LOCUS       NM_144727               1989 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens crystallin gamma N (CRYGN), transcript variant 1,
            mRNA.
ACCESSION   NM_144727
VERSION     NM_144727.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1989)
  AUTHORS   Breton,C.V., Siegmund,K.D., Joubert,B.R., Wang,X., Qui,W.,
            Carey,V., Nystad,W., Haberg,S.E., Ober,C., Nicolae,D., Barnes,K.C.,
            Martinez,F., Liu,A., Lemanske,R., Strunk,R., Weiss,S., London,S.,
            Gilliland,F. and Raby,B.
  CONSRTM   Asthma BRIDGE consortium
  TITLE     Prenatal tobacco smoke exposure is associated with childhood DNA
            CpG methylation
  JOURNAL   PLoS One 9 (6), e99716 (2014)
   PUBMED   24964093
  REMARK    Erratum:[PLoS One. 2014;9(10):e112422]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1989)
  AUTHORS   Graw,J.
  TITLE     Genetics of crystallins: cataract and beyond
  JOURNAL   Exp Eye Res 88 (2), 173-189 (2009)
   PUBMED   19007775
  REMARK    Review article
REFERENCE   3  (bases 1 to 1989)
  AUTHORS   Leparc,G.G. and Mitra,R.D.
  TITLE     Non-EST-based prediction of novel alternatively spliced cassette
            exons with cell signaling function in Caenorhabditis elegans and
            human
  JOURNAL   Nucleic Acids Res 35 (10), 3192-3202 (2007)
   PUBMED   17452356
REFERENCE   4  (bases 1 to 1989)
  AUTHORS   Wistow,G., Wyatt,K., David,L., Gao,C., Bateman,O., Bernstein,S.,
            Tomarev,S., Segovia,L., Slingsby,C. and Vihtelic,T.
  TITLE     gammaN-crystallin and the evolution of the betagamma-crystallin
            superfamily in vertebrates
  JOURNAL   FEBS J 272 (9), 2276-2291 (2005)
   PUBMED   15853812
  REMARK    GeneRIF: gammaN-crystallin represents an intermediate in the
            evolution of beta and gamma crystallins. Crygn is expressed in mice
            and other species but may be a pseudogene in humans.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005996.2.
            
            On Nov 22, 2019 this sequence version replaced NM_144727.2.
            
            Summary: This gene encodes a member of the crystallin family of
            proteins that are localized to the refractive structure of
            vertebrate eye lenses. The protein encoded by this gene is unique
            in that it has both beta and gamma crystallin protein motifs.
            Alternative splicing of this gene results in multiple transcript
            variants. [provided by RefSeq, Apr 2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372080.2115050.1, AF445455.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337323.3/ ENSP00000338613.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-245               AC005996.2         80752-80996
            246-494             AC005996.2         82649-82897
            495-640             AC005996.2         84568-84713
            641-1989            AC005996.2         90713-92061
FEATURES             Location/Qualifiers
     source          1..1989
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..1989
                     /gene="CRYGN"
                     /note="crystallin gamma N"
                     /db_xref="GeneID:155051"
                     /db_xref="HGNC:HGNC:20458"
                     /db_xref="MIM:609603"
     exon            1..245
                     /gene="CRYGN"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..773
                     /gene="CRYGN"
                     /note="isoform a is encoded by transcript variant 1;
                     gamma-crystallin N; gammaN-crystallin; gamma-N-crystallin"
                     /codon_start=1
                     /product="gamma-crystallin N isoform a"
                     /protein_id="NP_653328.1"
                     /db_xref="CCDS:CCDS5926.1"
                     /db_xref="GeneID:155051"
                     /db_xref="HGNC:HGNC:20458"
                     /db_xref="MIM:609603"
                     /translation="MAQRSGKITLYEGKHFTGQKLEVFGDCDNFQDRGFMNRVNSIHV
                     ESGAWVCFNHPDFRGQQFILEHGDYPDFFRWNSHSDHMGSCRPVGMHGEHFRLEIFEG
                     CNFTGQCLEFLEDSPFLQSRGWVKNCVNTIKVYGDGAAWSPRSFGAEDFQLSSSLQSD
                     QGPEEATTKPATTQPPFLTANL"
     exon            246..494
                     /gene="CRYGN"
                     /inference="alignment:Splign:2.1.0"
     exon            495..640
                     /gene="CRYGN"
                     /inference="alignment:Splign:2.1.0"
     exon            641..1989
                     /gene="CRYGN"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaacgcggag agcacaggga gaccccgggc agggcgggct gcactcgcgg tggcacaggg
       61 tggccgcggc gggtcccaac cgcctggtgg cccctcgggc ttagcacgcc cgacagcact
      121 aacgctccgg ggccggccca gcaaatcttt tgtccggggc ggcgctgagc cagcagggcg
      181 ctgcccggtg taaacgggga cccgcggaag gggcggggcg caccatggcg cagcgctcgg
      241 ggaagatcac tctctatgaa ggcaagcact tcacagggca gaagctggag gtcttcgggg
      301 actgtgacaa cttccaggac cggggcttta tgaaccgagt gaactccatc cacgtggaga
      361 gcggagcctg ggtctgcttc aatcaccccg acttccgggg ccagcagttc atcttggagc
      421 acggcgacta ccccgacttc ttccgctgga acagccacag tgaccacatg ggctcctgtc
      481 ggcctgtagg aatgcacgga gaacatttcc gcctagaaat cttcgagggt tgcaacttca
      541 cgggccagtg cctggagttc ctggaggaca gccccttcct ccagagcagg ggctgggtca
      601 agaactgtgt gaacaccatc aaggtgtacg gggacggagc agcatggagc cctagaagct
      661 tcggagctga ggacttccag ctgagcagct ctcttcaatc agatcaagga ccggaagagg
      721 ccaccacaaa accagcaaca acccagccac ctttcctgac tgcaaacctc tgagcctgga
      781 accgattgac atgtaaatgc acctgcaccg tttctgagcc gggagagtgt ttacttaaaa
      841 tcatgccctc agttttcatt tctctgccag tttgttaggg aggtggagcc ttctgtgtgt
      901 catatctgcc agcgggaggc cctccccacc catggcaagg gccctgtctc ttctgaaaca
      961 gccgtccaac cctccacccc acagcctcct tgggccttgg caccctgctg gcctcaggcc
     1021 tccacaatct cgcacctcag cccacagctg atgatggtga tgatgttgat gaatatttat
     1081 ggagcactga cttaatgcca ggctctgtag tagctggaat ctgtgtaatt ttacttatca
     1141 tatacaataa tgccaagatg atatgcttat caccactgta cagttgagga gagccagcca
     1201 cagacaggtt aagcaacttg cccagggtca cacagcagtc aggactaaaa cccaggtctg
     1261 gctggctgat tgatcctttt cgttcctaac cactcctcta tagagcacca cacatttgca
     1321 tatttagata tatttttgtc atgaatttgg cgcaaaccca aagcctctcc aggcctcaga
     1381 ccctgttctg tgaaatgagt gcaatcatgt ctgctgtacc aactgtatac ccttgtaaaa
     1441 gccaaaggcg tgacccatga gcgggtgcca tatgagggct ggttagtagt aggtgaccca
     1501 gtaggtgacg gggtggggaa gcaggcaggg gagtggcatc acaggagaga aggtaacttg
     1561 gctccaaact ccaacctgat tcccactcca tccctcacta ggatgtgaca ttggagaagc
     1621 cactgctgtg tgtctcagtg tcttcagacg tacagcagtg gtaatcattc cgccccctca
     1681 taggcaatta atgcctgggg aatgaaatga gaactgcagg ccccaccggt tcagtccagg
     1741 tccttgggag tcacgggaaa aaccaggcct agcagccctt cccatgagtt ccagaggctt
     1801 cccctgaact cttcctctcc tccccagcac caaggcttag cagcatctca ttaactggtg
     1861 atttaatgct tctcgaatgg gctttgtgct cctgggtgac ctccccctca ccccagcccc
     1921 ctgctcccta atctgtcagc aaatctgctt tttgtctgaa agaggaaaaa caagattccc
     1981 accaaagtg
//
