LOCUS       NM_015321               6879 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens CREB regulated transcription coactivator 1 (CRTC1),
            transcript variant 1, mRNA.
ACCESSION   NM_015321
VERSION     NM_015321.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6879)
  AUTHORS   Warmke,L.M., Strike,S.A., Fayad,L.M., Ahlawat,S., Liu,Y.J.,
            Mata,D.A., Rooper,L., Baraban,E., Zou,Y.S. and Gross,J.M.
  TITLE     Undifferentiated Round Cell Sarcoma With CRTC1::SS18 Fusion:
            Expanding Clinicopathologic Features of a Rare Translocation
            Sarcoma With Prominent Desmoplastic Stroma
  JOURNAL   Mod Pathol 37 (9), 100555 (2024)
   PUBMED   38972355
  REMARK    GeneRIF: Undifferentiated Round Cell Sarcoma With CRTC1::SS18
            Fusion: Expanding Clinicopathologic Features of a Rare
            Translocation Sarcoma With Prominent Desmoplastic Stroma.
REFERENCE   2  (bases 1 to 6879)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 6879)
  AUTHORS   Yamanaka,S., Suzuki,S., Ito,H., Sivasundaram,K., Hanamura,I.,
            Okubo,I., Yoshikawa,K., Ono,S., Takahara,T., Satou,A., Tsuzuki,T.,
            Ueda,R., Ogawa,T. and Fujimoto,Y.
  TITLE     Establishment of Mucoepidermoid Carcinoma Cell Lines from Surgical
            and Recurrence Biopsy Specimens
  JOURNAL   Int J Mol Sci 24 (2), 1722 (2023)
   PUBMED   36675234
  REMARK    GeneRIF: Establishment of Mucoepidermoid Carcinoma Cell Lines from
            Surgical and Recurrence Biopsy Specimens.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6879)
  AUTHORS   Hanna,J., Ko,J.S., Billings,S.D., Boivin,F., Beaudoux,O.,
            Pissaloux,D., Tirode,F., Laga,A., Fletcher,C.D.M. and de la
            Fouchardiere,A.
  TITLE     Cutaneous Melanocytic Tumor With CRTC1::TRIM11 Translocation : An
            Emerging Entity Analyzed in a Series of 41 Cases
  JOURNAL   Am J Surg Pathol 46 (11), 1457-1466 (2022)
   PUBMED   35993578
  REMARK    GeneRIF: Cutaneous Melanocytic Tumor With CRTC1::TRIM11
            Translocation : An Emerging Entity Analyzed in a Series of 41
            Cases.
REFERENCE   5  (bases 1 to 6879)
  AUTHORS   Yang,Y., Bolomsky,A., Oellerich,T., Chen,P., Ceribelli,M.,
            Haupl,B., Wright,G.W., Phelan,J.D., Huang,D.W., Lord,J.W., Van
            Winkle,C.K., Yu,X., Wisniewski,J., Wang,J.Q., Tosto,F.A., Beck,E.,
            Wilson,K., McKnight,C., Travers,J., Klumpp-Thomas,C., Smith,G.A.,
            Pittaluga,S., Maric,I., Kazandjian,D., Thomas,C.J. and Young,R.M.
  TITLE     Oncogenic RAS commandeers amino acid sensing machinery to
            aberrantly activate mTORC1 in multiple myeloma
  JOURNAL   Nat Commun 13 (1), 5469 (2022)
   PUBMED   36115844
  REMARK    GeneRIF: Oncogenic RAS commandeers amino acid sensing machinery to
            aberrantly activate mTORC1 in multiple myeloma.
            Erratum:[Nat Commun. 2022 Oct 3;13(1):5830. doi:
            10.1038/s41467-022-33618-w.. PMID: 36192480]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6879)
  AUTHORS   Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
            Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
            Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
  TITLE     Proteomic, functional, and domain-based analysis of in vivo 14-3-3
            binding proteins involved in cytoskeletal regulation and cellular
            organization
  JOURNAL   Curr Biol 14 (16), 1436-1450 (2004)
   PUBMED   15324660
REFERENCE   7  (bases 1 to 6879)
  AUTHORS   Enlund,F., Behboudi,A., Andren,Y., Oberg,C., Lendahl,U., Mark,J.
            and Stenman,G.
  TITLE     Altered Notch signaling resulting from expression of a WAMTP1-MAML2
            gene fusion in mucoepidermoid carcinomas and benign Warthin's
            tumors
  JOURNAL   Exp Cell Res 292 (1), 21-28 (2004)
   PUBMED   14720503
  REMARK    GeneRIF: cloning of a novel fusion gene in mucoepidermoid
            carcinomas & benign Warthin's tumors; the fusion, which results
            from a translocation, creates a chimeric gene in which exon 1 of a
            novel gene designated WAMTP1 is linked to exons 2-5 of MAML2
            [WAMPT1]
REFERENCE   8  (bases 1 to 6879)
  AUTHORS   Iourgenko,V., Zhang,W., Mickanin,C., Daly,I., Jiang,C.,
            Hexham,J.M., Orth,A.P., Miraglia,L., Meltzer,J., Garza,D.,
            Chirn,G.W., McWhinnie,E., Cohen,D., Skelton,J., Terry,R., Yu,Y.,
            Bodian,D., Buxton,F.P., Zhu,J., Song,C. and Labow,M.A.
  TITLE     Identification of a family of cAMP response element-binding protein
            coactivators by genome-scale functional analysis in mammalian cells
  JOURNAL   Proc Natl Acad Sci U S A 100 (21), 12147-12152 (2003)
   PUBMED   14506290
REFERENCE   9  (bases 1 to 6879)
  AUTHORS   Conkright,M.D., Canettieri,G., Screaton,R., Guzman,E., Miraglia,L.,
            Hogenesch,J.B. and Montminy,M.
  TITLE     TORCs: transducers of regulated CREB activity
  JOURNAL   Mol Cell 12 (2), 413-423 (2003)
   PUBMED   14536081
REFERENCE   10 (bases 1 to 6879)
  AUTHORS   Tonon,G., Modi,S., Wu,L., Kubo,A., Coxon,A.B., Komiya,T.,
            O'Neil,K., Stover,K., El-Naggar,A., Griffin,J.D., Kirsch,I.R. and
            Kaye,F.J.
  TITLE     t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates
            a novel fusion product that disrupts a Notch signaling pathway
  JOURNAL   Nat Genet 33 (2), 208-213 (2003)
   PUBMED   12539049
  REMARK    GeneRIF: cloning and functional analyses of the t(11;19) fusion
            oncogene:  t(11;19)(q21;p13) translocation in mucoepidermoid
            carcinoma creates a novel fusion product that disrupts a Notch
            signaling pathway.
            Erratum:[Nat Genet. 2003 Mar;33(3):430]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AU118537.1, BC028050.1, BC023614.2, AB014516.1, DB355148.1 and
            BM680095.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015321.2.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the shorter isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028050.1, SRR3476690.760605.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000321949.13/ ENSP00000323332.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AU118537.1         66-79
            15-1004             BC028050.1         12-1001
            1005-2498           BC023614.2         893-2386
            2499-6740           AB014516.1         2477-6718
            6741-6804           DB355148.1         74-137              c
            6805-6879           BM680095.1         18-92               c
FEATURES             Location/Qualifiers
     source          1..6879
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..6879
                     /gene="CRTC1"
                     /gene_synonym="Mam-2; MAML2; MECT1; TORC-1; TORC1; WAMTP1"
                     /note="CREB regulated transcription coactivator 1"
                     /db_xref="GeneID:23373"
                     /db_xref="HGNC:HGNC:16062"
                     /db_xref="MIM:607536"
     exon            1..149
                     /gene="CRTC1"
                     /gene_synonym="Mam-2; MAML2; MECT1; TORC-1; TORC1; WAMTP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1928
                     /gene="CRTC1"
                     /gene_synonym="Mam-2; MAML2; MECT1; TORC-1; TORC1; WAMTP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transducer of regulated cAMP response element-binding
                     protein (CREB) 1; mucoepidermoid carcinoma translocated
                     protein 1; Mastermind-like protein 2"
                     /codon_start=1
                     /product="CREB-regulated transcription coactivator 1
                     isoform 1"
                     /protein_id="NP_056136.2"
                     /db_xref="CCDS:CCDS32963.1"
                     /db_xref="GeneID:23373"
                     /db_xref="HGNC:HGNC:16062"
                     /db_xref="MIM:607536"
                     /translation="MATSNNPRKFSEKIALHNQKQAEETAAFEEVMKDLSLTRAARLQ
                     LQKSQYLQLGPSRGQYYGGSLPNVNQIGSGTMDLPFQTPFQSSGLDTSRTTRHHGLVD
                     RVYRERGRLGSPHRRPLSVDKHGRQADSCPYGTMYLSPPADTSWRRTNSDSALHQSTM
                     TPTQPESFSSGSQDVHQKRVLLLTVPGMEETTSEADKNLSKQAWDTKKTGSRPKSCEV
                     PGINIFPSADQENTTALIPATHNTGGSLPDLTNIHFPSPLPTPLDPEEPTFPALSSSS
                     STGNLAANLTHLGIGGAGQGMSTPGSSPQHRPAGVSPLSLSTEARRQQASPTLSPLSP
                     ITQAVAMDALSLEQQLPYAFFTQAGSQQPPPQPQPPPPPPPASQQPPPPPPPQAPVRL
                     PPGGPLLPSASLTRGPQPPPLAVTVPSSLPQSPPENPGQPSMGIDIASAPALQQYRTS
                     AGSPANQSPTSPVSNQGFSPGSSPQHTSTLGSVFGDAYYEQQMAARQANALSHQLEQF
                     NMMENAISSSSLYSPGSTLNYSQAAMMGLTGSHGSLPDSQQLGYASHSGIPNIILTVT
                     GESPPSLSKELTSSLAGVGDVSFDSDSQFPLDELKIDPLTLDGLHMLNDPDMVLADPA
                     TEDTFRMDRL"
     exon            150..266
                     /gene="CRTC1"
                     /gene_synonym="Mam-2; MAML2; MECT1; TORC-1; TORC1; WAMTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            267..404
                     /gene="CRTC1"
                     /gene_synonym="Mam-2; MAML2; MECT1; TORC-1; TORC1; WAMTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            405..466
                     /gene="CRTC1"
                     /gene_synonym="Mam-2; MAML2; MECT1; TORC-1; TORC1; WAMTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            467..561
                     /gene="CRTC1"
                     /gene_synonym="Mam-2; MAML2; MECT1; TORC-1; TORC1; WAMTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            562..647
                     /gene="CRTC1"
                     /gene_synonym="Mam-2; MAML2; MECT1; TORC-1; TORC1; WAMTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..688
                     /gene="CRTC1"
                     /gene_synonym="Mam-2; MAML2; MECT1; TORC-1; TORC1; WAMTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            689..909
                     /gene="CRTC1"
                     /gene_synonym="Mam-2; MAML2; MECT1; TORC-1; TORC1; WAMTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1034
                     /gene="CRTC1"
                     /gene_synonym="Mam-2; MAML2; MECT1; TORC-1; TORC1; WAMTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1343
                     /gene="CRTC1"
                     /gene_synonym="Mam-2; MAML2; MECT1; TORC-1; TORC1; WAMTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1448
                     /gene="CRTC1"
                     /gene_synonym="Mam-2; MAML2; MECT1; TORC-1; TORC1; WAMTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1535
                     /gene="CRTC1"
                     /gene_synonym="Mam-2; MAML2; MECT1; TORC-1; TORC1; WAMTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1716
                     /gene="CRTC1"
                     /gene_synonym="Mam-2; MAML2; MECT1; TORC-1; TORC1; WAMTP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..6879
                     /gene="CRTC1"
                     /gene_synonym="Mam-2; MAML2; MECT1; TORC-1; TORC1; WAMTP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2478..2483
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRTC1"
                     /gene_synonym="Mam-2; MAML2; MECT1; TORC-1; TORC1; WAMTP1"
                     /note="hexamer: AATAAA"
     polyA_site      2498
                     /gene="CRTC1"
                     /gene_synonym="Mam-2; MAML2; MECT1; TORC-1; TORC1; WAMTP1"
                     /note="major polyA site"
     regulatory      6856..6861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRTC1"
                     /gene_synonym="Mam-2; MAML2; MECT1; TORC-1; TORC1; WAMTP1"
                     /note="hexamer: AATAAA"
     polyA_site      6879
                     /gene="CRTC1"
                     /gene_synonym="Mam-2; MAML2; MECT1; TORC-1; TORC1; WAMTP1"
                     /note="major polyA site"
ORIGIN      
        1 gaggaggagg tggcggcgag aagatggcga cttcgaacaa tccgcggaaa ttcagcgaga
       61 agatcgcgct gcacaatcag aagcaggcgg aggagacggc ggccttcgag gaggtcatga
      121 aggacctgag cctgacgcgg gccgcgcggc tccagctcca gaaatcccag tacctgcaac
      181 tgggccccag ccgaggccag tactatggcg ggtccctgcc caacgtgaac cagatcggga
      241 gtggcaccat ggacctgccc ttccagaccc ccttccaatc ctcgggcctg gacaccagcc
      301 ggaccacccg gcaccatggg ctggtggaca gggtgtaccg ggagcgtggc cggctcggct
      361 ccccacaccg ccggcccctg tcagtggaca aacacggacg gcaggccgac agctgcccct
      421 atggcaccat gtacctctca ccacccgcgg acaccagctg gagaaggacc aattctgact
      481 ccgccctgca ccagagcaca atgacgccca cgcagccaga atcctttagc agtgggtccc
      541 aggacgtgca ccagaaaaga gtcttactgt taacagtccc aggaatggaa gagaccacat
      601 cagaggcaga caaaaacctt tccaagcaag catgggacac caagaagacg gggtccaggc
      661 ccaagtcctg tgaggtcccc ggaatcaaca tcttcccgtc tgccgaccag gaaaacacta
      721 cagccctgat ccccgccacc cacaacacag gggggtccct gcccgacctg accaacatcc
      781 acttcccctc cccgctcccg accccgctgg accccgagga gcccaccttc cctgcactga
      841 gcagctccag cagcaccggc aacctcgcgg ccaacctgac gcacctgggc atcggtggcg
      901 ccggccaggg aatgagcaca cctggctcct ctccacagca ccgcccagct ggcgtcagcc
      961 ccctgtccct gagcacagag gcaaggcgtc agcaggcatc gcccaccctg tccccgctgt
     1021 cacccatcac tcaggctgta gccatggacg ccctgtctct ggagcagcag ctgccctacg
     1081 ccttcttcac ccaggcgggc tcccagcagc caccgccgca gccccagccc ccgccgcctc
     1141 ctccacccgc gtcccagcag ccaccacccc cgccaccccc acaggcgccc gtccgcctgc
     1201 cccctggtgg ccccctgttg cccagcgcca gcctgactcg tgggccacag ccgcccccgc
     1261 ttgcagtcac ggtaccgtcc tctctccccc agtccccccc agagaaccct ggccagccat
     1321 cgatggggat cgacatcgcc tcggcgccgg ctctgcagca gtaccgcact agcgccggct
     1381 ccccggccaa ccagtctccc acctcgccag tctccaatca aggcttctcc ccagggagct
     1441 ccccgcaaca cacttccacc ctgggcagcg tgtttgggga cgcgtactat gagcagcaga
     1501 tggcggccag gcaggccaat gctctgtccc accagctgga gcagttcaac atgatggaga
     1561 acgccatcag ctccagcagc ctgtacagcc cgggctccac actcaactac tcgcaggcgg
     1621 ccatgatggg cctcacgggc agccacggga gcctgccgga ctcgcagcaa ctgggatacg
     1681 ccagccacag tggcatcccc aacatcatcc tcacagtgac aggagagtcc ccccccagcc
     1741 tctctaaaga actgaccagc tctctggccg gggtcggcga cgtcagcttc gactccgaca
     1801 gccagtttcc cctggacgaa ctcaagatcg accccctgac cctcgacgga ctgcacatgc
     1861 tcaacgaccc cgacatggtt ctggccgacc cagccaccga ggacaccttc cggatggacc
     1921 gcctgtgagc gggcacgccg gcaccctgcc gctcagccgt cccgacggcg cctccccagc
     1981 ccggggacgg ccgtgctccg tccctcgcca acggccgagc ttgtgattct gagcttgcaa
     2041 tgccgccaag cgccccccgc cagcccgccc ccggttgtcc acctcccgcg aagcccaatc
     2101 gcgaggccgc gagccgggcc gtccacccac ccgcccgccc agggctgggc tgggatcgga
     2161 ggccgtgagc ctcccgcccc tgcagaccct ccctgcactg gctccctcgc ccccagcccc
     2221 ggggcctgag ccgtcccctg taagatgcgg gaagtgtcag ctcccggcgt ggcgggcagg
     2281 ctcaggggag gggcgcgcat ggtccgccag ggctgtgggc cgtggcgcat tttccgactg
     2341 tttgtccagc tctcactgcc ttccttggtt cccggtcccc cagcccatcc gccatcccca
     2401 gcccgtggtc aggtagagag tgagccccac gccgccccag ggaggaggcg ccagagcgcg
     2461 gggcagacgc aaagtgaaat aaacactatt ttgacggctg tcttttatat ttctgagcac
     2521 acacagagcc ctggcgtcca ccggggcagg cgcaaagtgg acagagcatg cagggcggcg
     2581 gaccccccca cgaccctcct cgccctgtct ccatcccctc gaagccctgc ctcaccgcag
     2641 gcaggcccat cggtggccac ctttgccggg aagtgaccgg aaggccccgt gaggggtcga
     2701 acgcggaggc aggggttacc tcttggggct ttacaatccg tggcccctcc tgtcctgcac
     2761 tgtggtcacc ggtcctgtca tagatgctgt taatttaagg tacaggcaga ggtggccagg
     2821 ggagtttcat tgtggttttt ttttcctttt agtttctagt tacattttgg ttgtagatga
     2881 ctcgcttaat cttttaagcc aacacttgcc tgagagcatg tttttatttc agaaatccaa
     2941 ctttacctat tttttaagct aactggaaat ggaggccatg cgccccaaag cagcccgcca
     3001 cccacctgag tgtaagaagt gagtccggct tttgggtttc accccaagtt atctcaaaac
     3061 aaaagggctg gtcaggctgg gcagggcctt gtcaggagct cacggtaggc agaggtgcct
     3121 ctgccagggc cacagaacag acttccggga aggggccttg gcttttattg agggtctctc
     3181 aaagacccag cctgccagcc tctcccagag gtgcctgcta gtccttagag tgtgtgtgtg
     3241 aagatgccat gaccagtggc agctgagacc tctctgcccc aagagtgtgg gggactggca
     3301 gggagcgagg gtccccgaga cgaggaccac ggtcctccct gagaacctgg gtggaactgg
     3361 catttcatcc cctctccacc ctaccctctg gctcctagcc cacaccccct ctcttgggca
     3421 gcgtggtctg ctggctgccc cttcttggca gctcagggtc gtggcaggtg gacttggaga
     3481 cacacagcag tgtgtgtttt agtggcaggt ttcaggagca cctctaagac cagggtgaca
     3541 gggtacttgg gagctgtcct ggaccctccc cataccacgg gccctgcaag ggaggcatca
     3601 gggctggctt tgttttctgc tgttcttgga ataggaactg ctgttctgat ccccccaaaa
     3661 ctgcattgcg gctctcgctc gctcctgcct gccgggacag cgccttctgc tgagtccgtt
     3721 tatttgtagt gtcatggctg ctgctttcac tggggtcctg ggcaccctgg cttctgtcct
     3781 cagagctggg tttgatccta gcaaccatcc cttcctctct ttgcccggca atgcctttgg
     3841 catgtgtctg agcagccaag tggccactca taggagaagg ctccctggtc acgttgctcc
     3901 tgctgccgtc ttgttccaag gtgcgggggg gacactgttg gtctgtccag gtcaaggtcc
     3961 ctttctctta ccatgacaga ggctgggggc agacagcggg gacttttttt tttttttaag
     4021 aaaaactaca tgtacatagg agagtttcat taccattaga cttgtatgta ggacttaaaa
     4081 aaaaatggcc ttaataaaat tacaagcaac ccgcctggat gcggttttca aaagaaggca
     4141 ttgaggacca tgctaggaaa cctcataccc catccgtcca acctccggcg ggcgccactg
     4201 cttgtcctct ggtcttcggt gtggacagat aggagaggag ggatgcccac ctcggagcat
     4261 cccaggcccg tggcccattt tcagcatcct gaagccagat tcacagtgac attgtgttaa
     4321 cgtgacgacc ttggtccatt atggagttct ttttccaata agaacctggt ggaccgaggt
     4381 ccgagcttgc cagggacagt ggggcccacg cgagtacccg gggcccagcc aggagccagc
     4441 agccaggcgt ccctgtgttc cagaaggatt cacgcccctc ctggacctgg gcgggcctcc
     4501 cagggggtct gtatcacggc cttttgtgtg tgcgtacgtg tggttttttt aaatatcact
     4561 actacatatt cttgaattgc caagactttc tgaaacaaga cagcttaagg gaatcagcct
     4621 tttgctttgt gatgtgaaaa tactgtgatt tgacgagccg cttcctgagg ggcaggccca
     4681 cgtggggagg ttgcgccgtg tacatagacc cgccgtctgt gtccttggtc aggcccggat
     4741 gcttggtcta cactgggtta gaggctgctc tccccacgca cccatgtgct catggcttct
     4801 gcagaccctc tgctgggtac atcggtcccc tacggcgaag ttcagccagg gctctccctc
     4861 ctgagagcat ggcgtcccca ccttcctgtt tcgccgacgt cactacccag ggtggcaagt
     4921 cttgcaggca gagggtgtag cccaagttca gcctctctct gtgtcctcca gagaagaggg
     4981 ttctttgccc tcatcagggc cctgcttgtg ggttttcggc tctggggagg agagtgttgg
     5041 catcagtgtg tttggcctga tttcttcagg gggccaagct cccgggagga cccctagcca
     5101 ggagggcccc ccatgtccat ccatccctcc tgctggggct tggatgtcag gcttgggggc
     5161 tgtgagctgg gacctcgcct gagcccggtc aggtgggaca ggagcctgcc agaagcccat
     5221 ggggggccag gccgggtggc ttctatttta tttttttaga gatggggtct tgctgtgttg
     5281 cccaggctgg tctcggactc ctgggctcaa gcagtcctcc ctcctcggcc tcccaaagtt
     5341 ctggggctac aggtgtgagc cacttctgcc cagcatccca ggcctgaaca gccttggcag
     5401 gacccgtccc tagagggggc tctggtgcct cccttaggtg ggccttgagc tggtttttaa
     5461 ccaaacatcc ttccaaactc gggctgcgac ctgcttcctg agttttctgt atttccaagg
     5521 agccctccga ccagggagag gctggtggag taaggtccag cggtattcgg gggtcctctg
     5581 tcacctcgcc ctgaaaacag cagctcccat caccttcact gggtcccgat ggagccgtct
     5641 cagaggccga ggggccctct gtgtgggggt gggacgcagg ggctctcaga gcaagggcca
     5701 caaagccgat ggcacagatg tgcccctggg cctggcccgt cacccacatg tggtgccctg
     5761 ggccagggcg tgcgggcgcc agagccttcc ctacacagcc taagagcagg ggcaagactc
     5821 ggcccctcac tcaccctggg aggcctgcct gggctacatg gacacctggg tctctttcta
     5881 cccccattca ccatggacca ggggcctcca tttcctgggg gctcttgcgg catgtgattt
     5941 gggggtccct gggacattct cccgtcagct ccacctgagc caagtgtcct gttccctgcg
     6001 gcccttggcc ttccagggtc ctggccaggc aggggtcagg caccccatac tcttccgtgt
     6061 ggcacaggtg tccacccacc cccactggcc acagacacca ttctccccct gggagcagga
     6121 ggtggagtaa gttgtacccc caggcctggg tgctggggag ttcctgaggg catgggtggg
     6181 gcaggagtga gtgcctcgtg atcccagcct cagtttctct cttgtcactt tctcaaacct
     6241 gcaggtctca gggccccggg ctcctcctgg gcaggatggg gggcaggggc tgggccttgg
     6301 ggtggtgctg gctctgatga ttccagagcc tgtatccacc ttctgggctc ctggccagca
     6361 ccccaccccc aggagccagg gacaggtggc atgtgttggg gtcgggggat ggcccccatc
     6421 tcgaagtgtt ctggaatttg ggggcaaccc ttgcccagcc cagccatcaa gaacttctga
     6481 tctcctgccc accaggaggg gacttagcca tggacttggc cagtaggcct ggggagggag
     6541 ggctttggca gccaaagtcc actggccctg ccgtgcccct gagtaggaaa ctgtccccta
     6601 ggggctgggt ggccccactg atatatgcaa acccgccggt ccgagccctg ttcctgcctg
     6661 tgctcctctg tgcccaggct ggctctcccc caaccctagc atgtatactc tgccacggac
     6721 gtcccgtggg ccatgattgt gggcggccgc agcgggcggg ggcaggcggc tcagggcaca
     6781 ctcggccgtc cctgccccat cctctggcag ggctgctttt gtctttgtac ctttgcatcc
     6841 tttgtaatga aacgtaataa aaatccaacg ttttcgtca
//
