LOCUS       NM_001102576             645 bp    mRNA    linear   PRI 07-MAY-2023
DEFINITION  Homo sapiens chondrosarcoma associated gene 1 (CSAG1), transcript
            variant c, mRNA.
ACCESSION   NM_001102576
VERSION     NM_001102576.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 645)
  AUTHORS   Sapkota H, Wren JD and Gorbsky GJ.
  TITLE     CSAG1 maintains the integrity of the mitotic centrosome in cells
            with defective p53
  JOURNAL   J Cell Sci 133 (10) (2020)
   PUBMED   32295846
  REMARK    GeneRIF: CSAG1 maintains the integrity of the mitotic centrosome in
            cells with defective p53.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 645)
  AUTHORS   Qi Y, Lu H and Ai D.
  TITLE     Analysis of compensatory substitution and gene evolution on the
            MAGEA/CSAG-palindrome of the primate X chromosomes
  JOURNAL   Comput Biol Chem 42, 18-22 (2013)
   PUBMED   23257410
REFERENCE   3  (bases 1 to 645)
  AUTHORS   Szperl AM, Ricano-Ponce I, Li JK, Deelen P, Kanterakis A, Plagnol
            V, van Dijk F, Westra HJ, Trynka G, Mulder CJ, Swertz M, Wijmenga C
            and Zheng HC.
  TITLE     Exome sequencing in a family segregating for celiac disease
  JOURNAL   Clin Genet 80 (2), 138-147 (2011)
   PUBMED   21627641
REFERENCE   4  (bases 1 to 645)
  AUTHORS   Hansen MA, Nielsen JE, Retelska D, Larsen N and Leffers H.
  TITLE     A shared promoter region suggests a common ancestor for the human
            VCX/Y, SPANX, and CSAG gene families and the murine CYPT family
  JOURNAL   Mol Reprod Dev 75 (2), 219-229 (2008)
   PUBMED   17342728
REFERENCE   5  (bases 1 to 645)
  AUTHORS   Lin C, Mak S, Meitner PA, Wolf JM, Bluman EM, Block JA and Terek
            RM.
  TITLE     Cancer/testis antigen CSAGE is concurrently expressed with MAGE in
            chondrosarcoma
  JOURNAL   Gene 285 (1-2), 269-278 (2002)
   PUBMED   12039054
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF195880.1 and BC059947.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001102576.2.
            
            Summary: This gene encodes a member of a family of tumor antigens.
            The protein is expressed in chondrosarcomas, but may also be
            expressed in normal tissues such as testis. Alternative splicing of
            this gene results in two transcript variants encoding the same
            protein. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (c) differs in the 5' UTR compared
            to variant a. Variants a and c both encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189661.4064.1,
                                           SRR5189661.171495.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000452779.3/ ENSP00000396520.2
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AF195880.1         15-29
            16-642              BC059947.1         1-627
            643-645             AF195880.1         872-874
FEATURES             Location/Qualifiers
     source          1..645
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..645
                     /gene="CSAG1"
                     /gene_synonym="CSAGE; CT24.1"
                     /note="chondrosarcoma associated gene 1"
                     /db_xref="GeneID:158511"
                     /db_xref="HGNC:HGNC:24294"
                     /db_xref="MIM:300944"
     exon            1..54
                     /gene="CSAG1"
                     /gene_synonym="CSAGE; CT24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            55..114
                     /gene="CSAG1"
                     /gene_synonym="CSAGE; CT24.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..335
                     /gene="CSAG1"
                     /gene_synonym="CSAGE; CT24.1"
                     /note="cancer/testis antigen family 24, member 1; putative
                     chondrosarcoma-associated gene 1 protein; cancer/testis
                     antigen 24.1; cancer/testis antigen CSAGE"
                     /codon_start=1
                     /product="chondrosarcoma-associated gene 1 protein"
                     /protein_id="NP_001096046.2"
                     /db_xref="CCDS:CCDS76047.1"
                     /db_xref="GeneID:158511"
                     /db_xref="HGNC:HGNC:24294"
                     /db_xref="MIM:300944"
                     /translation="MSATTACWPAFTVLGEARGDQVDWSRLYRDTGLVKMSRKPRASS
                     PFSNNHPSTPKRFPRQPRREKGPVKEVPGTKGSP"
     exon            115..265
                     /gene="CSAG1"
                     /gene_synonym="CSAGE; CT24.1"
                     /inference="alignment:Splign:2.1.0"
     exon            266..645
                     /gene="CSAG1"
                     /gene_synonym="CSAGE; CT24.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      625..630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSAG1"
                     /gene_synonym="CSAGE; CT24.1"
                     /note="hexamer: AATGAA"
     polyA_site      645
                     /gene="CSAG1"
                     /gene_synonym="CSAGE; CT24.1"
                     /note="major polyA site"
ORIGIN      
        1 acagcagggg tggaactgga ttcttcctgg atggggatcc agatggaggt ggagggttga
       61 tttgggaagc agagcacagc agcccaaatt tgcttgtaat gtcggcgact acagcctgct
      121 ggcctgcctt cactgtcctg ggggaagctc ggggagacca ggtggactgg agtagactgt
      181 acagagacac tggtctggtg aagatgtcca ggaaaccacg agcctccagc ccattttcca
      241 acaaccaccc atcaacacca aagaggttcc caagacaacc cagaagggaa aagggacccg
      301 tcaaggaagt tccaggaaca aaaggctctc cctaaaagac caccgcttca aaaaaacctg
      361 aggaatggag tgggccaaca ctatccagcc actctgacca gccgaacgag gaactcaatc
      421 aaaatgcgcc atagcaggac cacaagggca aggagaccac cgccttctcc agtgcttcct
      481 tgggcagcca gtaattccca ggcaaggcca gagacttcaa gtctatctga aaagtctcca
      541 gaagtctaac cccagataaa tagccaacag ggtgtagagt acgttttaca ccccaaaggg
      601 tatgccccat ggtgatggaa ataaaatgaa catgttgtaa aatga
//
