LOCUS       NM_001007553            4097 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens cold shock domain containing E1 (CSDE1), transcript
            variant 1, mRNA.
ACCESSION   NM_001007553
VERSION     NM_001007553.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4097)
  AUTHORS   Kakumani,P.K., Ko,Y., Ramakrishna,S., Christopher,G., Dodgson,M.,
            Shrinet,J., Harvey,L.M., Shin,C. and Simard,M.J.
  TITLE     CSDE1 promotes miR-451 biogenesis
  JOURNAL   Nucleic Acids Res 51 (17), 9385-9396 (2023)
   PUBMED   37493604
  REMARK    GeneRIF: CSDE1 promotes miR-451 biogenesis.
REFERENCE   2  (bases 1 to 4097)
  AUTHORS   Liu,J., Zhang,N., Zeng,J., Wang,T., Shen,Y., Ma,C. and Yang,M.
  TITLE     N6 -methyladenosine-modified lncRNA ARHGAP5-AS1 stabilises CSDE1
            and coordinates oncogenic RNA regulons in hepatocellular carcinoma
  JOURNAL   Clin Transl Med 12 (11), e1107 (2022)
   PUBMED   36354136
REFERENCE   3  (bases 1 to 4097)
  AUTHORS   Smith,G.A., Padmanabhan,A., Lau,B.H., Pampana,A., Li,L., Lee,C.Y.,
            Pelonero,A., Nishino,T., Sadagopan,N., Xia,V.Q., Jain,R.,
            Natarajan,P., Wu,R.S., Black,B.L., Srivastava,D., Shokat,K.M. and
            Chorba,J.S.
  TITLE     Cold shock domain-containing protein E1 is a posttranscriptional
            regulator of the LDL receptor
  JOURNAL   Sci Transl Med 14 (662), eabj8670 (2022)
   PUBMED   36103516
  REMARK    GeneRIF: Cold shock domain-containing protein E1 is a
            posttranscriptional regulator of the LDL receptor.
REFERENCE   4  (bases 1 to 4097)
  AUTHORS   Kim,Y., Ko,J.Y., Lee,S.B., Oh,S., Park,J.W., Kang,H.G., Kim,D.H.,
            Chung,D., Lim,S., Kong,H., Kim,J., Yoo,K.H., Han,W., Chun,K.H. and
            Park,J.H.
  TITLE     Reduced miR-371b-5p expression drives tumor progression via
            CSDE1/RAC1 regulation in triple-negative breast cancer
  JOURNAL   Oncogene 41 (22), 3151-3161 (2022)
   PUBMED   35490208
  REMARK    GeneRIF: Reduced miR-371b-5p expression drives tumor progression
            via CSDE1/RAC1 regulation in triple-negative breast cancer.
REFERENCE   5  (bases 1 to 4097)
  AUTHORS   Avolio,R., Ingles-Ferrandiz,M., Ciocia,A., Coll,O., Bonnin,S.,
            Guitart,T., Ribo,A. and Gebauer,F.
  TITLE     Coordinated post-transcriptional control of oncogene-induced
            senescence by UNR/CSDE1
  JOURNAL   Cell Rep 38 (2), 110211 (2022)
   PUBMED   35021076
  REMARK    GeneRIF: Coordinated post-transcriptional control of
            oncogene-induced senescence by UNR/CSDE1.
REFERENCE   6  (bases 1 to 4097)
  AUTHORS   Grosset,C., Chen,C.Y., Xu,N., Sonenberg,N., Jacquemin-Sablon,H. and
            Shyu,A.B.
  TITLE     A mechanism for translationally coupled mRNA turnover: interaction
            between the poly(A) tail and a c-fos RNA coding determinant via a
            protein complex
  JOURNAL   Cell 103 (1), 29-40 (2000)
   PUBMED   11051545
REFERENCE   7  (bases 1 to 4097)
  AUTHORS   Hunt,S.L., Hsuan,J.J., Totty,N. and Jackson,R.J.
  TITLE     unr, a cellular cytoplasmic RNA-binding protein with five
            cold-shock domains, is required for internal initiation of
            translation of human rhinovirus RNA
  JOURNAL   Genes Dev 13 (4), 437-448 (1999)
   PUBMED   10049359
REFERENCE   8  (bases 1 to 4097)
  AUTHORS   Boussadia,O., Jacquemin-Sablon,H. and Dautry,F.
  TITLE     Exon skipping in the expression of the gene immediately upstream of
            N-ras (unr/NRU)
  JOURNAL   Biochim Biophys Acta 1172 (1-2), 64-72 (1993)
   PUBMED   8439573
REFERENCE   9  (bases 1 to 4097)
  AUTHORS   Nicolaiew,N., Triqueneaux,G. and Dautry,F.
  TITLE     Organization of the human N-ras locus: characterization of a gene
            located immediately upstream of N-ras
  JOURNAL   Oncogene 6 (5), 721-730 (1991)
   PUBMED   2052355
REFERENCE   10 (bases 1 to 4097)
  AUTHORS   Jeffers,M., Paciucci,R. and Pellicer,A.
  TITLE     Characterization of unr; a gene closely linked to N-ras
  JOURNAL   Nucleic Acids Res 18 (16), 4891-4899 (1990)
   PUBMED   2204029
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP202324.1, AB020692.1 and BU681634.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001007553.2.
            
            Transcript Variant: This variant (1) differs in the 5' UTR and
            coding sequence compared to variant 4. The resulting isoform (1) is
            shorter at the N-terminus compared to isoform 4. Variants 1 and 5
            both encode isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.247132.1,
                                           SRR1803613.114801.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358528.9/ ENSP00000351329.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BP202324.1         67-86
            21-4096             AB020692.1         1-4076
            4097-4097           BU681634.1         21-21               c
FEATURES             Location/Qualifiers
     source          1..4097
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.2"
     gene            1..4097
                     /gene="CSDE1"
                     /gene_synonym="D1S155E; UNR"
                     /note="cold shock domain containing E1"
                     /db_xref="GeneID:7812"
                     /db_xref="HGNC:HGNC:29905"
                     /db_xref="MIM:191510"
     exon            1..60
                     /gene="CSDE1"
                     /gene_synonym="D1S155E; UNR"
                     /inference="alignment:Splign:2.1.0"
     exon            61..447
                     /gene="CSDE1"
                     /gene_synonym="D1S155E; UNR"
                     /inference="alignment:Splign:2.1.0"
     CDS             448..2844
                     /gene="CSDE1"
                     /gene_synonym="D1S155E; UNR"
                     /note="isoform 1 is encoded by transcript variant 1;
                     upstream of NRAS; NRAS-related; cold shock
                     domain-containing protein E1; cold shock domain containing
                     E1, RNA binding; N-ras upstream gene protein"
                     /codon_start=1
                     /product="cold shock domain-containing protein E1 isoform
                     1"
                     /protein_id="NP_001007554.1"
                     /db_xref="CCDS:CCDS30812.1"
                     /db_xref="GeneID:7812"
                     /db_xref="HGNC:HGNC:29905"
                     /db_xref="MIM:191510"
                     /translation="MSFDPNLLHNNGHNGYPNGTSAALRETGVIEKLLTSYGFIQCSE
                     RQARLFFHCSQYNGNLQDLKVGDDVEFEVSSDRRTGKPIAVKLVKIKQEILPEERMNG
                     QVVCAVPHNLESKSPAAPGQSPTGSVCYERNGEVFYLTYTPEDVEGNVQLETGDKINF
                     VIDNNKHTGAVSARNIMLLKKKQARCQGVVCAMKEAFGFIERGDVVKEIFFHYSEFKG
                     DLETLQPGDDVEFTIKDRNGKEVATDVRLLPQGTVIFEDISIEHFEGTVTKVIPKVPS
                     KNQNDPLPGRIKVDFVIPKELPFGDKDTKSKVTLLEGDHVRFNISTDRRDKLERATNI
                     EVLSNTFQFTNEAREMGVIAAMRDGFGFIKCVDRDVRMFFHFSEILDGNQLHIADEVE
                     FTVVPDMLSAQRNHAIRIKKLPKGTVSFHSHSDHRFLGTVEKEATFSNPKTTSPNKGK
                     EKEAEDGIIAYDDCGVKLTIAFQAKDVEGSTSPQIGDKVEFSISDKQRPGQQVATCVR
                     LLGRNSNSKRLLGYVATLKDNFGFIETANHDKEIFFHYSEFSGDVDSLELGDMVEYSL
                     SKGKGNKVSAEKVNKTHSVNGITEEADPTIYSGKVIRPLRSVDPTQTEYQGMIEIVEE
                     GDMKGEVYPFGIVGMANKGDCLQKGESVKFQLCVLGQNAQTMAYNITPLRRATVECVK
                     DQFGFINYEVGDSKKLFFHVKEVQDGIELQAGDEVEFSVILNQRTGKCSACNVWRVCE
                     GPKAVAAPRPDRLVNRLKNITLDDASAPRLMVLRQPRGPDNSMGFGAERKIRQAGVID
                     "
     exon            448..646
                     /gene="CSDE1"
                     /gene_synonym="D1S155E; UNR"
                     /inference="alignment:Splign:2.1.0"
     exon            647..756
                     /gene="CSDE1"
                     /gene_synonym="D1S155E; UNR"
                     /inference="alignment:Splign:2.1.0"
     exon            757..849
                     /gene="CSDE1"
                     /gene_synonym="D1S155E; UNR"
                     /inference="alignment:Splign:2.1.0"
     exon            850..947
                     /gene="CSDE1"
                     /gene_synonym="D1S155E; UNR"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1029
                     /gene="CSDE1"
                     /gene_synonym="D1S155E; UNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1158
                     /gene="CSDE1"
                     /gene_synonym="D1S155E; UNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1284
                     /gene="CSDE1"
                     /gene_synonym="D1S155E; UNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1497
                     /gene="CSDE1"
                     /gene_synonym="D1S155E; UNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1638
                     /gene="CSDE1"
                     /gene_synonym="D1S155E; UNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1639..1803
                     /gene="CSDE1"
                     /gene_synonym="D1S155E; UNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1911
                     /gene="CSDE1"
                     /gene_synonym="D1S155E; UNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2087
                     /gene="CSDE1"
                     /gene_synonym="D1S155E; UNR"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2200
                     /gene="CSDE1"
                     /gene_synonym="D1S155E; UNR"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2320
                     /gene="CSDE1"
                     /gene_synonym="D1S155E; UNR"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2499
                     /gene="CSDE1"
                     /gene_synonym="D1S155E; UNR"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2663
                     /gene="CSDE1"
                     /gene_synonym="D1S155E; UNR"
                     /inference="alignment:Splign:2.1.0"
     exon            2664..2796
                     /gene="CSDE1"
                     /gene_synonym="D1S155E; UNR"
                     /inference="alignment:Splign:2.1.0"
     exon            2797..4097
                     /gene="CSDE1"
                     /gene_synonym="D1S155E; UNR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3700..3705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSDE1"
                     /gene_synonym="D1S155E; UNR"
                     /note="hexamer: AATAAA"
     polyA_site      3721
                     /gene="CSDE1"
                     /gene_synonym="D1S155E; UNR"
     regulatory      4068..4073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSDE1"
                     /gene_synonym="D1S155E; UNR"
                     /note="hexamer: AATAAA"
     polyA_site      4097
                     /gene="CSDE1"
                     /gene_synonym="D1S155E; UNR"
                     /note="major polyA site"
ORIGIN      
        1 cctacgtacc gggccgtgct gcttatggcg gcgctggaga gggggcgctg agctgttggg
       61 tatgaagtgt aacagaacag actttaccac ctgaaactgc tgcttcaagt tcagatcagg
      121 caaggaacaa acctcgtaac aactaacaag accaaagaag agtacactta agttgaagac
      181 acaacacttg atctgaaaca agaagtttgt gcctactcaa cagctttgaa agagcacttc
      241 ccaacgctgc tagtagtctt tgttttcttc agtgctgtac tgtgagattg cccggtacag
      301 cagcagttgt attctttatt agcttggtag atcattttct ctcgctcttt tttttaatac
      361 tagcaacttt catcctttga aacgtgtgct gaaaaagaag aatcagcaaa tactactgaa
      421 agtgcaatat ttgagtatca ctgcgagatg agctttgatc caaaccttct ccacaacaat
      481 ggacataatg ggtaccctaa tggtacttca gcagcactgc gtgaaactgg ggttattgaa
      541 aaactgttaa cctcttacgg atttattcag tgttcagaac gtcaagctag acttttcttc
      601 cactgttcac agtataatgg caacctgcaa gacttaaaag taggagatga tgttgaattt
      661 gaagtatcat cggaccgacg gactgggaaa cccattgctg ttaaactggt gaagataaaa
      721 caagaaatcc tccctgaaga acgaatgaat ggacaagttg tgtgcgctgt tcctcacaac
      781 ttagagagta aatctccagc tgccccgggt cagagtccaa cagggagtgt atgctacgaa
      841 cgtaatgggg aagtgtttta tctgacttac acccctgaag atgtcgaagg gaacgttcag
      901 ctggaaactg gagataaaat aaactttgta attgataaca ataaacatac tggtgctgta
      961 agtgctcgca acattatgct gttgaaaaag aaacaagccc gctgtcaggg agtagtttgt
     1021 gccatgaagg aggcatttgg ctttattgaa agaggtgatg ttgtaaaaga gatattcttt
     1081 cactatagtg aatttaaggg tgacttagaa accttacagc ctggcgatga tgtggaattc
     1141 acaatcaagg acagaaatgg taaagaagtt gcaacagatg tcagactatt gcctcaagga
     1201 acagtcattt ttgaagatat cagcattgaa cattttgaag gaactgtaac caaagttatc
     1261 ccaaaagtac ccagtaaaaa ccagaatgac ccattgccag gacgcatcaa agttgacttt
     1321 gtgatcccta aagaacttcc ctttggagac aaagatacga aatccaaggt gaccctgctg
     1381 gaaggtgacc atgttaggtt taatatttca acagaccgac gtgacaaatt agagcgagca
     1441 accaatatag aagttctgtc aaatacattt cagttcacta atgaagcccg agaaatgggt
     1501 gtgattgctg ccatgagaga tggttttggt ttcatcaagt gtgtggatcg tgatgttcgt
     1561 atgttcttcc acttcagtga aattctggat gggaaccagc tccatattgc agatgaagta
     1621 gagtttactg tggttcctga tatgctctct gctcaaagaa atcatgctat taggattaaa
     1681 aaacttccca agggcacggt ttcatttcat tcccattcag atcaccgttt tctgggcacg
     1741 gtagaaaaag aagccacttt ttccaatcct aaaaccacta gcccaaataa aggcaaagag
     1801 aaggaggctg aggatggcat tattgcttat gatgactgtg gggtgaaact gactattgct
     1861 tttcaagcca aggatgtgga aggatctact tctcctcaaa taggagataa ggttgaattt
     1921 agtattagtg acaaacagag gcctggacag caggttgcaa cttgtgtgcg acttttaggt
     1981 cgtaattcta actccaagag gctcttgggt tatgtggcaa ctctgaagga taattttgga
     2041 tttattgaaa cagccaatca tgataaggaa atctttttcc attacagtga gttctctggt
     2101 gatgttgata gcctggaact gggggacatg gtcgagtata gcttgtccaa aggcaaaggc
     2161 aacaaagtca gtgcagaaaa agtgaacaaa acacactcag tgaatggcat tactgaggaa
     2221 gctgatccca ccatttactc tggcaaagta attcgccccc tgaggagtgt tgatccaaca
     2281 cagactgagt accaaggaat gattgagatt gtggaggagg gcgatatgaa aggtgaggtc
     2341 tatccatttg gcatcgttgg gatggccaac aaaggggatt gcctgcagaa aggggagagc
     2401 gtcaagttcc aattgtgtgt cctgggccaa aatgcacaaa ctatggctta caacatcaca
     2461 cccctgcgca gggccacagt ggaatgtgtg aaagatcagt ttggcttcat taactatgaa
     2521 gtaggagata gcaagaagct ctttttccat gtgaaagaag ttcaggatgg cattgagcta
     2581 caggcaggag atgaggtgga gttctcagtg attcttaatc agcgcactgg caagtgcagc
     2641 gcctgtaatg tttggcgagt ctgtgagggc cccaaggctg ttgcagctcc tcgacctgat
     2701 cggttggtca atcgcttgaa gaatatcact ctggatgatg ccagtgctcc tcgcctaatg
     2761 gttcttcgtc agccaagggg accagataac tcaatggggt ttggtgcaga aagaaagatc
     2821 cgtcaagctg gtgtcattga ctaaccacat ccacaaagca caccattaat ccactatgat
     2881 caagttgggg ggaatctggt gaagggttct gaatatctcc ctcttcatcc ctcccgaaat
     2941 ctggaatact tattctattg agctattaca ccagttttaa caccttcctc gtgttatgtt
     3001 taaaaaaata aataaattta agaaaaccat tttaaataat gcacagttgc agcctggaaa
     3061 aacttaaggt ggcgccttat agtatcaatt ttaggagctt tatttggtgc atttaacgca
     3121 actggtaatt gcagaatcca ctttgcctgt gtaagtgaaa aatatagact gttatcttgt
     3181 tggccctatg aaattctgca cttttcatta tatactctac cttcattaat tacttctggc
     3241 aagatgttct gccttagcac tcagttgcat tcttttcctt tttcttcctg ttcattatgc
     3301 tttaattctg aggaccatat gagggtagaa tatattatct tttaaaaatt acaaaaattt
     3361 gtataggcaa accatttctt aaagttgatg gccaaatttt aaaatgttat ttttcatatc
     3421 atttataatc ttgtcacaat ccacttaaag aagtttggtt atatttcagt gaaaattttc
     3481 ttccagagta ggtttttttt cgtgggttgg ggggtaactt tactacaatt agtaagtatg
     3541 gtgcagaatt tcatgcaaat gaggagtgcc agcagtgtga taatttaaac atatttaaac
     3601 aaaaacaaaa aaaatgaatg cacaaacttg ctgctgctta gatcactgca gcttctagga
     3661 cccggtttct tttactgatt taaaaacaaa acaaaaaaaa ataaaaaagt tgtgcctgaa
     3721 atgaatcttg ttttttttta taagtagccg cctggttact gtgtcctgta aaatacagac
     3781 acttgaccct tggtgtagct tctgttcaac tttatatcac gggaatggat gggtctgatt
     3841 tcttggccct cttcttgaat tggccatata cagggtccct ggccagtgga ctgaaggctt
     3901 tgtctaagat gacaagggtc agctcagggg atgtggggga gggcggtttt atcttccccc
     3961 ttgtcgtttg aggttttgat ctctgggtaa agaggccgtt tatctttgta aacacgaaac
     4021 atttttgctt tctccagttt tctgttaatg gcgaaagaat ggaagcgaat aaagttttac
     4081 tgatttttga gacacta
//
