LOCUS       NM_014460               2530 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens cold shock domain containing C2 (CSDC2), mRNA.
ACCESSION   NM_014460
VERSION     NM_014460.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2530)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2530)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2530)
  AUTHORS   Vallejo,G., Mestre-Citrinovitz,A.C., Winterhager,E. and
            Saragueta,P.E.
  TITLE     CSDC2, a cold shock domain RNA-binding protein in decidualization
  JOURNAL   J Cell Physiol 234 (1), 740-748 (2018)
   PUBMED   30078185
  REMARK    GeneRIF: Uterine suppression of CSDC2 through
            intrauterine-injected-specific small interfering RNA (siRNA) led to
            abnormal decidualization in early pregnancy, with more extended
            antimesometrial area and with poor M development if compared with
            control siRNA-injected animals. These results suggest that CSDC2
            could be a regulator during decidua development.
REFERENCE   4  (bases 1 to 2530)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   5  (bases 1 to 2530)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   6  (bases 1 to 2530)
  AUTHORS   Raimondi,L., D'Asaro,M., Proia,P., Nastasi,T. and Di Liegro,I.
  TITLE     RNA-binding ability of PIPPin requires the entire protein
  JOURNAL   J Cell Mol Med 7 (1), 35-42 (2003)
   PUBMED   12767259
REFERENCE   7  (bases 1 to 2530)
  AUTHORS   Nastasi,T., Muzi,P., Beccari,S., Bellafiore,M., Dolo,V.,
            Bologna,M., Cestelli,A. and Di Liegro,I.
  TITLE     Specific neurons of brain cortex and cerebellum are PIPPin positive
  JOURNAL   Neuroreport 11 (10), 2233-2236 (2000)
   PUBMED   10923677
REFERENCE   8  (bases 1 to 2530)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   9  (bases 1 to 2530)
  AUTHORS   Nastasi,T., Scaturro,M., Bellafiore,M., Raimondi,L., Beccari,S.,
            Cestelli,A. and di Liegro,I.
  TITLE     PIPPin is a brain-specific protein that contains a cold-shock
            domain and binds specifically to H1 degrees and H3.3 mRNAs
  JOURNAL   J Biol Chem 274 (34), 24087-24093 (1999)
   PUBMED   10446180
REFERENCE   10 (bases 1 to 2530)
  AUTHORS   Castiglia,D., Scaturro,M., Nastasi,T., Cestelli,A. and Di Liegro,I.
  TITLE     PIPPin, a putative RNA-binding protein specifically expressed in
            the rat brain
  JOURNAL   Biochem Biophys Res Commun 218 (1), 390-394 (1996)
   PUBMED   8573167
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB168570.1, AL834417.1 and AL023553.5.
            
            On Nov 22, 2018 this sequence version replaced NM_014460.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.745591.1,
                                           SRR3476690.110234.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306149.12/ ENSP00000302485.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                DB168570.1         1-73
            74-115              DB168570.1         84-125
            116-197             AL834417.1         1-82
            198-198             AL023553.5         74735-74735
            199-1891            AL834417.1         84-1776
            1892-2151           AL023553.5         78897-79156
            2152-2530           AL834417.1         2038-2416
FEATURES             Location/Qualifiers
     source          1..2530
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..2530
                     /gene="CSDC2"
                     /gene_synonym="dJ347H13.2; PIPPIN"
                     /note="cold shock domain containing C2"
                     /db_xref="GeneID:27254"
                     /db_xref="HGNC:HGNC:30359"
                     /db_xref="MIM:617689"
     exon            1..174
                     /gene="CSDC2"
                     /gene_synonym="dJ347H13.2; PIPPIN"
                     /inference="alignment:Splign:2.1.0"
     exon            175..473
                     /gene="CSDC2"
                     /gene_synonym="dJ347H13.2; PIPPIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             298..759
                     /gene="CSDC2"
                     /gene_synonym="dJ347H13.2; PIPPIN"
                     /note="RNA-binding protein pippin; cold shock domain
                     containing C2, RNA binding"
                     /codon_start=1
                     /product="cold shock domain-containing protein C2"
                     /protein_id="NP_055275.1"
                     /db_xref="CCDS:CCDS14019.1"
                     /db_xref="GeneID:27254"
                     /db_xref="HGNC:HGNC:30359"
                     /db_xref="MIM:617689"
                     /translation="MTSESTSPPVVPPLHSPKSPVWPTFPFHREGSRVWERGGVPPRD
                     LPSPLPTKRTRTYSATARASAGPVFKGVCKQFSRSQGHGFITPENGSEDIFVHVSDIE
                     GEYVPVEGDEVTYKMCPIPPKNQKFQAVEVVLTQLAPHTPHETWSGQVVGS"
     exon            474..596
                     /gene="CSDC2"
                     /gene_synonym="dJ347H13.2; PIPPIN"
                     /inference="alignment:Splign:2.1.0"
     exon            597..2530
                     /gene="CSDC2"
                     /gene_synonym="dJ347H13.2; PIPPIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2507..2512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSDC2"
                     /gene_synonym="dJ347H13.2; PIPPIN"
                     /note="hexamer: AATAAA"
     polyA_site      2530
                     /gene="CSDC2"
                     /gene_synonym="dJ347H13.2; PIPPIN"
                     /note="major polyA site"
ORIGIN      
        1 gaggggctga ggtaccgccc gcgcgagcac acacagacac acacacacac acacacacac
       61 acacacacac acatcttcca gacccatccc ctgcctgcca gctccacgag ccagagagag
      121 acagagcgcg gacgccgcag gaggcagtgc ctggacccca gctgcccagg agagacggag
      181 cccgtggctg gtgaggccgc agagcagggc caggccgggc cctgcccgca aggacgacca
      241 aacccctcac cggcccctgg gccccagagc ccaccaggct ctcctgctgg ccccaccatg
      301 acttcagagt cgacgtcacc cccagttgtg cccccgctcc actcccccaa gtccccagtc
      361 tggcccacct tccccttcca cagggagggc agcagggtct gggagcgggg tggtgtccca
      421 cctcgggacc tacccagccc tctgcccacc aagcggacca ggacctattc agcgacagcc
      481 cgggcctcag ctggccccgt gttcaagggc gtctgtaagc agttctcacg ctcacagggc
      541 catggcttca tcacccccga gaacgggtcc gaggacatct tcgtacatgt gtctgacatc
      601 gagggggagt acgtgccagt ggagggcgac gaggtgacct acaagatgtg ccctatccct
      661 cccaagaacc agaagttcca ggccgtggag gtggtgctca ctcagctggc cccccacact
      721 ccccacgaga cgtggtctgg ccaggtcgtg ggctcctagg ctgagtggtt cacaggccag
      781 ctggccgggg gttggggagc cacacagggt gaacgggcag cagccggctc catgccccac
      841 tgccctggct gatgagtcct tcggtggcct cagtgtgcac gtctgtctgt ccgtctgtgc
      901 ttgtggctat gagcgtgtgc ctccacccac cccacgaccc gtgactactg tgcaagctgg
      961 ccaggaggta ggtggagggc aaggccacca gacctggctt cgcgctgtcc actgcctctc
     1021 tcctcccctc cctgccgcag acacgcagga cccgctcgcc ctcctgctta cccgtcccca
     1081 cggtgactga gctgcgagag cctgcgctgg gctcactccc tggcctccgc ccctgagctg
     1141 tcccgtgtca gtccctggcc cggagccagg ctctctgtgc tacttacatc tccctccctt
     1201 ggctgaggtc ccccgccaca gcctggaccc ttccctcaga agcctggccg atgggtgctt
     1261 ttggggagcc tctcagcctc tggcagggga ggaggactga cacggaggca cacaggcctc
     1321 tcactgccga ggccagcctt ccttcctgct ctgctctctc agtgccatgg agaggcagga
     1381 agaggggcct gagggcggaa ggggtttggg gctcccattt cgccggccag tccctcctcc
     1441 tcagcctggc agtggcgctg ggctccttcc cctgggctgt actgagccga gcccaggggt
     1501 ttgcagaggg tgggggtcca tctctccagc ttggctgcag acctccttta ccctgactca
     1561 caagccccac tgatgctctg ggccatgccc ggctgacggc tgctgtggat gccgcgaggg
     1621 acggacacac gtccggggca cccacgagga gggcccccag cctgggagac tggccctgcg
     1681 gcctccacgt caaactctct tcccaaagcc ctaacagacc agtggccgag gtgtggctct
     1741 tattgcatcc atccctgaag atgtgtggct gttgctgtca cctggagtcc ttttggggcc
     1801 aagatgtgtg tgcacccggg gtcgtggcca ttcactccca ggcaggggtg agggtggcct
     1861 ggcccaggag gccaggaagg agggccctgt ctgcctccac ctctgggtgc accccctgcc
     1921 taccaccctc ccttctagag agcacatcgc ctgaccgggg agaagtgggg ccgtggttcg
     1981 agggagggct ggccaggggt gggaccctta tgagactcag tctgtgagta aaactggggg
     2041 ctcaaatgcc caggatgagg ggatcagtga ctgtctagga ggatcccttg ccttgtaggt
     2101 gccccaagac cgcagggtag aaatcagccg ggatgcctgc atcccacccc cggccccagg
     2161 gcccaccaca taaaatctgg gagcccagag ctgctgaggt gtggtcagct cccctaaaat
     2221 gggcacggcc cagcctgtcc catgaggaat aaaggcccct ggcccccttg agagagggct
     2281 tgttggtgag ggctgactcc tgggggcccc caaggctccc ctcctgtggg gaggccacct
     2341 tttaaggcac cactagcagt caggatatgg tggcatcagc cctggggcct cctgggtggc
     2401 aggggggcag cagctctcct ccccactcac aggccctgca gtgctcattt ggaattcctc
     2461 ccaagacccc tggccaccca gaccccccat tcttcctaac actggcaata aaccctcaac
     2521 tgtgacccac
//
