LOCUS       NM_000395               4853 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens colony stimulating factor 2 receptor subunit beta
            (CSF2RB), transcript variant 2, mRNA.
ACCESSION   NM_000395
VERSION     NM_000395.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4853)
  AUTHORS   Charlet,A., Kappenstein,M., Keye,P., Klasener,K., Endres,C.,
            Poggio,T., Gorantla,S.P., Kreutmair,S., Sanger,J., Illert,A.L.,
            Miething,C., Reth,M., Duyster,J., Rummelt,C. and von Bubnoff,N.
  TITLE     The IL-3, IL-5, and GM-CSF common receptor beta chain mediates
            oncogenic activity of FLT3-ITD-positive AML
  JOURNAL   Leukemia 36 (3), 701-711 (2022)
   PUBMED   34750506
  REMARK    GeneRIF: The IL-3, IL-5, and GM-CSF common receptor beta chain
            mediates oncogenic activity of FLT3-ITD-positive AML.
REFERENCE   2  (bases 1 to 4853)
  AUTHORS   Rashid,M., Ali,R., Almuzzaini,B., Song,H., AlHallaj,A.,
            Abdulkarim,A.A., Mohamed Baz,O., Al Zahrani,H., Mustafa Sabeena,M.,
            Alharbi,W., Hussein,M. and Boudjelal,M.
  TITLE     Discovery of a novel potentially transforming somatic mutation in
            CSF2RB gene in breast cancer
  JOURNAL   Cancer Med 10 (22), 8138-8150 (2021)
   PUBMED   34729943
  REMARK    GeneRIF: Discovery of a novel potentially transforming somatic
            mutation in CSF2RB gene in breast cancer.
REFERENCE   3  (bases 1 to 4853)
  AUTHORS   Sakaue,S., Yamaguchi,E., Inoue,Y., Takahashi,M., Hirata,J.,
            Suzuki,K., Ito,S., Arai,T., Hirose,M., Tanino,Y., Nikaido,T.,
            Ichiwata,T., Ohkouchi,S., Hirano,T., Takada,T., Miyawaki,S.,
            Dofuku,S., Maeda,Y., Nii,T., Kishikawa,T., Ogawa,K., Masuda,T.,
            Yamamoto,K., Sonehara,K., Tazawa,R., Morimoto,K., Takaki,M.,
            Konno,S., Suzuki,M., Tomii,K., Nakagawa,A., Handa,T., Tanizawa,K.,
            Ishii,H., Ishida,M., Kato,T., Takeda,N., Yokomura,K., Matsui,T.,
            Watanabe,M., Inoue,H., Imaizumi,K., Goto,Y., Kida,H., Fujisawa,T.,
            Suda,T., Yamada,T., Satake,Y., Ibata,H., Hizawa,N., Mochizuki,H.,
            Kumanogoh,A., Matsuda,F., Nakata,K., Hirota,T., Tamari,M. and
            Okada,Y.
  TITLE     Genetic determinants of risk in autoimmune pulmonary alveolar
            proteinosis
  JOURNAL   Nat Commun 12 (1), 1032 (2021)
   PUBMED   33589587
  REMARK    GeneRIF: Genetic determinants of risk in autoimmune pulmonary
            alveolar proteinosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4853)
  AUTHORS   Schulte,V., Sipol,A., Burdach,S. and Rieger-Fackeldey,E.
  TITLE     The Truncated Splice Variant of the
            Granulocyte-Macrophage-Colony-Stimulating Factor Receptor beta-
            Chain in Peripheral Blood Serves as Severity Biomarker of
            Respiratory Failure in Newborns
  JOURNAL   Neonatology 118 (2), 187-193 (2021)
   PUBMED   33784678
  REMARK    GeneRIF: The Truncated Splice Variant of the
            Granulocyte-Macrophage-Colony-Stimulating Factor Receptor beta-
            Chain in Peripheral Blood Serves as Severity Biomarker of
            Respiratory Failure in Newborns.
REFERENCE   5  (bases 1 to 4853)
  AUTHORS   Denson,L.A., Jurickova,I., Karns,R., Shaw,K.A., Cutler,D.J.,
            Okou,D., Valencia,C.A., Dodd,A., Mondal,K., Aronow,B.J.,
            Haberman,Y., Linn,A., Price,A., Bezold,R., Lake,K., Jackson,K.,
            Walters,T.D., Griffiths,A., Baldassano,R.N., Noe,J.D., Hyams,J.S.,
            Crandall,W.V., Kirschner,B.S., Heyman,M.B., Snapper,S.,
            Guthery,S.L., Dubinsky,M.C., Leleiko,N.S., Otley,A.R., Xavier,R.J.,
            Stevens,C., Daly,M.J., Zwick,M.E. and Kugathasan,S.
  TITLE     Genetic and Transcriptomic Variation Linked to Neutrophil
            Granulocyte-Macrophage Colony-Stimulating Factor Signaling in
            Pediatric Crohn's Disease
  JOURNAL   Inflamm Bowel Dis 25 (3), 547-560 (2019)
   PUBMED   30124884
  REMARK    GeneRIF: Missense mutations in CSF2RB gene is associated with
            Pediatric Crohn's Disease.
REFERENCE   6  (bases 1 to 4853)
  AUTHORS   Sakamaki,K., Miyajima,I., Kitamura,T. and Miyajima,A.
  TITLE     Critical cytoplasmic domains of the common beta subunit of the
            human GM-CSF, IL-3 and IL-5 receptors for growth signal
            transduction and tyrosine phosphorylation
  JOURNAL   EMBO J 11 (10), 3541-3549 (1992)
   PUBMED   1396555
REFERENCE   7  (bases 1 to 4853)
  AUTHORS   Torigoe,T., O'Connor,R., Santoli,D. and Reed,J.C.
  TITLE     Interleukin-3 regulates the activity of the LYN protein-tyrosine
            kinase in myeloid-committed leukemic cell lines
  JOURNAL   Blood 80 (3), 617-624 (1992)
   PUBMED   1638019
REFERENCE   8  (bases 1 to 4853)
  AUTHORS   Tavernier,J., Tuypens,T., Plaetinck,G., Verhee,A., Fiers,W. and
            Devos,R.
  TITLE     Molecular basis of the membrane-anchored and two soluble isoforms
            of the human interleukin 5 receptor alpha subunit
  JOURNAL   Proc Natl Acad Sci U S A 89 (15), 7041-7045 (1992)
   PUBMED   1495999
REFERENCE   9  (bases 1 to 4853)
  AUTHORS   Shen,Y., Baker,E., Callen,D.F., Sutherland,G.R., Willson,T.A.,
            Rakar,S. and Gough,N.M.
  TITLE     Localization of the human GM-CSF receptor beta chain gene (CSF2RB)
            to chromosome 22q12.2-->q13.1
  JOURNAL   Cytogenet Cell Genet 61 (3), 175-177 (1992)
   PUBMED   1424804
REFERENCE   10 (bases 1 to 4853)
  AUTHORS   Hayashida,K., Kitamura,T., Gorman,D.M., Arai,K., Yokota,T. and
            Miyajima,A.
  TITLE     Molecular cloning of a second subunit of the receptor for human
            granulocyte-macrophage colony-stimulating factor (GM-CSF):
            reconstitution of a high-affinity GM-CSF receptor
  JOURNAL   Proc Natl Acad Sci U S A 87 (24), 9655-9659 (1990)
   PUBMED   1702217
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL008637.1, BC070085.1 and
            AL133392.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000395.2.
            
            Summary: The protein encoded by this gene is the common beta chain
            of the high affinity receptor for IL-3, IL-5 and CSF. Defects in
            this gene have been reported to be associated with protein alveolar
            proteinosis (PAP). [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.2969825.1,
                                           SRR14038194.2573355.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000403662.8/ ENSP00000384053.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AL008637.1         64998-65002
            6-2165              BC070085.1         1-2160
            2166-4853           AL133392.1         2648-5335
FEATURES             Location/Qualifiers
     source          1..4853
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     gene            1..4853
                     /gene="CSF2RB"
                     /gene_synonym="betaGMR; CD131; CDw131; IL3RB; IL5RB;
                     SMDP5"
                     /note="colony stimulating factor 2 receptor subunit beta"
                     /db_xref="GeneID:1439"
                     /db_xref="HGNC:HGNC:2436"
                     /db_xref="MIM:138981"
     exon            1..50
                     /gene="CSF2RB"
                     /gene_synonym="betaGMR; CD131; CDw131; IL3RB; IL5RB;
                     SMDP5"
                     /inference="alignment:Splign:2.1.0"
     exon            51..298
                     /gene="CSF2RB"
                     /gene_synonym="betaGMR; CD131; CDw131; IL3RB; IL5RB;
                     SMDP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..2916
                     /gene="CSF2RB"
                     /gene_synonym="betaGMR; CD131; CDw131; IL3RB; IL5RB;
                     SMDP5"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; interleukin 3 receptor/granulocyte-macrophage
                     colony stimulating factor 3 receptor, beta (high
                     affinity); cytokine receptor common subunit beta;
                     GM-CSF/IL-3/IL-5 receptor common beta-chain;
                     colony-stimulating factor-2 receptor, beta, low-affinity;
                     colony stimulating factor 2 receptor, beta, low-affinity
                     (granulocyte-macrophage); GM-CSF/IL-3/IL-5 receptor common
                     beta subunit; beta common cytokine receptor; beta-GM-CSF
                     receptor; colony stimulating factor 2 receptor beta common
                     subunit"
                     /codon_start=1
                     /product="cytokine receptor common subunit beta isoform 2
                     precursor"
                     /protein_id="NP_000386.1"
                     /db_xref="CCDS:CCDS13936.1"
                     /db_xref="GeneID:1439"
                     /db_xref="HGNC:HGNC:2436"
                     /db_xref="MIM:138981"
                     /translation="MVLAQGLLSMALLALCWERSLAGAEETIPLQTLRCYNDYTSHIT
                     CRWADTQDAQRLVNVTLIRRVNEDLLEPVSCDLSDDMPWSACPHPRCVPRRCVIPCQS
                     FVVTDVDYFSFQPDRPLGTRLTVTLTQHVQPPEPRDLQISTDQDHFLLTWSVALGSPQ
                     SHWLSPGDLEFEVVYKRLQDSWEDAAILLSNTSQATLGPEHLMPSSTYVARVRTRLAP
                     GSRLSGRPSKWSPEVCWDSQPGDEAQPQNLECFFDGAAVLSCSWEVRKEVASSVSFGL
                     FYKPSPDAGEEECSPVLREGLGSLHTRHHCQIPVPDPATHGQYIVSVQPRRAEKHIKS
                     SVNIQMAPPSLNVTKDGDSYSLRWETMKMRYEHIDHTFEIQYRKDTATWKDSKTETLQ
                     NAHSMALPALEPSTRYWARVRVRTSRTGYNGIWSEWSEARSWDTESVLPMWVLALIVI
                     FLTIAVLLALRFCGIYGYRLRRKWEEKIPNPSKSHLFQNGSAELWPPGSMSAFTSGSP
                     PHQGPWGSRFPELEGVFPVGFGDSEVSPLTIEDPKHVCDPPSGPDTTPAASDLPTEQP
                     PSPQPGPPAASHTPEKQASSFDFNGPYLGPPHSRSLPDILGQPEPPQEGGSQKSPPPG
                     SLEYLCLPAGGQVQLVPLAQAMGPGQAVEVERRPSQGAAGSPSLESGGGPAPPALGPR
                     VGGQDQKDSPVAIPMSSGDTEDPGVASGYVSSADLVFTPNSGASSVSLVPSLGLPSDQ
                     TPSLCPGLASGPPGAPGPVKSGFEGYVELPPIEGRSPRSPRNNPVPPEAKSPVLNPGE
                     RPADVSPTSPQPEGLLVLQQVGDYCFLPGLGPGPLSLRSKPSSPGPGPEIKNLDQAFQ
                     VKKPPGQAVPQVPVIQLFKALKQQDYLSLPPWEVNKPGEVC"
     exon            299..422
                     /gene="CSF2RB"
                     /gene_synonym="betaGMR; CD131; CDw131; IL3RB; IL5RB;
                     SMDP5"
                     /inference="alignment:Splign:2.1.0"
     exon            423..613
                     /gene="CSF2RB"
                     /gene_synonym="betaGMR; CD131; CDw131; IL3RB; IL5RB;
                     SMDP5"
                     /inference="alignment:Splign:2.1.0"
     exon            614..771
                     /gene="CSF2RB"
                     /gene_synonym="betaGMR; CD131; CDw131; IL3RB; IL5RB;
                     SMDP5"
                     /inference="alignment:Splign:2.1.0"
     exon            772..940
                     /gene="CSF2RB"
                     /gene_synonym="betaGMR; CD131; CDw131; IL3RB; IL5RB;
                     SMDP5"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1076
                     /gene="CSF2RB"
                     /gene_synonym="betaGMR; CD131; CDw131; IL3RB; IL5RB;
                     SMDP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1234
                     /gene="CSF2RB"
                     /gene_synonym="betaGMR; CD131; CDw131; IL3RB; IL5RB;
                     SMDP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1374
                     /gene="CSF2RB"
                     /gene_synonym="betaGMR; CD131; CDw131; IL3RB; IL5RB;
                     SMDP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1537
                     /gene="CSF2RB"
                     /gene_synonym="betaGMR; CD131; CDw131; IL3RB; IL5RB;
                     SMDP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1628
                     /gene="CSF2RB"
                     /gene_synonym="betaGMR; CD131; CDw131; IL3RB; IL5RB;
                     SMDP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1686
                     /gene="CSF2RB"
                     /gene_synonym="betaGMR; CD131; CDw131; IL3RB; IL5RB;
                     SMDP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1790
                     /gene="CSF2RB"
                     /gene_synonym="betaGMR; CD131; CDw131; IL3RB; IL5RB;
                     SMDP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..4853
                     /gene="CSF2RB"
                     /gene_synonym="betaGMR; CD131; CDw131; IL3RB; IL5RB;
                     SMDP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4831..4836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSF2RB"
                     /gene_synonym="betaGMR; CD131; CDw131; IL3RB; IL5RB;
                     SMDP5"
                     /note="hexamer: AATAAA"
     polyA_site      4853
                     /gene="CSF2RB"
                     /gene_synonym="betaGMR; CD131; CDw131; IL3RB; IL5RB;
                     SMDP5"
                     /note="major polyA site"
ORIGIN      
        1 actctgccta gaggctccag aagaagactg gtctctccca ccacacagag gcctggagga
       61 ggcagaggcc aggagggaga ggtcccaaga gcctgtgaaa tgggtctggc ctggctccca
      121 gctgggcagg aacacaggac ttcaggacac taaggaccct gtcatgccca tggccagcac
      181 ccaccagtgc tggtgcctgc ctgtccagag ctgaccaggg agatggtgct ggcccagggg
      241 ctgctctcca tggccctgct ggccctgtgc tgggagcgca gcctggcagg ggcagaagaa
      301 accatcccgc tgcagaccct gcgctgctac aacgactaca ccagccacat cacctgcagg
      361 tgggcagaca cccaggatgc ccagcggctc gtcaacgtga ccctcattcg ccgggtgaat
      421 gaggacctcc tggagccagt gtcctgtgac ctcagtgatg acatgccctg gtcagcctgc
      481 ccccatcccc gctgcgtgcc caggagatgt gtcattccct gccagagttt tgtcgtcact
      541 gacgttgact acttctcatt ccaaccagac aggcctctgg gcacccggct caccgtcact
      601 ctgacccagc atgtccagcc tcctgagccc agggacctgc agatcagcac cgaccaggac
      661 cacttcctgc tgacctggag tgtggccctt gggagtcccc agagccactg gttgtcccca
      721 ggggatctgg agtttgaggt ggtctacaag cggcttcagg actcttggga ggacgcagcc
      781 atcctcctct ccaacacctc ccaggccacc ctggggccag agcacctcat gcccagcagc
      841 acctacgtgg cccgagtacg gacccgcctg gccccaggtt ctcggctctc aggacgtccc
      901 agcaagtgga gcccagaggt ttgctgggac tcccagccag gggatgaggc ccagccccag
      961 aacctggagt gcttctttga cggggccgcc gtgctcagct gctcctggga ggtgaggaag
     1021 gaggtggcca gctcggtctc ctttggccta ttctacaagc ccagcccaga tgcaggggag
     1081 gaagagtgct ccccagtgct gagggagggg ctcggcagcc tccacaccag gcaccactgc
     1141 cagattcccg tgcccgaccc cgcgacccac ggccaataca tcgtctctgt tcagccaagg
     1201 agggcagaga aacacataaa gagctcagtg aacatccaga tggcccctcc atccctcaac
     1261 gtgaccaagg atggagacag ctacagcctg cgctgggaaa caatgaaaat gcgatacgaa
     1321 cacatagacc acacatttga gatccagtac aggaaagaca cggccacgtg gaaggacagc
     1381 aagaccgaga ccctccagaa cgcccacagc atggccctgc cagccctgga gccctccacc
     1441 aggtactggg ccagggtgag ggtcaggacc tcccgcaccg gctacaacgg gatctggagc
     1501 gagtggagtg aggcgcgctc ctgggacacc gagtcggtgc tgcctatgtg ggtgctggcc
     1561 ctcatcgtga tcttcctcac catcgctgtg ctcctggccc tccgcttctg tggcatctac
     1621 gggtacaggc tgcgcagaaa gtgggaggag aagatcccca accccagcaa gagccacctg
     1681 ttccagaacg ggagcgcaga gctttggccc ccaggcagca tgtcggcctt cactagcggg
     1741 agtcccccac accaggggcc gtggggcagc cgcttccctg agctggaggg ggtgttccct
     1801 gtaggattcg gggacagcga ggtgtcacct ctcaccatag aggaccccaa gcatgtctgt
     1861 gatccaccat ctgggcctga cacgactcca gctgcctcag atctacccac agagcagccc
     1921 cccagccccc agccaggccc gcctgccgcc tcccacacac ctgagaaaca ggcttccagc
     1981 tttgacttca atgggcccta cctggggccg ccccacagcc gctccctacc tgacatcctg
     2041 ggccagccgg agcccccaca ggagggtggg agccagaagt ccccacctcc agggtccctg
     2101 gagtacctgt gtctgcctgc tggggggcag gtgcaactgg tccctctggc ccaggcgatg
     2161 ggaccaggac aggccgtgga agtggagaga aggccgagcc agggggctgc agggagtccc
     2221 tccctggagt ccgggggagg ccctgcccct cctgctcttg ggccaagggt gggaggacag
     2281 gaccaaaagg acagccctgt ggctataccc atgagctctg gggacactga ggaccctgga
     2341 gtggcctctg gttatgtctc ctctgcagac ctggtattca ccccaaactc aggggcctcg
     2401 tctgtctccc tagttccctc tctgggcctc ccctcagacc agacccccag cttatgtcct
     2461 gggctggcca gtggaccccc tggagcccca ggccctgtga agtcagggtt tgagggctat
     2521 gtggagctcc ctccaattga gggccggtcc cccaggtcac caaggaacaa tcctgtcccc
     2581 cctgaggcca aaagccctgt cctgaaccca ggggaacgcc cggcagatgt gtccccaaca
     2641 tccccacagc ccgagggcct ccttgtcctg cagcaagtgg gcgactattg cttcctcccc
     2701 ggcctggggc ccggccctct ctcgctccgg agtaaacctt cttccccggg acccggtcct
     2761 gagatcaaga acctagacca ggcttttcaa gtcaagaagc ccccaggcca ggctgtgccc
     2821 caggtgcccg tcattcagct cttcaaagcc ctgaagcagc aggactacct gtctctgccc
     2881 ccttgggagg tcaacaagcc tggggaggtg tgttgagacc cccaggccta gacaggcaag
     2941 gggatggaga gggcttgcct tccctcccgc ctgaccttcc tcagtcattt ctgcaaagcc
     3001 aaggggcagc ctcctgtcaa ggtagctaga ggcctgggaa aggagatagc cttgctccgg
     3061 cccccttgac cttcagcaaa tcacttctct ccctgcgctc acacagacac acacacacac
     3121 acgtacatgc acacattttt cctgtcaggt taacttattt gtaggttctg cattattaga
     3181 actttctaga tatactcatt ccatctcccc ctcatttttt taatcaggtt tccttgcttt
     3241 tgccattttt cttccttctt ttttcactga tttattatga gagtggggct gaggtctgag
     3301 ctgagcctta tcagactgag atgcggctgg ttgtgttgag gacttgtgtg ggctgcctgt
     3361 ccccggcagt cgctgatgca catgacatga ttctcatctg ggtgcagagg tgggaggcac
     3421 caggtgggca cccgtggggg ttagggcttg gaagagtggc acaggactgg gcacgctcag
     3481 tgaggctcag ggaattcaga ctagcctcga ttgtcactcc gagaaatggg catggtattg
     3541 ggggtcgggg gggcggtgca agggacgcac atgagagact gtttgggagc ttctggggag
     3601 ccctgctagt tgtctcagtg atgtctgtgg gacctccagt cccttgagac cccacgtcat
     3661 gtagagaagt taacggccca agtggtgggc aggctggcgg gacctgggga acatcaggag
     3721 aggagtccag agcccacgtc tactgcggaa aagtcagggg aaactgccaa acaaaggaaa
     3781 atgccccaaa ggcatatatg ctttagggcc tttggtccaa atggcccggg tggccactct
     3841 tccagataga ccaggcaact ctccctccca ccggccacag atgaggggct gctgatctat
     3901 gcctgggcct gcaccaggga ttatggttct tttaaatctt tgcctttcag atacaggaaa
     3961 aataatggca ttaaattgct ttaatttgca ttattttagt tatccagttt gcacatattt
     4021 ttataggtat cttaggcatc gattggtatt ttttaactgg gccaagccca ttaaggtctt
     4081 tcttctgttg ggtgctatca ttttctgatt aagtcttttt gactattgac atacagtctt
     4141 tcacagatgg tggagtgttt ttcccccaaa tctgttgttt gtcttataat gttgtatatg
     4201 aggttttatg gtgtatgaat atgaatgctt ctgtaatgtc aaacagatcc ctagtaaact
     4261 ccttcttcac ttttactgtc agatttacaa aggtcctccc attgcaaagc agtgtttgtc
     4321 ctaatttata tattgttttt ctagttcatt ttgtgtttcc aacttttcat gtaaaatttt
     4381 aattattttt gaatgtgtgg atgtgagact gaggtgcctt ttggtactga aattcttttt
     4441 ccatgtacct gaagtgttac ttttgtgata taggaaatcc ttgtatatat actttattgg
     4501 tccctaggct tcctattttg ttaccttgct ttctctatgg catccaccat tttgattgtt
     4561 ctacttttat gatatgtttt cataagtggt taagcaagta ttctcgttac ttttgctctt
     4621 aaatccctat tcattacagc aatgttggtg gtcaaagaaa atgataaaca acttgaatgt
     4681 tcaatggtcc tgaaatacat aacaacattt tagtacattg taaagtagaa tcctctgttc
     4741 ataatgaaca agatgaacca atgtggatta gaaagaagtc cgagatatta attccaaaat
     4801 atccagacat tgttaaaggg aaaaaattgc aataaaatat ttgtaacata aaa
//
