LOCUS       NM_181715               2631 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens CREB regulated transcription coactivator 2 (CRTC2),
            mRNA.
ACCESSION   NM_181715
VERSION     NM_181715.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2631)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 2631)
  AUTHORS   Carper,M.B., Goel,S., Zhang,A.M., Damrauer,J.S., Cohen,S.,
            Zimmerman,M.P., Gentile,G.M., Parag-Sharma,K., Murphy,R.M.,
            Sato,K., Nickel,K.P., Kimple,R.J., Yarbrough,W.G. and Amelio,A.L.
  TITLE     Activation of the CREB Coactivator CRTC2 by Aberrant Mitogen
            Signaling promotes oncogenic functions in HPV16 positive head and
            neck cancer
  JOURNAL   Neoplasia 29, 100799 (2022)
   PUBMED   35504112
  REMARK    GeneRIF: Activation of the CREB Coactivator CRTC2 by Aberrant
            Mitogen Signaling promotes oncogenic functions in HPV16 positive
            head and neck cancer.
REFERENCE   3  (bases 1 to 2631)
  AUTHORS   Mi,Z., Song,Y., Wang,J., Liu,Z., Cao,X., Dang,L., Lu,Y., Sun,Y.,
            Xiong,H., Zhang,L. and Chen,Y.
  TITLE     cAMP-Induced Nuclear Condensation of CRTC2 Promotes Transcription
            Elongation and Cystogenesis in Autosomal Dominant Polycystic Kidney
            Disease
  JOURNAL   Adv Sci (Weinh) 9 (10), e2104578 (2022)
   PUBMED   35037420
  REMARK    GeneRIF: cAMP-Induced Nuclear Condensation of CRTC2 Promotes
            Transcription Elongation and Cystogenesis in Autosomal Dominant
            Polycystic Kidney Disease.
REFERENCE   4  (bases 1 to 2631)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 2631)
  AUTHORS   Wu,Z., Huang,X., Feng,Y., Handschin,C., Feng,Y., Gullicksen,P.S.,
            Bare,O., Labow,M., Spiegelman,B. and Stevenson,S.C.
  TITLE     Transducer of regulated CREB-binding proteins (TORCs) induce
            PGC-1alpha transcription and mitochondrial biogenesis in muscle
            cells
  JOURNAL   Proc Natl Acad Sci U S A 103 (39), 14379-14384 (2006)
   PUBMED   16980408
  REMARK    GeneRIF: These results strongly suggest that TORCs play a key role
            in linking these external signals to the transcriptional program of
            adaptive mitochondrial biogenesis by activating PGC-1alpha gene
            transcription.
REFERENCE   6  (bases 1 to 2631)
  AUTHORS   Siu,Y.T., Chin,K.T., Siu,K.L., Yee Wai Choy,E., Jeang,K.T. and
            Jin,D.Y.
  TITLE     TORC1 and TORC2 coactivators are required for tax activation of the
            human T-cell leukemia virus type 1 long terminal repeats
  JOURNAL   J Virol 80 (14), 7052-7059 (2006)
   PUBMED   16809310
  REMARK    GeneRIF: Thus, both TORC1/2 and p300 families of coactivators are
            essential for optimal activation of HTLV-1 transcription by Tax.
REFERENCE   7  (bases 1 to 2631)
  AUTHORS   Al-Hakim,A.K., Goransson,O., Deak,M., Toth,R., Campbell,D.G.,
            Morrice,N.A., Prescott,A.R. and Alessi,D.R.
  TITLE     14-3-3 cooperates with LKB1 to regulate the activity and
            localization of QSK and SIK
  JOURNAL   J Cell Sci 118 (Pt 23), 5661-5673 (2005)
   PUBMED   16306228
REFERENCE   8  (bases 1 to 2631)
  AUTHORS   Screaton,R.A., Conkright,M.D., Katoh,Y., Best,J.L., Canettieri,G.,
            Jeffries,S., Guzman,E., Niessen,S., Yates,J.R. 3rd, Takemori,H.,
            Okamoto,M. and Montminy,M.
  TITLE     The CREB coactivator TORC2 functions as a calcium- and
            cAMP-sensitive coincidence detector
  JOURNAL   Cell 119 (1), 61-74 (2004)
   PUBMED   15454081
REFERENCE   9  (bases 1 to 2631)
  AUTHORS   Iourgenko,V., Zhang,W., Mickanin,C., Daly,I., Jiang,C.,
            Hexham,J.M., Orth,A.P., Miraglia,L., Meltzer,J., Garza,D.,
            Chirn,G.W., McWhinnie,E., Cohen,D., Skelton,J., Terry,R., Yu,Y.,
            Bodian,D., Buxton,F.P., Zhu,J., Song,C. and Labow,M.A.
  TITLE     Identification of a family of cAMP response element-binding protein
            coactivators by genome-scale functional analysis in mammalian cells
  JOURNAL   Proc Natl Acad Sci U S A 100 (21), 12147-12152 (2003)
   PUBMED   14506290
REFERENCE   10 (bases 1 to 2631)
  AUTHORS   Conkright,M.D., Canettieri,G., Screaton,R., Guzman,E., Miraglia,L.,
            Hogenesch,J.B. and Montminy,M.
  TITLE     TORCs: transducers of regulated CREB activity
  JOURNAL   Mol Cell 12 (2), 413-423 (2003)
   PUBMED   14536081
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY360172.1, BC053562.1,
            AY726597.1 and BM987537.1.
            
            On Nov 23, 2018 this sequence version replaced NM_181715.2.
            
            Summary: This gene encodes a member of the transducers of regulated
            cAMP response element-binding protein activity family of
            transcription coactivators. These proteins promote the
            transcription of genes targeted by the cAMP response
            element-binding protein, and therefore play an important role in
            many cellular processes. Under basal conditions the encoded protein
            is phosphorylated by AMP-activated protein kinase or the
            salt-inducible kinases and is sequestered in the cytoplasm. Upon
            activation by elevated cAMP or calcium, the encoded protein
            translocates to the nucleus and increases target gene expression.
            Single nucleotide polymorphisms in this gene may increase the risk
            of type 2 diabetes. A pseudogene of this gene is located on the
            long arm of chromosome 5. [provided by RefSeq, Dec 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053562.1, SRR1803611.28709.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368633.2/ ENSP00000357622.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AY360172.1         16-60
            46-1305             BC053562.1         1-1260
            1306-2555           AY726597.1         1130-2379
            2556-2631           BM987537.1         22-97               c
FEATURES             Location/Qualifiers
     source          1..2631
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..2631
                     /gene="CRTC2"
                     /gene_synonym="TORC-2; TORC2"
                     /note="CREB regulated transcription coactivator 2"
                     /db_xref="GeneID:200186"
                     /db_xref="HGNC:HGNC:27301"
                     /db_xref="MIM:608972"
     exon            1..268
                     /gene="CRTC2"
                     /gene_synonym="TORC-2; TORC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..2197
                     /gene="CRTC2"
                     /gene_synonym="TORC-2; TORC2"
                     /note="transducer of regulated cAMP response
                     element-binding protein (CREB) 2"
                     /codon_start=1
                     /product="CREB-regulated transcription coactivator 2"
                     /protein_id="NP_859066.1"
                     /db_xref="CCDS:CCDS30875.1"
                     /db_xref="GeneID:200186"
                     /db_xref="HGNC:HGNC:27301"
                     /db_xref="MIM:608972"
                     /translation="MATSGANGPGSATASASNPRKFSEKIALQKQRQAEETAAFEEVM
                     MDIGSTRLQAQKLRLAYTRSSHYGGSLPNVNQIGSGLAEFQSPLHSPLDSSRSTRHHG
                     LVERVQRDPRRMVSPLRRYTRHIDSSPYSPAYLSPPPESSWRRTMAWGNFPAEKGQLF
                     RLPSALNRTSSDSALHTSVMNPSPQDTYPGPTPPSILPSRRGGILDGEMDPKVPAIEE
                     NLLDDKHLLKPWDAKKLSSSSSRPRSCEVPGINIFPSPDQPANVPVLPPAMNTGGSLP
                     DLTNLHFPPPLPTPLDPEETAYPSLSGGNSTSNLTHTMTHLGISRGMGLGPGYDAPGL
                     HSPLSHPSLQSSLSNPNLQASLSSPQPQLQGSHSHPSLPASSLARHVLPTTSLGHPSL
                     SAPALSSSSSSSSTSSPVLGAPSYPASTPGASPHHRRVPLSPLSLLAGPADARRSQQQ
                     LPKQFSPTMSPTLSSITQGVPLDTSKLSTDQRLPPYPYSSPSLVLPTQPHTPKSLQQP
                     GLPSQSCSVQSSGGQPPGRQSHYGTPYPPGPSGHGQQSYHRPMSDFNLGNLEQFSMES
                     PSASLVLDPPGFSEGPGFLGGEGPMGGPQDPHTFNHQNLTHCSRHGSGPNIILTGDSS
                     PGFSKEIAAALAGVPGFEVSAAGLELGLGLEDELRMEPLGLEGLNMLSDPCALLPDPA
                     VEESFRSDRLQ"
     exon            269..370
                     /gene="CRTC2"
                     /gene_synonym="TORC-2; TORC2"
                     /inference="alignment:Splign:2.1.0"
     exon            371..487
                     /gene="CRTC2"
                     /gene_synonym="TORC-2; TORC2"
                     /inference="alignment:Splign:2.1.0"
     exon            488..549
                     /gene="CRTC2"
                     /gene_synonym="TORC-2; TORC2"
                     /inference="alignment:Splign:2.1.0"
     exon            550..618
                     /gene="CRTC2"
                     /gene_synonym="TORC-2; TORC2"
                     /inference="alignment:Splign:2.1.0"
     exon            619..722
                     /gene="CRTC2"
                     /gene_synonym="TORC-2; TORC2"
                     /inference="alignment:Splign:2.1.0"
     exon            723..752
                     /gene="CRTC2"
                     /gene_synonym="TORC-2; TORC2"
                     /inference="alignment:Splign:2.1.0"
     exon            753..817
                     /gene="CRTC2"
                     /gene_synonym="TORC-2; TORC2"
                     /inference="alignment:Splign:2.1.0"
     exon            818..867
                     /gene="CRTC2"
                     /gene_synonym="TORC-2; TORC2"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1112
                     /gene="CRTC2"
                     /gene_synonym="TORC-2; TORC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1519
                     /gene="CRTC2"
                     /gene_synonym="TORC-2; TORC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1789
                     /gene="CRTC2"
                     /gene_synonym="TORC-2; TORC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1976
                     /gene="CRTC2"
                     /gene_synonym="TORC-2; TORC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2631
                     /gene="CRTC2"
                     /gene_synonym="TORC-2; TORC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2612..2617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRTC2"
                     /gene_synonym="TORC-2; TORC2"
                     /note="hexamer: AATAAA"
     polyA_site      2631
                     /gene="CRTC2"
                     /gene_synonym="TORC-2; TORC2"
                     /note="major polyA site"
ORIGIN      
        1 gggttcgcgg tgctcgctga ggcggcggtg gctacggctg gaggagccgg gccgaggccg
       61 cggcggaggc cgcggctggt actgggaggg tggcagggag ggacggggaa ggaagatggc
      121 gacgtcgggg gcgaacgggc ctggttcggc cacggcctcg gcttccaatc cgcgcaaatt
      181 tagtgagaag attgcgctgc agaagcagcg tcaggccgag gagacggcgg ccttcgagga
      241 ggtgatgatg gacatcggct ccacccggtt acaggcccaa aaactgcgac tggcatacac
      301 aaggagctct cattatggtg ggtctctgcc caatgttaac cagattggct ctggcctggc
      361 cgagttccag agccccctcc actcaccttt ggattcatct cggagcactc ggcaccatgg
      421 gctggtggaa cgggtgcagc gagatcctcg aagaatggtg tccccacttc gccgatacac
      481 ccgccacatt gacagctctc cctatagtcc tgcctactta tctcctcccc cagagtctag
      541 ctggcgaagg acgatggcct ggggcaattt ccctgcagag aaggggcagt tgtttcgact
      601 accatctgca cttaacagga caagctctga ctctgccctt catacaagtg tgatgaaccc
      661 cagtccccag gatacctacc caggccccac acctcccagc atcctgccca gccgacgtgg
      721 gggtattctg gatggtgaaa tggaccccaa agtacctgct attgaggaga acttgctaga
      781 tgacaagcat ttgctgaagc catgggatgc taagaagcta tcctcatcct cttcccgacc
      841 tcggtcctgt gaagtccctg gaattaacat ctttccatct cctgaccagc ctgccaatgt
      901 gcctgtcctc ccacctgcca tgaacacggg gggctcccta cctgacctca ccaacctgca
      961 ctttccccca ccactgccca cccccctgga ccctgaagag acagcctacc ctagcctgag
     1021 tgggggcaac agtacctcca atttgaccca caccatgact cacctgggca tcagcagggg
     1081 catgggcctg ggcccaggct atgatgcacc aggacttcat tcacctctca gccacccatc
     1141 cctgcagtcc tccctaagca atcccaacct ccaggcttcc ctgagcagtc ctcagcccca
     1201 gcttcagggc tcccacagcc acccctctct gcctgcctcc tccttggccc gccatgtact
     1261 gcccaccacc tccctgggcc acccctcact cagtgctccg gctctctcct cctcctcttc
     1321 ctcctcctcc acttcatctc ctgttttggg cgccccctct taccctgctt ctacccctgg
     1381 ggcctccccc caccaccgcc gtgtgcccct cagccccctg agtttgctcg cgggcccagc
     1441 cgacgccaga aggtcccaac agcagctgcc caaacagttt tcgccaacaa tgtcacccac
     1501 cttgtcttcc atcactcagg gcgtccccct ggataccagt aaactgtcca ctgaccagcg
     1561 gttaccccca tacccataca gctccccaag tctggttctg cctacccagc cccacacccc
     1621 aaagtctcta cagcagccag ggctgccctc tcagtcttgt tcagtgcagt cctcaggtgg
     1681 gcagccccca ggcaggcagt ctcattatgg gacaccgtac ccacctgggc ccagtgggca
     1741 tgggcaacag tcttaccacc ggccaatgag tgacttcaac ctggggaatc tggagcagtt
     1801 cagcatggag agcccatcag ccagcctggt gctggatccc cctggctttt ctgaagggcc
     1861 tggattttta gggggtgagg ggccaatggg tggcccccag gatccccaca ccttcaacca
     1921 ccagaacttg acccactgtt cccgccatgg ctcagggcct aacatcatcc tcacagggga
     1981 ctcctctcca ggtttctcta aggagattgc agcagccctg gccggagtgc ctggctttga
     2041 ggtgtcagca gctggattgg agctagggct tgggctagaa gatgagctgc gcatggagcc
     2101 actgggcctg gaagggctaa acatgctgag tgacccctgt gccctgctgc ctgatcctgc
     2161 tgtggaggag tcattccgca gtgaccggct ccaatgaggg cacctcatca ccatccctct
     2221 tcttggcccc atcccccacc accattcctt tcctcccttc cccctggcag gtagagactc
     2281 tactctctgt ccccagatcc tctttctagc atgaatgaag gatgccaaga atgagaaaaa
     2341 gcaaggggtt tgtccaggtg gcccctgaat tctgcgcaag ggatgggcct gggggaactc
     2401 aagggagggc ctaaagcact tgtaactttg aaccgtctgt ctggaggtca gagcctgttg
     2461 gaaagcaggg gtagagggga gccctggaag cagggctttt ccggatgcct aggggtgggc
     2521 agtgccagcc cctcctcacc actcttcccc ttgcagtgga ggagagagcc agagtggata
     2581 ctatttttta ttaaatatat tattatatgt taataaaaaa atcatatcaa a
//
