LOCUS       NM_022769               5214 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens CREB regulated transcription coactivator 3 (CRTC3),
            transcript variant 1, mRNA.
ACCESSION   NM_022769
VERSION     NM_022769.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5214)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5214)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 5214)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 5214)
  AUTHORS   Mares-Garcia,A.S., Ortiz Magdaleno,M., Gordillo-Moscoso,A.,
            Cardenas-Galindo,M.G., Avila Hernandez,I.N., Escobar-Garcia,D.M.,
            Marquez-Lucero,A. and Pozos-Guillen,A.
  TITLE     Morphological and biological properties of silica nanoparticles for
            CRTC3-siRNA delivery and downregulation of the RGS2 expression in
            preadipocytes
  JOURNAL   J Biomater Appl 36 (4), 626-637 (2021)
   PUBMED   33947275
  REMARK    GeneRIF: Morphological and biological properties of silica
            nanoparticles for CRTC3-siRNA delivery and downregulation of the
            RGS2 expression in preadipocytes.
REFERENCE   5  (bases 1 to 5214)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 5214)
  AUTHORS   Hishiki,T., Ohshima,T., Ego,T. and Shimotohno,K.
  TITLE     BCL3 acts as a negative regulator of transcription from the human
            T-cell leukemia virus type 1 long terminal repeat through
            interactions with TORC3
  JOURNAL   J Biol Chem 282 (39), 28335-28343 (2007)
   PUBMED   17644518
  REMARK    GeneRIF: BCL3 functions as a repressor of HTLV-1 LTR-mediated
            transcription through interactions with TORC3
REFERENCE   7  (bases 1 to 5214)
  AUTHORS   Wu,Z., Huang,X., Feng,Y., Handschin,C., Feng,Y., Gullicksen,P.S.,
            Bare,O., Labow,M., Spiegelman,B. and Stevenson,S.C.
  TITLE     Transducer of regulated CREB-binding proteins (TORCs) induce
            PGC-1alpha transcription and mitochondrial biogenesis in muscle
            cells
  JOURNAL   Proc Natl Acad Sci U S A 103 (39), 14379-14384 (2006)
   PUBMED   16980408
  REMARK    GeneRIF: These results strongly suggest that TORCs play a key role
            in linking these external signals to the transcriptional program of
            adaptive mitochondrial biogenesis by activating PGC-1alpha gene
            transcription.
REFERENCE   8  (bases 1 to 5214)
  AUTHORS   Koga,H., Ohshima,T. and Shimotohno,K.
  TITLE     Enhanced activation of tax-dependent transcription of human T-cell
            leukemia virus type I (HTLV-I) long terminal repeat by TORC3
  JOURNAL   J Biol Chem 279 (51), 52978-52983 (2004)
   PUBMED   15466468
  REMARK    GeneRIF: transducer of regulated cyclic AMP-response
            element-binding protein 3 (TORC3), a co-activator of CREB, is
            involved in Tax-induced transcriptional activation from the HTLV-I
            LTR
REFERENCE   9  (bases 1 to 5214)
  AUTHORS   Iourgenko,V., Zhang,W., Mickanin,C., Daly,I., Jiang,C.,
            Hexham,J.M., Orth,A.P., Miraglia,L., Meltzer,J., Garza,D.,
            Chirn,G.W., McWhinnie,E., Cohen,D., Skelton,J., Terry,R., Yu,Y.,
            Bodian,D., Buxton,F.P., Zhu,J., Song,C. and Labow,M.A.
  TITLE     Identification of a family of cAMP response element-binding protein
            coactivators by genome-scale functional analysis in mammalian cells
  JOURNAL   Proc Natl Acad Sci U S A 100 (21), 12147-12152 (2003)
   PUBMED   14506290
REFERENCE   10 (bases 1 to 5214)
  AUTHORS   Conkright,M.D., Canettieri,G., Screaton,R., Guzman,E., Miraglia,L.,
            Hogenesch,J.B. and Montminy,M.
  TITLE     TORCs: transducers of regulated CREB activity
  JOURNAL   Mol Cell 12 (2), 413-423 (2003)
   PUBMED   14536081
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY057135.1, HY109267.1,
            AK074170.1, AY360173.1, BP238198.1, DB288138.1, BP365179.1,
            CN298837.1, AC021422.25, AL360259.1 and AI969212.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_022769.4.
            
            Summary: This gene is a member of the CREB regulated transcription
            coactivator gene family. This family regulates CREB-dependent gene
            transcription in a phosphorylation-independent manner and may be
            selective for cAMP-responsive genes. The protein encoded by this
            gene may induce mitochondrial biogenesis and attenuate
            catecholamine signaling in adipose tissue. A translocation event
            between this gene and Notch coactivator mastermind-like gene 2,
            which results in a fusion protein, has been reported in
            mucoepidermoid carcinomas. Alternative splicing results in multiple
            transcript variants that encode different protein isoforms.
            [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY360173.1, DRR138518.395417.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268184.11/ ENSP00000268184.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-363               HY057135.1         2-364
            364-544             HY109267.1         351-531
            545-837             AK074170.1         53-345
            838-949             AY360173.1         696-807
            950-957             BP238198.1         155-162
            958-1507            DB288138.1         1-550
            1508-1800           BP365179.1         290-582
            1801-2349           CN298837.1         153-701
            2350-2714           AC021422.25        14196-14560
            2715-5200           AL360259.1         1-2486
            5201-5214           AI969212.1         17-30               c
FEATURES             Location/Qualifiers
     source          1..5214
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..5214
                     /gene="CRTC3"
                     /gene_synonym="TORC-3; TORC3"
                     /note="CREB regulated transcription coactivator 3"
                     /db_xref="GeneID:64784"
                     /db_xref="HGNC:HGNC:26148"
                     /db_xref="MIM:608986"
     exon            1..281
                     /gene="CRTC3"
                     /gene_synonym="TORC-3; TORC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..2009
                     /gene="CRTC3"
                     /gene_synonym="TORC-3; TORC3"
                     /note="isoform a is encoded by transcript variant 1;
                     transducer of regulated cAMP response element-binding
                     protein (CREB) 3; transducer of regulated CREB protein 3"
                     /codon_start=1
                     /product="CREB-regulated transcription coactivator 3
                     isoform a"
                     /protein_id="NP_073606.3"
                     /db_xref="CCDS:CCDS32331.1"
                     /db_xref="GeneID:64784"
                     /db_xref="HGNC:HGNC:26148"
                     /db_xref="MIM:608986"
                     /translation="MAASPGSGSANPRKFSEKIALHTQRQAEETRAFEQLMTDLTLSR
                     VQFQKLQQLRLTQYHGGSLPNVSQLRSSASEFQPSFHQADNVRGTRHHGLVERPSRNR
                     FHPLHRRSGDKPGRQFDGSAFGANYSSQPLDESWPRQQPPWKDEKHPGFRLTSALNRT
                     NSDSALHTSALSTKPQDPYGGGGQSAWPAPYMGFCDGENNGHGEVASFPGPLKEENLL
                     NVPKPLPKQLWETKEIQSLSGRPRSCDVGGGNAFPHNGQNLGLSPFLGTLNTGGSLPD
                     LTNLHYSTPLPASLDTTDHHFGSMSVGNSVNNIPAAMTHLGIRSSSGLQSSRSNPSIQ
                     ATLNKTVLSSSLNNHPQTSVPNASALHPSLRLFSLSNPSLSTTNLSGPSRRRQPPVSP
                     LTLSPGPEAHQGFSRQLSSTSPLAPYPTSQMVSSDRSQLSFLPTEAQAQVSPPPPYPA
                     PQELTQPLLQQPRAPEAPAQQPQAASSLPQSDFQLLPAQGSSLTNFFPDVGFDQQSMR
                     PGPAFPQQVPLVQQGSRELQDSFHLRPSPYSNCGSLPNTILPEDSSTSLFKDLNSALA
                     GLPEVSLNVDTPFPLEEELQIEPLSLDGLNMLSDSSMGLLDPSVEETFRADRL"
     exon            282..380
                     /gene="CRTC3"
                     /gene_synonym="TORC-3; TORC3"
                     /inference="alignment:Splign:2.1.0"
     exon            381..500
                     /gene="CRTC3"
                     /gene_synonym="TORC-3; TORC3"
                     /inference="alignment:Splign:2.1.0"
     exon            501..562
                     /gene="CRTC3"
                     /gene_synonym="TORC-3; TORC3"
                     /inference="alignment:Splign:2.1.0"
     exon            563..625
                     /gene="CRTC3"
                     /gene_synonym="TORC-3; TORC3"
                     /inference="alignment:Splign:2.1.0"
     exon            626..726
                     /gene="CRTC3"
                     /gene_synonym="TORC-3; TORC3"
                     /inference="alignment:Splign:2.1.0"
     exon            727..762
                     /gene="CRTC3"
                     /gene_synonym="TORC-3; TORC3"
                     /inference="alignment:Splign:2.1.0"
     exon            763..848
                     /gene="CRTC3"
                     /gene_synonym="TORC-3; TORC3"
                     /inference="alignment:Splign:2.1.0"
     exon            849..898
                     /gene="CRTC3"
                     /gene_synonym="TORC-3; TORC3"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1116
                     /gene="CRTC3"
                     /gene_synonym="TORC-3; TORC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1415
                     /gene="CRTC3"
                     /gene_synonym="TORC-3; TORC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1616
                     /gene="CRTC3"
                     /gene_synonym="TORC-3; TORC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1697
                     /gene="CRTC3"
                     /gene_synonym="TORC-3; TORC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1800
                     /gene="CRTC3"
                     /gene_synonym="TORC-3; TORC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..5214
                     /gene="CRTC3"
                     /gene_synonym="TORC-3; TORC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5183..5188
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRTC3"
                     /gene_synonym="TORC-3; TORC3"
                     /note="hexamer: ATTAAA"
     polyA_site      5214
                     /gene="CRTC3"
                     /gene_synonym="TORC-3; TORC3"
                     /note="major polyA site"
ORIGIN      
        1 ggctccgggg ccgcggcggc tcctctgccg ggtcgcgccg gacgactggc ttcgggcggc
       61 ggccccggcg gcctgtggac ggacgggtgg gccgaggtac aggccccacg gccgccgtct
      121 cccgcttctg cccgcgcaga gtccgcgcca tggccgcctc gccgggctcg ggcagcgcca
      181 acccgcggaa gttcagtgag aagatcgcgc tgcacacgca gagacaggcc gaggagacgc
      241 gggccttcga gcagctcatg accgacctca ccctgtcgcg ggttcaattt cagaagcttc
      301 agcaactgcg ccttacacag taccatggag gatccttacc aaatgtgagc cagctgcgga
      361 gcagtgcgtc agagtttcag ccgtcatttc accaagctga taatgttcgg ggaacccgcc
      421 atcacgggct ggtggagagg ccatccagga accgcttcca ccccctccac cgaaggtctg
      481 gggacaagcc agggcgacaa tttgatggta gtgcttttgg agccaattat tcctcacagc
      541 ctctggatga gagttggcca aggcagcagc ctccttggaa agacgaaaag catcctgggt
      601 tcaggctgac atctgcactt aacaggacca attctgattc tgctcttcac acgagtgctc
      661 tgagtaccaa gccccaggac ccctatggag gagggggcca gtcggcctgg cctgccccat
      721 acatgggttt ctgtgatggt gagaataatg gacatgggga agtagcatct ttccctggcc
      781 cattgaaaga agagaatctg ttaaatgttc cgaagccact gccaaaacaa ctgtgggaga
      841 ccaaggagat tcagtccctg tcaggacgcc ctcgatcctg tgatgttgga ggtggcaatg
      901 cttttccaca taatggtcaa aacctaggcc tctcaccctt cttggggacc ttgaacactg
      961 gagggtcatt gccagatcta accaacctcc actactcgac acccctgcca gcctccctgg
     1021 acaccaccga ccaccacttt ggcagtatga gtgtggggaa tagtgtgaac aacatcccag
     1081 ctgctatgac ccacctgggt ataagaagct cctctggtct ccagagttct cggagtaacc
     1141 cctccatcca agccacgctc aataagactg tgctttcctc ttccttaaat aaccacccac
     1201 agacatctgt tcccaacgca tctgctcttc acccttcgct ccgtctgttt tcccttagca
     1261 acccatctct ttccaccaca aacctgagcg gcccgtctcg gcgtcggcag cctcccgtca
     1321 gccctctcac gctttctcct ggccctgaag cacatcaagg tttcagcaga cagctgtctt
     1381 caaccagccc actggcccca tatcctacct cccagatggt gtcctcagac cgaagccaac
     1441 tttcctttct gcccacagaa gctcaagccc aggtgtcgcc gccaccccct taccctgcac
     1501 cccaggagct cacccagccc ctcctgcagc agccccgcgc ccctgaggcc cctgcccagc
     1561 agccccaggc agcctcctca ctgccacagt cagactttca gcttctcccg gcccagggct
     1621 catctttgac caacttcttc ccagatgtgg gttttgacca gcagtccatg aggccaggcc
     1681 ctgcctttcc tcaacaggtg cctctggtgc aacaaggttc ccgagaactg caggactctt
     1741 ttcatttgag accaagcccg tattccaact gcgggagtct cccgaacacc atcctgccag
     1801 aagactccag caccagcctg ttcaaagacc tcaacagtgc gctggcaggc ctgcctgagg
     1861 tcagcctgaa cgtggacact ccatttccac tggaagagga gctgcagatt gaacccctga
     1921 gcctggacgg actcaacatg ttaagtgact ccagcatggg cctgctggac ccctctgttg
     1981 aagagacgtt tcgagctgac agactgtgaa cagaaggcag tggaacagaa gaatgttttt
     2041 ctgcaacagc caaaatagaa tggaatagaa tgaagccagc tgataccacg ggctttcgtt
     2101 atcttgacat agaaggaagc aatgccacgg ctccagggtt tcagatgaga tcccatctca
     2161 gacactgtgg cttcctccag atcacacagc tttgtactgc ctctcccgcc tgtggccaaa
     2221 gtcgtgttgc agcaggcagg ctgcttggag cttcccatga actggaaagc tcacctccac
     2281 tgcatctttt tactggccat ccagtcagcc gatgtgtaag agtaggaaat actgtgtcac
     2341 tggaggcctc cgtagcattg tgtagtgtgc tcagaaccac tgatctccgt ccgcaccgaa
     2401 ggcgggcccg gagtgggagg ctcggcctgg ggcggcggca ccggagaggg cacctcgatg
     2461 cctgctctga cctgacccag agggcgaggc cctccagcgg gggacattcc caggctgagt
     2521 ggaccccacg gctctctccc acgcctggat tacgacatga agtttttacc acaagcccga
     2581 gggcaggctt gagttaggca gactgaaggc taattttcat tttctcccag ctggtttctg
     2641 ctgcttcaga aaagtacacc ttttccttat ggaccagagg aagaggaaga ccattttatc
     2701 agtcactgaa aagagtcccc tggcactgat gagcctgaag agaactgtgc tcctcctcgg
     2761 gggctgggga aggaagacag ggactgcagg tgtctcatac tcagtggcct ccagacaaac
     2821 tccagacaag cacagacctc cccactaaga gcagccagag ggagctggtg aggccctaac
     2881 cccacccacc gagcaactga gcttccccat ccctccccag agctgtgtct ctgtgggctg
     2941 ggagtctaat gtcacccccc tagaccgtaa gctccttgag ggcagggaca gtgccttatc
     3001 attgttgaac ccgtagcacc taacacgtgc gtggcagcac agtcgtgtgc tggagtgagt
     3061 gctgcagaac cgtgcgtgca gcgcatgatg aatgagtgcg tccgccatgc cgtaaggcag
     3121 gctcacctgt agctatcccc ttccctgcca gatcttctca gagctttagc ttttctagca
     3181 ctcgtgccta tggtgaagca tgcactttaa tatgctttta acactaggtg accaaatcac
     3241 agtgaagccg ggcactgcat tctccttggg ctgtgctcca cgcgggtggg tgggagctgt
     3301 cttctgagta catccggaag ggctgagcag gtgagtgccc tgagcatcct ggctgggccc
     3361 cacccaggaa gatcttcctt ctcagatcca cgtttggctc taaattgctt caagtagaga
     3421 ttcattcttt gaggttgaaa aaatagttta tagtaaaacg aaggcctaat tcatggaagc
     3481 atcattagtc atcaatacct tctcataaaa tagatgggcc agatttccac caccgcctgc
     3541 ctcctctaac ttgggtgatg ccagtaggtt tgaagggggc agagcactgc agggggaggg
     3601 gggggtctag gctgtgagag gacagggtgg agaggaggag aaccctgaag gagagacgga
     3661 agatgccagg acctttgctt ggacagccat tgcccttcca ggagaccctg gagtgtactg
     3721 agggttgctg gactgttcca cccagaggag caaggctgta caatgagggt ctgaatctgg
     3781 cacacctgtc ccttatgtaa aaggagtcgt ggtcacaaga ccctgggctg gttagcctct
     3841 cccgacctca ttccatttct atcttctgac cttgcctctc atctttaaaa taaccctcat
     3901 ggggtgcccc tccaccttcc tctggaatcc aagtattcct gtttcacatt tgccccaaat
     3961 ctttgctgtg gaattgggaa atcaaaccag agtcctcctc gcctgatttc cagctcagga
     4021 agggcctgct ggcctgccct gttcccagtt acactttcag atccctttgt gctcaagatc
     4081 tcagaggggg tggctttttg ttaaagagcc ttcagtcgca atgctaccca gcaccccatg
     4141 tgccaaaaga aaccagctcc tgtgtcaaag ggcttccaaa cctgatctca ctctcaacag
     4201 gcgatggtgc tgatgtttca agaattgtgt ttttataaaa cagaggtctc agcatagtca
     4261 ctcttcacat agtgccttac ccatgggtat cgtcatatcc gggtcccagt tcagtttgtc
     4321 tgcacagcag ccaccctgcc tggcaacaga gaccccaaga cctacacagt gaaccctact
     4381 gccccaaagg cgttctccag gtgacttgtg aaaacagacc tccggggaag tgatttattg
     4441 ggggtgtaca ctgggggcaa tatggtttag cactgaattc aatttgtcct taggtctatg
     4501 agtgagtccg atcttttctt gtgaaaggtt ttgggcatcg tacaacccac tctgcctaga
     4561 aggtgtggag gactcaccac gggcagggtc gccctggccc acagcacgtg agcctgcact
     4621 cactgcggcc tttgtaacaa aaccagttgt ggtcctcagc atttgaagca gctgcatact
     4681 tcagagtaaa ctatttttca ttatttagtt ttgtcacaag aaatcgacca ttgtactact
     4741 ctcacttaca gcagttaaac agcatagaac taaaaacctg tctgcatttc cattttttct
     4801 ttctgtatgg ttgtgggttt taggacatag ggggttagga gaaggggttt cttgatcatg
     4861 tcatgaattc tcctttgtcc tgtttctcct gtttcatttc tcctccgcct gctgtatatt
     4921 acctgagctg gtgttgtatc ttcaagtcca tatgcgtatt tgcagacctt tcctgttccc
     4981 actcttgttg gctcttctga tttatgcaca gatggttccc agcatgtgtc cagtgcttca
     5041 tggatgggac catcccagca actaatcaga cttcctgcca gtgtcctaac ccccagggca
     5101 ccctgttcaa ccatatttaa aaattggaat ttgtataaag ttgcttccaa gttttataat
     5161 gcatcatttt acatcttttg taattaaaag catcacaatg aggttgtctc tgca
//
