LOCUS       NM_153605              10779 bp    mRNA    linear   PRI 10-MAR-2024
DEFINITION  Homo sapiens crystallin beta-gamma domain containing 3 (CRYBG3),
            mRNA.
ACCESSION   NM_153605 XM_003118522 XM_003119905
VERSION     NM_153605.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10779)
  AUTHORS   Zheng,L., Luo,C., Yang,N., Pei,H., Ji,M., Shu,Y., Zhang,Z.,
            Dong,S., Wang,X., Li,X., Zhang,W., Wang,Y., Li,B., Hei,T.K.,
            Zhou,G. and Chang,L.
  TITLE     Ionizing radiation-induced long noncoding RNA CRYBG3 regulates
            YAP/TAZ through mechanotransduction
  JOURNAL   Cell Death Dis 13 (3), 209 (2022)
   PUBMED   35246511
  REMARK    GeneRIF: Ionizing radiation-induced long noncoding RNA CRYBG3
            regulates YAP/TAZ through mechanotransduction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10779)
  AUTHORS   Wu,A., Tang,J., Guo,Z., Dai,Y., Nie,J., Hu,W., Liu,N., Ye,C.,
            Li,S., Pei,H. and Zhou,G.
  TITLE     Long Non-Coding RNA CRYBG3 Promotes Lung Cancer Metastasis via
            Activating the eEF1A1/MDM2/MTBP Axis
  JOURNAL   Int J Mol Sci 22 (6), 3211 (2021)
   PUBMED   33809929
  REMARK    GeneRIF: Long Non-Coding RNA CRYBG3 Promotes Lung Cancer Metastasis
            via Activating the eEF1A1/MDM2/MTBP Axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10779)
  AUTHORS   Burgers,P.P., van der Heyden,M.A., Kok,B., Heck,A.J. and
            Scholten,A.
  TITLE     A systematic evaluation of protein kinase A-A-kinase anchoring
            protein interaction motifs
  JOURNAL   Biochemistry 54 (1), 11-21 (2015)
   PUBMED   25097019
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110491.5, AK296966.1, AK091199.1, AF451988.1 and BM974654.1.
            
            On Nov 22, 2018 this sequence version replaced NM_153605.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments and RNAseq data.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1966682,
                              SAMEA1968189 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000389622.7/ ENSP00000374273.3
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AC110491.5         123065-123093       c
            30-4290             AK296966.1         1-4261
            4291-7039           AC110491.5         67067-69815         c
            7040-7084           AC110491.5         65356-65400         c
            7085-7200           AC110491.5         65004-65119         c
            7201-7348           AC110491.5         63885-64032         c
            7349-7485           AC110491.5         58337-58473         c
            7486-7600           AC110491.5         56649-56763         c
            7601-7636           AC110491.5         55714-55749         c
            7637-7770           AC110491.5         52111-52244         c
            7771-7897           AC110491.5         49019-49145         c
            7898-8040           AC110491.5         46079-46221         c
            8041-8167           AC110491.5         45841-45967         c
            8168-8200           AC110491.5         44619-44651         c
            8201-8272           AC110491.5         32866-32937         c
            8273-9708           AK091199.1         715-2150
            9709-10758          AF451988.1         1797-2846
            10759-10779         BM974654.1         18-38               c
FEATURES             Location/Qualifiers
     source          1..10779
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q11.2"
     gene            1..10779
                     /gene="CRYBG3"
                     /gene_synonym="DKFZp667G2110; vlAKAP"
                     /note="crystallin beta-gamma domain containing 3"
                     /db_xref="GeneID:131544"
                     /db_xref="HGNC:HGNC:34427"
                     /db_xref="MIM:620146"
     exon            1..345
                     /gene="CRYBG3"
                     /gene_synonym="DKFZp667G2110; vlAKAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..9109
                     /gene="CRYBG3"
                     /gene_synonym="DKFZp667G2110; vlAKAP"
                     /note="beta/gamma crystallin domain-containing protein 3;
                     beta-gamma crystallin domain containing 3"
                     /codon_start=1
                     /product="very large A-kinase anchor protein"
                     /protein_id="NP_705833.3"
                     /db_xref="CCDS:CCDS43113.2"
                     /db_xref="GeneID:131544"
                     /db_xref="HGNC:HGNC:34427"
                     /db_xref="MIM:620146"
                     /translation="MSSGRRRGSAPWHSFSRFFAPRSPSRDKEEEEEERPGTSPPPAP
                     GRSAASVENEPMSTSQKKENVLSSEAVKIRQSEDKRNHAEKPVTLPVQEDPKKAYDLS
                     SSTSDTKIGESDRQPKESFFQFLGNLFNISGKSSLGEAKQSSFKDDQDKTEKDLQNPS
                     DHHEDGIKREREIFSGSLRTQTHPTEEQDSNSSELSDAFSLDTTQDSDQETTNLLKQI
                     DGKPEKPSVTYATYRGPRHIGKYLKQQTGLATVNTLDRENESSDSSTNRHIDPGSEIE
                     AGVLPLLLSASTDSSMKGNLLEGPLEDSDCSKTSFNKENSLTNNPELQNIASSNNLLN
                     KNAWGSIERNRSSPSSVTNSSYDGESDSQHHLSCEPVSQTNRNLVCSALLTGSNHRKV
                     PCSPDFQRVTTTENTIKENSTVMSNRTLVQREELVEPQGPAISDFSCSKSDGSDTTEQ
                     ESTNLPSPNKSIRHEHLQLPESECSDKQTIDSSSKQAATHTNIIALQRHAVTDTEFVN
                     EGKRLSAQDSQKNVAVREIRRETESASAGESIASSHVKAPEDKIESLPKDTDQYFETK
                     AKKLDFRSHDKIPHIRMNKKDLASLNYISESAVVASLGNENAPELKFELNRSHISETP
                     LDSESPQQAEVSPDAKTSLSLDCKKLNFSISPPTFVSGVGMLSKLDIPDLMNEGSPVP
                     IETGNVNIVGISYQPRKCKEENVKNHVEAAGRKSPPPSFCLEYTSAIFEFKEVLSNSE
                     KCQVLPGSEASGPHLTGLELLSFDSGNLSKDCSSILSQDPNRVELVSSNTKANMSIIE
                     KSDSLSLEAKTANIVSKAEIDGQNNVLVESHSGRGKTISLSKVSLSKVEPRNISQDKM
                     SSFPLKITHVPEKPILSELTFLEVEQGKRFQSINHNEIGEKCSDAGLKENCQAELSPA
                     ASKYEDKPEPEVDALGSPPALLKSNISWILPPIHDEKISRQMAQNCEAHTCVFHQSLD
                     ICGTKKISGHSEMAELSLTNISPKFQETGSMKVNSPFLDSDSSLEKNSSASEDSSFLK
                     VPSVLKLEKKSSSYRKKENIHFLNGGIDSVSSSSSYPEEVSMIVNSHKPQNNLDSIQV
                     TKDLTHEGTSVTNLLYPTTSYLEFETSVSIGTEVTPFQEHFGIYTGKISIDFPTAAQF
                     DNLVEAETGAVAGPAASVNSSGQQCSEASAEHIEARRRAHDQLLDLKSSLLKKADTLI
                     GEIFNSVREELKFKHTVSTCQEHIAIEGIMNLGTLKEDISEKNPSEVTLTEIQQTEGL
                     EEQGMENMSEVKEKPCVSPTVGEKNLLVDPNSMNVSCLLEDKARELVNEIIYVAQEKL
                     RNDTFEDTEDTWDSELQANTSKILNSDSVKPHDVVREFLVSEQPVNQSTQISENKVLN
                     EFFSLSNLASGTESIKGGEIVLYQKSLFSGNGSGLSDSINLQESDTVLLAEDMSHKRL
                     DDRVKTHLFRSEDCNETMEIENVDNNKTETEDRRTLVLNFKWPPLVNDDIHAPGTSKS
                     SLSDSLVCISEKNLPGHSKNTPLAMSDVGKVHKKDNEINIGKIELIPSMLETGKTNKK
                     DAELNILKYEAVPPMIEMGRIHKMDAELNVTKTEPKANVFKMGEVYQMDAESCIEKTE
                     GSAVILGMEKAYKMKDTEGDIGKIEVIPMMPEVKNIHQKDAEGDIVKTEMTPVTVDME
                     NIYQTHAEGDIGKTGTIALSEVENIHQKGGEGISEKAEVIPVTLAMENTYQKDAEGDI
                     GKAEVMPVRLEMENTYPKDTERDGGKTEVMPLALEVVNTYQKNAKGFTGNTEGSVLKM
                     EATYRKTAEEVIKNTEIVPCVLKVKEAHETAPAPLEMEKACKRDVKETIGATVSTPSV
                     IEMEKISPEDRGENIGKHKVLPAVVDIEKIHGTGLELTTKQGEAMLPAFESKTPQEYA
                     EGSVEETKEEPTEIKEGLIAHENRLPTYFRGYESPTLSKDYEGYPAPAMPDFQPGDTT
                     VRLDKRMSLTAIYDKRRETDYSDKGYNLAFVSQDEQENSSFTILYEEPLQEEDKYASA
                     EARQTQSVLFHDTSADSMPVLACERSESRTDLVHHFEKGTKLGETFDSDSSEMFLSVE
                     AKRYKIYPLALSPIYEDDSSQEDILSSEVSPGHHGPRKSRDSENQSSSVLSLLQSVSE
                     RLKMNFDEDDREAADEEEEEEEAAVLHKGDLRAGSGERVTFQLPDPSITFYPDDQESV
                     GISKNSYVMPNEPTTSNLQVGLWPEKTSFLQKSDLTSKLHSSLKSAYHQYLQTSQSHS
                     SEKGARFGGIFQEPVSKYFRVQDSPGRLSPFIENVDKQTLRCNPRPGKMVIYDLHEST
                     YKQEVYCNIPDATSWSFPNGVLIKVVRGCWILYEKPHFRGQKCVLEEGEKVLNRDWIL
                     QNRRHPQRNFILGSLKRVLKDCSIPEIELFPQSDPACCPVYIQRAVPNLEELNISKSV
                     SFTVKSGVWLAYPDINFKGQATVLEEDHGLFEISTAEMKSLHPLQMGGLKVEMPMNLK
                     VIIYEKPHFHGQAKEFSEHIDSVPNFLKNNGDFHRIGSIRVIGGVWVAYEKEHFKGQQ
                     FLLEEGDFEDSNACGALSSPILSFRYLQANFIESSVTLFESDLESGKFIDITNQEISD
                     LEEIGFGSKTRSIHVKSGVWVAYQQKFFCGEQYILEKGKYKCFFDWGGSNNIIMSIRP
                     IQLEPLGINEPPHLLKAFSKPGFQGECIDFTEETSDLTSLMPCSFKVLRGCWLLYYQE
                     DMFVNHCVLEEGLYADLTSCGCPASKVKSLKPIDYVFEEPSISLFALEHCEGRELHLE
                     EAVNSVLNKDLHFYTQSVWVKSGLWIAYEGSNFLGRQILLRPNEIPNWTAFSRWKTIG
                     SLRPMKQPAVYIRIKNRAQGEYLTVTGSLADTRATSVCISPYSGKNTQIWYYCRGLFK
                     SKASDTCLDVIGGRDTPGAKVALWTEHGQFRQKWRLNKNGTISSYLSDQLVLDVKGGN
                     YCDKTHVIVNQPLEGEETQKWDIEIL"
     exon            346..412
                     /gene="CRYBG3"
                     /gene_synonym="DKFZp667G2110; vlAKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            413..843
                     /gene="CRYBG3"
                     /gene_synonym="DKFZp667G2110; vlAKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            844..7039
                     /gene="CRYBG3"
                     /gene_synonym="DKFZp667G2110; vlAKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            7040..7084
                     /gene="CRYBG3"
                     /gene_synonym="DKFZp667G2110; vlAKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            7085..7200
                     /gene="CRYBG3"
                     /gene_synonym="DKFZp667G2110; vlAKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            7201..7348
                     /gene="CRYBG3"
                     /gene_synonym="DKFZp667G2110; vlAKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            7349..7485
                     /gene="CRYBG3"
                     /gene_synonym="DKFZp667G2110; vlAKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            7486..7600
                     /gene="CRYBG3"
                     /gene_synonym="DKFZp667G2110; vlAKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            7601..7636
                     /gene="CRYBG3"
                     /gene_synonym="DKFZp667G2110; vlAKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            7637..7770
                     /gene="CRYBG3"
                     /gene_synonym="DKFZp667G2110; vlAKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            7771..7897
                     /gene="CRYBG3"
                     /gene_synonym="DKFZp667G2110; vlAKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            7898..8040
                     /gene="CRYBG3"
                     /gene_synonym="DKFZp667G2110; vlAKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            8041..8167
                     /gene="CRYBG3"
                     /gene_synonym="DKFZp667G2110; vlAKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            8168..8200
                     /gene="CRYBG3"
                     /gene_synonym="DKFZp667G2110; vlAKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            8201..8310
                     /gene="CRYBG3"
                     /gene_synonym="DKFZp667G2110; vlAKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            8311..8437
                     /gene="CRYBG3"
                     /gene_synonym="DKFZp667G2110; vlAKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            8438..8577
                     /gene="CRYBG3"
                     /gene_synonym="DKFZp667G2110; vlAKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            8578..8701
                     /gene="CRYBG3"
                     /gene_synonym="DKFZp667G2110; vlAKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            8702..8860
                     /gene="CRYBG3"
                     /gene_synonym="DKFZp667G2110; vlAKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            8861..9020
                     /gene="CRYBG3"
                     /gene_synonym="DKFZp667G2110; vlAKAP"
                     /inference="alignment:Splign:2.1.0"
     exon            9021..10779
                     /gene="CRYBG3"
                     /gene_synonym="DKFZp667G2110; vlAKAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10741..10746
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRYBG3"
                     /gene_synonym="DKFZp667G2110; vlAKAP"
                     /note="hexamer: AATAAA"
     polyA_site      10758
                     /gene="CRYBG3"
                     /gene_synonym="DKFZp667G2110; vlAKAP"
                     /note="major polyA site"
ORIGIN      
        1 ggcgtgagga gctgccgcgc gaggagcgcg tcgcgtccgc acttctcctg cccgagagag
       61 actgagccgc gctggcagct cgcgtcgagt cggtctgccc tagccgcatc ccgcggcgcc
      121 cggtcgggct ccgggcacca ggcaacacct aggccgttcc cttcagacag ccccgggcca
      181 gcggccccct cgggaaatgt ccagcggccg cagaaggggc agcgccccct ggcacagctt
      241 ctcccggttc ttcgctcccc gaagtccttc ccgggacaag gaagaggaag aggaggagag
      301 gccggggacg agcccgcctc cagctccagg ccggtccgct gccagtgttg aaaatgagcc
      361 catgagcaca agtcagaaaa aggaaaatgt actttcatca gaagcagtaa agattcgcca
      421 aagtgaggac aaaaggaacc atgctgagaa gccagtcact cttccagtgc aggaagatcc
      481 caaaaaggca tatgatcttt ccagttccac ttcagatacc aaaataggag aaagtgacag
      541 acagccaaaa gaaagctttt ttcagtttct tggtaactta ttcaatatct cggggaaatc
      601 atctctaggt gaagctaagc agtcttcttt caaagatgac caggataaaa ctgagaagga
      661 tttacaaaat cccagtgacc atcatgaaga cgggatcaaa agggagagag agattttcag
      721 tggctcccta agaacccaga cacatccaac agaagaacaa gactctaact catccgaact
      781 ctcagatgct ttttctttgg atacaacaca agacagtgac caagaaacca ctaatttgct
      841 aaaacaaatc gatggtaaac cagagaagcc ttcagtaaca tatgcaacat atcgaggccc
      901 aagacacatt gggaaatatt taaagcaaca gacaggcttg gcaactgtga ataccttgga
      961 cagagaaaat gaaagttctg actctagtac aaacagacac attgaccctg gaagtgagat
     1021 tgaggctggg gtactgccac tgttgttatc agctagtaca gactcatcta tgaaaggaaa
     1081 tctacttgaa ggcccattag aagactctga ttgtagcaaa acaagtttca acaaggaaaa
     1141 ttctttgaca aataacccag aactgcagaa tattgcctct tccaataatc ttttaaataa
     1201 aaatgcttgg gggagtattg agagaaatag gtcatcccct tcttctgtga ctaactccag
     1261 ctacgatgga gaatctgact cacagcacca tttaagttgt gaaccggttt ctcagactaa
     1321 cagaaatttg gtatgttcag cattgttaac aggaagtaac catcgcaaag tcccttgcag
     1381 cccagatttt cagagagtaa ctacaacaga aaatacgata aaagaaaaca gcactgtgat
     1441 gagtaatagg acattggtgc aaagagagga gcttgttgag cctcagggcc ctgctatttc
     1501 tgatttctct tgtagtaaat ctgatgggag tgacactact gagcaggaaa gtacaaattt
     1561 gccaagtcca aataaatcaa ttaggcatga acatctgcag ttgccagaga gtgagtgttc
     1621 tgacaagcaa accatagata gctcatcaaa gcaagctgcc actcacacca atatcattgc
     1681 tcttcagaga catgctgtga cagacacaga atttgtaaat gaaggaaaga gattgtctgc
     1741 ccaagactca cagaaaaatg tggctgttag agaaatcagg cgagaaacag aaagtgcctc
     1801 agctggtgaa tccatagctt caagtcatgt aaaagctcca gaagataaaa ttgagtcatt
     1861 acccaaagat actgaccaat actttgaaac caaagccaaa aagcttgatt ttaggtcaca
     1921 tgataaaatt cctcatatta gaatgaataa aaaagacctg gcctctttaa attacatcag
     1981 tgaatcagca gttgtagcaa gcttaggaaa tgaaaatgca cctgagttga aatttgaact
     2041 taatagaagt cacatttcag aaactcctct tgactctgag agtcctcaac aagctgaagt
     2101 atcacctgat gctaaaacat ctcttagcct tgactgtaaa aaactaaatt tcagtatttc
     2161 acctcctacc tttgtttctg gagttgggat gctgagcaag ttggatattc ctgatttaat
     2221 gaatgagggt tctcctgtgc ccattgaaac tgggaatgtc aacattgttg gtatttccta
     2281 tcagcctagg aagtgtaaag aagaaaatgt gaaaaaccat gttgaggctg caggcaggaa
     2341 gagtcctcct ccttcctttt gccttgaata tacatctgca atttttgaat tcaaagaagt
     2401 tctttctaat agtgaaaaat gccaggttct tccaggttct gaagccagtg gccctcactt
     2461 aactgggttg gagctattga gctttgactc tggaaacctc tctaaggatt gcagttccat
     2521 tttatctcaa gaccctaata gagtagagtt agtgtcttca aacactaaag caaatatgag
     2581 cataatagag aagtctgatt ctctttcctt ggaagccaaa actgctaaca ttgtatcaaa
     2641 agctgaaatt gatggtcaga acaatgttct tgtggagtca cattctggaa gaggaaaaac
     2701 tatatccttg tccaaggtat ctctttcaaa agtggagccc agaaacattt ctcaggataa
     2761 aatgtcttct tttccattga aaattaccca tgttccagaa aagcctattt tgtcagaatt
     2821 aacctttcta gaagttgaac agggcaaacg ttttcaatca attaatcata atgagatagg
     2881 agagaaatgt tcagatgctg gccttaaaga gaattgccaa gctgagcttt ctcctgctgc
     2941 ctccaaatat gaagataagc cagaaccaga ggtagatgcc ttaggctctc ctcctgctct
     3001 tcttaaaagt aatatatctt ggattttacc acctattcat gatgaaaaaa tcagtaggca
     3061 aatggcgcag aattgtgaag ctcacacttg tgtgtttcat caatctttgg atatttgtgg
     3121 gactaaaaag atttctggtc actcagaaat ggcggaactc agcttaacta atatttcccc
     3181 taaattccaa gaaactggca gcatgaaagt aaattcacct tttctggatt ctgattccag
     3241 tttggaaaaa aattcttctg catctgagga ctcaagcttc cttaaagtac cttctgtgct
     3301 gaaattggaa aagaaatcct catcttacag aaagaaagag aacatccatt ttttaaatgg
     3361 tggtattgat agtgtgtcat cttcctctag ttaccctgaa gaagttagca tgatagtaaa
     3421 ttcacataag ccccaaaata atttggattc tatacaagtt accaaagatc tcacacatga
     3481 aggtacctct gtaactaacc tgttgtaccc tactacctct tatttggaat ttgaaacgtc
     3541 tgtctcaatt gggacagaag taaccccatt tcaggaacat tttgggattt atactgggaa
     3601 gatatccatt gatttcccaa ctgctgccca atttgacaat ctcgtggaag cagagactgg
     3661 agcagttgct gggcctgcag cgtcagttaa cagctcaggc caacagtgtt ctgaagcctc
     3721 tgctgagcac atagaagcca ggagaagagc acatgaccaa cttttggacc tcaaaagtag
     3781 tttactcaaa aaggccgata cattgattgg tgagattttt aattctgtca gggaagaact
     3841 aaaattcaaa cacacagtga gtacctgcca ggagcatata gccatagaag gtataatgaa
     3901 tctgggtacc ctgaaagaag acatctctga gaaaaaccca tcagaagtga cactaacaga
     3961 aatacaacag acagagggtt tggaagagca aggcatggaa aacatgtcag aagtcaaaga
     4021 gaagccctgt gtttcaccaa cagttggtga gaagaatctt cttgttgatc ctaatagtat
     4081 gaatgtatct tgtttgttag aagataaagc tagggaatta gtcaatgaga ttatttatgt
     4141 agcccaagaa aaattgagaa atgatacttt tgaagatact gaggatactt gggattctga
     4201 acttcaggct aatacttcaa aaattctgaa cagtgatagt gttaagccac atgatgtagt
     4261 tagagagttc ttggtttcag aacagccagt aaatcaaagc acacaaatta gtgaaaataa
     4321 agtattaaat gaattcttct ccctaagtaa cttagctagt ggcacagagt caattaaggg
     4381 aggagaaatt gttctctacc aaaaatccct attttctgga aatggatctg gactgtctga
     4441 tagtataaat ttgcaggaat cagatacggt tttactagct gaagacatgt cacataaacg
     4501 gttagatgat agggtaaaaa cacatttatt tcgcagtgag gactgtaatg agacaatgga
     4561 aatagagaat gtggataata acaaaactga gacagaggac agaagaactc ttgtattaaa
     4621 tttcaaatgg cctccacttg tgaatgatga catccatgca cctggtacat ctaaaagcag
     4681 tttgtctgat agccttgtat gtatatctga aaaaaacttg ccaggacaca gtaaaaacac
     4741 acctcttgca atgtcagatg tagggaaagt acacaagaag gataatgaaa taaatatagg
     4801 gaaaattgaa cttatacctt ccatgttaga aacagggaaa acaaacaaaa aggatgctga
     4861 attgaatatt ctgaaatatg aggcagtccc tcctatgata gaaatgggaa gaatacataa
     4921 aatggatgct gaattgaatg tcacgaaaac tgagccaaaa gctaatgttt ttaaaatggg
     4981 agaagtatac caaatggatg ccgagagctg tattgaaaaa actgagggat cagctgtcat
     5041 tttaggaatg gaaaaagctt ataagatgaa ggatactgaa ggggatattg gcaaaattga
     5101 ggtgatacct atgatgccag aagtgaaaaa tatccaccaa aaggatgctg aaggggatat
     5161 tgtaaagact gagatgacac ctgttacagt agacatggaa aatatttacc aaacgcatgc
     5221 tgaaggggat attggcaaga ctgggacgat agccttgtca gaagtggaaa atatccacca
     5281 aaaaggtggt gaagggatta gtgaaaaggc tgaagtgata cccgttacat tagcaatgga
     5341 aaatacttac caaaaggatg ctgaagggga tattggaaag gctgaagtga tgcctgtgag
     5401 gttagaaatg gaaaatactt acccaaagga tactgaaaga gacggtggca aaactgaggt
     5461 gatgcccctt gcattagagg tagtaaatac ttaccaaaaa aatgccaaag gttttaccgg
     5521 gaacactgaa gggtctgtgt tgaaaatgga agctacttac cgaaagactg ctgaagaggt
     5581 cattaagaat actgaaatag taccgtgtgt gttaaaagtg aaggaagcac acgagacagc
     5641 acctgccccc ttagaaatgg aaaaagcatg caagagagat gttaaagaga ctattggagc
     5701 aactgtgtcc acaccctctg tgatagaaat ggaaaaaata tccccagaag atcgtggtga
     5761 gaatattggg aaacacaaag tgttacccgc agtggtagac attgagaaaa tacatggaac
     5821 aggactagaa ttgaccacta aacaagggga ggccatgctt cctgcatttg aaagtaaaac
     5881 accacaagag tatgctgaag ggagtgttga agaaacaaag gaagagccta cagaaataaa
     5941 ggaaggcttg atagcacatg aaaatagact tcctacatat ttcaggggat atgaatcccc
     6001 tacattaagt aaggattatg agggctaccc agccccagca atgccagatt ttcaacctgg
     6061 ggataccaca gtaagactag acaaaagaat gtctcttact gcaatatatg acaagaggag
     6121 agagacagat tatagtgaca aaggatataa tttagctttt gtttctcaag atgaacaaga
     6181 aaattcttcc tttactatat tatacgaaga gccccttcaa gaggaggaca agtatgcttc
     6241 cgcagaagca agacaaacac agtctgtctt gtttcatgat acgtccgctg acagcatgcc
     6301 tgttctggca tgtgaaaggt ctgagagtag aactgacctt gtccatcact ttgaaaaagg
     6361 tactaaatta ggtgagacat ttgatagtga tagttcagaa atgttcttat cagtggaggc
     6421 caaaaggtac aaaatttatc ctttagcatt gtctcccatt tatgaggatg acagctcaca
     6481 ggaggacatt ctatctagtg aggtttcacc tggtcaccat ggccccagga aatcaagaga
     6541 cagtgaaaac cagtcctctt ctgttttatc ccttctccag tcagtgtcag aacgtttaaa
     6601 gatgaatttt gatgaagatg acagagaggc agctgatgag gaagaagagg aggaggaggc
     6661 agcagtattg cataaaggag atctgagagc tggaagtggg gagcgtgtta ccttccagtt
     6721 gccagatcct tccatcacat tttaccctga tgaccaggag agcgttggaa tttctaagaa
     6781 ttcatatgtg atgccaaatg aacctactac ctccaatctg caagttggtc tgtggccaga
     6841 aaagacctcg tttctccaga aatctgacct tacttctaaa ctacattctt ctttaaagag
     6901 tgcttatcat cagtatctgc agacttccca aagtcattcc tcagaaaaag gagccagatt
     6961 tggtggaatt tttcaggaac cagtgtcaaa atatttccgt gttcaagaca gcccaggcag
     7021 attgagccca tttatagaga atgttgacaa acaaactctg agatgtaacc caagacctgg
     7081 gaagatggtt atctatgatc tccatgaaag tacatataaa caagaagtct actgtaatat
     7141 tcctgatgct acatcatggt cttttccaaa tggagttcta ataaaagttg taaggggctg
     7201 ctggatttta tatgagaaac cacatttccg aggtcagaaa tgtgtgctag aagaagggga
     7261 aaaggtgtta aatcgtgact ggattcttca gaacagaagg catccacaaa gaaactttat
     7321 attgggttct ctcaaacgtg tcttaaagga ctgcagcatt ccagaaatag agcttttccc
     7381 acaatctgac ccagcctgtt gtcctgtcta catacagaga gcagtcccca atttggaaga
     7441 actgaatatc tccaaatctg tgtccttcac tgtgaagtca ggagtttggc ttgcctaccc
     7501 agatattaat tttaagggac aagctacagt tctggaggaa gaccatgggc tctttgagat
     7561 ttctacagca gaaatgaaat cattacatcc gcttcaaatg ggtggactga aagtggaaat
     7621 gcccatgaac ttaaaggtta ttatttatga aaaacctcac ttccatggac aggctaaaga
     7681 gtttagtgaa catatagatt ctgttcctaa ttttttgaaa aataatggag attttcacag
     7741 aattggatca attcgtgtca ttggtggagt gtgggttgcc tatgaaaaag aacattttaa
     7801 aggccagcag tttctgcttg aagaaggaga ctttgaagac agtaatgctt gtggtgcatt
     7861 aagtagccct atcttgtctt tccggtactt acaagctaat tttatagaat cttctgtcac
     7921 actatttgaa tctgacctag aaagtgggaa gtttattgac attacaaatc aggaaatttc
     7981 tgatttggaa gaaattggct ttggcagtaa aacaagatcc attcatgtta aaagtggagt
     8041 atgggttgcc taccagcaaa agttcttctg tggagaacaa tacattttag aaaaagggaa
     8101 atacaaatgc ttttttgact ggggaggatc aaataatata atcatgtcga tacggccaat
     8161 ccaactggaa ccacttggga taaatgaacc tccgcatttg ctcaaagcat tcagcaaacc
     8221 agggttccaa ggtgaatgta tagattttac agaagaaact tctgatttga cttcactcat
     8281 gccatgttct tttaaagttc ttcgaggttg ctggctcctc tattaccaag aagacatgtt
     8341 tgttaatcac tgtgtgttag aagaaggcct ctatgctgac cttacttcct gcggttgccc
     8401 agcatctaaa gtcaaatctc tcaagcccat tgactatgtt tttgaagaac cctccatcag
     8461 cctttttgct ctggagcatt gtgagggaag agagttacat ctagaagagg ctgtgaactc
     8521 tgttctgaac aaggacctac acttctacac ccagtctgtg tgggtaaaaa gtggactatg
     8581 gatagcttat gaaggatcca atttcttggg aagacaaatc ctactcaggc ctaatgagat
     8641 cccaaactgg acagcattca gcagatggaa aacaattggt tccctccgtc ctatgaagca
     8701 gcctgcagtg tacatcagaa taaagaaccg tgcccagggt gaatatctga cagtcactgg
     8761 aagtctagca gacaccaggg caacatctgt gtgcatttct ccctatagtg gaaagaatac
     8821 tcagatctgg tactactgcc gaggactctt taaatccaag gccagtgata catgtcttga
     8881 tgtgattggt ggccgggaca cacctggagc taaagtagct ctatggactg aacatgggca
     8941 attcaggcag aagtggagac tgaataaaaa tggaactatc agctcttatc tcagtgatca
     9001 acttgtcctt gatgttaaag gaggaaatta ttgtgacaag actcatgtaa ttgtaaatca
     9061 gcccctggag ggagaagaaa cacagaaatg ggacattgaa atattgtgag agaatcaaca
     9121 tccctagaaa gatccctaga aagagcaaag aaggaaacac atctgtcatt gtcttgtgga
     9181 cgtggaaagg aagctactgt cctcacactc ctggatcact gagcagaatg aacattttct
     9241 ccagcctctg agactatcgc tcttaaccat ggaaaagctc aaaatattct tgccattact
     9301 cagtgttcct ataaagaaaa tattatgata tcttggaaag gttctattcc tgatctccag
     9361 ctgtggtgag caagtttcct gaagtgttta ttttctctca tatccaccaa acgtgaatcc
     9421 tgttcctgat ggcccgttat tggacactgg tgatgctatt atcctgtatt atttattaat
     9481 atcctaccta gatgcttgta tgagtacaaa gcataaagaa acagatttct ataggtcaag
     9541 tcatactttt gcaaacagat gagtaatttt ttagcaacac ctgaaaatat actaaacttt
     9601 cctagataaa ctttaaggtt tctatactga ggcttttata atgaacgcac ctcgttaagt
     9661 atttatactt gtaactaacc ccaggcaggg acctcagctt tgttaggaat aaggcacaag
     9721 aagtattttc tgtagctatt gtttcctcag tccttcaaac taaaaaagta caaataaata
     9781 acctatggcc aaacttgcac tgttacgtgt taaccaagac atccctttag gtgacaagac
     9841 tctataacag tggttacctg tctccatgtt gacacttcat cctagattta aggagaggca
     9901 tcaatttttt tttttttttg cctcaagaga aatttcaaat atccaaatta aaacacagta
     9961 gcatttgaac cttgacctta ccatctcttt aagtaaacgt ggagttgatt tctctactaa
    10021 ataacagaaa cctcagtttt tcactcccat tgtaagtaac ttttatttaa gtaagtaaaa
    10081 tcaggtagga aatcaccttt gacttagctt ccagtagtca ttaccacctt ttactgcaca
    10141 attcacaagc atgttttcct ggtgaattgg actgaaaatt acattttgac aacttttttt
    10201 ccttttatcc ccaacttttg ccagaaagca gaaaaatgct ctatttttat aaagaaagat
    10261 taaattctcc aatgatattt taaaaaatat caacctacat gcactttaga atgtaaaata
    10321 acaatgacta ttttaaactc gaagacccac tattttgagt attttttata gactttaaat
    10381 actgggtttt tttcctcctt caatctcagg cttttctcca tcttttaagc agcctctgta
    10441 actccctttt gtccataggt gttgcgtgcc tctcatctgt ggggaagtat tatttaataa
    10501 aatttatgtt acaggataac tttattttaa tgggcatggg cttgtctata cacaaaggta
    10561 tgtatatttt cattataaaa aaccagttta aaattttttc ttattttaat tgtttgaaat
    10621 ttttctagag ccaaagaagc tctttaaaga agttgtttct tccaaagaac aaagccaggt
    10681 taatgacatt caattctaaa tgatacattg gaattgtgcc ttttctacca cactggatta
    10741 aataaacttg tcaaaatatg gttttgtcat tttctgaga
//
