LOCUS       NM_001317                821 bp    mRNA    linear   PRI 27-APR-2025
DEFINITION  Homo sapiens chorionic somatomammotropin hormone 1 (CSH1), mRNA.
ACCESSION   NM_001317
VERSION     NM_001317.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 821)
  AUTHORS   Friedrich,C., Neugebauer,L., Zamora,M., Robles,J.P., Martinez de la
            Escalera,G., Clapp,C., Bertsch,T. and Triebel,J.
  TITLE     Plasmin generates vasoinhibin-like peptides by cleaving prolactin
            and placental lactogen
  JOURNAL   Mol Cell Endocrinol 538, 111471 (2021)
   PUBMED   34601001
  REMARK    GeneRIF: Plasmin generates vasoinhibin-like peptides by cleaving
            prolactin and placental lactogen.
REFERENCE   2  (bases 1 to 821)
  AUTHORS   Cattini,P.A., Jin,Y., Jarmasz,J.S., Noorjahan,N. and Bock,M.E.
  TITLE     Obesity and regulation of human placental lactogen production in
            pregnancy
  JOURNAL   J Neuroendocrinol 32 (11), e12859 (2020)
   PUBMED   32500948
  REMARK    GeneRIF: Obesity and regulation of human placental lactogen
            production in pregnancy.
            Review article
REFERENCE   3  (bases 1 to 821)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 821)
  AUTHORS   Prager,S., Wollmann,H.A., Mergenthaler,S., Mavany,M., Eggermann,K.,
            Ranke,M.B. and Eggermann,T.
  TITLE     Characterization of genomic variants in CSH1 and GH2, two candidate
            genes for Silver-Russell syndrome in 17q24-q25
  JOURNAL   Genet Test 7 (3), 259-263 (2003)
   PUBMED   14642004
  REMARK    GeneRIF: a role for CSH1 haploinsufficiency in the etiology of
            growth retardation
REFERENCE   5  (bases 1 to 821)
  AUTHORS   Selby,M.J., Barta,A., Baxter,J.D., Bell,G.I. and Eberhardt,N.L.
  TITLE     Analysis of a major human chorionic somatomammotropin gene.
            Evidence for two functional promoter elements
  JOURNAL   J Biol Chem 259 (21), 13131-13138 (1984)
   PUBMED   6208192
REFERENCE   6  (bases 1 to 821)
  AUTHORS   Roskam,W.G. and Rougeon,F.
  TITLE     Molecular cloning and nucleotide sequence of the human growth
            hormone structural gene
  JOURNAL   Nucleic Acids Res 7 (2), 305-320 (1979)
   PUBMED   386281
REFERENCE   7  (bases 1 to 821)
  AUTHORS   Martial,J.A., Hallewell,R.A., Baxter,J.D. and Goodman,H.M.
  TITLE     Human growth hormone: complementary DNA cloning and expression in
            bacteria
  JOURNAL   Science 205 (4406), 602-607 (1979)
   PUBMED   377496
REFERENCE   8  (bases 1 to 821)
  AUTHORS   Seeburg,P.H., Shine,J., Martial,J.A., Ullrich,A., Baxter,J.D. and
            Goodman,H.M.
  TITLE     Nucleotide sequence of part of the gene for human chorionic
            somatomammotropin: purification of DNA complementary to predominant
            mRNA species
  JOURNAL   Cell 12 (1), 157-165 (1977)
   PUBMED   71212
REFERENCE   9  (bases 1 to 821)
  AUTHORS   Li,C.H., Dixon,J.S. and Chung,D.
  TITLE     Amino acid sequence of human chorionic somatomammotropin
  JOURNAL   Arch Biochem Biophys 155 (1), 95-110 (1973)
   PUBMED   4712450
REFERENCE   10 (bases 1 to 821)
  AUTHORS   Sherwood,L.M., Handwerger,S., McLaurin,W.D. and Lanner,M.
  TITLE     Amino-acid sequence of human placental lactogen
  JOURNAL   Nat New Biol 233 (36), 59-61 (1971)
   PUBMED   5286363
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AU134786.2, BG436049.1 and
            BC020756.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001317.5.
            
            Summary: The protein encoded by this gene is a member of the
            somatotropin/prolactin family of hormones and plays an important
            role in growth control. The gene is located at the growth hormone
            locus on chromosome 17 along with four other related genes in the
            same transcriptional orientation; an arrangement which is thought
            to have evolved by a series of gene duplications. Although the five
            genes share a remarkably high degree of sequence identity, they are
            expressed selectively in different tissues. Alternative splicing
            generates additional isoforms of each of the five growth hormones,
            leading to further diversity and potential for specialization. This
            particular family member is expressed mainly in the placenta and
            utilizes multiple transcription initiation sites. Expression of the
            identical mature proteins for chorionic somatomammotropin hormones
            1 and 2 is upregulated during development, although the ratio of 1
            to 2 increases by term. Mutations in this gene result in placental
            lactogen deficiency and Silver-Russell syndrome. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX395942.2, AL547300.3 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2149398
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316193.13/ ENSP00000316416.8
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AU134786.2         88-88
            2-156               BG436049.1         2-156
            157-821             BC020756.1         212-876
FEATURES             Location/Qualifiers
     source          1..821
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.3"
     gene            1..821
                     /gene="CSH1"
                     /gene_synonym="CS-1; CSA; CSMT; GHB3; hCS-1; hCS-A; PL"
                     /note="chorionic somatomammotropin hormone 1"
                     /db_xref="GeneID:1442"
                     /db_xref="HGNC:HGNC:2440"
                     /db_xref="MIM:150200"
     exon            1..73
                     /gene="CSH1"
                     /gene_synonym="CS-1; CSA; CSMT; GHB3; hCS-1; hCS-A; PL"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..717
                     /gene="CSH1"
                     /gene_synonym="CS-1; CSA; CSMT; GHB3; hCS-1; hCS-A; PL"
                     /note="chorionic somatomammotropin A; choriomammotropin;
                     placental lactogen; growth hormone B3; Chorionic
                     somatomammotropin hormone 2; chorionic
                     somatomammotropin-1"
                     /codon_start=1
                     /product="chorionic somatomammotropin hormone 1 precursor"
                     /protein_id="NP_001308.1"
                     /db_xref="CCDS:CCDS11649.1"
                     /db_xref="GeneID:1442"
                     /db_xref="HGNC:HGNC:2440"
                     /db_xref="MIM:150200"
                     /translation="MAPGSRTSLLLAFALLCLPWLQEAGAVQTVPLSRLFDHAMLQAH
                     RAHQLAIDTYQEFEETYIPKDQKYSFLHDSQTSFCFSDSIPTPSNMEETQQKSNLELL
                     RISLLLIESWLEPVRFLRSMFANNLVYDTSDSDDYHLLKDLEEGIQTLMGRLEDGSRR
                     TGQILKQTYSKFDTNSHNHDALLKNYGLLYCFRKDMDKVETFLRMVQCRSVEGSCGF"
     exon            74..234
                     /gene="CSH1"
                     /gene_synonym="CS-1; CSA; CSMT; GHB3; hCS-1; hCS-A; PL"
                     /inference="alignment:Splign:2.1.0"
     exon            235..354
                     /gene="CSH1"
                     /gene_synonym="CS-1; CSA; CSMT; GHB3; hCS-1; hCS-A; PL"
                     /inference="alignment:Splign:2.1.0"
     exon            355..519
                     /gene="CSH1"
                     /gene_synonym="CS-1; CSA; CSMT; GHB3; hCS-1; hCS-A; PL"
                     /inference="alignment:Splign:2.1.0"
     exon            520..821
                     /gene="CSH1"
                     /gene_synonym="CS-1; CSA; CSMT; GHB3; hCS-1; hCS-A; PL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      802..807
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSH1"
                     /gene_synonym="CS-1; CSA; CSMT; GHB3; hCS-1; hCS-A; PL"
                     /note="hexamer: AATAAA"
     polyA_site      821
                     /gene="CSH1"
                     /gene_synonym="CS-1; CSA; CSMT; GHB3; hCS-1; hCS-A; PL"
                     /note="major polyA site"
ORIGIN      
        1 taggatccca aggcccaact ccccgaacca ctcagggtcc tgtggacagc tcacctagtg
       61 gcaatggctc caggctcccg gacgtccctg ctcctggctt ttgccctgct ctgcctgccc
      121 tggcttcaag aggctggtgc cgtccaaacc gttcccttat ccaggctttt tgaccacgct
      181 atgctccaag cccatcgcgc gcaccagctg gccattgaca cctaccagga gtttgaagaa
      241 acctatatcc caaaggacca gaagtattca ttcctgcatg actcccagac ctccttctgc
      301 ttctcagact ctattccgac accctccaac atggaggaaa cgcaacagaa atccaatcta
      361 gagctgctcc gcatctccct gctgctcatc gagtcgtggc tggagcccgt gcggttcctc
      421 aggagtatgt tcgccaacaa cctggtgtat gacacctcgg acagcgatga ctatcacctc
      481 ctaaaggacc tagaggaagg catccaaacg ctgatgggga ggctggaaga cggcagccgc
      541 cggactgggc agatcctcaa gcagacctac agcaagtttg acacaaactc gcacaaccat
      601 gacgcactgc tcaagaacta cgggctgctc tactgcttca ggaaggacat ggacaaggtc
      661 gagacattcc tgcgcatggt gcagtgccgc tctgtggagg gcagctgtgg cttctaggtg
      721 cccgagtagc atcctgtgac ccctccccag tgcctctcct ggccctgaag gtgccactcc
      781 agtgcccacc agccttgtcc taataaaatt aagttgtatc a
//
