LOCUS       NM_001316               3550 bp    mRNA    linear   PRI 24-MAR-2025
DEFINITION  Homo sapiens chromosome segregation 1 like (CSE1L), transcript
            variant 1, mRNA.
ACCESSION   NM_001316
VERSION     NM_001316.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3550)
  AUTHORS   Li,G., Li,R., Wang,W., Sun,M. and Wang,X.
  TITLE     DDX27 regulates oral squamous cell carcinoma development through
            targeting CSE1L
  JOURNAL   Life Sci 340, 122479 (2024)
   PUBMED   38301874
  REMARK    GeneRIF: DDX27 regulates oral squamous cell carcinoma development
            through targeting CSE1L.
REFERENCE   2  (bases 1 to 3550)
  AUTHORS   Kapinos,L.E., Kalita,J., Kassianidou,E., Rencurel,C. and Lim,R.Y.H.
  TITLE     Mechanism of exportin retention in the cell nucleus
  JOURNAL   J Cell Biol 223 (2) (2024)
   PUBMED   38241019
  REMARK    GeneRIF: Mechanism of exportin retention in the cell nucleus.
REFERENCE   3  (bases 1 to 3550)
  AUTHORS   Liu,X.Y., Wang,Y.H., Wang,J., Quan,J.K., Li,X.D. and Guan,K.P.
  TITLE     The role of CSE1L silencing in the regulation of proliferation and
            apoptosis via the AMPK/mTOR signaling pathway in chronic myeloid
            leukemia
  JOURNAL   Hematology 28 (1), 1-9 (2023)
   PUBMED   36652402
  REMARK    GeneRIF: The role of CSE1L silencing in the regulation of
            proliferation and apoptosis via the AMPK/mTOR signaling pathway in
            chronic myeloid leukemia.
REFERENCE   4  (bases 1 to 3550)
  AUTHORS   Guo,H.R., Wang,X., Zhang,H. and Guan,K.P.
  TITLE     [Expression and Clinical Significance of CAS in Acute Myeloid
            Leukemia Patients]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 30 (3), 744-749 (2022)
   PUBMED   35680799
  REMARK    GeneRIF: [Expression and Clinical Significance of CAS in Acute
            Myeloid Leukemia Patients].
REFERENCE   5  (bases 1 to 3550)
  AUTHORS   Chang,C.C., Kao,W.Y., Liu,C.Y., Su,H.H., Kan,Y.A., Lin,P.Y.,
            Ku,W.C., Chang,K.W., Yang,R.N. and Huang,C.J.
  TITLE     Butyrate supplementation regulates expression of chromosome
            segregation 1-like protein to reverse the genetic distortion caused
            by p53 mutations in colorectal cancer
  JOURNAL   Int J Oncol 60 (6) (2022)
   PUBMED   35417036
  REMARK    GeneRIF: Butyrate supplementation regulates expression of
            chromosome segregation 1like protein to reverse the genetic
            distortion caused by p53 mutations in colorectal cancer.
REFERENCE   6  (bases 1 to 3550)
  AUTHORS   Herold,A., Truant,R., Wiegand,H. and Cullen,B.R.
  TITLE     Determination of the functional domain organization of the importin
            alpha nuclear import factor
  JOURNAL   J Cell Biol 143 (2), 309-318 (1998)
   PUBMED   9786944
REFERENCE   7  (bases 1 to 3550)
  AUTHORS   Kutay,U., Bischoff,F.R., Kostka,S., Kraft,R. and Gorlich,D.
  TITLE     Export of importin alpha from the nucleus is mediated by a specific
            nuclear transport factor
  JOURNAL   Cell 90 (6), 1061-1071 (1997)
   PUBMED   9323134
REFERENCE   8  (bases 1 to 3550)
  AUTHORS   Brinkmann,U., Brinkmann,E., Gallo,M., Scherf,U. and Pastan,I.
  TITLE     Role of CAS, a human homologue to the yeast chromosome segregation
            gene CSE1, in toxin and tumor necrosis factor mediated apoptosis
  JOURNAL   Biochemistry 35 (21), 6891-6899 (1996)
   PUBMED   8639641
REFERENCE   9  (bases 1 to 3550)
  AUTHORS   Brinkmann,U., Gallo,M., Polymeropoulos,M.H. and Pastan,I.
  TITLE     The human CAS (cellular apoptosis susceptibility) gene mapping on
            chromosome 20q13 is amplified in BT474 breast cancer cells and part
            of aberrant chromosomes in breast and colon cancer cell lines
  JOURNAL   Genome Res 6 (3), 187-194 (1996)
   PUBMED   8963895
REFERENCE   10 (bases 1 to 3550)
  AUTHORS   Brinkmann,U., Brinkmann,E., Gallo,M. and Pastan,I.
  TITLE     Cloning and characterization of a cellular apoptosis susceptibility
            gene, the human homologue to the yeast chromosome segregation gene
            CSE1
  JOURNAL   Proc Natl Acad Sci U S A 92 (22), 10427-10431 (1995)
   PUBMED   7479798
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC402014.1, BC109314.2,
            AI973168.1 and AI018123.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001316.3.
            
            Summary: Proteins that carry a nuclear localization signal (NLS)
            are transported into the nucleus by the importin-alpha/beta
            heterodimer. Importin-alpha binds the NLS, while importin-beta
            mediates translocation through the nuclear pore complex. After
            translocation, RanGTP binds importin-beta and displaces
            importin-alpha. Importin-alpha must then be returned to the
            cytoplasm, leaving the NLS protein behind. The protein encoded by
            this gene binds strongly to NLS-free importin-alpha, and this
            binding is released in the cytoplasm by the combined action of
            RANBP1 and RANGAP1. In addition, the encoded protein may play a
            role both in apoptosis and in cell proliferation. Alternatively
            spliced transcript variants have been found for this gene.
            [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript, and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF053641.1, SRR1660803.80327.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262982.3/ ENSP00000262982.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DC402014.1         67-87
            22-3321             BC109314.2         1-3300
            3322-3544           AI973168.1         1-223               c
            3545-3550           AI018123.1         13-18               c
FEATURES             Location/Qualifiers
     source          1..3550
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.13"
     gene            1..3550
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /note="chromosome segregation 1 like"
                     /db_xref="GeneID:1434"
                     /db_xref="HGNC:HGNC:2431"
                     /db_xref="MIM:601342"
     exon            1..112
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            113..208
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..3039
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     importin-alpha re-exporter; CSE1 chromosome segregation
                     1-like; cellular apoptosis susceptibility protein;
                     exportin-2; exp2; chromosome segregation 1-like protein;
                     epididymis secretory sperm binding protein; BCR/ABL1
                     fusion; BCR/ABL fusion protein"
                     /codon_start=1
                     /product="exportin-2 isoform 1"
                     /protein_id="NP_001307.2"
                     /db_xref="CCDS:CCDS13412.1"
                     /db_xref="GeneID:1434"
                     /db_xref="HGNC:HGNC:2431"
                     /db_xref="MIM:601342"
                     /translation="MELSDANLQTLTEYLKKTLDPDPAIRRPAEKFLESVEGNQNYPL
                     LLLTLLEKSQDNVIKVCASVTFKNYIKRNWRIVEDEPNKICEADRVAIKANIVHLMLS
                     SPEQIQKQLSDAISIIGREDFPQKWPDLLTEMVNRFQSGDFHVINGVLRTAHSLFKRY
                     RHEFKSNELWTEIKLVLDAFALPLTNLFKATIELCSTHANDASALRILFSSLILISKL
                     FYSLNFQDLPEFFEDNMETWMNNFHTLLTLDNKLLQTDDEEEAGLLELLKSQICDNAA
                     LYAQKYDEEFQRYLPRFVTAIWNLLVTTGQEVKYDLLVSNAIQFLASVCERPHYKNLF
                     EDQNTLTSICEKVIVPNMEFRAADEEAFEDNSEEYIRRDLEGSDIDTRRRAACDLVRG
                     LCKFFEGPVTGIFSGYVNSMLQEYAKNPSVNWKHKDAAIYLVTSLASKAQTQKHGITQ
                     ANELVNLTEFFVNHILPDLKSANVNEFPVLKADGIKYIMIFRNQVPKEHLLVSIPLLI
                     NHLQAESIVVHTYAAHALERLFTMRGPNNATLFTAAEIAPFVEILLTNLFKALTLPGS
                     SENEYIMKAIMRSFSLLQEAIIPYIPTLITQLTQKLLAVSKNPSKPHFNHYMFEAICL
                     SIRITCKANPAAVVNFEEALFLVFTEILQNDVQEFIPYVFQVMSLLLETHKNDIPSSY
                     MALFPHLLQPVLWERTGNIPALVRLLQAFLERGSNTIASAAADKIPGLLGVFQKLIAS
                     KANDHQGFYLLNSIIEHMPPESVDQYRKQIFILLFQRLQNSKTTKFIKSFLVFINLYC
                     IKYGALALQEIFDGIQPKMFGMVLEKIIIPEIQKVSGNVEKKICAVGITKLLTECPPM
                     MDTEYTKLWTPLLQSLIGLFELPEDDTIPDEEHFIDIEDTPGYQTAFSQLAFAGKKEH
                     DPVGQMVNNPKIHLAQSLHKLSTACPGRVPSMVSTSLNAEALQYLQGYLQAASVTLL"
     exon            209..351
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            352..453
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            454..599
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            600..690
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            691..798
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            799..891
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1059
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1189
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1255
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1458
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1543
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1605
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1742
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1846
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1944
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2095
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2304
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            2305..2402
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..2488
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..2570
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2717
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            2718..2949
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:2.1.0"
     exon            2950..3550
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3167..3172
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /note="hexamer: ATTAAA"
     polyA_site      3189
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /note="major polyA site"
     regulatory      3458..3463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /note="hexamer: AGTAAA"
     polyA_site      3486
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
     regulatory      3524..3529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
                     /note="hexamer: AATAAA"
     polyA_site      3550
                     /gene="CSE1L"
                     /gene_synonym="CAS; CSE1; XPO2"
ORIGIN      
        1 gtcgcgccat tttgccgggg tttgaatgtg aggcggagcg gcggcaggag cgggtagtgc
       61 cagctacggt ccgcggctgg ggttccctcc tccgtttctg tatccccacg agatcctata
      121 gcaatggaac tcagcgatgc aaatctgcaa acactaacag aatatttaaa gaaaacactt
      181 gatcctgatc ctgccatccg acgtccagct gagaaatttc ttgaatctgt tgaaggaaat
      241 cagaattatc cactgttgct tttgacatta ctggagaagt cccaggataa tgttatcaaa
      301 gtatgtgctt cagtaacatt caaaaactat attaaaagga actggagaat tgttgaagat
      361 gaaccaaaca aaatttgtga agccgatcga gtggccatta aagccaacat agtgcacttg
      421 atgcttagca gcccagagca aattcagaag cagttaagtg atgcaattag cattattggc
      481 agagaagatt ttccacagaa atggcctgac ttgctgacag aaatggtgaa tcgctttcag
      541 agtggagatt tccatgttat taatggagtc ctccgtacag cacattcatt atttaaaaga
      601 taccgtcatg aatttaagtc aaacgagtta tggactgaaa ttaagcttgt tctggatgcc
      661 tttgctttgc ctttgactaa tctttttaag gccactattg aactctgcag tacccatgca
      721 aatgatgcct ctgccctgag gattctgttt tcttccctga tcctgatctc aaaattgttc
      781 tatagtttaa actttcagga tctccctgaa ttttttgaag ataatatgga aacttggatg
      841 aataattttc atactctctt aacattggat aataagcttt tacaaactga tgatgaagag
      901 gaagccggct tattggagct cttaaaatcc cagatttgtg ataatgccgc actctatgca
      961 caaaagtacg atgaagaatt ccagcgatac ctgcctcgtt ttgttacagc catctggaat
     1021 ttactagtta caacgggtca agaggttaaa tatgatttgt tggtaagtaa tgcaattcaa
     1081 tttctggctt cagtttgtga gagacctcat tataagaatc tatttgagga ccagaacacg
     1141 ctgacaagta tctgtgaaaa ggttattgtg cctaacatgg aatttagagc tgctgatgaa
     1201 gaagcatttg aagataattc tgaggagtac ataaggagag atttggaagg atctgatatt
     1261 gatactagac gcagggctgc ttgtgatctg gtacgaggat tatgcaagtt ttttgaggga
     1321 cctgtgacag gaatcttctc tggttatgtt aattccatgc tgcaggaata cgcaaaaaat
     1381 ccatctgtca actggaaaca caaagatgca gccatctacc tagtgacatc tttggcatca
     1441 aaagcccaaa cacagaagca tggaattaca caagcaaatg aacttgtaaa cctaactgag
     1501 ttctttgtga atcacatcct ccctgattta aaatcagcta atgtgaatga atttcctgtc
     1561 cttaaagctg acggtatcaa atatattatg atttttagaa atcaagtgcc aaaagaacat
     1621 cttttagtct cgattcctct cttgattaat catcttcaag ctgaaagtat tgttgttcat
     1681 acttacgcag ctcatgctct tgaacggctc tttactatgc gagggcctaa caatgccact
     1741 ctctttacag ctgcagaaat cgcaccgttt gttgagattc tgctaacaaa ccttttcaaa
     1801 gctctcacac ttcctggctc ttcagaaaat gaatatatta tgaaagctat catgagaagt
     1861 ttttctctcc tacaagaagc cataatcccc tacatcccta ctctcatcac tcagcttaca
     1921 cagaagctat tagctgttag taagaaccca agcaaacctc actttaatca ctacatgttt
     1981 gaagcaatat gtttatccat aagaataact tgcaaagcta accctgctgc tgttgtaaat
     2041 tttgaggagg ctttgttttt ggtgtttact gaaatcttac aaaatgatgt gcaagaattt
     2101 attccatacg tctttcaagt gatgtctttg cttctggaaa cacacaaaaa tgacatcccg
     2161 tcttcctata tggccttatt tcctcatctc cttcagccag tgctttggga aagaacagga
     2221 aatattcctg ctctagtgag gcttcttcaa gcattcttag aacgcggttc aaacacaata
     2281 gcaagtgctg cagctgacaa aattcctggg ttactaggtg tctttcagaa gctgattgca
     2341 tccaaagcaa atgaccacca aggtttttat cttctaaaca gtataataga gcacatgcct
     2401 cctgaatcag ttgaccaata taggaaacaa atcttcattc tgctattcca gagacttcag
     2461 aattccaaaa caaccaagtt tatcaagagt tttttagtct ttattaattt gtattgcata
     2521 aaatatgggg cactagcact acaagaaata tttgatggta tacaaccaaa aatgtttgga
     2581 atggttttgg aaaaaattat tattcctgaa attcagaagg tatctggaaa tgtagagaaa
     2641 aagatctgtg cggttggcat aaccaaatta ctaacagaat gtcccccaat gatggacact
     2701 gagtatacca aactgtggac tccattatta cagtctttga ttggtctttt tgagttaccc
     2761 gaagatgata ccattcctga tgaggaacat tttattgaca tagaagatac accaggatat
     2821 cagactgcct tctcacagtt ggcatttgct gggaaaaaag agcatgatcc tgtaggtcaa
     2881 atggtgaata accccaaaat tcacctggca cagtcacttc acaagttgtc taccgcctgt
     2941 ccaggaaggg ttccatcaat ggtgagcacc agcctgaatg cagaagcgct ccagtatctc
     3001 caagggtacc ttcaggcagc cagtgtgaca ctgctttaaa ctgcattttt ctaatgggct
     3061 aaacccagat ggtttcctag gaaatcacag gcttctgagc acagctgcat taaaacaaag
     3121 gaagttctcc ttttgaactt gtcacgaatt ccatcttgta aaggatatta aatgttgctt
     3181 taacctgaac cttgagcaaa ttagttggtt tgtgtgatca tacagttatg tgggtggctt
     3241 ctagtttgca acttcaaggg acaagtatta atagttcagt gtatggcgtt ggtttgtgtt
     3301 gagcgtttgc acggtttgga taatcttaaa ttttgacgga cactgtggag actttctgtt
     3361 actaaatcct tttgttttga agctgttgct atttgtattt ctcttgtcct ttatattttt
     3421 tgtctgttta tttacgcttt tattggaaat gtgaataagt aaagaattac ttgtgttact
     3481 tgccaagcag tgcacatttc atagtttcaa atctgtaatc agcaataaaa atcctaaaat
     3541 atgtacctaa
//
