LOCUS       NM_001288705            3820 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens colony stimulating factor 1 receptor (CSF1R),
            transcript variant 2, mRNA.
ACCESSION   NM_001288705
VERSION     NM_001288705.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3820)
  AUTHORS   Beerepoot,S., Wolf,N.I., van der Knaap,M.S., Nierkens,S. and
            Plantinga,M.
  TITLE     Heterozygous missense CSF1R variants hamper in vitro CD34+-derived
            dendritic cell generation but not in vivo dendritic cell
            development
  JOURNAL   Mol Immunol 174, 41-46 (2024)
   PUBMED   39182279
  REMARK    GeneRIF: Heterozygous missense CSF1R variants hamper in vitro
            CD34+-derived dendritic cell generation but not in vivo dendritic
            cell development.
REFERENCE   2  (bases 1 to 3820)
  AUTHORS   Schmitz,A.S., Raju,J., Kohler,W., Klebe,S., Cheheb,K., Reschke,F.,
            Biskup,S., Haack,T.B., Roeben,B., Kellner,M., Rahner,N., Bloch,T.,
            Lemke,J., Bender,B., Schols,L., Hengel,H. and Hayer,S.N.
  TITLE     Novel variants in CSF1R associated with adult-onset
            leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)
  JOURNAL   J Neurol 271 (9), 6025-6037 (2024)
   PUBMED   39031193
  REMARK    GeneRIF: Novel variants in CSF1R associated with adult-onset
            leukoencephalopathy with axonal spheroids and pigmented glia
            (ALSP).
REFERENCE   3  (bases 1 to 3820)
  AUTHORS   Orsenigo,F., Stewart,A., Hammer,C.P., Clarke,E., Simpkin,D.,
            Attia,H., Rockall,T., Gordon,S. and Martinez,F.O.
  TITLE     Unifying considerations and evidence of macrophage activation
            mosaicism through human CSF1R and M1/M2 genes
  JOURNAL   Cell Rep 43 (6), 114352 (2024)
   PUBMED   38870011
  REMARK    GeneRIF: Unifying considerations and evidence of macrophage
            activation mosaicism through human CSF1R and M1/M2 genes.
REFERENCE   4  (bases 1 to 3820)
  AUTHORS   Dorion,M.F., Casas,D., Shlaifer,I., Yaqubi,M., Fleming,P.,
            Karpilovsky,N., Chen,C.X., Nicouleau,M., Piscopo,V.E.C.,
            MacDougall,E.J., Alluli,A., Goldsmith,T.M., Schneider,A.,
            Dorion,S., Aprahamian,N., MacDonald,A., Thomas,R.A., Dudley,R.W.R.,
            Hall,J.A., Fon,E.A., Antel,J.P., Stratton,J.A., Durcan,T.M., La
            Piana,R. and Healy,L.M.
  TITLE     An adapted protocol to derive microglia from stem cells and its
            application in the study of CSF1R-related disorders
  JOURNAL   Mol Neurodegener 19 (1), 31 (2024)
   PUBMED   38576039
  REMARK    GeneRIF: An adapted protocol to derive microglia from stem cells
            and its application in the study of CSF1R-related disorders.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3820)
  AUTHORS   Lamprecht,B., Walter,K., Kreher,S., Kumar,R., Hummel,M., Lenze,D.,
            Kochert,K., Bouhlel,M.A., Richter,J., Soler,E., Stadhouders,R.,
            Johrens,K., Wurster,K.D., Callen,D.F., Harte,M.F., Giefing,M.,
            Barlow,R., Stein,H., Anagnostopoulos,I., Janz,M., Cockerill,P.N.,
            Siebert,R., Dorken,B., Bonifer,C. and Mathas,S.
  TITLE     Derepression of an endogenous long terminal repeat activates the
            CSF1R proto-oncogene in human lymphoma
  JOURNAL   Nat Med 16 (5), 571-579 (2010)
   PUBMED   20436485
REFERENCE   6  (bases 1 to 3820)
  AUTHORS   Vanderver,A., Tonduti,D., Schiffmann,R., Schmidt,J. and van der
            Knaap,M.S.
  TITLE     Leukodystrophy Overview - RETIRED CHAPTER, FOR HISTORICAL REFERENCE
            ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   24501781
REFERENCE   7  (bases 1 to 3820)
  AUTHORS   Dulski,J., Sundal,C. and Wszolek,Z.K.
  TITLE     CSF1R-Related Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   22934315
REFERENCE   8  (bases 1 to 3820)
  AUTHORS   Gout,I., Dhand,R., Panayotou,G., Fry,M.J., Hiles,I., Otsu,M. and
            Waterfield,M.D.
  TITLE     Expression and characterization of the p85 subunit of the
            phosphatidylinositol 3-kinase complex and a related p85 beta
            protein by using the baculovirus expression system
  JOURNAL   Biochem J 288 (Pt 2) (Pt 2), 395-405 (1992)
   PUBMED   1334406
REFERENCE   9  (bases 1 to 3820)
  AUTHORS   Roberts,W.M., Shapiro,L.H., Ashmun,R.A. and Look,A.T.
  TITLE     Transcription of the human colony-stimulating factor-1 receptor
            gene is regulated by separate tissue-specific promoters
  JOURNAL   Blood 79 (3), 586-593 (1992)
   PUBMED   1531036
REFERENCE   10 (bases 1 to 3820)
  AUTHORS   Galland,F., Stefanova,M., Lafage,M. and Birnbaum,D.
  TITLE     Localization of the 5' end of the MCF2 oncogene to human chromosome
            15q15----q23
  JOURNAL   Cytogenet Cell Genet 60 (2), 114-116 (1992)
   PUBMED   1611909
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011382.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 25, 2019 this sequence version replaced NM_001288705.2.
            
            Summary: The protein encoded by this gene is the receptor for
            colony stimulating factor 1, a cytokine which controls the
            production, differentiation, and function of macrophages. This
            receptor mediates most if not all of the biological effects of this
            cytokine. Ligand binding activates the receptor kinase through a
            process of oligomerization and transphosphorylation. The encoded
            protein is a tyrosine kinase transmembrane receptor and member of
            the CSF1/PDGF receptor family of tyrosine-protein kinases.
            Mutations in this gene have been associated with a predisposition
            to myeloid malignancy. The first intron of this gene contains a
            transcriptionally inactive ribosomal protein L7 processed
            pseudogene oriented in the opposite direction. Alternative splicing
            results in multiple transcript variants. Expression of a splice
            variant from an LTR promoter has been found in Hodgkin lymphoma
            (HL), HL cell lines and anaplastic large cell lymphoma. [provided
            by RefSeq, Mar 2017].
            
            Transcript Variant: This variant (2) uses an internal transcription
            initiation site compared to variant 4. Variants 1, 2, 4, and 5 all
            encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047521.1, SRR14038193.2451616.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000675795.1/ ENSP00000501699.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               AC011382.4         38712-38887         c
            177-434             AC011382.4         33100-33357         c
            435-719             AC011382.4         32385-32669         c
            720-856             AC011382.4         30445-30581         c
            857-1016            AC011382.4         29609-29768         c
            1017-1209           AC011382.4         25634-25826         c
            1210-1325           AC011382.4         22789-22904         c
            1326-1446           AC011382.4         22515-22635         c
            1447-1637           AC011382.4         22206-22396         c
            1638-1753           AC011382.4         20548-20663         c
            1754-1880           AC011382.4         14056-14182         c
            1881-1985           AC011382.4         13824-13928         c
            1986-2096           AC011382.4         13195-13305         c
            2097-2259           AC011382.4         12033-12195         c
            2260-2348           AC011382.4         9837-9925           c
            2349-2446           AC011382.4         9620-9717           c
            2447-2569           AC011382.4         8552-8674           c
            2570-2681           AC011382.4         8359-8470           c
            2682-2781           AC011382.4         7570-7669           c
            2782-2890           AC011382.4         6655-6763           c
            2891-3820           AC011382.4         5628-6557           c
FEATURES             Location/Qualifiers
     source          1..3820
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q32"
     gene            1..3820
                     /gene="CSF1R"
                     /gene_synonym="BANDDOS; C-FMS; CD115; CSF-1R; CSFR; FIM2;
                     FMS; GPSC; HDLS; HDLS1; M-CSF-R"
                     /note="colony stimulating factor 1 receptor"
                     /db_xref="GeneID:1436"
                     /db_xref="HGNC:HGNC:2433"
                     /db_xref="MIM:164770"
     exon            1..176
                     /gene="CSF1R"
                     /gene_synonym="BANDDOS; C-FMS; CD115; CSF-1R; CSFR; FIM2;
                     FMS; GPSC; HDLS; HDLS1; M-CSF-R"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..3046
                     /gene="CSF1R"
                     /gene_synonym="BANDDOS; C-FMS; CD115; CSF-1R; CSFR; FIM2;
                     FMS; GPSC; HDLS; HDLS1; M-CSF-R"
                     /EC_number="2.7.10.1"
                     /note="isoform a precursor is encoded by transcript
                     variant 2; McDonough feline sarcoma viral (v-fms) oncogene
                     homolog; CD115 antigen; FMS proto-oncogene; macrophage
                     colony stimulating factor I receptor; CSF-1 receptor;
                     proto-oncogene c-Fms"
                     /codon_start=1
                     /product="macrophage colony-stimulating factor 1 receptor
                     isoform a precursor"
                     /protein_id="NP_001275634.1"
                     /db_xref="CCDS:CCDS4302.1"
                     /db_xref="GeneID:1436"
                     /db_xref="HGNC:HGNC:2433"
                     /db_xref="MIM:164770"
                     /translation="MGPGVLLLLLVATAWHGQGIPVIEPSVPELVVKPGATVTLRCVG
                     NGSVEWDGPPSPHWTLYSDGSSSILSTNNATFQNTGTYRCTEPGDPLGGSAAIHLYVK
                     DPARPWNVLAQEVVVFEDQDALLPCLLTDPVLEAGVSLVRVRGRPLMRHTNYSFSPWH
                     GFTIHRAKFIQSQDYQCSALMGGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGE
                     AAQIVCSASSVDVNFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNY
                     SCVASNVQGKHSTSMFFRVVESAYLNLSSEQNLIQEVTVGEGLNLKVMVEAYPGLQGF
                     NWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYSFLARNPGGWRAL
                     TFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDRCDEAQVLQVW
                     DDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIPISAGAHTH
                     PPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIESYEGNSYTFIDP
                     TQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHA
                     DEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAM
                     LGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQ
                     DLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFG
                     LARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPY
                     PGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQA
                     QEDRRERDYTNLPSSSRSGGSGSSSSELEEESSSEHLTCCEQGDIAQPLLQPNNYQFC
                     "
     exon            177..434
                     /gene="CSF1R"
                     /gene_synonym="BANDDOS; C-FMS; CD115; CSF-1R; CSFR; FIM2;
                     FMS; GPSC; HDLS; HDLS1; M-CSF-R"
                     /inference="alignment:Splign:2.1.0"
     exon            435..719
                     /gene="CSF1R"
                     /gene_synonym="BANDDOS; C-FMS; CD115; CSF-1R; CSFR; FIM2;
                     FMS; GPSC; HDLS; HDLS1; M-CSF-R"
                     /inference="alignment:Splign:2.1.0"
     exon            720..856
                     /gene="CSF1R"
                     /gene_synonym="BANDDOS; C-FMS; CD115; CSF-1R; CSFR; FIM2;
                     FMS; GPSC; HDLS; HDLS1; M-CSF-R"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1016
                     /gene="CSF1R"
                     /gene_synonym="BANDDOS; C-FMS; CD115; CSF-1R; CSFR; FIM2;
                     FMS; GPSC; HDLS; HDLS1; M-CSF-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1209
                     /gene="CSF1R"
                     /gene_synonym="BANDDOS; C-FMS; CD115; CSF-1R; CSFR; FIM2;
                     FMS; GPSC; HDLS; HDLS1; M-CSF-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1325
                     /gene="CSF1R"
                     /gene_synonym="BANDDOS; C-FMS; CD115; CSF-1R; CSFR; FIM2;
                     FMS; GPSC; HDLS; HDLS1; M-CSF-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1446
                     /gene="CSF1R"
                     /gene_synonym="BANDDOS; C-FMS; CD115; CSF-1R; CSFR; FIM2;
                     FMS; GPSC; HDLS; HDLS1; M-CSF-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1637
                     /gene="CSF1R"
                     /gene_synonym="BANDDOS; C-FMS; CD115; CSF-1R; CSFR; FIM2;
                     FMS; GPSC; HDLS; HDLS1; M-CSF-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1753
                     /gene="CSF1R"
                     /gene_synonym="BANDDOS; C-FMS; CD115; CSF-1R; CSFR; FIM2;
                     FMS; GPSC; HDLS; HDLS1; M-CSF-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..1880
                     /gene="CSF1R"
                     /gene_synonym="BANDDOS; C-FMS; CD115; CSF-1R; CSFR; FIM2;
                     FMS; GPSC; HDLS; HDLS1; M-CSF-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..1985
                     /gene="CSF1R"
                     /gene_synonym="BANDDOS; C-FMS; CD115; CSF-1R; CSFR; FIM2;
                     FMS; GPSC; HDLS; HDLS1; M-CSF-R"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2096
                     /gene="CSF1R"
                     /gene_synonym="BANDDOS; C-FMS; CD115; CSF-1R; CSFR; FIM2;
                     FMS; GPSC; HDLS; HDLS1; M-CSF-R"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2259
                     /gene="CSF1R"
                     /gene_synonym="BANDDOS; C-FMS; CD115; CSF-1R; CSFR; FIM2;
                     FMS; GPSC; HDLS; HDLS1; M-CSF-R"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..2348
                     /gene="CSF1R"
                     /gene_synonym="BANDDOS; C-FMS; CD115; CSF-1R; CSFR; FIM2;
                     FMS; GPSC; HDLS; HDLS1; M-CSF-R"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2446
                     /gene="CSF1R"
                     /gene_synonym="BANDDOS; C-FMS; CD115; CSF-1R; CSFR; FIM2;
                     FMS; GPSC; HDLS; HDLS1; M-CSF-R"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..2569
                     /gene="CSF1R"
                     /gene_synonym="BANDDOS; C-FMS; CD115; CSF-1R; CSFR; FIM2;
                     FMS; GPSC; HDLS; HDLS1; M-CSF-R"
                     /inference="alignment:Splign:2.1.0"
     exon            2570..2681
                     /gene="CSF1R"
                     /gene_synonym="BANDDOS; C-FMS; CD115; CSF-1R; CSFR; FIM2;
                     FMS; GPSC; HDLS; HDLS1; M-CSF-R"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..2781
                     /gene="CSF1R"
                     /gene_synonym="BANDDOS; C-FMS; CD115; CSF-1R; CSFR; FIM2;
                     FMS; GPSC; HDLS; HDLS1; M-CSF-R"
                     /inference="alignment:Splign:2.1.0"
     exon            2782..2890
                     /gene="CSF1R"
                     /gene_synonym="BANDDOS; C-FMS; CD115; CSF-1R; CSFR; FIM2;
                     FMS; GPSC; HDLS; HDLS1; M-CSF-R"
                     /inference="alignment:Splign:2.1.0"
     exon            2891..3820
                     /gene="CSF1R"
                     /gene_synonym="BANDDOS; C-FMS; CD115; CSF-1R; CSFR; FIM2;
                     FMS; GPSC; HDLS; HDLS1; M-CSF-R"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3798..3803
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSF1R"
                     /gene_synonym="BANDDOS; C-FMS; CD115; CSF-1R; CSFR; FIM2;
                     FMS; GPSC; HDLS; HDLS1; M-CSF-R"
                     /note="hexamer: ATTAAA"
     polyA_site      3820
                     /gene="CSF1R"
                     /gene_synonym="BANDDOS; C-FMS; CD115; CSF-1R; CSFR; FIM2;
                     FMS; GPSC; HDLS; HDLS1; M-CSF-R"
                     /note="major polyA site"
ORIGIN      
        1 aaacagccag tgcagaggag aggaacgtgt gtccagtgtc ccgatccctg cggagctagt
       61 agctgagagc tctgtgccct gggcaccttg cagccctgca cctgcctgcc acttccccac
      121 cgaggccatg ggcccaggag ttctgctgct cctgctggtg gccacagctt ggcatggtca
      181 gggaatccca gtgatagagc ccagtgtccc tgagctggtc gtgaagccag gagcaacggt
      241 gaccttgcga tgtgtgggca atggcagcgt ggaatgggat ggccccccat cacctcactg
      301 gaccctgtac tctgatggct ccagcagcat cctcagcacc aacaacgcta ccttccaaaa
      361 cacggggacc tatcgctgca ctgagcctgg agaccccctg ggaggcagcg ccgccatcca
      421 cctctatgtc aaagaccctg cccggccctg gaacgtgcta gcacaggagg tggtcgtgtt
      481 cgaggaccag gacgcactac tgccctgtct gctcacagac ccggtgctgg aagcaggcgt
      541 ctcgctggtg cgtgtgcgtg gccggcccct catgcgccac accaactact ccttctcgcc
      601 ctggcatggc ttcaccatcc acagggccaa gttcattcag agccaggact atcaatgcag
      661 tgccctgatg ggtggcagga aggtgatgtc catcagcatc cggctgaaag tgcagaaagt
      721 catcccaggg cccccagcct tgacactggt gcctgcagag ctggtgcgga ttcgagggga
      781 ggctgcccag atcgtgtgct cagccagcag cgttgatgtt aactttgatg tcttcctcca
      841 acacaacaac accaagctcg caatccctca acaatctgac tttcataata accgttacca
      901 aaaagtcctg accctcaacc tcgatcaagt agatttccaa catgccggca actactcctg
      961 cgtggccagc aacgtgcagg gcaagcactc cacctccatg ttcttccggg tggtagagag
     1021 tgcctacttg aacttgagct ctgagcagaa cctcatccag gaggtgaccg tgggggaggg
     1081 gctcaacctc aaagtcatgg tggaggccta cccaggcctg caaggtttta actggaccta
     1141 cctgggaccc ttttctgacc accagcctga gcccaagctt gctaatgcta ccaccaagga
     1201 cacatacagg cacaccttca ccctctctct gccccgcctg aagccctctg aggctggccg
     1261 ctactccttc ctggccagaa acccaggagg ctggagagct ctgacgtttg agctcaccct
     1321 tcgatacccc ccagaggtaa gcgtcatatg gacattcatc aacggctctg gcaccctttt
     1381 gtgtgctgcc tctgggtacc cccagcccaa cgtgacatgg ctgcagtgca gtggccacac
     1441 tgataggtgt gatgaggccc aagtgctgca ggtctgggat gacccatacc ctgaggtcct
     1501 gagccaggag cccttccaca aggtgacggt gcagagcctg ctgactgttg agaccttaga
     1561 gcacaaccaa acctacgagt gcagggccca caacagcgtg gggagtggct cctgggcctt
     1621 catacccatc tctgcaggag cccacacgca tcccccggat gagttcctct tcacaccagt
     1681 ggtggtcgcc tgcatgtcca tcatggcctt gctgctgctg ctgctcctgc tgctattgta
     1741 caagtataag cagaagccca agtaccaggt ccgctggaag atcatcgaga gctatgaggg
     1801 caacagttat actttcatcg accccacgca gctgccttac aacgagaagt gggagttccc
     1861 ccggaacaac ctgcagtttg gtaagaccct cggagctgga gcctttggga aggtggtgga
     1921 ggccacggcc tttggtctgg gcaaggagga tgctgtcctg aaggtggctg tgaagatgct
     1981 gaagtccacg gcccatgctg atgagaagga ggccctcatg tccgagctga agatcatgag
     2041 ccacctgggc cagcacgaga acatcgtcaa ccttctggga gcctgtaccc atggaggccc
     2101 tgtactggtc atcacggagt actgttgcta tggcgacctg ctcaactttc tgcgaaggaa
     2161 ggctgaggcc atgctgggac ccagcctgag ccccggccag gaccccgagg gaggcgtcga
     2221 ctataagaac atccacctcg agaagaaata tgtccgcagg gacagtggct tctccagcca
     2281 gggtgtggac acctatgtgg agatgaggcc tgtctccact tcttcaaatg actccttctc
     2341 tgagcaagac ctggacaagg aggatggacg gcccctggag ctccgggacc tgcttcactt
     2401 ctccagccaa gtagcccagg gcatggcctt cctcgcttcc aagaattgca tccaccggga
     2461 cgtggcagcg cgtaacgtgc tgttgaccaa tggtcatgtg gccaagattg gggacttcgg
     2521 gctggctagg gacatcatga atgactccaa ctacattgtc aagggcaatg cccgcctgcc
     2581 tgtgaagtgg atggccccag agagcatctt tgactgtgtc tacacggttc agagcgacgt
     2641 ctggtcctat ggcatcctcc tctgggagat cttctcactt gggctgaatc cctaccctgg
     2701 catcctggtg aacagcaagt tctataaact ggtgaaggat ggataccaaa tggcccagcc
     2761 tgcatttgcc ccaaagaata tatacagcat catgcaggcc tgctgggcct tggagcccac
     2821 ccacagaccc accttccagc agatctgctc cttccttcag gagcaggccc aagaggacag
     2881 gagagagcgg gactatacca atctgccgag cagcagcaga agcggtggca gcggcagcag
     2941 cagcagtgag ctggaggagg agagctctag tgagcacctg acctgctgcg agcaagggga
     3001 tatcgcccag cccttgctgc agcccaacaa ctatcagttc tgctgaggag ttgacgacag
     3061 ggagtaccac tctcccctcc cacaaacttc aactcctcca tggatggggc gacacgggga
     3121 gaacatacaa actctgcctt cggtcatttc actcaacagc tcggcccagc tctgaaactt
     3181 gggaaggtga gggattcagg ggaggtcaga ggatcccact tcctgagcat gggccatcac
     3241 tgccagtcag gggctggggg ctgagccctc acccccccct cccctactgt tctcatggtg
     3301 ttggcctcgt gtttgctatg ccaactagta gaaccttctt tcctaatccc cttatcttca
     3361 tggaaatgga ctgactttat gcctatgaag tccccaggag ctacactgat actgagaaaa
     3421 ccaggctctt tggggctaga cagactggca gagagtgaga tctccctctc tgagaggagc
     3481 agcagatgct cacagaccac actcagctca ggccccttgg agcaggatgg ctcctctaag
     3541 aatctcacag gacctcttag tctctgccct atacgccgcc ttcactccac agcctcaccc
     3601 ctcccacccc catactggta ctgctgtaat gagccaagtg gcagctaaaa gttgggggtg
     3661 ttctgcccag tcccgtcatt ctgggctaga aggcagggga ccttggcatg tggctggcca
     3721 caccaagcag gaagcacaaa ctcccccaag ctgactcatc ctaactaaca gtcacgccgt
     3781 gggatgtctc tgtccacatt aaactaacag cattaatgca
//
