LOCUS       NM_172219               1504 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens colony stimulating factor 3 (CSF3), transcript variant
            2, mRNA.
ACCESSION   NM_172219
VERSION     NM_172219.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1504)
  AUTHORS   Aymonnier,K., Bosetta,E., Leborgne,N.G.F., Ullmer,A., Le Gall,M.,
            De Chiara,A., Salnot,V., Many,S., Scapini,P., Wicks,I.,
            Chatfield,S., Martin,K.R. and Witko-Sarsat,V.
  TITLE     G-CSF reshapes the cytosolic PCNA scaffold and modulates glycolysis
            in neutrophils
  JOURNAL   J Leukoc Biol 115 (2), 205-221 (2024)
   PUBMED   37824822
  REMARK    GeneRIF: G-CSF reshapes the cytosolic PCNA scaffold and modulates
            glycolysis in neutrophils.
REFERENCE   2  (bases 1 to 1504)
  AUTHORS   Ott,A., Tutdibi,E., Goedicke-Fritz,S., Schope,J., Zemlin,M. and
            Nourkami-Tutdibi,N.
  TITLE     Serum cytokines MCP-1 and GCS-F as potential biomarkers in
            pediatric inflammatory bowel disease
  JOURNAL   PLoS One 18 (11), e0288147 (2023)
   PUBMED   37922289
  REMARK    GeneRIF: Serum cytokines MCP-1 and GCS-F as potential biomarkers in
            pediatric inflammatory bowel disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1504)
  AUTHORS   Salemme,V., Vedelago,M., Sarcinella,A., Moietta,F.,
            Piccolantonio,A., Moiso,E., Centonze,G., Manco,M., Guala,A.,
            Lamolinara,A., Angelini,C., Morellato,A., Natalini,D., Calogero,R.,
            Incarnato,D., Oliviero,S., Conti,L., Iezzi,M., Tosoni,D.,
            Bertalot,G., Freddi,S., Tucci,F.A., De Sanctis,F., Frusteri,C.,
            Ugel,S., Bronte,V., Cavallo,F., Provero,P., Gai,M., Taverna,D.,
            Turco,E., Pece,S. and Defilippi,P.
  TITLE     p140Cap inhibits beta-Catenin in the breast cancer stem cell
            compartment instructing a protective anti-tumor immune response
  JOURNAL   Nat Commun 14 (1), 2350 (2023)
   PUBMED   37169737
  REMARK    GeneRIF: p140Cap inhibits beta-Catenin in the breast cancer stem
            cell compartment instructing a protective anti-tumor immune
            response.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1504)
  AUTHORS   Matos,I., Barvalia,M., Chehal,M.K., Robertson,A.G., Kulic,I.,
            Silva,J.A.F.D., Ranganathan,A., Short,A., Huang,Y.H., Long,E.,
            Priatel,J.J., Dhanji,S., Nelson,B.H., Krebs,D.L. and Harder,K.W.
  TITLE     Tumor-derived GCSF Alters Tumor and Systemic Immune System Cell
            Subset Composition and Signaling
  JOURNAL   Cancer Res Commun 3 (3), 404-419 (2023)
   PUBMED   36911097
  REMARK    GeneRIF: Tumor-derived GCSF Alters Tumor and Systemic Immune System
            Cell Subset Composition and Signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1504)
  AUTHORS   Zou,J., Zhao,Z., Song,X., Zhang,G., Li,H., Zhang,Q. and Pyykko,I.
  TITLE     Elevated G-CSF, IL8, and HGF in patients with definite Meniere's
            disease may indicate the role of NET formation in triggering
            autoimmunity and autoinflammation
  JOURNAL   Sci Rep 12 (1), 16309 (2022)
   PUBMED   36175465
  REMARK    GeneRIF: Elevated G-CSF, IL8, and HGF in patients with definite
            Meniere's disease may indicate the role of NET formation in
            triggering autoimmunity and autoinflammation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1504)
  AUTHORS   Zink,T., Ross,A., Ambrosius,D., Rudolph,R. and Holak,T.A.
  TITLE     Secondary structure of human granulocyte colony-stimulating factor
            derived from NMR spectroscopy
  JOURNAL   FEBS Lett 314 (3), 435-439 (1992)
   PUBMED   1281794
REFERENCE   7  (bases 1 to 1504)
  AUTHORS   Sallerfors,B. and Olofsson,T.
  TITLE     Granulocyte-macrophage colony-stimulating factor (GM-CSF) and
            granulocyte colony-stimulating factor (G-CSF) secretion by adherent
            monocytes measured by quantitative immunoassays
  JOURNAL   Eur J Haematol 49 (4), 199-207 (1992)
   PUBMED   1281454
REFERENCE   8  (bases 1 to 1504)
  AUTHORS   Kubota,N., Orita,T., Hattori,K., Oh-eda,M., Ochi,N. and Yamazaki,T.
  TITLE     Structural characterization of natural and recombinant human
            granulocyte colony-stimulating factors
  JOURNAL   J Biochem 107 (3), 486-492 (1990)
   PUBMED   1692828
REFERENCE   9  (bases 1 to 1504)
  AUTHORS   Souza,L.M., Boone,T.C., Gabrilove,J., Lai,P.H., Zsebo,K.M.,
            Murdock,D.C., Chazin,V.R., Bruszewski,J., Lu,H., Chen,K.K.,
            Barendt,J., Platzer,E., Moore,M.A.S., Mertelsmann,R. and Welte,K.
  TITLE     Recombinant human granulocyte colony-stimulating factor: effects on
            normal and leukemic myeloid cells
  JOURNAL   Science 232 (4746), 61-65 (1986)
   PUBMED   2420009
REFERENCE   10 (bases 1 to 1504)
  AUTHORS   Nagata,S., Tsuchiya,M., Asano,S., Yamamoto,O., Hirata,Y.,
            Kubota,N., Oheda,M., Nomura,H. and Yamazaki,T.
  TITLE     The chromosomal gene structure and two mRNAs for human granulocyte
            colony-stimulating factor
  JOURNAL   EMBO J 5 (3), 575-581 (1986)
   PUBMED   2423327
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB127794.1, X03655.1,
            AK313509.1 and BC033245.1.
            
            On Jun 2, 2019 this sequence version replaced NM_172219.2.
            
            Summary: This gene encodes a member of the IL-6 superfamily of
            cytokines. The encoded cytokine controls the production,
            differentiation, and function of granulocytes. Granulocytes are a
            type of white blood cell that are part of the innate immune
            response. A modified form of this protein is commonly administered
            to manage chemotherapy-induced neutropenia. Alternatively spliced
            transcript variants have been described for this gene. [provided by
            RefSeq, May 2020].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site compared to variant 1, resulting in a shorter isoform
            (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138517.1001308.1,
                                           DRR138517.128732.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in cytokine storm inflammatory
                                      response
            MANE Ensembl match     :: ENST00000394149.8/ ENSP00000377705.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 CB127794.1         80-84
            6-580               X03655.1           1-575
            581-581             AK313509.1         585-585
            582-1494            X03655.1           577-1489
            1495-1504           BC033245.1         1644-1653
FEATURES             Location/Qualifiers
     source          1..1504
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.1"
     gene            1..1504
                     /gene="CSF3"
                     /gene_synonym="C17orf33; CSF3OS; GCSF"
                     /note="colony stimulating factor 3"
                     /db_xref="GeneID:1440"
                     /db_xref="HGNC:HGNC:2438"
                     /db_xref="MIM:138970"
     exon            1..75
                     /gene="CSF3"
                     /gene_synonym="C17orf33; CSF3OS; GCSF"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..650
                     /gene="CSF3"
                     /gene_synonym="C17orf33; CSF3OS; GCSF"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; pluripoietin; filgrastim; lenograstim;
                     granulocyte-colony stimulating factor"
                     /codon_start=1
                     /product="granulocyte colony-stimulating factor isoform b
                     precursor"
                     /protein_id="NP_757373.1"
                     /db_xref="CCDS:CCDS42314.1"
                     /db_xref="GeneID:1440"
                     /db_xref="HGNC:HGNC:2438"
                     /db_xref="MIM:138970"
                     /translation="MAGPATQSPMKLMALQLLLWHSALWTVQEATPLGPASSLPQSFL
                     LKCLEQVRKIQGDGAALQEKLCATYKLCHPEELVLLGHSLGIPWAPLSSCPSQALQLA
                     GCLSQLHSGLFLYQGLLQALEGISPELGPTLDTLQLDVADFATTIWQQMEELGMAPAL
                     QPTQGAMPAFASAFQRRAGGVLVASHLQSFLEVSYRVLRHLAQP"
     exon            76..230
                     /gene="CSF3"
                     /gene_synonym="C17orf33; CSF3OS; GCSF"
                     /inference="alignment:Splign:2.1.0"
     exon            231..338
                     /gene="CSF3"
                     /gene_synonym="C17orf33; CSF3OS; GCSF"
                     /inference="alignment:Splign:2.1.0"
     exon            339..485
                     /gene="CSF3"
                     /gene_synonym="C17orf33; CSF3OS; GCSF"
                     /inference="alignment:Splign:2.1.0"
     exon            486..1504
                     /gene="CSF3"
                     /gene_synonym="C17orf33; CSF3OS; GCSF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1486..1491
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSF3"
                     /gene_synonym="C17orf33; CSF3OS; GCSF"
                     /note="hexamer: AATAAA"
     polyA_site      1504
                     /gene="CSF3"
                     /gene_synonym="C17orf33; CSF3OS; GCSF"
                     /note="major polyA site"
ORIGIN      
        1 agcccggagc ctgcagccca gccccaccca gacccatggc tggacctgcc acccagagcc
       61 ccatgaagct gatggccctg cagctgctgc tgtggcacag tgcactctgg acagtgcagg
      121 aagccacccc cctgggccct gccagctccc tgccccagag cttcctgctc aagtgcttag
      181 agcaagtgag gaagatccag ggcgatggcg cagcgctcca ggagaagctg tgtgccacct
      241 acaagctgtg ccaccccgag gagctggtgc tgctcggaca ctctctgggc atcccctggg
      301 ctcccctgag cagctgcccc agccaggccc tgcagctggc aggctgcttg agccaactcc
      361 atagcggcct tttcctctac caggggctcc tgcaggccct ggaagggatc tcccccgagt
      421 tgggtcccac cttggacaca ctgcagctgg acgtcgccga ctttgccacc accatctggc
      481 agcagatgga agaactggga atggcccctg ccctgcagcc cacccagggt gccatgccgg
      541 ccttcgcctc tgctttccag cgccgggcag gaggggtcct ggttgcctcc catctgcaga
      601 gcttcctgga ggtgtcgtac cgcgttctac gccaccttgc ccagccctga gccaagccct
      661 ccccatccca tgtatttatc tctatttaat atttatgtct atttaagcct catatttaaa
      721 gacagggaag agcagaacgg agccccaggc ctctgtgtcc ttccctgcat ttctgagttt
      781 cattctcctg cctgtagcag tgagaaaaag ctcctgtcct cccatcccct ggactgggag
      841 gtagataggt aaataccaag tatttattac tatgactgct ccccagccct ggctctgcaa
      901 tgggcactgg gatgagccgc tgtgagcccc tggtcctgag ggtccccacc tgggaccctt
      961 gagagtatca ggtctcccac gtgggagaca agaaatccct gtttaatatt taaacagcag
     1021 tgttccccat ctgggtcctt gcacccctca ctctggcctc agccgactgc acagcggccc
     1081 ctgcatcccc ttggctgtga ggcccctgga caagcagagg tggccagagc tgggaggcat
     1141 ggccctgggg tcccacgaat ttgctgggga atctcgtttt tcttcttaag acttttggga
     1201 catggtttga ctcccgaaca tcaccgacgc gtctcctgtt tttctgggtg gcctcgggac
     1261 acctgccctg cccccacgag ggtcaggact gtgactcttt ttagggccag gcaggtgcct
     1321 ggacatttgc cttgctggac ggggactggg gatgtgggag ggagcagaca ggaggaatca
     1381 tgtcaggcct gtgtgtgaaa ggaagctcca ctgtcaccct ccacctcttc accccccact
     1441 caccagtgtc ccctccactg tcacattgta actgaacttc aggataataa agtgtttgcc
     1501 tcca
//
