LOCUS       NM_004075               2987 bp    mRNA    linear   PRI 07-MAY-2024
DEFINITION  Homo sapiens cryptochrome circadian regulator 1 (CRY1), transcript
            variant 4, mRNA.
ACCESSION   NM_004075
VERSION     NM_004075.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2987)
  AUTHORS   Ma,J., Chen,S., Liu,J., Liao,Y., Li,L., Wang,C.C., Song,S.,
            Feng,R., Hu,H. and Quan,S.
  TITLE     Cryptochrome 1 regulates ovarian granulosa cell senescence through
            NCOA4-mediated ferritinophagy
  JOURNAL   Free Radic Biol Med 217, 1-14 (2024)
   PUBMED   38522484
  REMARK    GeneRIF: Cryptochrome 1 regulates ovarian granulosa cell senescence
            through NCOA4-mediated ferritinophagy.
REFERENCE   2  (bases 1 to 2987)
  AUTHORS   Chiou,Y.Y., Lee,C.Y., Yang,H.W., Cheng,W.C. and Ji,K.D.
  TITLE     Circadian modulation of glucose utilization via CRY1-mediated
            repression of Pdk1 expression
  JOURNAL   J Biol Chem 300 (2), 105637 (2024)
   PUBMED   38199564
  REMARK    GeneRIF: Circadian modulation of glucose utilization via
            CRY1-mediated repression of Pdk1 expression.
REFERENCE   3  (bases 1 to 2987)
  AUTHORS   Liu,D., Xie,Z., Gu,P., Li,X., Zhang,Y., Wang,X., Chen,Z., Deng,S.,
            Shu,Y. and Li,J.D.
  TITLE     Cry1Delta11 mutation induces ADHD-like symptoms through hyperactive
            dopamine D1 receptor signaling
  JOURNAL   JCI Insight 8 (16), e170434 (2023)
   PUBMED   37606043
  REMARK    GeneRIF: Cry1Delta11 mutation induces ADHD-like symptoms through
            hyperactive dopamine D1 receptor signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2987)
  AUTHORS   Sancar,A.
  TITLE     Regulation of the mammalian circadian clock by cryptochrome
  JOURNAL   J Biol Chem 279 (33), 34079-34082 (2004)
   PUBMED   15123698
  REMARK    Review article
REFERENCE   5  (bases 1 to 2987)
  AUTHORS   van der Horst,G.T., Muijtjens,M., Kobayashi,K., Takano,R.,
            Kanno,S., Takao,M., de Wit,J., Verkerk,A., Eker,A.P., van
            Leenen,D., Buijs,R., Bootsma,D., Hoeijmakers,J.H. and Yasui,A.
  TITLE     Mammalian Cry1 and Cry2 are essential for maintenance of circadian
            rhythms
  JOURNAL   Nature 398 (6728), 627-630 (1999)
   PUBMED   10217146
REFERENCE   6  (bases 1 to 2987)
  AUTHORS   Kobayashi,K., Kanno,S., Smit,B., van der Horst,G.T., Takao,M. and
            Yasui,A.
  TITLE     Characterization of photolyase/blue-light receptor homologs in
            mouse and human cells
  JOURNAL   Nucleic Acids Res 26 (22), 5086-5092 (1998)
   PUBMED   9801304
REFERENCE   7  (bases 1 to 2987)
  AUTHORS   Zhao,S. and Sancar,A.
  TITLE     Human blue-light photoreceptor hCRY2 specifically interacts with
            protein serine/threonine phosphatase 5 and modulates its activity
  JOURNAL   Photochem Photobiol 66 (5), 727-731 (1997)
   PUBMED   9383998
REFERENCE   8  (bases 1 to 2987)
  AUTHORS   Hsu,D.S., Zhao,X., Zhao,S., Kazantsev,A., Wang,R.P., Todo,T.,
            Wei,Y.F. and Sancar,A.
  TITLE     Putative human blue-light photoreceptors hCRY1 and hCRY2 are
            flavoproteins
  JOURNAL   Biochemistry 35 (44), 13871-13877 (1996)
   PUBMED   8909283
REFERENCE   9  (bases 1 to 2987)
  AUTHORS   van der Spek,P.J., Kobayashi,K., Bootsma,D., Takao,M., Eker,A.P.
            and Yasui,A.
  TITLE     Cloning, tissue expression, and mapping of a human photolyase
            homolog with similarity to plant blue-light receptors
  JOURNAL   Genomics 37 (2), 177-182 (1996)
   PUBMED   8921389
REFERENCE   10 (bases 1 to 2987)
  AUTHORS   Todo,T., Ryo,H., Yamamoto,K., Toh,H., Inui,T., Ayaki,H., Nomura,T.
            and Ikenaga,M.
  TITLE     Similarity among the Drosophila (6-4)photolyase, a human photolyase
            homolog, and the DNA photolyase-blue-light photoreceptor family
  JOURNAL   Science 272 (5258), 109-112 (1996)
   PUBMED   8600518
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB454192.1, BJ993835.1,
            AK290552.1 and BC017466.1.
            
            On Nov 24, 2018 this sequence version replaced NM_004075.4.
            
            Summary: This gene encodes a flavin adenine dinucleotide-binding
            protein that is a key component of the circadian core oscillator
            complex, which regulates the circadian clock. This gene is
            upregulated by CLOCK/ARNTL heterodimers but then represses this
            upregulation in a feedback loop using PER/CRY heterodimers to
            interact with CLOCK/ARNTL. Polymorphisms in this gene have been
            associated with altered sleep patterns. The encoded protein is
            widely conserved across plants and animals. Loss of the related
            gene in mouse results in a shortened circadian cycle in complete
            darkness. [provided by RefSeq, Jan 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D83702.1, BC017466.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2147920
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000008527.10/ ENSP00000008527.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               DB454192.1         329-486
            159-421             BJ993835.1         176-438
            422-2635            AK290552.1         30-2243
            2636-2987           BC017466.1         2367-2718
FEATURES             Location/Qualifiers
     source          1..2987
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.3"
     gene            1..2987
                     /gene="CRY1"
                     /gene_synonym="DSPD; PHLL1"
                     /note="cryptochrome circadian regulator 1"
                     /db_xref="GeneID:1407"
                     /db_xref="HGNC:HGNC:2384"
                     /db_xref="MIM:601933"
     exon            1..746
                     /gene="CRY1"
                     /gene_synonym="DSPD; PHLL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             589..2349
                     /gene="CRY1"
                     /gene_synonym="DSPD; PHLL1"
                     /note="isoform d is encoded by transcript variant 4;
                     cryptochrome-1; cryptochrome 1 (photolyase-like);
                     cryptochrome circadian clock 1"
                     /codon_start=1
                     /product="cryptochrome-1 isoform d"
                     /protein_id="NP_004066.1"
                     /db_xref="CCDS:CCDS9112.1"
                     /db_xref="GeneID:1407"
                     /db_xref="HGNC:HGNC:2384"
                     /db_xref="MIM:601933"
                     /translation="MGVNAVHWFRKGLRLHDNPALKECIQGADTIRCVYILDPWFAGS
                     SNVGINRWRFLLQCLEDLDANLRKLNSRLFVIRGQPADVFPRLFKEWNITKLSIEYDS
                     EPFGKERDAAIKKLATEAGVEVIVRISHTLYDLDKIIELNGGQPPLTYKRFQTLISKM
                     EPLEIPVETITSEVIEKCTTPLSDDHDEKYGVPSLEELGFDTDGLSSAVWPGGETEAL
                     TRLERHLERKAWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKKV
                     KKNSSPPLSLYGQLLWREFFYTAATNNPRFDKMEGNPICVQIPWDKNPEALAKWAEGR
                     TGFPWIDAIMTQLRQEGWIHHLARHAVACFLTRGDLWISWEEGMKVFEELLLDADWSI
                     NAGSWMWLSCSSFFQQFFHCYCPVGFGRRTDPNGDYIRRYLPVLRGFPAKYIYDPWNA
                     PEGIQKVAKCLIGVNYPKPMVNHAEASRLNIERMKQIYQQLSRYRGLGLLASVPSNPN
                     GNGGFMGYSAENIPGCSSSGSCSQGSGILHYAHGDSQQTHLLKQGRSSMGTGLSGGKR
                     PSQEEDTQSIGPKVQRQSTN"
     exon            747..855
                     /gene="CRY1"
                     /gene_synonym="DSPD; PHLL1"
                     /inference="alignment:Splign:2.1.0"
     exon            856..998
                     /gene="CRY1"
                     /gene_synonym="DSPD; PHLL1"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1183
                     /gene="CRY1"
                     /gene_synonym="DSPD; PHLL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1272
                     /gene="CRY1"
                     /gene_synonym="DSPD; PHLL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1413
                     /gene="CRY1"
                     /gene_synonym="DSPD; PHLL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1725
                     /gene="CRY1"
                     /gene_synonym="DSPD; PHLL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1877
                     /gene="CRY1"
                     /gene_synonym="DSPD; PHLL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..2080
                     /gene="CRY1"
                     /gene_synonym="DSPD; PHLL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2173
                     /gene="CRY1"
                     /gene_synonym="DSPD; PHLL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2245
                     /gene="CRY1"
                     /gene_synonym="DSPD; PHLL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2349
                     /gene="CRY1"
                     /gene_synonym="DSPD; PHLL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2987
                     /gene="CRY1"
                     /gene_synonym="DSPD; PHLL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2964..2969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRY1"
                     /gene_synonym="DSPD; PHLL1"
                     /note="hexamer: ATTAAA"
     polyA_site      2987
                     /gene="CRY1"
                     /gene_synonym="DSPD; PHLL1"
                     /note="major polyA site"
ORIGIN      
        1 agagtcaccc gggcagcctc gggaccggtc accggccggc aaccgtccag cggcctcgac
       61 caccgcctct agcctccgtt cccggtcctt tctcccgggc cgagagacag cgtcgccgac
      121 aggggctcat tcccctccgg ttctcctcgg tgactcacct cgggcgggcc gttttgtctt
      181 taggggccgc cttggtgggg cgaggtttcc gtgacgaatc tcctggggcc gtccgtgccg
      241 gctcgggccg tcgtggcggc tcgagctcct ggaacttgct caggctccgg aggtccgagg
      301 ccctcgaagt tatgcgtcgc ctccaggcgg ttgcggcggg cgcgggctcc taaagggcgt
      361 cacacccgga ctccgccgac taggcaacct ccattcatct ttccactgcg cctccggcgc
      421 ccccgccttc tccggtcccc tcctcggagt cattttttcc tgttccccct ctgccgccct
      481 ttcctcacgc cccgggtgag gcaattctct tggaagcgaa ggtgtcggct atgagccgga
      541 gcctccttcc ttgaatttct ccgtggagga cccgccgcgc cccccggcat gggggtgaac
      601 gccgtgcact ggttccgaaa ggggctccgg ctccacgaca accccgccct gaaggagtgc
      661 attcagggcg ccgacaccat ccgctgcgtc tacatcctgg acccctggtt cgccggctcc
      721 tccaatgtgg gcatcaacag gtggcgattt ttgcttcagt gtcttgagga tcttgatgcc
      781 aatctacgaa aattaaactc ccgtctgttt gtgattcgtg gacaaccagc agatgtgttt
      841 cccaggcttt tcaaggaatg gaacattact aaactttcaa ttgagtatga ttctgagccc
      901 tttggaaagg aacgagacgc agctattaag aaactggcaa ctgaagctgg agtagaagtc
      961 attgtaagaa tttcacatac attatatgac ctagacaaga tcatagaact caatggtgga
     1021 caaccgcctc taacttataa aagattccag actctcatca gcaaaatgga accactagag
     1081 ataccagtag agacaattac ttcagaagtg atagaaaagt gcacaactcc tctgtctgat
     1141 gaccatgatg agaaatatgg agtcccttca ctggaagagc taggttttga tacagatggc
     1201 ttatcctctg cagtgtggcc aggtggagaa actgaagcac ttactcgttt ggaaaggcat
     1261 ttggaaagaa aagcttgggt ggcaaatttt gaaagacctc gaatgaatgc gaattctctg
     1321 cttgcaagcc ctactggact tagtccttat ctccgatttg gttgtttgtc atgtcgactg
     1381 ttttacttca aactaacaga tctctacaaa aaggtaaaga agaacagttc ccctcccctt
     1441 tccctttatg ggcaactgtt atggcgtgaa tttttctata cagcagcaac aaataatcca
     1501 cgctttgata aaatggaagg aaaccctatc tgtgttcaga ttccttggga taaaaatcct
     1561 gaggctttag ccaaatgggc ggaaggccgg acaggctttc catggattga tgccatcatg
     1621 acacagcttc gtcaggaggg ttggattcat catctagcca ggcatgcagt tgcttgcttc
     1681 ctgacacgag gggacctgtg gattagttgg gaagaaggaa tgaaggtatt tgaagaatta
     1741 ttgcttgatg cagattggag cataaatgct ggaagttgga tgtggctgtc ttgtagttcc
     1801 ttttttcaac agttttttca ctgctattgc cctgttggtt ttggtaggag aacagatccc
     1861 aatggagact atatcaggcg ttatttgcct gtcctaagag gcttccctgc aaaatatatc
     1921 tatgatccct ggaatgcacc agaaggtatc caaaaggtag ccaaatgttt gataggagtt
     1981 aattatccta aaccaatggt gaaccatgct gaggcaagcc gtttgaatat cgaaaggatg
     2041 aaacagatct atcagcagct ttcacgatat agaggactag gtcttctggc atcagtacct
     2101 tctaatccta atgggaatgg aggcttcatg ggatattctg cagaaaatat cccaggttgt
     2161 agcagcagtg gaagttgctc tcaagggagt ggtattttac actatgctca tggcgacagt
     2221 cagcaaactc acctgttgaa gcaaggaaga agctccatgg gcactggtct cagtggtggg
     2281 aaacgtccta gtcaggaaga ggacacacag agtattggtc ctaaagtcca gagacagagc
     2341 actaattaga aaacattcag gaggaatact gttgcagctg aaattggtgg ggagttcaat
     2401 acttttcaat taagttattt aaaaatattc ttcattgatg gaaagcagtt acatattgaa
     2461 atatgttgtt tctaatgaca tttctgtggt ttttaacttt ttaatgaatt tcacagagga
     2521 caattggtaa tttgtatata aagaacttgg caagagaatt tgcttaatgt aaatataaac
     2581 agtcacaatt agtatagacc catcgatata tttttgataa tttttcatgt atggtaaagt
     2641 taaaatgaca aattgatatt ctgatataaa actcaaagtt ttgaagtcag tgggaaaaaa
     2701 ggaggttttt agactttctt aaaagacgtt aaaattttag gacagaattt tcttgatgtt
     2761 gtttgatcta actttgcact ctttgataat aatgttttag ataatgtgcg taatccaaat
     2821 tggtattgta gcctctgtta acacagacag tatatgtttt aaactttgat gtaaaccttt
     2881 ttagacccaa acttgtggaa gtatcatgtg ttaagttctc tgtctctgtt tctttgttca
     2941 tttattacta aaatgaactt gttattaaag tatatgcaaa tatgaaa
//
