LOCUS       NM_001356505            5271 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens CRYZL2P-SEC16B readthrough (CRYZL2P-SEC16B),
            transcript variant 1, mRNA.
ACCESSION   NM_001356505
VERSION     NM_001356505.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5271)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5271)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 5271)
  AUTHORS   Bian,Y., Song,C., Cheng,K., Dong,M., Wang,F., Huang,J., Sun,D.,
            Wang,L., Ye,M. and Zou,H.
  TITLE     An enzyme assisted RP-RPLC approach for in-depth analysis of human
            liver phosphoproteome
  JOURNAL   J Proteomics 96, 253-262 (2014)
   PUBMED   24275569
REFERENCE   4  (bases 1 to 5271)
  AUTHORS   Yonekawa,S., Furuno,A., Baba,T., Fujiki,Y., Ogasawara,Y.,
            Yamamoto,A., Tagaya,M. and Tani,K.
  TITLE     Sec16B is involved in the endoplasmic reticulum export of the
            peroxisomal membrane biogenesis factor peroxin 16 (Pex16) in
            mammalian cells
  JOURNAL   Proc Natl Acad Sci U S A 108 (31), 12746-12751 (2011)
   PUBMED   21768384
REFERENCE   5  (bases 1 to 5271)
  AUTHORS   Witte,K., Schuh,A.L., Hegermann,J., Sarkeshik,A., Mayers,J.R.,
            Schwarze,K., Yates,J.R. 3rd, Eimer,S. and Audhya,A.
  TITLE     TFG-1 function in protein secretion and oncogenesis
  JOURNAL   Nat Cell Biol 13 (5), 550-558 (2011)
   PUBMED   21478858
REFERENCE   6  (bases 1 to 5271)
  AUTHORS   Budnik,A., Heesom,K.J. and Stephens,D.J.
  TITLE     Characterization of human Sec16B: indications of specialized,
            non-redundant functions
  JOURNAL   Sci Rep 1, 77 (2011)
   PUBMED   22355596
REFERENCE   7  (bases 1 to 5271)
  AUTHORS   Bechtel,S., Rosenfelder,H., Duda,A., Schmidt,C.P., Ernst,U.,
            Wellenreuther,R., Mehrle,A., Schuster,C., Bahr,A., Blocker,H.,
            Heubner,D., Hoerlein,A., Michel,G., Wedler,H., Kohrer,K.,
            Ottenwalder,B., Poustka,A., Wiemann,S. and Schupp,I.
  TITLE     The full-ORF clone resource of the German cDNA Consortium
  JOURNAL   BMC Genomics 8, 399 (2007)
   PUBMED   17974005
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5271)
  AUTHORS   Bhattacharyya,D. and Glick,B.S.
  TITLE     Two mammalian Sec16 homologues have nonredundant functions in
            endoplasmic reticulum (ER) export and transitional ER organization
  JOURNAL   Mol Biol Cell 18 (3), 839-849 (2007)
   PUBMED   17192411
REFERENCE   9  (bases 1 to 5271)
  AUTHORS   Misawa,H. and Yamaguchi,M.
  TITLE     Gene expression for a novel protein RGPR-p117 in various species:
            the stimulation by intracellular signaling factors
  JOURNAL   J Cell Biochem 87 (2), 188-193 (2002)
   PUBMED   12244571
REFERENCE   10 (bases 1 to 5271)
  AUTHORS   Misawa,H. and Yamaguchi,M.
  TITLE     Molecular cloning and sequencing of the cDNA coding for a novel
            regucalcin gene promoter region-related protein in rat, mouse and
            human liver
  JOURNAL   Int J Mol Med 8 (5), 513-520 (2001)
   PUBMED   11605020
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL359075.15, AL356279.8 and AL160007.10.
            
            On Aug 13, 2020 this sequence version replaced NM_001356505.1.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring CRYZL2P (crystallin zeta like
            2 pseudogene) and SEC16B (SEC16 homolog B, endoplasmic reticulum
            export factor) genes on chromosome 1. The readthrough transcript
            encodes a protein that shares sequence identity with the downstream
            gene product. [provided by RefSeq, Oct 2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.63401.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 89866, 730102
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                AL359075.15        66842-66921         c
            81-188              AL359075.15        66639-66746         c
            189-285             AL359075.15        63650-63746         c
            286-344             AL359075.15        61972-62030         c
            345-410             AL359075.15        61375-61440         c
            411-520             AL359075.15        60496-60605         c
            521-621             AL359075.15        55100-55200         c
            622-850             AL359075.15        51385-51613         c
            851-957             AL359075.15        13901-14007         c
            958-1314            AL356279.8         23338-23694         c
            1315-1427           AL356279.8         21548-21660         c
            1428-1548           AL356279.8         20702-20822         c
            1549-1657           AL356279.8         19826-19934         c
            1658-1802           AL356279.8         17245-17389         c
            1803-1951           AL356279.8         16446-16594         c
            1952-2013           AL356279.8         15997-16058         c
            2014-2149           AL356279.8         14495-14630         c
            2150-2380           AL356279.8         13787-14017         c
            2381-2478           AL356279.8         9934-10031          c
            2479-2560           AL356279.8         7569-7650           c
            2561-2678           AL356279.8         3480-3597           c
            2679-2790           AL356279.8         2075-2186           c
            2791-2896           AL160007.10        110948-111053       c
            2897-3037           AL160007.10        108287-108427       c
            3038-3142           AL160007.10        106997-107101       c
            3143-3218           AL160007.10        106089-106164       c
            3219-3518           AL160007.10        103601-103900       c
            3519-3586           AL160007.10        102685-102752       c
            3587-3739           AL160007.10        99871-100023        c
            3740-3838           AL160007.10        99601-99699         c
            3839-3950           AL160007.10        99085-99196         c
            3951-4030           AL160007.10        98877-98956         c
            4031-4129           AL160007.10        96932-97030         c
            4130-5271           AL160007.10        95175-96316         c
FEATURES             Location/Qualifiers
     source          1..5271
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.2"
     gene            1..5271
                     /gene="CRYZL2P-SEC16B"
                     /note="CRYZL2P-SEC16B readthrough"
                     /db_xref="GeneID:111240474"
                     /db_xref="HGNC:HGNC:53757"
     exon            1..80
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            81..188
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            189..285
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            286..344
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            345..410
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            411..520
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            521..621
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            622..850
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            851..957
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1314
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     CDS             1016..4201
                     /gene="CRYZL2P-SEC16B"
                     /note="SEC16 homolog B; leucine zipper transcription
                     regulator 2; regucalcin gene promoter region-related
                     protein p117"
                     /codon_start=1
                     /product="protein transport protein Sec16B"
                     /protein_id="NP_001343434.1"
                     /db_xref="GeneID:111240474"
                     /db_xref="HGNC:HGNC:53757"
                     /translation="MELWAPQRLPQTRGKATAPSKDPDRGFRRDGHHRPVPHSWHNGE
                     RFHQWQDNRGSPQPQQEPRADHQQQPHYASRPGDWHQPVSGVDYYEGGYRNQLYSRPG
                     YENSYQSYQSPTMREEYAYGSYYYHGHPQWLQEERVPRQRSPYIWHEDYREQKYLDEH
                     HYENQHSPFGTNSETHFQSNSRNPCKDSPASNSGQEWPGELFPGSLLAEAQKNKPSLA
                     SESNLLQQRESGLSSSSYELSQYIRDAPERDDPPASAAWSPVQADVSSAGPKAPMKFY
                     IPHVPVSFGPGGQLVHVGPSSPTDGQAALVELHSMEVILNDSEEQEEMRSFSGPLIRE
                     DVHKVDIMTFCQQKAAQSCKSETLGSRDSALLWQLLVLLCRQNGSMVGSDIAELLMQD
                     CKKLEKYKRQPPVANLINLTDEDWPVLSSGTPNLLTGEIPPSVETPAQIVEKFTRLLY
                     YGRKKEALEWAMKNHLWGHALFLSSKMDPQTYSWVMSGFTSTLALNDPLQTLFQLMSG
                     RIPQAATCCGEKQWGDWRPHLAVILSNQAGDPELYQRAIVAIGDTLAGKGLVEAAHFC
                     YLMAHVPFGHYTVKTDHLVLLGSSHSQEFLKFATTEAIQRTEIFEYCQMLGRPKSFIP
                     SFQVYKLLYASRLADYGLVSQALHYCEAIGAAVLSQGESSHPVLLVELIKLAEKLKLS
                     DPLVLERRSGDRDLEPDWLAQLRRQLEQKVAGDIGDPHPTRSDISGAGGTTTENTFYQ
                     DFSGCQGYSEAPGYRSALWLTPEQTCLLQPSPQQPFPLQPGSYPAGGGAGQTGTPRPF
                     YSVPETHLPGTGSSVAVTEATGGTVWEEMLQTHLGPGENTVSQETSQPPDGQEVISKP
                     QTPLAARPRSISESSASSAKEDEKESSDEADKNSPRNTAQRGKLGDGKEHTKSSGFGW
                     FSWFRSKPTKNASPAGDEDSSDSPDSEQETPRASSPHQAGLGLSLTPSPESPPLPDVS
                     AFSRGRGGGEGRGSASSGGAAAGAGVGGLSGPESVSFELCSNPGVLLPPPALKGAVPL
                     YNPSQVPQLPTATSLNRPNRLAQRRYPTQPC"
     exon            1315..1427
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1548
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1657
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1802
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1951
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2013
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2149
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..2380
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2478
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            2479..2560
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            2561..2678
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            2679..2790
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            2791..2896
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            2897..3037
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            3038..3142
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            3143..3218
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            3219..3518
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            3519..3586
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            3587..3739
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            3740..3838
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            3839..3950
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            3951..4030
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            4031..4129
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     exon            4130..5271
                     /gene="CRYZL2P-SEC16B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5245..5250
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRYZL2P-SEC16B"
                     /note="hexamer: ATTAAA"
     polyA_site      5271
                     /gene="CRYZL2P-SEC16B"
                     /note="major polyA site"
ORIGIN      
        1 actccccctc gcccctcgct gggcttggcc ttggcggccg tgctctgcag gcagtgcctc
       61 cctcgggcgt gggtctgcag gagagccgga cagggcagcg gccggcacta ccgcgctgcg
      121 atttgcgcag agctgaagaa gcccctgacc attgaagagg tggcccccgc cccgtcgggc
      181 ctcacgaggt cagagttgat gtccatttct gtggagttaa ctttggtgat attttgatct
      241 gccgtgatca atatcaggaa aggccccatc ttcccttcac acctggaatg gacttttctg
      301 ggacagtatt ggagacaggc acagatgtca ggacagttaa agagggagat agagttattg
      361 gcacaagaaa ctttaattgt atggctgaag aatgcgtcac tgaccagaag gacctgtggc
      421 agattccaga aaaggtctcc ctataagaag ctgctgtcct ccctataact tatggcactg
      481 cgatttttgc tcttgagcat tgggcccgta cccagcctgg gtaatatagc tgctgctgga
      541 agtgacgaga agtgcaagct ggcgatgcag aggggtgcgc agtccagcgt gaactacagt
      601 cagggcagcc tgaaggatgc acctggcatg ggagggcagg attgtggtgg tgggatttgc
      661 tggaggaaac attgcttctg aaccagccaa ccttctgctc ctgaagaata tctctgctat
      721 gggcctgtac tgtggtcaat acaaagatat gaactttccc gtcttctcca agagcctatc
      781 ttcagtgctt cagtactgcc agcaagggtg catccagcta tatgtcagaa tggttttcaa
      841 gctggacgag ataagcagaa gacatcttta ggattctttt gtgtgtttgg aacagagaga
      901 ggaaaaaccc agatccattt aagattcagc agagggcttg gaagcctaag agttcaggaa
      961 gataaaataa ctgcacaact tactcaaaac ccaggacaaa ttcagagagt caaggatgga
     1021 actttgggct ccccagaggc tgccccagac acgagggaag gccacagcac cctcaaagga
     1081 tccagaccga gggtttcgga gagatggaca tcatcggcct gtccctcact cttggcacaa
     1141 tggagagagg tttcaccaat ggcaagacaa ccgtgggagc ccccagccac agcaggagcc
     1201 cagggcagac catcagcagc agccccatta tgcatccagg ccaggggact ggcatcagcc
     1261 tgtgtctgga gttgactatt acgaaggtgg ttatcgcaat cagttgtatt caaggccagg
     1321 ttatgagaat tcatatcaga gctatcagtc tcccacaatg agggaggaat atgcttatgg
     1381 aagttattac tatcatggac acccacagtg gctgcaggaa gaaagagtgc caaggcaacg
     1441 gagtccttat atctggcacg aagattaccg agagcaaaag taccttgatg aacatcatta
     1501 tgaaaaccag cacagtccat ttggaacaaa tagtgagacc cacttccaat ctaacagtag
     1561 gaacccttgt aaagacagcc ctgcttccaa ctctggacag gagtggccgg gggagctgtt
     1621 tccagggagc ctgcttgctg aggcccagaa aaataagcca tcattggcta gtgagtccaa
     1681 ccttctccag cagcgtgagt ctggtctcag ctccagcagc tatgagctca gtcagtacat
     1741 cagagatgcc ccggagcggg atgatccccc agcttcagca gcttggagtc cagttcaggc
     1801 tgatgtctcc tcagctggtc ccaaagcacc catgaagttc tacatccctc atgttcctgt
     1861 gagtttcggg ccaggaggtc agctggtgca tgtaggtccc agctctccca ctgacgggca
     1921 agcagccctt gttgaactgc acagcatgga ggttattctt aatgattccg aagagcaaga
     1981 ggagatgaga agtttctcag gacccttgat tagggaagat gtacataagg tggatattat
     2041 gacgttttgc cagcagaaag cagctcagag ctgcaaatct gagacactgg ggagcagaga
     2101 ctcagctcta ctgtggcagc tcttggttct cctttgtcgc cagaatgggt ccatggtggg
     2161 gtctgacatc gctgagctgc taatgcaaga ctgcaagaag ctggagaagt acaagcggca
     2221 gccccctgtg gccaacctca tcaacctgac cgatgaggac tggccagtgc tgagctctgg
     2281 gaccccgaac ctgctcacgg gagagatccc ccccagtgtg gagacacctg cgcagatcgt
     2341 ggagaaattc actaggctgc tctactatgg aaggaagaag gaagccttgg agtgggccat
     2401 gaagaaccac ttgtggggcc atgctttgtt cctgtccagc aagatggacc cacagaccta
     2461 cagctgggtc atgagtggct tcaccagcac gctggcgctc aatgacccac tgcagaccct
     2521 cttccagctc atgtcgggga ggattccaca ggcagccacg tgttgtggag aaaagcagtg
     2581 gggagactgg aggcctcact tggctgtgat tctgtcgaat caggctgggg acccagagct
     2641 gtatcagcgt gcgattgttg ccattgggga caccctggct gggaaggggc ttgtggaggc
     2701 agctcacttc tgctatctca tggctcacgt gccctttggc cactacaccg tgaagacaga
     2761 ccatctggtc ttgctgggca gcagccacag tcaagagttt ttgaaatttg caacaactga
     2821 ggcaatccag aggacggaaa tcttcgagta ctgtcagatg ctgggccgcc ccaaatcctt
     2881 catcccttct ttccaggtgt ataagctcct ttatgcttcc cgtctggcag attatggcct
     2941 cgtgtcccag gctttgcatt actgcgaagc cattggtgca gctgtcttga gccagggaga
     3001 gagcagtcac cctgtgctat tagtggaact catcaagcta gcagagaaac tgaagctgtc
     3061 agatcctctg gttttagaaa gacgcagtgg agacagggac ctggagccag attggctagc
     3121 gcaacttcgg aggcagctgg agcaaaaggt agcaggagac attggggatc ctcatcctac
     3181 tcgctcagat atttcgggag ccggaggaac aacaacagaa aacactttct accaggactt
     3241 ttctggatgt caaggctact ctgaagcccc tgggtaccgc tcagctctgt ggctgacacc
     3301 tgagcagacc tgcctgctcc agcccagccc acagcagccc tttcccctcc agccgggctc
     3361 ctacccagca ggagggggtg cagggcagac agggacaccg aggccttttt actcagttcc
     3421 tgagacccat ctaccaggga ctggcagcag cgtggcagtg acagaggcca ctggaggaac
     3481 agtctgggag gaaatgctgc agacacacct gggccctgga gagaacacag tgtctcaaga
     3541 aacttcccag cctcctgatg gccaagaggt catttccaaa ccacagacac cattggctgc
     3601 tagaccacga agtatttctg agagttccgc cagttcagcc aaggaggatg agaaggagtc
     3661 ctctgatgag gctgataaaa actctccccg aaatactgcc cagagaggca agctcggaga
     3721 tgggaaggag catacaaaga gctcagggtt tggctggttc agctggtttc gatcgaagcc
     3781 caccaagaac gcatcccccg ctggagacga ggactcctca gacagccctg actctgagca
     3841 ggagaccccc agagcatctt ctccccacca ggctggcctg ggcctctcac tgacaccttc
     3901 ccctgagtcc ccacctctgc cggatgttag tgccttctcc aggggcagag gtgggggtga
     3961 aggccgagga tccgcatcca gcgggggagc agctgcgggc gctggggttg gaggcttgtc
     4021 tggaccagag agtgtttcct ttgagctctg ctccaaccct ggtgttcttc ttcctccacc
     4081 tgccttaaaa ggggctgttc ctctttacaa cccatctcag gtgcctcagc tgcccacggc
     4141 cactagcctg aatcggccaa atcgcctagc tcagcgtcgc tatcccaccc agccatgctg
     4201 agaataaaca cacgtcccag gctcatctcc caggactgaa actttcttgc tctctttttc
     4261 tcaatctccc agcccctctc taccatattg ggaccctcaa gaggtttgtg ctagcccgat
     4321 gcctccaccg ggcacttaga aggcaagagg acaggatctc tcaagacaca gcacaattca
     4381 gtctcttaag attagcttca caatgatgga aattatttca tcaggtggaa agtctgggtc
     4441 taatagcaga ctgcacatga gcagagtgac atggtggtgg cacttatggt ggtggcttga
     4501 gagccttggg gaaattaggg ccctaacagc tagaatcaaa gatgataccg cagggccctg
     4561 tagcaagaaa tgggaagcag ggggaggggc aggggctcag aacaatattc tagaccaact
     4621 ttgactactt cctgtcttag taatagacca atacatggct ctatttagca aagtttttat
     4681 actgaaactt gattattgct gccctttata atttcctctt caatgatatt tcagcagttt
     4741 ccctcttggt cctagttttg tgcacatttt tttgaatgtg gttcagatta attatatttc
     4801 tctcactttc ttagctggtc ctattttttc acattctggc atgtggctat caagttagat
     4861 tgctgtaggc atcatattgt catggtaact actgaaccta atgatgcaga tggatggcac
     4921 atcagtataa taaatgatgg aaaacggttc ctaaaaattc atccctttca taagagggga
     4981 agaatgagtg cctgatattg ttaatacctc cctttctacc tcaggccttt gcaaattgat
     5041 gttcagaggg tcactggagt gagagggagg aggggggcgt cttggaaatt tccatttctc
     5101 ttttcaaacc caaaatagga atgactcttg ctgtttgtca gatttgctga aaattgctcc
     5161 tcacaaagaa catttttttt tgtacatgta attgtaaata caggtttagt acgttaatgt
     5221 tctatagttc tgatattgat aataattaaa cccagataat tttatagcaa a
//
