LOCUS       NM_001395334             855 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens CSAG family member 2 (CSAG2), mRNA.
ACCESSION   NM_001395334 XM_006724857
VERSION     NM_001395334.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 855)
  AUTHORS   Yang,X. and Potts,P.R.
  TITLE     CSAG2 is a cancer-specific activator of SIRT1
  JOURNAL   EMBO Rep 21 (9), e50912 (2020)
   PUBMED   32761762
  REMARK    GeneRIF: CSAG2 is a cancer-specific activator of SIRT1.
REFERENCE   2  (bases 1 to 855)
  AUTHORS   Karam,J.A., Huang,S., Fan,J., Stanfield,J., Schultz,R.A.,
            Pong,R.C., Sun,X., Mason,R.P., Xie,X.J., Niu,G., Chen,X.,
            Frenkel,E.P., Sagalowsky,A.I. and Hsieh,J.T.
  TITLE     Upregulation of TRAG3 gene in urothelial carcinoma of the bladder
  JOURNAL   Int J Cancer 128 (12), 2823-2832 (2011)
   PUBMED   20734393
  REMARK    GeneRIF: TRAG3 was significantly higher in T24-L and T24-B than
            T24-P. TRAG3 gene expression is likely controlled by DNA
            methylation but not histone acetylation
REFERENCE   3  (bases 1 to 855)
  AUTHORS   Fourcade,J., Sun,Z., Kudela,P., Janjic,B., Kirkwood,J.M.,
            El-Hafnawy,T. and Zarour,H.M.
  TITLE     Human tumor antigen-specific helper and regulatory T cells share
            common epitope specificity but exhibit distinct T cell repertoire
  JOURNAL   J Immunol 184 (12), 6709-6718 (2010)
   PUBMED   20483736
REFERENCE   4  (bases 1 to 855)
  AUTHORS   Bredenbeck,A., Hollstein,V.M., Trefzer,U., Sterry,W., Walden,P. and
            Losch,F.O.
  TITLE     Coordinated expression of clustered cancer/testis genes encoded in
            a large inverted repeat DNA structure
  JOURNAL   Gene 415 (1-2), 68-73 (2008)
   PUBMED   18395366
REFERENCE   5  (bases 1 to 855)
  AUTHORS   Janjic,B., Andrade,P., Wang,X.F., Fourcade,J., Almunia,C.,
            Kudela,P., Brufsky,A., Jacobs,S., Friedland,D., Stoller,R.,
            Gillet,D., Herberman,R.B., Kirkwood,J.M., Maillere,B. and
            Zarour,H.M.
  TITLE     Spontaneous CD4+ T cell responses against TRAG-3 in patients with
            melanoma and breast cancers
  JOURNAL   J Immunol 177 (4), 2717-2727 (2006)
   PUBMED   16888034
  REMARK    GeneRIF: TRAG-3-specific CD4+ T cells recognize in vitro not only
            peptide pulsed antigen presenting cells but also autologous
            dendritic cells loaded with the TRAG-3 protein.
REFERENCE   6  (bases 1 to 855)
  AUTHORS   Chen,Z., Zhu,B. and Wu,Y.
  TITLE     Expression of TRAG-3 antigen in non-small-cell lung carcinomas
  JOURNAL   Lung Cancer 38 (1), 101-102 (2002)
   PUBMED   12367802
REFERENCE   7  (bases 1 to 855)
  AUTHORS   Lin,C., Mak,S., Meitner,P.A., Wolf,J.M., Bluman,E.M., Block,J.A.
            and Terek,R.M.
  TITLE     Cancer/testis antigen CSAGE is concurrently expressed with MAGE in
            chondrosarcoma
  JOURNAL   Gene 285 (1-2), 269-278 (2002)
   PUBMED   12039054
REFERENCE   8  (bases 1 to 855)
  AUTHORS   Nimmrich,I., Erdmann,S., Melchers,U., Finke,U., Hentsch,S.,
            Moyer,M.P., Hoffmann,I. and Muller,O.
  TITLE     Seven genes that are differentially transcribed in colorectal tumor
            cell lines
  JOURNAL   Cancer Lett 160 (1), 37-43 (2000)
   PUBMED   11098082
REFERENCE   9  (bases 1 to 855)
  AUTHORS   Feller,A.J., Duan,Z., Penson,R., Toh,H.C. and Seiden,M.V.
  TITLE     TRAG-3, a novel cancer/testis antigen, is overexpressed in the
            majority of melanoma cell lines and malignant melanoma
  JOURNAL   Anticancer Res 20 (6B), 4147-4151 (2000)
   PUBMED   11205240
REFERENCE   10 (bases 1 to 855)
  AUTHORS   Duan,Z., Feller,A.J., Toh,H.C., Makastorsis,T. and Seiden,M.V.
  TITLE     TRAG-3, a novel gene, isolated from a taxol-resistant ovarian
            carcinoma cell line
  JOURNAL   Gene 229 (1-2), 75-81 (1999)
   PUBMED   10095106
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC244102.3.
            
            On Jun 24, 2021 this sequence version replaced XM_006724857.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ315569.1, SRR7346977.803672.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000638741.2/ ENSP00000491733.1
            RefSeq Select criteria :: based on manual assertion, longest
                                      protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-475               AC244102.3         123359-123833       c
            476-855             AC244102.3         122821-123200       c
FEATURES             Location/Qualifiers
     source          1..855
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..855
                     /gene="CSAG2"
                     /gene_synonym="CSAG3B; CT24.2; TRAG-3; TRAG3"
                     /note="CSAG family member 2"
                     /db_xref="GeneID:102723547"
                     /db_xref="HGNC:HGNC:16847"
                     /db_xref="MIM:301096"
     exon            1..475
                     /gene="CSAG2"
                     /gene_synonym="CSAG3B; CT24.2; TRAG-3; TRAG3"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..545
                     /gene="CSAG2"
                     /gene_synonym="CSAG3B; CT24.2; TRAG-3; TRAG3"
                     /note="chondrosarcoma-associated gene 2/3 protein-like;
                     taxol resistance associated gene 3; CSAG family, member
                     3B; cancer/testis antigen family 24, member 2;
                     cancer/testis antigen 24.2; taxol-resistant-associated
                     gene 3 protein"
                     /codon_start=1
                     /product="chondrosarcoma-associated gene 2/3 protein"
                     /protein_id="NP_001382263.1"
                     /db_xref="CCDS:CCDS94689.1"
                     /db_xref="GeneID:102723547"
                     /db_xref="HGNC:HGNC:16847"
                     /db_xref="MIM:301096"
                     /translation="MWMGLIQLVEGVKRKDQGFLEKEFYHKTNIKMRCEFLACWPAFT
                     VLGEAWRDQVDWSRLLRDTGLVKMSRKPRASSPLSNNHPPTPKRRGSGRHPLNPGPEA
                     LSKFPRQPGREKGPIKEVPGTKGSP"
     exon            476..855
                     /gene="CSAG2"
                     /gene_synonym="CSAG3B; CT24.2; TRAG-3; TRAG3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      830..835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSAG2"
                     /gene_synonym="CSAG3B; CT24.2; TRAG-3; TRAG3"
                     /note="hexamer: AATAAA"
     polyA_site      855
                     /gene="CSAG2"
                     /gene_synonym="CSAG3B; CT24.2; TRAG-3; TRAG3"
                     /note="major polyA site"
ORIGIN      
        1 caagatatgt gcaatggcta gtactatgtg tcaacttgtc taggctatac tgctcagctg
       61 tgtggtcaaa cagtagtcta gatgttgctg tgaaggtatt ttgtagatgt gatcaacatt
      121 tacaatcagt tgattttaag taaagcagtt taacttccat aatgtggatg ggcctcatcc
      181 aattagttga aggtgttaag agaaaagacc aaggtttcct ggaaaaggaa ttctaccaca
      241 agactaacat aaaaatgcgc tgtgagtttc tagcctgctg gcctgccttc actgtcctgg
      301 gggaggcttg gagagaccag gtggactgga gtagactgtt gagagacact ggtctggtga
      361 agatgtccag gaaaccacga gcctccagcc cattgtccaa caaccaccca ccaacaccaa
      421 agaggcgagg aagtggaagg catcctctca accctggccc agaagcccta tcaaagttcc
      481 caagacaacc cggaagggaa aagggaccca tcaaggaagt tccaggaaca aaaggctctc
      541 cctaaaagac cgccgcttca aaaaaacctg aggaatggag tgggccaaca ctatccagcc
      601 actctgacca gccgaacgag gaactcaatc aaaatgagcc atagcgggac cacaagggca
      661 aggagaccac caccttctcc agtctctctt cggacagcca gtaattcccg ggcaaggcca
      721 gagacttcaa gtctatctga aaagtctcca gaggtctaac cccagataaa tagccaacag
      781 ggtgtagagt acattttaca ccccaaagag tgtgccccat ggtgatgaaa ataaagtgaa
      841 catgttgcaa aatga
//
