LOCUS       NM_145858               1598 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens crystallin zeta like 1 (CRYZL1), mRNA.
ACCESSION   NM_145858 NM_005111
VERSION     NM_145858.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1598)
  AUTHORS   Quentin,D., Schuhmacher,J.S., Klink,B.U., Lauer,J., Shaikh,T.R.,
            Huis In 't Veld,P.J., Welp,L.M., Urlaub,H., Zerial,M. and
            Raunser,S.
  TITLE     Structural basis of mRNA binding by the human FERRY Rab5 effector
            complex
  JOURNAL   Mol Cell 83 (11), 1856-1871 (2023)
   PUBMED   37267906
REFERENCE   2  (bases 1 to 1598)
  AUTHORS   Schuhmacher,J.S., Tom Dieck,S., Christoforidis,S., Landerer,C.,
            Davila Gallesio,J., Hersemann,L., Seifert,S., Schafer,R., Giner,A.,
            Toth-Petroczy,A., Kalaidzidis,Y., Bohnsack,K.E., Bohnsack,M.T.,
            Schuman,E.M. and Zerial,M.
  TITLE     The Rab5 effector FERRY links early endosomes with mRNA
            localization
  JOURNAL   Mol Cell 83 (11), 1839-1855 (2023)
   PUBMED   37267905
REFERENCE   3  (bases 1 to 1598)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1598)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1598)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   6  (bases 1 to 1598)
  AUTHORS   Rietveld,C.A., Esko,T., Davies,G., Pers,T.H., Turley,P.,
            Benyamin,B., Chabris,C.F., Emilsson,V., Johnson,A.D., Lee,J.J., de
            Leeuw,C., Marioni,R.E., Medland,S.E., Miller,M.B., Rostapshova,O.,
            van der Lee,S.J., Vinkhuyzen,A.A., Amin,N., Conley,D.,
            Derringer,J., van Duijn,C.M., Fehrmann,R., Franke,L., Glaeser,E.L.,
            Hansell,N.K., Hayward,C., Iacono,W.G., Ibrahim-Verbaas,C.,
            Jaddoe,V., Karjalainen,J., Laibson,D., Lichtenstein,P.,
            Liewald,D.C., Magnusson,P.K., Martin,N.G., McGue,M., McMahon,G.,
            Pedersen,N.L., Pinker,S., Porteous,D.J., Posthuma,D.,
            Rivadeneira,F., Smith,B.H., Starr,J.M., Tiemeier,H., Timpson,N.J.,
            Trzaskowski,M., Uitterlinden,A.G., Verhulst,F.C., Ward,M.E.,
            Wright,M.J., Davey Smith,G., Deary,I.J., Johannesson,M., Plomin,R.,
            Visscher,P.M., Benjamin,D.J., Cesarini,D. and Koellinger,P.D.
  TITLE     Common genetic variants associated with cognitive performance
            identified using the proxy-phenotype method
  JOURNAL   Proc Natl Acad Sci U S A 111 (38), 13790-13794 (2014)
   PUBMED   25201988
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):E380. doi:
            10.1073/pnas.1424631112.. PMID: 25572966]
REFERENCE   7  (bases 1 to 1598)
  AUTHORS   Fernandez,M.R., Porte,S., Crosas,E., Barbera,N., Farres,J.,
            Biosca,J.A. and Pares,X.
  TITLE     Human and yeast zeta-crystallins bind AU-rich elements in RNA
  JOURNAL   Cell Mol Life Sci 64 (11), 1419-1427 (2007)
   PUBMED   17497241
  REMARK    GeneRIF: Data show that human and yeast zeta-crystallins bind
            AU-rich elements in RNA.
REFERENCE   8  (bases 1 to 1598)
  AUTHORS   Hu,Y.H., Warnatz,H.J., Vanhecke,D., Wagner,F., Fiebitz,A.,
            Thamm,S., Kahlem,P., Lehrach,H., Yaspo,M.L. and Janitz,M.
  TITLE     Cell array-based intracellular localization screening reveals novel
            functional features of human chromosome 21 proteins
  JOURNAL   BMC Genomics 7, 155 (2006)
   PUBMED   16780588
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1598)
  AUTHORS   Kim,M.Y., Lee,H.K., Park,J.S., Park,S.H., Kwon,H.B. and Soh,J.
  TITLE     Identification of a zeta-crystallin (quinone reductase)-like 1 gene
            (CRYZL1) mapped to human chromosome 21q22.1
  JOURNAL   Genomics 57 (1), 156-159 (1999)
   PUBMED   10191096
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB037192.1, BC033023.2 and
            CA426424.1.
            
            On Nov 22, 2018 this sequence version replaced NM_145858.2.
            
            Summary: This gene encodes a protein that has sequence similarity
            to zeta crystallin, also known as quinone oxidoreductase. This zeta
            crystallin-like protein also contains an NAD(P)H binding site.
            Alternatively spliced transcript variants have been observed but
            their full-length nature has not been completely determined.
            [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.3152.1,
                                           SRR3476690.602373.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381554.8/ ENSP00000370966.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                DB037192.1         114-146
            34-1241             BC033023.2         1-1208
            1242-1598           CA426424.1         16-372              c
FEATURES             Location/Qualifiers
     source          1..1598
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.11"
     gene            1..1598
                     /gene="CRYZL1"
                     /gene_synonym="4P11; FERRY4; Fy-4; QOH-1"
                     /note="crystallin zeta like 1"
                     /db_xref="GeneID:9946"
                     /db_xref="HGNC:HGNC:2420"
                     /db_xref="MIM:603920"
     exon            1..61
                     /gene="CRYZL1"
                     /gene_synonym="4P11; FERRY4; Fy-4; QOH-1"
                     /inference="alignment:Splign:2.1.0"
     exon            62..133
                     /gene="CRYZL1"
                     /gene_synonym="4P11; FERRY4; Fy-4; QOH-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1117
                     /gene="CRYZL1"
                     /gene_synonym="4P11; FERRY4; Fy-4; QOH-1"
                     /note="quinone reductase-like 1; protein 4P11;
                     zeta-crystallin homolog; quinone oxidoreductase homolog 1;
                     crystallin, zeta (quinone reductase)-like 1; ferry
                     endosomal RAB5 effector complex subunit 4"
                     /codon_start=1
                     /product="quinone oxidoreductase-like protein 1"
                     /protein_id="NP_665857.2"
                     /db_xref="CCDS:CCDS13633.2"
                     /db_xref="GeneID:9946"
                     /db_xref="HGNC:HGNC:2420"
                     /db_xref="MIM:603920"
                     /translation="MKGLYFQQSSTDEEITFVFQEKEDLPVTEDNFVKLQVKACALSQ
                     INTKLLAEMKMKKDLFPVGREIAGIVLDVGSKVSFFQPDDEVVGILPLDSEDPGLCEV
                     VRVHEHYLVHKPEKVTWTEAAGSIRDGVRAYTALHYLSHLSPGKSVLIMDGASAFGTI
                     AIQLAHHRGAKVISTACSLEDKQCLERFRPPIARVIDVSNGKVHVAESCLEETGGLGV
                     DIVLDAGVRLYSKDDEPAVKLQLLPHKHDIITLLGVGGHWVTTEENLQLDPPDSHCLF
                     LKGATLAFLNDEVWNLSNVQQGKYLCILKDVMEKLSTGVFRPQLDEPIPLYEAKVSME
                     AVQKNQGRKKQVVQF"
     exon            134..211
                     /gene="CRYZL1"
                     /gene_synonym="4P11; FERRY4; Fy-4; QOH-1"
                     /inference="alignment:Splign:2.1.0"
     exon            212..284
                     /gene="CRYZL1"
                     /gene_synonym="4P11; FERRY4; Fy-4; QOH-1"
                     /inference="alignment:Splign:2.1.0"
     exon            285..329
                     /gene="CRYZL1"
                     /gene_synonym="4P11; FERRY4; Fy-4; QOH-1"
                     /inference="alignment:Splign:2.1.0"
     exon            330..398
                     /gene="CRYZL1"
                     /gene_synonym="4P11; FERRY4; Fy-4; QOH-1"
                     /inference="alignment:Splign:2.1.0"
     exon            399..532
                     /gene="CRYZL1"
                     /gene_synonym="4P11; FERRY4; Fy-4; QOH-1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..644
                     /gene="CRYZL1"
                     /gene_synonym="4P11; FERRY4; Fy-4; QOH-1"
                     /inference="alignment:Splign:2.1.0"
     exon            645..743
                     /gene="CRYZL1"
                     /gene_synonym="4P11; FERRY4; Fy-4; QOH-1"
                     /inference="alignment:Splign:2.1.0"
     exon            744..865
                     /gene="CRYZL1"
                     /gene_synonym="4P11; FERRY4; Fy-4; QOH-1"
                     /inference="alignment:Splign:2.1.0"
     exon            866..971
                     /gene="CRYZL1"
                     /gene_synonym="4P11; FERRY4; Fy-4; QOH-1"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1017
                     /gene="CRYZL1"
                     /gene_synonym="4P11; FERRY4; Fy-4; QOH-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1598
                     /gene="CRYZL1"
                     /gene_synonym="4P11; FERRY4; Fy-4; QOH-1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1351
                     /gene="CRYZL1"
                     /gene_synonym="4P11; FERRY4; Fy-4; QOH-1"
                     /note="major polyA site"
     regulatory      1442..1447
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRYZL1"
                     /gene_synonym="4P11; FERRY4; Fy-4; QOH-1"
                     /note="hexamer: GATAAA"
     polyA_site      1473
                     /gene="CRYZL1"
                     /gene_synonym="4P11; FERRY4; Fy-4; QOH-1"
                     /note="major polyA site"
     polyA_site      1598
                     /gene="CRYZL1"
                     /gene_synonym="4P11; FERRY4; Fy-4; QOH-1"
                     /note="major polyA site"
ORIGIN      
        1 gacgaaggac tggaaggtgg cggtggtgaa ggtgcaggcc gttggggcgg ctcagaggca
       61 ggtgactatg aaaggcttat atttccaaca gagttccaca gatgaagaaa taacatttgt
      121 atttcaagaa aaggaagatc ttcctgttac agaggataac tttgtgaaac ttcaagttaa
      181 agcttgtgct ctgagccaga taaatacaaa gcttctggca gaaatgaaga tgaaaaagga
      241 tttatttcct gttgggagag aaattgctgg aattgtatta gatgttggaa gcaaggtatc
      301 attctttcaa ccagatgatg aagtagttgg aattttgccc ctggactctg aagaccctgg
      361 actttgtgaa gttgttagag tacatgagca ttacttggtt cataaaccag aaaaggtcac
      421 atggacggaa gcagcaggaa gcattcggga tggagtgcgt gcctatacag ctctgcatta
      481 tctttctcat ctctctcctg gaaaatcagt gctgataatg gatggagcaa gtgcatttgg
      541 tacaatagct attcagttag cacatcatag aggagccaaa gtgatttcaa cagcatgcag
      601 ccttgaagat aagcagtgcc ttgaaagatt cagacctccc atagcccgag tgattgatgt
      661 atctaatggg aaagttcatg ttgctgaaag ctgtttggaa gaaacaggtg gcctgggagt
      721 agatattgtc ctagatgctg gagtgagatt atatagtaaa gatgatgaac cagctgtaaa
      781 actacaacta ctaccacata aacatgatat catcacactt cttggtgttg gaggccactg
      841 ggtaacaaca gaagaaaacc ttcagttgga tcctccagat agccactgcc ttttcctcaa
      901 gggagcaacg ttagctttcc tgaatgatga agtttggaat ttgtcaaatg tacaacaggg
      961 aaaatatctt tgtatcttaa aggatgtgat ggagaagtta tcaactggtg ttttcagacc
     1021 tcagttggat gaacccattc cactgtatga ggcaaaagtt tccatggaag ctgttcagaa
     1081 aaatcaagga agaaaaaagc aagttgttca attttaattt tcttctttct cagacctcag
     1141 tcggatgaac atattccagt atttgaagcc agaattttct ttggaaattg ttgagaaaaa
     1201 ccaaggaaga taaaacaagt tgcattttta agcacgtttc tctgctaaga caagatgctc
     1261 agttgacaca tttgaaaagt gtttgaaaaa ttcttgtgca aatgatcaag ataattctat
     1321 aattaacatc ttaagggaat ttttctaaaa accttttcat tgtttctata tattttgccc
     1381 ctgctataaa attccttcca tgaagaaaac tgctgctttc agcaaaagtc acactactct
     1441 tgataaaagc tgttgcaggc ctttgctaag ctatcaaagt aacgtattaa ttttgtatca
     1501 actccgttct caacaccttc cttaagtctt tgctgtcata atttaagcat ttgagtatat
     1561 tttgaagtct taaaagactt agcccatagg cacttaaa
//
