LOCUS       NM_001161529            1967 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens colony stimulating factor 2 receptor subunit alpha
            (CSF2RA), transcript variant 7, mRNA.
ACCESSION   NM_001161529
VERSION     NM_001161529.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1967)
  AUTHORS   Shima,K., Arumugam,P., Sallese,A., Horio,Y., Ma,Y., Trapnell,C.,
            Wessendarp,M., Chalk,C., McCarthy,C., Carey,B.C., Trapnell,B.C. and
            Suzuki,T.
  TITLE     A murine model of hereditary pulmonary alveolar proteinosis caused
            by homozygous Csf2ra gene disruption
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 322 (3), L438-L448 (2022)
   PUBMED   35043685
  REMARK    GeneRIF: A murine model of hereditary pulmonary alveolar
            proteinosis caused by homozygous Csf2ra gene disruption.
REFERENCE   2  (bases 1 to 1967)
  AUTHORS   Evren,E., Ringqvist,E., Doisne,J.M., Thaller,A., Sleiers,N.,
            Flavell,R.A., Di Santo,J.P. and Willinger,T.
  TITLE     CD116+ fetal precursors migrate to the perinatal lung and give rise
            to human alveolar macrophages
  JOURNAL   J Exp Med 219 (2) (2022)
   PUBMED   35019940
  REMARK    GeneRIF: CD116+ fetal precursors migrate to the perinatal lung and
            give rise to human alveolar macrophages.
REFERENCE   3  (bases 1 to 1967)
  AUTHORS   van Helvoort,E.M., Eijkelkamp,N., Lafeber,F.P.J.G. and
            Mastbergen,S.C.
  TITLE     Expression of granulocyte macrophage-colony stimulating factor and
            its receptor in the synovium of osteoarthritis patients is
            negatively correlated with pain
  JOURNAL   Rheumatology (Oxford) 59 (11), 3452-3457 (2020)
   PUBMED   32365364
  REMARK    GeneRIF: Expression of granulocyte macrophage-colony stimulating
            factor and its receptor in the synovium of osteoarthritis patients
            is negatively correlated with pain.
REFERENCE   4  (bases 1 to 1967)
  AUTHORS   Huang,R., Cao,Y., Li,H., Hu,Z., Zhang,H., Zhang,L., Su,W., Xu,Y.,
            Liang,L., Melgiri,N.D., Jiang,L. and Li,X.
  TITLE     miR-532-3p-CSF2RA Axis as a Key Regulator of Vulnerable
            Atherosclerotic Plaque Formation
  JOURNAL   Can J Cardiol 36 (11), 1782-1794 (2020)
   PUBMED   32473103
  REMARK    GeneRIF: miR-532-3p-CSF2RA Axis as a Key Regulator of Vulnerable
            Atherosclerotic Plaque Formation.
REFERENCE   5  (bases 1 to 1967)
  AUTHORS   De Alessandris,S., Ferguson,G.J., Dodd,A.J., Juss,J.K.,
            Devaprasad,A., Piper,S., Wyatt,O., Killick,H., Corkill,D.J.,
            Cohen,E.S., Pandit,A., Radstake,T.R.D.J., Simmonds,R.,
            Condliffe,A.M., Sleeman,M.A., Cowburn,A.S., Finch,D.K. and
            Chilvers,E.R.
  TITLE     Neutrophil GM-CSF receptor dynamics in acute lung injury
  JOURNAL   J Leukoc Biol 105 (6), 1183-1194 (2019)
   PUBMED   30942918
  REMARK    GeneRIF: These data show that loss of membrane GM-CSFRalpha
            following GM-CSF exposure does not preclude sustained
            GM-CSF/GM-CSFRalpha signaling and that this receptor plays a key
            role in ligand clearance. Hence neutrophilic activation via GM-CSFR
            may play an important role in neutrophilic lung inflammation even
            in the absence of high GM-CSF levels or GM-CSFRalpha expression.
REFERENCE   6  (bases 1 to 1967)
  AUTHORS   Rappold,G., Willson,T.A., Henke,A. and Gough,N.M.
  TITLE     Arrangement and localization of the human GM-CSF receptor alpha
            chain gene CSF2RA within the X-Y pseudoautosomal region
  JOURNAL   Genomics 14 (2), 455-461 (1992)
   PUBMED   1358805
REFERENCE   7  (bases 1 to 1967)
  AUTHORS   Raines,M.A., Liu,L., Quan,S.G., Joe,V., DiPersio,J.F. and
            Golde,D.W.
  TITLE     Identification and molecular cloning of a soluble human
            granulocyte-macrophage colony-stimulating factor receptor
  JOURNAL   Proc Natl Acad Sci U S A 88 (18), 8203-8207 (1991)
   PUBMED   1832774
REFERENCE   8  (bases 1 to 1967)
  AUTHORS   Crosier,K.E., Wong,G.G., Mathey-Prevot,B., Nathan,D.G. and
            Sieff,C.A.
  TITLE     A functional isoform of the human granulocyte/macrophage
            colony-stimulating factor receptor has an unusual cytoplasmic
            domain
  JOURNAL   Proc Natl Acad Sci U S A 88 (17), 7744-7748 (1991)
   PUBMED   1715577
REFERENCE   9  (bases 1 to 1967)
  AUTHORS   Hayashida,K., Kitamura,T., Gorman,D.M., Arai,K., Yokota,T. and
            Miyajima,A.
  TITLE     Molecular cloning of a second subunit of the receptor for human
            granulocyte-macrophage colony-stimulating factor (GM-CSF):
            reconstitution of a high-affinity GM-CSF receptor
  JOURNAL   Proc Natl Acad Sci U S A 87 (24), 9655-9659 (1990)
   PUBMED   1702217
REFERENCE   10 (bases 1 to 1967)
  AUTHORS   Gough,N.M., Gearing,D.P., Nicola,N.A., Baker,E., Pritchard,M.,
            Callen,D.F. and Sutherland,G.R.
  TITLE     Localization of the human GM-CSF receptor gene to the X-Y
            pseudoautosomal region
  JOURNAL   Nature 345 (6277), 734-736 (1990)
   PUBMED   1972780
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX649553.6.
            
            On Mar 24, 2020 this sequence version replaced NM_001161529.1.
            
            Summary: The protein encoded by this gene is the alpha subunit of
            the heterodimeric receptor for colony stimulating factor 2, a
            cytokine which controls the production, differentiation, and
            function of granulocytes and macrophages. The encoded protein is a
            member of the cytokine family of receptors. This gene is found in
            the pseudoautosomal region (PAR) of the X and Y chromosomes.
            Multiple transcript variants encoding different isoforms have been
            found for this gene, with some of the isoforms being membrane-bound
            and others being soluble. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC071835.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153307, SAMEA2162823
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                BX649553.6         41816-41881
            67-130              BX649553.6         47757-47820
            131-282             BX649553.6         55411-55562
            283-384             BX649553.6         55680-55781
            385-527             BX649553.6         58780-58922
            528-651             BX649553.6         61521-61644
            652-781             BX649553.6         61761-61890
            782-954             BX649553.6         63339-63511
            955-1088            BX649553.6         67330-67463
            1089-1118           BX649553.6         68429-68458
            1119-1254           BX649553.6         73493-73628
            1255-1351           BX649553.6         76925-77021
            1352-1433           BX649553.6         78448-78529
            1434-1967           BX649553.6         82404-82937
FEATURES             Location/Qualifiers
     source          1..1967
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /chromosome="Y"
                     /map="X"
                     /map="Y"
     gene            1..1967
                     /gene="CSF2RA"
                     /gene_synonym="alphaGMR; CD116; CDw116; CSF2R; CSF2RAX;
                     CSF2RAY; CSF2RX; CSF2RY; GM-CSF-R-alpha; GMCSFR;
                     GMCSFR-alpha; GMR; GMR-alpha; SMDP4"
                     /note="colony stimulating factor 2 receptor subunit alpha"
                     /db_xref="GeneID:1438"
                     /db_xref="HGNC:HGNC:2435"
                     /db_xref="MIM:306250"
                     /db_xref="MIM:425000"
     exon            1..66
                     /gene="CSF2RA"
                     /gene_synonym="alphaGMR; CD116; CDw116; CSF2R; CSF2RAX;
                     CSF2RAY; CSF2RX; CSF2RY; GM-CSF-R-alpha; GMCSFR;
                     GMCSFR-alpha; GMR; GMR-alpha; SMDP4"
                     /inference="alignment:Splign:2.1.0"
     exon            67..130
                     /gene="CSF2RA"
                     /gene_synonym="alphaGMR; CD116; CDw116; CSF2R; CSF2RAX;
                     CSF2RAY; CSF2RX; CSF2RY; GM-CSF-R-alpha; GMCSFR;
                     GMCSFR-alpha; GMR; GMR-alpha; SMDP4"
                     /inference="alignment:Splign:2.1.0"
     exon            131..282
                     /gene="CSF2RA"
                     /gene_synonym="alphaGMR; CD116; CDw116; CSF2R; CSF2RAX;
                     CSF2RAY; CSF2RX; CSF2RY; GM-CSF-R-alpha; GMCSFR;
                     GMCSFR-alpha; GMR; GMR-alpha; SMDP4"
                     /inference="alignment:Splign:2.1.0"
     exon            283..384
                     /gene="CSF2RA"
                     /gene_synonym="alphaGMR; CD116; CDw116; CSF2R; CSF2RAX;
                     CSF2RAY; CSF2RX; CSF2RY; GM-CSF-R-alpha; GMCSFR;
                     GMCSFR-alpha; GMR; GMR-alpha; SMDP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             309..1511
                     /gene="CSF2RA"
                     /gene_synonym="alphaGMR; CD116; CDw116; CSF2R; CSF2RAX;
                     CSF2RAY; CSF2RX; CSF2RY; GM-CSF-R-alpha; GMCSFR;
                     GMCSFR-alpha; GMR; GMR-alpha; SMDP4"
                     /note="isoform a precursor is encoded by transcript
                     variant 7; granulocyte-macrophage colony-stimulating
                     factor receptor alpha chain; CD116 antigen; GM-CSF
                     receptor alpha subunit; granulocyte-macrophage
                     colony-stimulating factor receptor subunit alpha; colony
                     stimulating factor 2 receptor, alpha, low-affinity
                     (granulocyte-macrophage); alpha-GM-CSF receptor; colony
                     stimulating factor 2 receptor alpha subunit"
                     /codon_start=1
                     /product="granulocyte-macrophage colony-stimulating factor
                     receptor subunit alpha isoform a precursor"
                     /protein_id="NP_001155001.1"
                     /db_xref="CCDS:CCDS35191.1"
                     /db_xref="GeneID:1438"
                     /db_xref="HGNC:HGNC:2435"
                     /db_xref="MIM:306250"
                     /db_xref="MIM:425000"
                     /translation="MLLLVTSLLLCELPHPAFLLIPEKSDLRTVAPASSLNVRFDSRT
                     MNLSWDCQENTTFSKCFLTDKKNRVVEPRLSNNECSCTFREICLHEGVTFEVHVNTSQ
                     RGFQQKLLYPNSGREGTAAQNFSCFIYNADLMNCTWARGPTAPRDVQYFLYIRNSKRR
                     REIRCPYYIQDSGTHVGCHLDNLSGLTSRNYFLVNGTSREIGIQFFDSLLDTKKIERF
                     NPPSNVTVRCNTTHCLVRWKQPRTYQKLSYLDFQYQLDVHRKNTQPGTENLLINVSGD
                     LENRYNFPSSEPRAKHSVKIRAADVRILNWSSWSEAIEFGSDDGNLGSVYIYVLLIVG
                     TLVCGIVLGFLFKRFLRIQRLFPPVPQIKDKLNDNHEVEDEIIWEEFTPEEGKGYREE
                     VLTVKEIT"
     exon            385..527
                     /gene="CSF2RA"
                     /gene_synonym="alphaGMR; CD116; CDw116; CSF2R; CSF2RAX;
                     CSF2RAY; CSF2RX; CSF2RY; GM-CSF-R-alpha; GMCSFR;
                     GMCSFR-alpha; GMR; GMR-alpha; SMDP4"
                     /inference="alignment:Splign:2.1.0"
     exon            528..651
                     /gene="CSF2RA"
                     /gene_synonym="alphaGMR; CD116; CDw116; CSF2R; CSF2RAX;
                     CSF2RAY; CSF2RX; CSF2RY; GM-CSF-R-alpha; GMCSFR;
                     GMCSFR-alpha; GMR; GMR-alpha; SMDP4"
                     /inference="alignment:Splign:2.1.0"
     exon            652..781
                     /gene="CSF2RA"
                     /gene_synonym="alphaGMR; CD116; CDw116; CSF2R; CSF2RAX;
                     CSF2RAY; CSF2RX; CSF2RY; GM-CSF-R-alpha; GMCSFR;
                     GMCSFR-alpha; GMR; GMR-alpha; SMDP4"
                     /inference="alignment:Splign:2.1.0"
     exon            782..954
                     /gene="CSF2RA"
                     /gene_synonym="alphaGMR; CD116; CDw116; CSF2R; CSF2RAX;
                     CSF2RAY; CSF2RX; CSF2RY; GM-CSF-R-alpha; GMCSFR;
                     GMCSFR-alpha; GMR; GMR-alpha; SMDP4"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1088
                     /gene="CSF2RA"
                     /gene_synonym="alphaGMR; CD116; CDw116; CSF2R; CSF2RAX;
                     CSF2RAY; CSF2RX; CSF2RY; GM-CSF-R-alpha; GMCSFR;
                     GMCSFR-alpha; GMR; GMR-alpha; SMDP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1118
                     /gene="CSF2RA"
                     /gene_synonym="alphaGMR; CD116; CDw116; CSF2R; CSF2RAX;
                     CSF2RAY; CSF2RX; CSF2RY; GM-CSF-R-alpha; GMCSFR;
                     GMCSFR-alpha; GMR; GMR-alpha; SMDP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1254
                     /gene="CSF2RA"
                     /gene_synonym="alphaGMR; CD116; CDw116; CSF2R; CSF2RAX;
                     CSF2RAY; CSF2RX; CSF2RY; GM-CSF-R-alpha; GMCSFR;
                     GMCSFR-alpha; GMR; GMR-alpha; SMDP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1351
                     /gene="CSF2RA"
                     /gene_synonym="alphaGMR; CD116; CDw116; CSF2R; CSF2RAX;
                     CSF2RAY; CSF2RX; CSF2RY; GM-CSF-R-alpha; GMCSFR;
                     GMCSFR-alpha; GMR; GMR-alpha; SMDP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1433
                     /gene="CSF2RA"
                     /gene_synonym="alphaGMR; CD116; CDw116; CSF2R; CSF2RAX;
                     CSF2RAY; CSF2RX; CSF2RY; GM-CSF-R-alpha; GMCSFR;
                     GMCSFR-alpha; GMR; GMR-alpha; SMDP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1967
                     /gene="CSF2RA"
                     /gene_synonym="alphaGMR; CD116; CDw116; CSF2R; CSF2RAX;
                     CSF2RAY; CSF2RX; CSF2RY; GM-CSF-R-alpha; GMCSFR;
                     GMCSFR-alpha; GMR; GMR-alpha; SMDP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1935..1940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSF2RA"
                     /gene_synonym="alphaGMR; CD116; CDw116; CSF2R; CSF2RAX;
                     CSF2RAY; CSF2RX; CSF2RY; GM-CSF-R-alpha; GMCSFR;
                     GMCSFR-alpha; GMR; GMR-alpha; SMDP4"
                     /note="hexamer: AATAAA"
     regulatory      1942..1947
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSF2RA"
                     /gene_synonym="alphaGMR; CD116; CDw116; CSF2R; CSF2RAX;
                     CSF2RAY; CSF2RX; CSF2RY; GM-CSF-R-alpha; GMCSFR;
                     GMCSFR-alpha; GMR; GMR-alpha; SMDP4"
                     /note="hexamer: AATAAA"
     polyA_site      1954
                     /gene="CSF2RA"
                     /gene_synonym="alphaGMR; CD116; CDw116; CSF2R; CSF2RAX;
                     CSF2RAY; CSF2RX; CSF2RY; GM-CSF-R-alpha; GMCSFR;
                     GMCSFR-alpha; GMR; GMR-alpha; SMDP4"
                     /note="major polyA site"
     polyA_site      1967
                     /gene="CSF2RA"
                     /gene_synonym="alphaGMR; CD116; CDw116; CSF2R; CSF2RAX;
                     CSF2RAY; CSF2RX; CSF2RY; GM-CSF-R-alpha; GMCSFR;
                     GMCSFR-alpha; GMR; GMR-alpha; SMDP4"
ORIGIN      
        1 actcagaagc gggagtctcc gagagaagaa aagcaggtgg aaggagagga agcggatgcc
       61 gtggggttta cagcaggaaa atccgtggag acagcagatc cgagaagcgg cgatgtttgc
      121 gtagaaccct gtcagctgag ccatgaccca tgaaccatgg aagcttgact ctagattgac
      181 catcttgaga tgccaaagat gtccacgtcc taatcccatg tgggagacag aataatggcc
      241 ctgcagacct tcccagctgg ccatgacccc tcatttgacc agctcttccc ttctctctga
      301 ccagcaccat gcttctcctg gtgacaagcc ttctgctctg tgagttacca cacccagcat
      361 tcctcctgat cccagagaaa tcggatctgc gaacagtggc accagcctct agtctcaatg
      421 tgaggtttga ctccaggacg atgaatttaa gctgggactg ccaagaaaac acaaccttca
      481 gcaagtgttt cttaactgac aagaagaaca gagtcgtgga acccaggctc agtaacaacg
      541 aatgttcgtg cacatttcgt gaaatttgtc tgcatgaagg agtcacattt gaggttcacg
      601 tgaatactag tcaaagagga tttcaacaga aactgcttta tccaaattca ggaagggagg
      661 gtaccgctgc tcagaatttc tcctgtttca tctacaatgc ggatttaatg aactgtacct
      721 gggcgagggg tccgacggcc ccccgtgacg tccagtattt tttgtacata cgaaactcaa
      781 agagaaggag ggagatccgg tgtccttatt acatacaaga ctcaggaacc catgtgggat
      841 gtcacctgga taacctgtca ggattaacgt ctcgcaatta ctttctggtt aacggaacca
      901 gccgagaaat tggcatccaa ttctttgatt cacttttgga cacaaagaaa atagaacgat
      961 tcaaccctcc cagcaatgtc accgtacgtt gcaacacgac gcactgcctc gtacggtgga
     1021 aacagcccag gacctatcag aagctgtcgt acctggactt tcagtaccag ctggacgtcc
     1081 acagaaagaa tacccagcct ggcacggaaa acctactgat taatgtttct ggtgatttgg
     1141 aaaatagata caactttcca agctctgagc ccagagcaaa acacagtgtg aagatcagag
     1201 ctgcagacgt ccgcatcttg aattggagct cctggagtga agccattgaa tttggttctg
     1261 acgacgggaa cctcggctct gtgtacattt atgtgctcct aatcgtggga acccttgtct
     1321 gtggcatcgt cctcggcttc ctctttaaaa ggttccttag gatacagcgg ctgttcccgc
     1381 cagttccaca gatcaaagac aaactgaatg ataaccatga ggtggaagac gagatcatct
     1441 gggaggaatt caccccagag gaagggaaag gctaccgcga agaggtcttg accgtgaagg
     1501 aaattacctg agacccagag ggtgtaggaa tggcatggac atctccgcct ccgcgacacg
     1561 ggggaactgt tttcttgatg atgctgtgaa cctttatatc attttctatg tttttattta
     1621 aaaacatgac atttggggcc aggcgcggtg gctcacgcct gtaatcccag cactttggga
     1681 ggccaaggca ggcggatcac ctgaggtcag gagttcaaga ccagcctgcc caacatggtg
     1741 aaaccccatc tggactaaaa atgcagaaat ttacccaggc acggcggcgg acgcccatca
     1801 tcccagctac ttgggaggct gaggcaggag aattgcttga acccgtgagg cggaggttgt
     1861 agtgagccaa gatcgcacca ttgcacacca acctgcgtga cagagcaaga ttgcatctca
     1921 aaacaaacaa taataataaa taataaaaac ctgatatttg gctgggc
//
