LOCUS       NM_001129826             844 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens CSAG family member 3 (CSAG3), transcript variant 1,
            mRNA.
ACCESSION   NM_001129826
VERSION     NM_001129826.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 844)
  AUTHORS   Yang,X. and Potts,P.R.
  TITLE     CSAG2 is a cancer-specific activator of SIRT1
  JOURNAL   EMBO Rep 21 (9), e50912 (2020)
   PUBMED   32761762
REFERENCE   2  (bases 1 to 844)
  AUTHORS   Fourcade,J., Sun,Z., Kudela,P., Janjic,B., Kirkwood,J.M.,
            El-Hafnawy,T. and Zarour,H.M.
  TITLE     Human tumor antigen-specific helper and regulatory T cells share
            common epitope specificity but exhibit distinct T cell repertoire
  JOURNAL   J Immunol 184 (12), 6709-6718 (2010)
   PUBMED   20483736
REFERENCE   3  (bases 1 to 844)
  AUTHORS   Bredenbeck,A., Hollstein,V.M., Trefzer,U., Sterry,W., Walden,P. and
            Losch,F.O.
  TITLE     Coordinated expression of clustered cancer/testis genes encoded in
            a large inverted repeat DNA structure
  JOURNAL   Gene 415 (1-2), 68-73 (2008)
   PUBMED   18395366
REFERENCE   4  (bases 1 to 844)
  AUTHORS   Materna,V., Surowiak,P., Kaplenko,I., Spaczynski,M., Duan,Z.,
            Zabel,M., Dietel,M. and Lage,H.
  TITLE     Taxol-resistance-associated gene-3 (TRAG-3/CSAG2) expression is
            predictive for clinical outcome in ovarian carcinoma patients
  JOURNAL   Virchows Arch 450 (2), 187-194 (2007)
   PUBMED   17216190
REFERENCE   5  (bases 1 to 844)
  AUTHORS   Janjic,B., Andrade,P., Wang,X.F., Fourcade,J., Almunia,C.,
            Kudela,P., Brufsky,A., Jacobs,S., Friedland,D., Stoller,R.,
            Gillet,D., Herberman,R.B., Kirkwood,J.M., Maillere,B. and
            Zarour,H.M.
  TITLE     Spontaneous CD4+ T cell responses against TRAG-3 in patients with
            melanoma and breast cancers
  JOURNAL   J Immunol 177 (4), 2717-2727 (2006)
   PUBMED   16888034
REFERENCE   6  (bases 1 to 844)
  AUTHORS   Ohta,M., Tanaka,F., Sadanaga,N., Yamaguchi,H., Inoue,H. and Mori,M.
  TITLE     Expression of the TRAG-3 gene in human esophageal cancer: the
            frequent synchronous expression of MAGE-3 gene
  JOURNAL   Oncol Rep 15 (6), 1529-1532 (2006)
   PUBMED   16685391
REFERENCE   7  (bases 1 to 844)
  AUTHORS   Chen,Z., Zhu,B. and Wu,Y.
  TITLE     Expression of TRAG-3 antigen in non-small-cell lung carcinomas
  JOURNAL   Lung Cancer 38 (1), 101-102 (2002)
   PUBMED   12367802
REFERENCE   8  (bases 1 to 844)
  AUTHORS   Nimmrich,I., Erdmann,S., Melchers,U., Finke,U., Hentsch,S.,
            Moyer,M.P., Hoffmann,I. and Muller,O.
  TITLE     Seven genes that are differentially transcribed in colorectal tumor
            cell lines
  JOURNAL   Cancer Lett 160 (1), 37-43 (2000)
   PUBMED   11098082
REFERENCE   9  (bases 1 to 844)
  AUTHORS   Feller,A.J., Duan,Z., Penson,R., Toh,H.C. and Seiden,M.V.
  TITLE     TRAG-3, a novel cancer/testis antigen, is overexpressed in the
            majority of melanoma cell lines and malignant melanoma
  JOURNAL   Anticancer Res 20 (6B), 4147-4151 (2000)
   PUBMED   11205240
REFERENCE   10 (bases 1 to 844)
  AUTHORS   Duan,Z., Feller,A.J., Toh,H.C., Makastorsis,T. and Seiden,M.V.
  TITLE     TRAG-3, a novel gene, isolated from a taxol-resistant ovarian
            carcinoma cell line
  JOURNAL   Gene 229 (1-2), 75-81 (1999)
   PUBMED   10095106
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC244102.3.
            
            On Jun 2, 2019 this sequence version replaced NM_001129826.2.
            
            Transcript Variant: This variant (1, also known as TRAG-3L)
            represents the longest transcript and encodes the longer isoform
            (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF136715.1, SRR7346977.1048693.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000599845.3/ ENSP00000491011.1
            RefSeq Select criteria :: based on manual assertion, longest
                                      protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-467               AC244102.3         173778-174244
            468-844             AC244102.3         174403-174779
FEATURES             Location/Qualifiers
     source          1..844
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..844
                     /gene="CSAG3"
                     /gene_synonym="CSAG3A; CT24.2"
                     /note="CSAG family member 3"
                     /db_xref="GeneID:389903"
                     /db_xref="HGNC:HGNC:26237"
                     /db_xref="MIM:301097"
     exon            1..467
                     /gene="CSAG3"
                     /gene_synonym="CSAG3A; CT24.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..537
                     /gene="CSAG3"
                     /gene_synonym="CSAG3A; CT24.2"
                     /note="isoform a is encoded by transcript variant 1; CSAG
                     family, member 3A; chondrosarcoma-associated gene 2/3
                     protein; cancer/testis antigen 24.2;
                     taxol-resistant-associated gene 3 protein; taxol
                     resistance associated gene 3"
                     /codon_start=1
                     /product="chondrosarcoma-associated gene 2/3 protein
                     isoform a"
                     /protein_id="NP_001123298.1"
                     /db_xref="GeneID:389903"
                     /db_xref="HGNC:HGNC:26237"
                     /db_xref="MIM:301097"
                     /translation="MWMGLIQLVEGVKRKDQGFLEKEFYHKTNIKMRCEFLACWPAFT
                     VLGEAWRDQVDWSRLLRDAGLVKMSRKPRASSPLSNNHPPTPKRRGSGRHPLNPGPEA
                     LSKFPRQPGREKGPIKEVPGTKGSP"
     exon            468..844
                     /gene="CSAG3"
                     /gene_synonym="CSAG3A; CT24.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      822..827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSAG3"
                     /gene_synonym="CSAG3A; CT24.2"
                     /note="hexamer: AATAAA"
     polyA_site      844
                     /gene="CSAG3"
                     /gene_synonym="CSAG3A; CT24.2"
                     /note="major polyA site"
ORIGIN      
        1 gtgcaatggc tagtactatg tgtcaacttg tctaggctat actgctcagc tgtgtggtca
       61 aacagtagtc tagatgttgc tgtgaaggta ttttgtagat gtgatcaaca tttacaatca
      121 gttgatttta agtaaagcag tttaacttcc ataatgtgga tgggcctcat ccaattagtt
      181 gaaggtgtta agagaaaaga ccaaggtttc ctggaaaagg aattctacca caagactaac
      241 ataaaaatgc gctgtgagtt tctagcctgc tggcctgcct tcactgtcct gggggaggct
      301 tggagagacc aggtggactg gagtagactg ttgagagacg ctggtctggt gaagatgtcc
      361 aggaaaccac gagcctccag cccattgtcc aacaaccacc caccaacacc aaagaggcga
      421 ggaagtggaa ggcatcctct caaccctggc ccagaagccc tatcaaagtt cccaagacaa
      481 cccggaaggg aaaagggacc catcaaggaa gttccaggaa caaaaggctc tccctaaaag
      541 accgccgctt caaaaaaacc tgaggaatgg agtgggccaa cactatccag ccactctgac
      601 cagccgaacg aggaactcaa tcaaaatgag ccatagcggg accacaaggg caaggagacc
      661 accaccttct ccagtctctc ttcggacagc cagtaattcc cgggcaaggc cagagacttc
      721 aagtctatct gaaaagtctc cagaggtcta accccagata aatagccaac agggtgtaga
      781 gtacatttta caccccaaag agtgtgcccc atggtgatga aaataaagtg aacatgttgc
      841 aaaa
//
