagata tgtatttgta agttattggt ggctcattta aactgtatca
    12481 tacagtaatg ccagcatttt tatttaatag gtcatcgtct tccttttata gctgttttac
    12541 ttcattgaat acgatcatgt acccagtgtt aactctttgt tgttgtccct ttcaaatatg
    12601 gataactctg tgaacagtct tgactttttg tatcatgaga cagagtgcct aagagaaacc
    12661 cttgcacctg ggagcgctgc ttggctctat ctctacaaca tttaatgaat ttcttgtaaa
    12721 ccactttgag atacattgtt ttggaaattc atacaatttt ctcaacatgg tactctactg
    12781 gcaggatgca gttttaaatt ttatgccatc agttatttat tcttgtttat tcaaatgact
    12841 gcaataacaa tgattcattc attaatgtta aggctaatac atttaagatc ttgtttaaac
    12901 aatgtttctt ctgcaactgg ctactcctct tatattaatg catacacttt tgtaaagaag
    12961 tatattttta tgaaaagaaa ctttgtaaaa gtatgatgta aattttcagt gcaatgtaaa
    13021 caaaataaaa atggataatt gcttttgtaa aa
//
