LOCUS       NM_000757               3994 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens colony stimulating factor 1 (CSF1), transcript variant
            1, mRNA.
ACCESSION   NM_000757
VERSION     NM_000757.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3994)
  AUTHORS   Sun,X., Xu,L., Ma,S., Du,J., Gu,H. and Wang,J.
  TITLE     CSF1 is expressed by the intestinal epithelial cells to regulate
            Mphi macrophages and maintain epithelial homeostasis and is
            downregulated in neonates with necrotizing enterocolitis
  JOURNAL   BMC Pediatr 24 (1), 608 (2024)
   PUBMED   39342173
  REMARK    GeneRIF: CSF1 is expressed by the intestinal epithelial cells to
            regulate Mphi macrophages and maintain epithelial homeostasis and
            is downregulated in neonates with necrotizing enterocolitis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3994)
  AUTHORS   Harber,K.J., Nguyen,T.A., Schomakers,B.V., Heister,D.A.F., de
            Vries,H.E., van Weeghel,M., Van den Bossche,J. and de
            Winther,M.P.J.
  TITLE     Adenine is an anti-inflammatory metabolite found to be more
            abundant in M-CSF over GM-CSF-differentiated human macrophages
  JOURNAL   Immunol Lett 265, 23-30 (2024)
   PUBMED   38142781
  REMARK    GeneRIF: Adenine is an anti-inflammatory metabolite found to be
            more abundant in M-CSF over GM-CSF-differentiated human
            macrophages.
REFERENCE   3  (bases 1 to 3994)
  AUTHORS   Zhang,S., Ren,D., Hou,H., Yao,L. and Yuan,H.
  TITLE     M-CSF secreted by gastric cancer cells exacerbates the progression
            of gastric cancer by increasing the expression of SHP2 in
            tumor-associated macrophages
  JOURNAL   Aging (Albany NY) 15 (24), 15525-15534 (2023)
   PUBMED   38159254
  REMARK    GeneRIF: M-CSF secreted by gastric cancer cells exacerbates the
            progression of gastric cancer by increasing the expression of SHP2
            in tumor-associated macrophages.
REFERENCE   4  (bases 1 to 3994)
  AUTHORS   Yamanishi,K., Yasuda,S., Masui,Y., Nishida,T., Shindo,Y.,
            Takano,M., Ohmoto,Y., Takahashi,M. and Adachi,M.
  TITLE     The structure of recombinant human carboxy-terminal-truncated
            macrophage colony-stimulating factor derived from mammalian cells
  JOURNAL   J Biochem 114 (2), 255-262 (1993)
   PUBMED   8262907
REFERENCE   5  (bases 1 to 3994)
  AUTHORS   Pandit,J., Bohm,A., Jancarik,J., Halenbeck,R., Koths,K. and
            Kim,S.H.
  TITLE     Three-dimensional structure of dimeric human recombinant macrophage
            colony-stimulating factor
  JOURNAL   Science 258 (5086), 1358-1362 (1992)
   PUBMED   1455231
REFERENCE   6  (bases 1 to 3994)
  AUTHORS   Suzu,S., Ohtsuki,T., Yanai,N., Takatsu,Z., Kawashima,T., Takaku,F.,
            Nagata,N. and Motoyoshi,K.
  TITLE     Identification of a high molecular weight macrophage
            colony-stimulating factor as a glycosaminoglycan-containing species
  JOURNAL   J Biol Chem 267 (7), 4345-4348 (1992)
   PUBMED   1531650
REFERENCE   7  (bases 1 to 3994)
  AUTHORS   Saltman,D.L., Dolganov,G.M., Hinton,L.M. and Lovett,M.
  TITLE     Reassignment of the human macrophage colony stimulating factor gene
            to chromosome 1p13-21
  JOURNAL   Biochem Biophys Res Commun 182 (3), 1139-1143 (1992)
   PUBMED   1540160
REFERENCE   8  (bases 1 to 3994)
  AUTHORS   Sakai,N., Umeda,T., Suzuki,H., Ishimatsu,Y. and Shikita,M.
  TITLE     Macrophage colony-stimulating factor purified from normal human
            urine. Amino-terminal sequence and amino acid composition
  JOURNAL   FEBS Lett 222 (2), 341-344 (1987)
   PUBMED   3498652
REFERENCE   9  (bases 1 to 3994)
  AUTHORS   Ladner,M.B., Martin,G.A., Noble,J.A., Nikoloff,D.M., Tal,R.,
            Kawasaki,E.S. and White,T.J.
  TITLE     Human CSF-1: gene structure and alternative splicing of mRNA
            precursors
  JOURNAL   EMBO J 6 (9), 2693-2698 (1987)
   PUBMED   3500041
REFERENCE   10 (bases 1 to 3994)
  AUTHORS   Kawasaki,E.S., Ladner,M.B., Wang,A.M., Van Arsdell,J., Warren,M.K.,
            Coyne,M.Y., Schweickart,V.L., Lee,M.T., Wilson,K.J., Boosman,A. et
            al.
  TITLE     Molecular cloning of a complementary DNA encoding human
            macrophage-specific colony-stimulating factor (CSF-1)
  JOURNAL   Science 230 (4723), 291-296 (1985)
   PUBMED   2996129
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL450468.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_000757.5.
            
            Summary: The protein encoded by this gene is a cytokine that
            controls the production, differentiation, and function of
            macrophages. The active form of the protein is found
            extracellularly as a disulfide-linked homodimer, and is thought to
            be produced by proteolytic cleavage of membrane-bound precursors.
            The encoded protein may be involved in development of the placenta.
            Alternate splicing results in multiple transcript variants.
            [provided by RefSeq, Sep 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            CCDS Note: This CCDS representation uses a downstream in-frame AUG
            start codon, which is supported by homology and publication data.
            The use of the 5'-most in-frame AUG in the transcript would result
            in a 74 aa N-terminal extension, but this N-terminal extension is
            not conserved in other species, and it would eliminate an
            N-terminal signal peptide, which is known to be present based on
            experimental evidence (PMIDs 8262907, 3498652).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853564.1540.1, AK291660.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329608.11/ ENSP00000327513.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               AL450468.6         67413-67626
            215-337             AL450468.6         70823-70945
            338-400             AL450468.6         72198-72260
            401-571             AL450468.6         73857-74027
            572-719             AL450468.6         78411-78558
            720-1744            AL450468.6         79730-80754
            1745-1797           AL450468.6         81340-81392
            1798-1853           AL450468.6         81711-81766
            1854-3994           AL450468.6         85416-87556
FEATURES             Location/Qualifiers
     source          1..3994
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..3994
                     /gene="CSF1"
                     /gene_synonym="CSF-1; MCSF; PG-M-CSF"
                     /note="colony stimulating factor 1"
                     /db_xref="GeneID:1435"
                     /db_xref="HGNC:HGNC:2432"
                     /db_xref="MIM:120420"
     exon            1..214
                     /gene="CSF1"
                     /gene_synonym="CSF-1; MCSF; PG-M-CSF"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1840
                     /gene="CSF1"
                     /gene_synonym="CSF-1; MCSF; PG-M-CSF"
                     /EC_number="2.7.10.1"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; lanimostim; colony stimulating factor 1
                     (macrophage); macrophage colony stimulating factor 1;
                     CSF1-hERV-LTR71B fusion protein; proteoglycan macrophage
                     colony-stimulating factor"
                     /codon_start=1
                     /product="macrophage colony-stimulating factor 1 isoform a
                     precursor"
                     /protein_id="NP_000748.4"
                     /db_xref="CCDS:CCDS816.1"
                     /db_xref="GeneID:1435"
                     /db_xref="HGNC:HGNC:2432"
                     /db_xref="MIM:120420"
                     /translation="MTAPGAAGRCPPTTWLGSLLLLVCLLASRSITEEVSEYCSHMIG
                     SGHLQSLQRLIDSQMETSCQITFEFVDQEQLKDPVCYLKKAFLLVQDIMEDTMRFRDN
                     TPNAIAIVQLQELSLRLKSCFTKDYEEHDKACVRTFYETPLQLLEKVKNVFNETKNLL
                     DKDWNIFSKNCNNSFAECSSQDVVTKPDCNCLYPKAIPSSDPASVSPHQPLAPSMAPV
                     AGLTWEDSEGTEGSSLLPGEQPLHTVDPGSAKQRPPRSTCQSFEPPETPVVKDSTIGG
                     SPQPRPSVGAFNPGMEDILDSAMGTNWVPEEASGEASEIPVPQGTELSPSRPGGGSMQ
                     TEPARPSNFLSASSPLPASAKGQQPADVTGTALPRVGPVRPTGQDWNHTPQKTDHPSA
                     LLRDPPEPGSPRISSLRPQGLSNPSTLSAQPQLSRSHSSGSVLPLGELEGRRSTRDRR
                     SPAEPEGGPASEGAARPLPRFNSVPLTDTGHERQSEGSFSPQLQESVFHLLVPSVILV
                     LLAVGGLLFYRWRRRSHQEPQRADSPLEQPEGSPLTQDDRQVELPV"
     exon            215..337
                     /gene="CSF1"
                     /gene_synonym="CSF-1; MCSF; PG-M-CSF"
                     /inference="alignment:Splign:2.1.0"
     exon            338..400
                     /gene="CSF1"
                     /gene_synonym="CSF-1; MCSF; PG-M-CSF"
                     /inference="alignment:Splign:2.1.0"
     exon            401..571
                     /gene="CSF1"
                     /gene_synonym="CSF-1; MCSF; PG-M-CSF"
                     /inference="alignment:Splign:2.1.0"
     exon            572..719
                     /gene="CSF1"
                     /gene_synonym="CSF-1; MCSF; PG-M-CSF"
                     /inference="alignment:Splign:2.1.0"
     exon            720..1744
                     /gene="CSF1"
                     /gene_synonym="CSF-1; MCSF; PG-M-CSF"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1797
                     /gene="CSF1"
                     /gene_synonym="CSF-1; MCSF; PG-M-CSF"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1853
                     /gene="CSF1"
                     /gene_synonym="CSF-1; MCSF; PG-M-CSF"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..3994
                     /gene="CSF1"
                     /gene_synonym="CSF-1; MCSF; PG-M-CSF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3972..3977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSF1"
                     /gene_synonym="CSF-1; MCSF; PG-M-CSF"
                     /note="hexamer: AATAAA"
     polyA_site      3994
                     /gene="CSF1"
                     /gene_synonym="CSF-1; MCSF; PG-M-CSF"
                     /note="major polyA site"
ORIGIN      
        1 gaggctcggc ccggggaaag tgaaagtttg cctgggtcct ctcggcgcca gagccgctct
       61 ccgcatccca ggacagcggt gcggccctcg gccggggcgc ccactccgca gcagccagcg
      121 agcgagcgag cgagcgaggg cggccgacgc gcccggccgg gacccagctg cccgtatgac
      181 cgcgccgggc gccgccgggc gctgccctcc cacgacatgg ctgggctccc tgctgttgtt
      241 ggtctgtctc ctggcgagca ggagtatcac cgaggaggtg tcggagtact gtagccacat
      301 gattgggagt ggacacctgc agtctctgca gcggctgatt gacagtcaga tggagacctc
      361 gtgccaaatt acatttgagt ttgtagacca ggaacagttg aaagatccag tgtgctacct
      421 taagaaggca tttctcctgg tacaagacat aatggaggac accatgcgct tcagagataa
      481 cacccccaat gccatcgcca ttgtgcagct gcaggaactc tctttgaggc tgaagagctg
      541 cttcaccaag gattatgaag agcatgacaa ggcctgcgtc cgaactttct atgagacacc
      601 tctccagttg ctggagaagg tcaagaatgt ctttaatgaa acaaagaatc tccttgacaa
      661 ggactggaat attttcagca agaactgcaa caacagcttt gctgaatgct ccagccaaga
      721 tgtggtgacc aagcctgatt gcaactgcct gtaccccaaa gccatcccta gcagtgaccc
      781 ggcctctgtc tcccctcatc agcccctcgc cccctccatg gcccctgtgg ctggcttgac
      841 ctgggaggac tctgagggaa ctgagggcag ctccctcttg cctggtgagc agcccctgca
      901 cacagtggat ccaggcagtg ccaagcagcg gccacccagg agcacctgcc agagctttga
      961 gccgccagag accccagttg tcaaggacag caccatcggt ggctcaccac agcctcgccc
     1021 ctctgtcggg gccttcaacc ccgggatgga ggatattctt gactctgcaa tgggcactaa
     1081 ttgggtccca gaagaagcct ctggagaggc cagtgagatt cccgtacccc aagggacaga
     1141 gctttccccc tccaggccag gagggggcag catgcagaca gagcccgcca gacccagcaa
     1201 cttcctctca gcatcttctc cactccctgc atcagcaaag ggccaacagc cggcagatgt
     1261 aactggtacc gccttgccca gggtgggccc cgtgaggccc actggccagg actggaatca
     1321 caccccccag aagacagacc atccatctgc cctgctcaga gaccccccgg agccaggctc
     1381 tcccaggatc tcatcactgc gcccccaggg cctcagcaac ccctccaccc tctctgctca
     1441 gccacagctt tccagaagcc actcctcggg cagcgtgctg ccccttgggg agctggaggg
     1501 caggaggagc accagggatc ggaggagccc cgcagagcca gaaggaggac cagcaagtga
     1561 aggggcagcc aggcccctgc cccgttttaa ctccgttcct ttgactgaca caggccatga
     1621 gaggcagtcc gagggatcct tcagcccgca gctccaggag tctgtcttcc acctgctggt
     1681 gcccagtgtc atcctggtct tgctggccgt cggaggcctc ttgttctaca ggtggaggcg
     1741 gcggagccat caagagcctc agagagcgga ttctcccttg gagcaaccag agggcagccc
     1801 cctgactcag gatgacagac aggtggaact gccagtgtag agggaattct aagctggacg
     1861 cacagaacag tctctccgtg ggaggagaca ttatggggcg tccaccacca cccctccctg
     1921 gccatcctcc tggaatgtgg tctgccctcc accagagctc ctgcctgcca ggactggacc
     1981 agagcagcca ggctggggcc cctctgtctc aacccgcaga cccttgactg aatgagagag
     2041 gccagaggat gctccccatg ctgccactat ttattgtgag ccctggaggc tcccatgtgc
     2101 ttgaggaagg ctggtgagcc cggctcagga ccctcttccc tcaggggctg caccctcctc
     2161 tcactccctt ccatgccgga acccaggcca gggacccacc ggcctgtggt ttgtgggaaa
     2221 gcagggtgga cgctgaggag tgaaagaacc ctgcacccag agggcctgcc tggtgccaag
     2281 gtatcccagc ctggacaggc atggacctgt ctccagagag aggagcctga agttcgtggg
     2341 gcgggacagc gtcggcctga tttcccgtaa aggtgtgcag cctgagagac gggaagagga
     2401 ggcctctgga cctgctggtc tgcactgaca gcctgaaggg tctacaccct cggctcacct
     2461 aagtgccctg tgctggttgc caggcgcaga ggggaggcca gccctgccct caggacctgc
     2521 ctgacctgcc agtgatgcca agagggggat caagcactgg cctctgcccc tcctccttcc
     2581 agcacctgcc agagcttctc caggaggcca agcagaggct cccctcatga aggaagccat
     2641 tgcactgtga acactgtacc tgcctgctga acagcctgcc cccgtccatc catgagccag
     2701 catccgtccg tcctccactc tccagcctct ccccagcctc ctgcactgag ctggcctcac
     2761 cagtcgactg agggagcccc tcagccctga ccttctcctg acctggcctt tgactccccg
     2821 gagtggagtg gggtgggaga acctcctggg ccgccagcca gagccggtct ttaggctgtg
     2881 ttgttcgccc aggtttctgc atcttgcact ttgacattcc caagagggaa gggactagtg
     2941 ggagagagca agggagggga gggcacagac agagaggcta cagggcgagc tctgactgaa
     3001 gatgggcctt tgaaatatag gtatgcacct gaggttgggg gagggtctgc actcccaaac
     3061 cccagcgcag tgtcctttcc ctgctgccga caggaacctg gggctgaaca ggttatccct
     3121 gtcaggagcc ctggactggg ctgcatctca gccccacctg catggtatcc agctcccatc
     3181 cacttctcac ccttctttcc tcctgacctt ggtcagcagt gatgacctcc aactctcacc
     3241 caccccctct accatcacct ctaaccaggc aagccagggt gggagagcaa tcaggagagc
     3301 caggcctcag cttccaatgc ctggagggcc tccactttgt ggccagcctg tggtggtggc
     3361 tctgaggcct aggcaacgag cgacagggct gccagttgcc cctgggttcc tttgtgctgc
     3421 tgtgtgcctc ctctcctgcc gccctttgtc ctccgctaag agaccctgcc ctacctggcc
     3481 gctgggcccc gtgactttcc cttcctgccc aggaaagtga gggtcggctg gccccacctt
     3541 ccctgtcctg atgccgacag cttagggaag ggcagtgaac ttgcatatgg ggcttagcct
     3601 tctagtcaca gcctctatat ttgatgctag aaaacacata tttttaaatg gaagaaaaat
     3661 aaaaaggcat tcccccttca tccccctacc ttaaacatat aatattttaa aggtcaaaaa
     3721 agcaatccaa cccactgcag aagctctttt tgagcacttg gtggcatcag agcaggagga
     3781 gccccagagc cacctctggt gtccccccag gctacctgct caggaacccc ttctgttctc
     3841 tgagaagtca agagaggaca ttggctcacg cactgtgaga ttttgttttt atacttggaa
     3901 gtggtgaatt attttatata aagtcattta aatatctatt taaaagatag gaagctgctt
     3961 atatatttaa taataaaaga agtgcacaag ctgc
//
