LOCUS       NM_001889               1908 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens crystallin zeta (CRYZ), transcript variant 2, mRNA.
ACCESSION   NM_001889
VERSION     NM_001889.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1908)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1908)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1908)
  AUTHORS   Lulli,M., Nencioni,D., Papucci,L. and Schiavone,N.
  TITLE     Zeta-crystallin: a moonlighting player in cancer
  JOURNAL   Cell Mol Life Sci 77 (6), 965-976 (2020)
   PUBMED   31563996
  REMARK    GeneRIF: Zeta-crystallin is a moonlighting protein endowed with two
            main different functions: (1) mRNA binding with stabilizing
            activity; (2) NADPH:quinone oxidoreductase. Zeta-crystallin has
            been clearly demonstrated to stabilize mRNAs encoding proteins
            involved in renal glutamine catabolism during metabolic acidosis
            resulting in ammoniagenesis and bicarbonate ion production that
            concur to compensate such condition. [review]
            Review article
REFERENCE   4  (bases 1 to 1908)
  AUTHORS   Qi,Q., Menzaghi,C., Smith,S., Liang,L., de Rekeneire,N.,
            Garcia,M.E., Lohman,K.K., Miljkovic,I., Strotmeyer,E.S.,
            Cummings,S.R., Kanaya,A.M., Tylavsky,F.A., Satterfield,S., Ding,J.,
            Rimm,E.B., Trischitta,V., Hu,F.B., Liu,Y. and Qi,L.
  TITLE     Genome-wide association analysis identifies TYW3/CRYZ and NDST4
            loci associated with circulating resistin levels
  JOURNAL   Hum Mol Genet 21 (21), 4774-4780 (2012)
   PUBMED   22843503
  REMARK    GeneRIF: Our results suggest that genetic variants in TYW3/CRYZ and
            NDST4 loci may be involved in the regulation of circulating
            resistin levels
REFERENCE   5  (bases 1 to 1908)
  AUTHORS   Crosas,E., Porte,S., Moeini,A., Farres,J., Biosca,J.A., Pares,X.
            and Fernandez,M.R.
  TITLE     Novel alkenal/one reductase activity of yeast NADPH:quinone
            reductase Zta1p. Prospect of the functional role for the
            zeta-crystallin family
  JOURNAL   Chem Biol Interact 191 (1-3), 32-37 (2011)
   PUBMED   21276778
  REMARK    GeneRIF: role of Zta1p in the yeast adaptation to some stress types
            and the general functional significance of zeta-crystallins
REFERENCE   6  (bases 1 to 1908)
  AUTHORS   Shao,M., Liu,Z., Tao,E. and Chen,B.
  TITLE     [Polymorphism of MAO-B gene and NAD(P)H: quinone oxidoreductase
            gene in Parkinson's disease]
  JOURNAL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 18 (2), 122-124 (2001)
   PUBMED   11295131
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1908)
  AUTHORS   Wang,W., Liu,L.Q., Higuchi,C.M. and Chen,H.
  TITLE     Induction of NADPH:quinone reductase by dietary phytoestrogens in
            colonic Colo205 cells
  JOURNAL   Biochem Pharmacol 56 (2), 189-195 (1998)
   PUBMED   9698072
REFERENCE   8  (bases 1 to 1908)
  AUTHORS   Heinzmann,C., Kojis,T.L., Gonzalez,P., Rao,P.V., Zigler,J.S. Jr.,
            Polymeropoulos,M.H., Klisak,I., Sparkes,R.S., Mohandas,T. and
            Bateman,J.B.
  TITLE     Assignment of the zeta-crystallin gene (CRYZ) to human chromosome
            1p22-p31 and identification of restriction fragment length
            polymorphisms
  JOURNAL   Genomics 23 (2), 403-407 (1994)
   PUBMED   7835889
REFERENCE   9  (bases 1 to 1908)
  AUTHORS   Gonzalez,P., Rao,P.V. and Zigler,J.S. Jr.
  TITLE     Organization of the human zeta-crystallin/quinone reductase gene
            (CRYZ)
  JOURNAL   Genomics 21 (2), 317-324 (1994)
   PUBMED   8088825
REFERENCE   10 (bases 1 to 1908)
  AUTHORS   Gonzalez,P., Rao,P.V. and Zigler,J.S. Jr.
  TITLE     Molecular cloning and sequencing of zeta-crystallin/quinone
            reductase cDNA from human liver
  JOURNAL   Biochem Biophys Res Commun 191 (3), 902-907 (1993)
   PUBMED   8466529
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA256305.1 and BC039578.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001889.3.
            
            Summary: Crystallins are separated into two classes:
            taxon-specific, or enzyme, and ubiquitous. The latter class
            constitutes the major proteins of vertebrate eye lens and maintains
            the transparency and refractive index of the lens. The former class
            is also called phylogenetically-restricted crystallins. This gene
            encodes a taxon-specific crystallin protein which has
            NADPH-dependent quinone reductase activity distinct from other
            known quinone reductases. It lacks alcohol dehydrogenase activity
            although by similarity it is considered a member of the
            zinc-containing alcohol dehydrogenase family. Unlike other
            mammalian species, in humans, lens expression is low. Alternatively
            spliced transcript variants encoding different isoforms have been
            found for this gene. One pseudogene is known to exist. [provided by
            RefSeq, Sep 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.124126.1,
                                           SRR1660805.144752.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN04284274 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340866.10/ ENSP00000339399.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-519               DA256305.1         43-561
            520-1908            BC039578.1         500-1888
FEATURES             Location/Qualifiers
     source          1..1908
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.1"
     gene            1..1908
                     /gene="CRYZ"
                     /note="crystallin zeta"
                     /db_xref="GeneID:1429"
                     /db_xref="HGNC:HGNC:2419"
                     /db_xref="MIM:123691"
     exon            1..95
                     /gene="CRYZ"
                     /inference="alignment:Splign:2.1.0"
     exon            96..219
                     /gene="CRYZ"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1098
                     /gene="CRYZ"
                     /EC_number="1.6.5.5"
                     /note="isoform a is encoded by transcript variant 2;
                     NADPH:quinone reductase; quinone oxidoreductase;
                     crystallin, zeta (quinone reductase); epididymis secretory
                     sperm binding protein"
                     /codon_start=1
                     /product="quinone oxidoreductase isoform a"
                     /protein_id="NP_001880.2"
                     /db_xref="CCDS:CCDS665.1"
                     /db_xref="GeneID:1429"
                     /db_xref="HGNC:HGNC:2419"
                     /db_xref="MIM:123691"
                     /translation="MATGQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHA
                     CGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGG
                     YAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGG
                     VGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGI
                     DIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTK
                     EEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMILLL"
     exon            220..372
                     /gene="CRYZ"
                     /inference="alignment:Splign:2.1.0"
     exon            373..536
                     /gene="CRYZ"
                     /inference="alignment:Splign:2.1.0"
     exon            537..588
                     /gene="CRYZ"
                     /inference="alignment:Splign:2.1.0"
     exon            589..738
                     /gene="CRYZ"
                     /inference="alignment:Splign:2.1.0"
     exon            739..840
                     /gene="CRYZ"
                     /inference="alignment:Splign:2.1.0"
     exon            841..936
                     /gene="CRYZ"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1908
                     /gene="CRYZ"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1885..1890
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRYZ"
                     /note="hexamer: AATAAA"
     polyA_site      1908
                     /gene="CRYZ"
                     /note="major polyA site"
ORIGIN      
        1 gtggagcctg caaaagttgg agaaggtgtg gcagtcctca tttctgtgga atctgaagaa
       61 gcccacgcag attttaattc ccactctaga ttctgtatct agatcaccat ggcgactgga
      121 cagaagttga tgagagctgt tagagttttt gaatttggtg ggccagaagt cctgaaattg
      181 cgatcagata ttgcagtacc gattccaaaa gaccatcagg ttctaatcaa ggtccatgca
      241 tgtggtgtca accccgtgga gacatacatt cgctctggta cttatagtag aaaaccactc
      301 ttaccctata ctcctggctc agatgtggct ggggtgatag aagctgttgg agataatgca
      361 tctgctttca agaaaggtga cagagttttc actagcagca cgatctctgg gggttatgca
      421 gagtatgctc ttgcagcaga ccacactgtt tacaaactac ctgaaaaact ggactttaaa
      481 caaggagctg ccatcggcat tccatatttt actgcttatc gagctctgat ccacagtgcc
      541 tgtgtgaaag ctggagagag tgttctggtt catggggcaa gtggaggagt tggattagca
      601 gcatgccaaa ttgctagagc ttatggctta aagattttgg gcactgctgg tactgaggaa
      661 ggacaaaaga ttgttttgca aaatggagcc catgaagtgt tcaatcacag agaagtgaat
      721 tacattgata aaattaagaa gtatgttggt gagaaaggaa ttgatataat tattgaaatg
      781 ttagctaatg taaatcttag taaagacttg agtcttctgt cacatggagg acgagtgata
      841 gttgttggca gcagaggtac tattgaaata aacccacgag acaccatggc aaaggagtcg
      901 agtataattg gagttactct cttttcctca accaaggagg aatttcagca atatgcagca
      961 gcccttcaag ctggaatgga aattggctgg ttgaaacctg tgataggttc tcaatatcca
     1021 ttggagaagg tggccgaggc tcatgaaaat atcattcatg gtagtggggc tactggaaaa
     1081 atgattcttc tcttatgatg attaattctt tcatggattt cctatgtaat tagaggtact
     1141 gtctttcccc cagttgtact taccctatct tttctttaat taacattcga ttccatgagc
     1201 ttcttatgtg aaaaaataag atttttcttt agagagcaga agcagaagag taaaatttat
     1261 tgtatagcta gcaatatttt tttatgccat ctgtctcaaa tcaaagagtc atcatagtag
     1321 gaaataacat gttagttgtc atttggcatg agtgtgcatt ccagtaattc ttaattgata
     1381 tttgattaat tccatacctt tgattaaaac atgctagttc aaaataagac tgctcagttt
     1441 ccaagggttt tcaagcctac ttacctttat aaaggttctc tagtctctga ttagccatga
     1501 ctgtattgga ctttgaacat tttctgaact aaaaacctct attctaaact aatctcattt
     1561 ggatgtgtaa gtcttttgta aaggcaagaa taaataatat ccaggacaat ttattagttt
     1621 tctcagtatt ttcccaaata ttagaatatt tacttcatta ttggttggct gccaatgacc
     1681 ccatatgttc tgtgagaata gtagctttat ctttgatata atacatagtc tccaaatagg
     1741 taatacttcg caattgatta gattttcaga gtagatttag agttatctgt ttttctggtg
     1801 agggtcaaat atttttgtta attaagctca caaatttgat aaattaagaa ttatctgcat
     1861 ttgtctcgta acataataat gtgtaataaa gtctatagaa aattaaaa
//
