LOCUS       NM_001039775            5239 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens crystallin beta-gamma domain containing 2 (CRYBG2),
            mRNA.
ACCESSION   NM_001039775 XM_930398 XM_934725 XM_939136 XM_944018
VERSION     NM_001039775.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5239)
  AUTHORS   Zhou,W., Zhang,Y., Zhang,S. and Yang,Z.
  TITLE     Absent in melanoma 1-like (AIM1L) serves as a novel candidate for
            overall survival in hepatocellular carcinoma
  JOURNAL   Bioengineered 12 (1), 2750-2762 (2021)
   PUBMED   34130591
  REMARK    GeneRIF: Absent in melanoma 1-like (AIM1L) serves as a novel
            candidate for overall survival in hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 5239)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   3  (bases 1 to 5239)
  AUTHORS   Szafranski,K., Schindler,S., Taudien,S., Hiller,M., Huse,K.,
            Jahn,N., Schreiber,S., Backofen,R. and Platzer,M.
  TITLE     Violating the splicing rules: TG dinucleotides function as
            alternative 3' splice sites in U2-dependent introns
  JOURNAL   Genome Biol 8 (8), R154 (2007)
   PUBMED   17672918
  REMARK    GeneRIF: The apparent occurrence of an unusual TG 3' splice site in
            intron 2 is critically discussed.
REFERENCE   4  (bases 1 to 5239)
  AUTHORS   Fu,G.K., Wang,J.T., Yang,J., Au-Young,J. and Stuve,L.L.
  TITLE     Circular rapid amplification of cDNA ends for high-throughput
            extension cloning of partial genes
  JOURNAL   Genomics 84 (1), 205-210 (2004)
   PUBMED   15203218
REFERENCE   5  (bases 1 to 5239)
  AUTHORS   Teichmann,U., Ray,M.E., Ellison,J., Graham,C., Wistow,G.,
            Meltzer,P.S., Trent,J.M. and Pavan,W.J.
  TITLE     Cloning and tissue expression of the mouse ortholog of AIM1, a
            betagamma-crystallin superfamily member
  JOURNAL   Mamm Genome 9 (9), 715-720 (1998)
   PUBMED   9716656
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK000902.1, DA439029.1, CD628851.1, DA456217.1, AL451139.40,
            DR004727.1 and AK095339.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001039775.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The full-length transcript structure is
            predicted based on partial human and full-length homologous
            transcript alignments from cow GeneID:507142 and mouse
            GeneID:230806.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853560.596.1,
                                           SRR18074969.2893412.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308182.10/ ENSP00000310435.6
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               AK000902.1         1-190
            191-602             DA439029.1         177-588
            603-1327            AK000902.1         603-1327
            1328-1472           CD628851.1         237-381
            1473-1988           DA456217.1         14-529
            1989-2855           AL451139.40        80354-81220         c
            2856-3451           DR004727.1         142-737
            3452-5239           AK095339.1         496-2283
FEATURES             Location/Qualifiers
     source          1..5239
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..5239
                     /gene="CRYBG2"
                     /gene_synonym="AIM1L"
                     /note="crystallin beta-gamma domain containing 2"
                     /db_xref="GeneID:55057"
                     /db_xref="HGNC:HGNC:17295"
                     /db_xref="MIM:619765"
     exon            1..95
                     /gene="CRYBG2"
                     /gene_synonym="AIM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            96..3063
                     /gene="CRYBG2"
                     /gene_synonym="AIM1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..5136
                     /gene="CRYBG2"
                     /gene_synonym="AIM1L"
                     /note="beta-gamma crystallin domain containing 2; absent
                     in melanoma 1-like protein; absent in melanoma 1 like"
                     /codon_start=1
                     /product="beta/gamma crystallin domain-containing protein
                     2"
                     /protein_id="NP_001034864.2"
                     /db_xref="GeneID:55057"
                     /db_xref="HGNC:HGNC:17295"
                     /db_xref="MIM:619765"
                     /translation="MEEAGGPMARAKARVVSATLTWRQRPPTQEEIKHGFHKVSLVSG
                     AQMEAPQKEMFEFSRREEVEVNGFATQEEETVNCQGPRDTAGSKNFQSHGPIFSKKYI
                     PPPKEKRPEGRLKEAVDQSDGSRQAPRTEPPCVGAMARTELLVPLPGPREPSPHPGVG
                     LTSGSSRSLEEYRVTRTVRTTTVVGGHVDRRMSSSVTVRPVSSGEALPRGRQVSRMVP
                     PVVVGSPPGSPSRSQAVKVLSNLVPAGHSPPASHLPRPTAGGPRSTGLGSTVGAALRQ
                     LPETGTAELKDSSALASTGIPASAHLPKNQDAPAACPDRDQGRAPDARACELWQVLGA
                     PSSTELPLQTSQGQASVPSSPRLETHVPSPGLTHPAKQPVVPTHPGARLTPLVLPPKK
                     KDGPVDPPAATVLPMVRSEHVTVPGQPPAPSTTRRKDVPSPGGLSAPSSPRNKFVQNS
                     ENVPVLPFTQREVVKGPGAPAASSPTRKEVVQGSSASAASSPTWKEVVKGPGAPAASS
                     PTQKEVVQGSSAPAALFPTWKEVVKGPGAPDASFPTWKEVVKGPGAPAASSPTQKEVV
                     QGSGAPAALSTTPKEVVKGPGAPAASSPTQKEVVKGPCAPAASSPTQKEVVQGSGAPA
                     ALSPKSTEVVQGPKGSSSIQKEAVQGIAGSLAPPLTKEETVQGPIAPATSLPKQDKGV
                     QDSEGSPISSLTQKEVVQDPDALPAPSSSVDRVSPSPGGTPAPVPTGAEASTESQLVS
                     DPTEGKTCTETSREEDEVALAADLEIFLDTLRSMEPPEILRTHRLPRAPRSSYLSMYA
                     TLPAIEEDQLGPWVLGPGPQEVPSLEEKEEEEEEEPENPYLSDDEKLQRRQEKAGPSP
                     SRDLHPARPTQVSCSPLEMMKKHVAGTKGPHSELGLELQGGSRPTSRLGGSLLFGSLV
                     PTAKEASTPEPLGTKLSALLPHGAPGLRKVPGQLPLLCSERSSPTEKLACSLPLEGWS
                     PALKTQGKLNTRPGKVIFFSESGCQGSGREVWGDIVDASGWAPVASIRVVRGCWVLYE
                     EPEFRGQKLVLPEGDMELRTPGTKWSPQGIGSLRRVVWDYSTPEISLFSEEGLKGEQV
                     KLTEALKNSQGLEKPLQVASATVSAGLWLLYPKPLFEDTPYILEPGEYPTSEAWGTSD
                     PSVGSLKPMRLGCPSVEKPGEPRAVVYEAPGFQGRSWEVSRDIYNLQQPEDSQSPHLA
                     SVGSLRVLGGCWVGYEKEGFRGHQYLLEEGEYPDWSHWGGYDELLTSLRVIRTDFGDP
                     AVVLFEAMDFEGHGVEVSKALPDVELVQHGPSTQAIHVLSGVWVAYQEVGFSGEQYVL
                     EKGVYRNCEDWGAGNSTLASLQPVLQVGEHDLHFVSKIQLFSRPDFLGDHFSFEDDQA
                     ALPASFRPQSCRVHGGSWILFDETNFEGDQHILSEGEFPTLTAMGCLASTVLGSLQKV
                     SLHFSEPSIFLYGLECFEGKEIELSREVRSLQAEGFNNHVLSVRIKGGIWVLCEHSDF
                     RGRQWLVGSCEITNWLTYSGTQRVGSLYPIKQRRVYFRLWNAALGGFLAVPDHVEDMK
                     AGRVVVADPQAGGSCIWYYEDGLLKNQMAPTMSLQVIGPPSPGSKVVLWAESRLPRQT
                     WSISESGHICSQMFEGQILDVKGGRGYDRDHVVLWEPDEDRASQIWTIHVL"
     exon            3064..3111
                     /gene="CRYBG2"
                     /gene_synonym="AIM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            3112..3224
                     /gene="CRYBG2"
                     /gene_synonym="AIM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            3225..3354
                     /gene="CRYBG2"
                     /gene_synonym="AIM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            3355..3494
                     /gene="CRYBG2"
                     /gene_synonym="AIM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            3495..3621
                     /gene="CRYBG2"
                     /gene_synonym="AIM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            3622..3657
                     /gene="CRYBG2"
                     /gene_synonym="AIM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            3658..3794
                     /gene="CRYBG2"
                     /gene_synonym="AIM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            3795..3921
                     /gene="CRYBG2"
                     /gene_synonym="AIM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            3922..4061
                     /gene="CRYBG2"
                     /gene_synonym="AIM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            4062..4188
                     /gene="CRYBG2"
                     /gene_synonym="AIM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            4189..4221
                     /gene="CRYBG2"
                     /gene_synonym="AIM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            4222..4334
                     /gene="CRYBG2"
                     /gene_synonym="AIM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            4335..4464
                     /gene="CRYBG2"
                     /gene_synonym="AIM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            4465..4604
                     /gene="CRYBG2"
                     /gene_synonym="AIM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            4605..4728
                     /gene="CRYBG2"
                     /gene_synonym="AIM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            4729..4887
                     /gene="CRYBG2"
                     /gene_synonym="AIM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            4888..5047
                     /gene="CRYBG2"
                     /gene_synonym="AIM1L"
                     /inference="alignment:Splign:2.1.0"
     exon            5048..5239
                     /gene="CRYBG2"
                     /gene_synonym="AIM1L"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      5239
                     /gene="CRYBG2"
                     /gene_synonym="AIM1L"
                     /note="major polyA site"
ORIGIN      
        1 agctgagagc ccaatcgcat caggggagca cggcccagca gcaggagctc caggctggct
       61 ggacacctgg gtccccacgc agactgtgag tagagggagc tggaccacag tgggacaagg
      121 acacctccag acaggttgcc agggccccac atggaggagg caggtgggcc catggcccgg
      181 gccaaggccc gagtggtaag tgccacattg acatggcggc agcggccccc cacccaggaa
      241 gagatcaaac atggttttca caaggtgtcc ctggtgtcag gggcccagat ggaagccccg
      301 cagaaggaga tgtttgagtt cagccgtcga gaggaagtgg aagtcaatgg ctttgcaaca
      361 caggaagaag agactgtgaa ttgccagggc cctcgggata cagctggctc caagaacttc
      421 cagagccatg gacccatctt ttccaagaag tacataccac ctcccaagga gaaaaggcct
      481 gaggggaggc tgaaggaggc tgtggaccag agtgatggca gccgccaagc tcccaggact
      541 gagcccccat gtgtgggagc tatggccagg actgagcttt tggttcccct gcctgggccc
      601 cgagagccaa gtccccaccc aggtgtaggt ctcaccagtg gtagctcccg gagcctcgag
      661 gaataccgag tgacacgcac tgtgcggacc accacagtgg tgggaggtca tgtggaccgg
      721 cggatgagca gctctgtgac tgtgaggcca gtgtcctcag gcgaggccct gccacggggc
      781 cgtcaggtct cccgcatggt gccgccagtg gtggtgggct ccccaccagg ctcgcccagc
      841 cgcagccagg ccgtgaaagt gctaagtaac ctcgtgcctg ctgggcacag cccccctgcc
      901 agtcacctgc ccaggcccac ggctggcggg ccaaggagca caggtctggg cagcacagtg
      961 ggggcagcct tgaggcagct gcctgagacc gggacagcag agcttaaaga cagctctgcc
     1021 ctggcctcta caggcatccc agccagtgct cacctgccta agaatcagga tgcccctgca
     1081 gcctgtccgg acagagacca gggcagagcc ccggatgcca gggcctgtga gctctggcag
     1141 gtgctgggag cccccagttc cactgagctc cctctccaga cttctcaggg tcaagcatca
     1201 gtcccctcct ctcccagact cgagacccat gtcccctctc ctggcctaac tcaccctgca
     1261 aagcagcctg tggtgcccac tcaccccggg gcccggctca ctccccttgt tctgccccct
     1321 aaaaaaaagg acgggcccgt ggacccccct gctgccaccg tcctgcccat ggtgaggagc
     1381 gagcatgtga cagtccctgg acaacctcct gctccatcca ctacaagaag gaaggatgtc
     1441 cccagcccag gaggtctttc tgctccatcg tccccaagga ataagtttgt tcagaactct
     1501 gaaaatgtcc ctgtcctccc ctttacccag agggaggtcg tgaagggccc cggtgctcct
     1561 gctgcctcat ctcccacccg gaaggaggtg gtgcaggggt ccagtgcttc tgctgcctcg
     1621 tcccccacct ggaaagaggt cgtgaagggc cctggtgctc ctgctgcctc atctcccacc
     1681 cagaaggagg tggtgcaggg gtccagtgct cctgctgcct tgttccccac ctggaaagag
     1741 gtcgtgaagg gccccggtgc tcctgatgcc tcatttccca cctggaaaga ggttgtgaag
     1801 ggccctggtg ctcctgctgc ctcatccccc acccagaagg aggtggtgca ggggtctggt
     1861 gctcctgctg ccttgtccac caccccaaaa gaggttgtga agggccctgg tgctcctgct
     1921 gcctcatcgc ccacccagaa agaggttgtg aagggcccct gtgctcctgc tgcctcatct
     1981 cccacccaga aggaggtggt gcaggggtct ggtgctcctg ctgccttgtc ccccaagtca
     2041 actgaggttg tccagggccc aaaaggcagc agtagcatcc aaaaagaggc tgtccagggt
     2101 attgcaggca gccttgcccc gcccctcacc aaggaagaga ctgttcaagg cccaattgct
     2161 cctgccacct cactccccaa acaggataag ggggtccagg actctgaagg gagccccatc
     2221 tcatctctca cccagaaaga ggttgtgcag gaccctgatg ctctccctgc cccatcttcc
     2281 tcagtggaca gggtgtcccc cagcccagga ggcacccctg ccccagtgcc aacaggagca
     2341 gaggccagca cggagtccca gcttgtctct gatcccaccg agggcaagac gtgcacagag
     2401 acatcaaggg aggaggatga ggtggccctg gccgctgacc tggagatatt cctggatacg
     2461 ctgcggagca tggagccccc tgagatcctc cgcactcacc ggctgccacg agcccctcgc
     2521 tcctcctacc tgtccatgta cgccacgctg cctgccattg aggaggacca gctggggcca
     2581 tgggtgctgg gccccggacc ccaggaggtg ccttcactgg aagagaaaga ggaggaggag
     2641 gaggaggaac cagagaaccc ctatctgagt gacgatgaga agctccagcg caggcaggag
     2701 aaagctgggc ccagcccctc cagggacctc caccctgcca gacccaccca ggtctcctgc
     2761 tctcctctgg agatgatgaa gaagcatgta gcaggaacca agggccccca ctcagagctg
     2821 ggattggaac tgcagggagg cagcaggccc acttcccgtc ttggaggcag ccttctgttc
     2881 ggcagtctgg tgcctaccgc caaggaggcc tccaccccgg aaccgctggg cacaaaacta
     2941 tctgctctgc tgccccatgg ggcaccgggg ctcaggaagg tgccaggaca gttgcccctg
     3001 ctttgcagtg aaagatcatc cccaacggag aagcttgcct gttccctgcc cctggagggg
     3061 tggagcccag ccttaaagac ccagggcaag ctgaacacca ggcctggaaa ggtgatcttc
     3121 ttctcagagt ctggctgcca aggcagtggc agggaggtct ggggagacat cgttgatgcc
     3181 tcaggctggg cccccgtagc ctccataagg gtagttcgag gctgctgggt gctgtacgaa
     3241 gagccagagt tccggggtca gaagctggtc ctgcctgaag gagacatgga actcagaacc
     3301 ccagggacaa agtggagtcc ccaaggcatc ggctccctaa ggagggttgt ctgggactac
     3361 agcaccccgg aaatcagcct cttctctgag gagggcctca agggggagca agtgaagcta
     3421 acagaggcct tgaagaattc ccagggtctg gagaagcccc tgcaggtggc atctgccacc
     3481 gtctctgcag gactgtggct actgtacccc aaaccattat tcgaagacac tccctacatc
     3541 ctggaacctg gagagtaccc cacctcagag gcctggggca catcggaccc cagcgtgggc
     3601 tccctgaagc ccatgagatt gggctgccca agtgtggaga agccagggga gcccagggct
     3661 gtggtgtatg aggccccagg ctttcagggc cgcagctggg aagtgagccg agacatctac
     3721 aaccttcagc agccagagga cagccagagc ccccacctgg cctctgtggg gtccctgaga
     3781 gttctcggag gctgctgggt gggctacgag aaggagggct tccggggcca ccagtatctg
     3841 ctggaggagg gggaataccc agactggtca cactggggag gctatgacga gttgctgacc
     3901 tccctccggg tcatccggac ggacttcggg gacccggccg tcgtgctatt tgaggccatg
     3961 gacttcgagg ggcacggcgt ggaggtgagc aaggcattgc cggatgtgga gctggtgcaa
     4021 cacggcccca gcacacaggc catccacgtg ctcagcggcg tgtgggtggc ctaccaggag
     4081 gtgggcttct ccggggaaca gtacgtgctg gagaagggcg tgtatcgtaa ctgcgaggac
     4141 tggggcgctg gcaacagcac cctcgcctcg ctgcagccgg tcctacaggt cggggagcac
     4201 gatctgcact tcgtctcaaa gattcagctt ttctcccgcc ccgactttct gggcgaccac
     4261 ttctctttcg aagatgacca ggccgctctg cccgcctcct tccgacctca gtcctgccgg
     4321 gtccacggcg gcagctggat cctgtttgat gagacgaact tcgagggtga ccagcacatt
     4381 ctctctgagg gcgagttccc cactctcacg gccatgggct gcctcgcctc cacagtcctg
     4441 ggctctctcc agaaggtatc cctgcacttt tcagagcctt ccattttcct gtatggactc
     4501 gagtgcttcg aggggaagga gatcgagctc agcagggagg tgcggagcct gcaagccgag
     4561 ggcttcaaca accatgtgct gtctgtgcgg atcaaggggg gcatttgggt gctatgtgaa
     4621 cacagtgact tccggggccg ccagtggctg gtgggaagct gcgagatcac caactggctg
     4681 acctacagcg gcacccagag ggtgggctcc ctctacccca tcaagcagcg ccgggtttat
     4741 ttccgcctct ggaatgcagc actgggggga ttcctggcag tgccggacca tgtggaggac
     4801 atgaaagcag gccgtgtggt ggtcgccgac ccccaagctg gaggtagctg catctggtac
     4861 tacgaggatg ggctgctgaa gaaccagatg gcccccacca tgagcctaca ggtgattgga
     4921 ccccctagcc caggctccaa ggtggtgctg tgggccgaga gccgcctgcc gcgccagacg
     4981 tggagcatca gtgaatcggg ccacatctgc agccagatgt tcgaaggcca gatcctggac
     5041 gtgaagggag gccggggcta cgaccgggac cacgtggtgc tatgggagcc ggatgaggac
     5101 agggcatccc agatctggac tatccacgtg ctttgaaact tttcccctca ccctccagcc
     5161 ctggaggctt ttgctgggat gaatgttttt atagggtttt tgttgtaaca taagctattt
     5221 tctaatatgc tgccaggta
//
