LOCUS       NM_006371               6595 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens cartilage associated protein (CRTAP), transcript
            variant 1, mRNA.
ACCESSION   NM_006371 XM_940457
VERSION     NM_006371.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6595)
  AUTHORS   Zhou,B., Gao,P., Hu,J., Lin,X., Sun,L., Zhang,Q., Jiang,Y.,
            Wang,O., Xia,W., Xing,X. and Li,M.
  TITLE     Genetic Analysis, Phenotypic Spectrum and Functional Study of Rare
            Osteogenesis Imperfecta Caused by CRTAP Variants
  JOURNAL   J Clin Endocrinol Metab 109 (7), 1803-1813 (2024)
   PUBMED   38214665
  REMARK    GeneRIF: Genetic Analysis, Phenotypic Spectrum and Functional Study
            of Rare Osteogenesis Imperfecta Caused by CRTAP Variants.
REFERENCE   2  (bases 1 to 6595)
  AUTHORS   Kuptanon,C., Thamkunanon,V., Srichomthong,C., Theerapanon,T.,
            Suphapeetiporn,K., Porntaveetus,T. and Shotelersuk,V.
  TITLE     Novel BMP1, CRTAP, and SERPINF1 variants causing autosomal
            recessive osteogenesis imperfecta
  JOURNAL   Clin Genet 102 (3), 242-243 (2022)
   PUBMED   35703132
  REMARK    GeneRIF: Novel BMP1, CRTAP, and SERPINF1 variants causing autosomal
            recessive osteogenesis imperfecta.
REFERENCE   3  (bases 1 to 6595)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 6595)
  AUTHORS   Caudevilla Lafuente,P., Izquierdo-Alvarez,S. and Labarta
            Aizpun,J.I.
  TITLE     Osteogenesis imperfecta caused by COL1A1, CRTAP and LEPRE1
            mutations. Report of 2cases
  JOURNAL   Med Clin (Barc) 153 (8), 336-337 (2019)
   PUBMED   30389107
  REMARK    GeneRIF: Osteogenesis imperfecta caused by COL1A1, CRTAP and LEPRE1
            mutations. Report of 2cases.', trans 'Osteogenesis imperfecta
            causada por mutacion en los genes COL1A1, CRTAP y LEPRE1. Estudio
            de 2casos.
REFERENCE   5  (bases 1 to 6595)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   6  (bases 1 to 6595)
  AUTHORS   Baldridge,D., Schwarze,U., Morello,R., Lennington,J., Bertin,T.K.,
            Pace,J.M., Pepin,M.G., Weis,M., Eyre,D.R., Walsh,J., Lambert,D.,
            Green,A., Robinson,H., Michelson,M., Houge,G., Lindman,C.,
            Martin,J., Ward,J., Lemyre,E., Mitchell,J.J., Krakow,D.,
            Rimoin,D.L., Cohn,D.H., Byers,P.H. and Lee,B.
  TITLE     CRTAP and LEPRE1 mutations in recessive osteogenesis imperfecta
  JOURNAL   Hum Mutat 29 (12), 1435-1442 (2008)
   PUBMED   18566967
  REMARK    GeneRIF: Screening of 78 subjects diagnosed with osteogenesis
            imperfecta type II or III, identified three probands with mutations
            in CRTAP and 16 with mutations in LEPRE1.
REFERENCE   7  (bases 1 to 6595)
  AUTHORS   Morello,R., Bertin,T.K., Chen,Y., Hicks,J., Tonachini,L.,
            Monticone,M., Castagnola,P., Rauch,F., Glorieux,F.H., Vranka,J.,
            Bachinger,H.P., Pace,J.M., Schwarze,U., Byers,P.H., Weis,M.,
            Fernandes,R.J., Eyre,D.R., Yao,Z., Boyce,B.F. and Lee,B.
  TITLE     CRTAP is required for prolyl 3- hydroxylation and mutations cause
            recessive osteogenesis imperfecta
  JOURNAL   Cell 127 (2), 291-304 (2006)
   PUBMED   17055431
  REMARK    GeneRIF: complexes with prolyl 3-hydroxylase 1 (P3H1) to decrease
            prolyl 3 hydroxylation; dysregulation of prolyl 3 hydroxylation is
            a mechanism for connective tissue disease
REFERENCE   8  (bases 1 to 6595)
  AUTHORS   Morello,R., Tonachini,L., Monticone,M., Viggiano,L., Rocchi,M.,
            Cancedda,R. and Castagnola,P.
  TITLE     cDNA cloning, characterization and chromosome mapping of Crtap
            encoding the mouse cartilage associated protein
  JOURNAL   Matrix Biol 18 (3), 319-324 (1999)
   PUBMED   10429950
REFERENCE   9  (bases 1 to 6595)
  AUTHORS   Tonachini,L., Morello,R., Monticone,M., Skaug,J., Scherer,S.W.,
            Cancedda,R. and Castagnola,P.
  TITLE     cDNA cloning, characterization and chromosome mapping of the gene
            encoding human cartilage associated protein (CRTAP)
  JOURNAL   Cytogenet Cell Genet 87 (3-4), 191-194 (1999)
   PUBMED   10702664
REFERENCE   10 (bases 1 to 6595)
  AUTHORS   Castagnola,P., Gennari,M., Morello,R., Tonachini,L., Marin,O.,
            Gaggero,A. and Cancedda,R.
  TITLE     Cartilage associated protein (CASP) is a novel developmentally
            regulated chick embryo protein
  JOURNAL   J Cell Sci 110 (Pt 12), 1351-1359 (1997)
   PUBMED   9217321
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA335701.1, AJ006470.1,
            AC112211.2 and AK027235.1.
            
            On Aug 31, 2019 this sequence version replaced NM_006371.4.
            
            Summary: The protein encoded by this gene is similar to the chicken
            and mouse CRTAP genes. The encoded protein is a scaffolding protein
            that may influence the activity of at least one member of the
            cytohesin/ARNO family in response to specific cellular stimuli.
            Defects in this gene are associated with osteogenesis imperfecta, a
            connective tissue disorder characterized by bone fragility and low
            bone mass. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.328616.1,
                                           SRR14038197.1675809.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320954.11/ ENSP00000323696.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                DA335701.1         57-117
            62-1656             AJ006470.1         9-1603
            1657-5161           AC112211.2         178723-182227
            5162-6595           AK027235.1         515-1948
FEATURES             Location/Qualifiers
     source          1..6595
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.3"
     gene            1..6595
                     /gene="CRTAP"
                     /gene_synonym="CASP; LEPREL3; OI7; P3H5"
                     /note="cartilage associated protein"
                     /db_xref="GeneID:10491"
                     /db_xref="HGNC:HGNC:2379"
                     /db_xref="MIM:605497"
     exon            1..535
                     /gene="CRTAP"
                     /gene_synonym="CASP; LEPREL3; OI7; P3H5"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1270
                     /gene="CRTAP"
                     /gene_synonym="CASP; LEPREL3; OI7; P3H5"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; leprecan-like 3; prolyl 3-hydroxylase family
                     member 5 (non-enzymatic)"
                     /codon_start=1
                     /product="cartilage-associated protein isoform 1
                     precursor"
                     /protein_id="NP_006362.1"
                     /db_xref="CCDS:CCDS2657.1"
                     /db_xref="GeneID:10491"
                     /db_xref="HGNC:HGNC:2379"
                     /db_xref="MIM:605497"
                     /translation="MEPGRRGAAALLALLCVACALRAGRAQYERYSFRSFPRDELMPL
                     ESAYRHALDKYSGEHWAESVGYLEISLRLHRLLRDSEAFCHRNCSAAPQPEPAAGLAS
                     YPELRLFGGLLRRAHCLKRCKQGLPAFRQSQPSREVLADFQRREPYKFLQFAYFKANN
                     LPKAIAAAHTFLLKHPDDEMMKRNMAYYKSLPGAEDYIKDLETKSYESLFIRAVRAYN
                     GENWRTSITDMELALPDFFKAFYECLAACEGSREIKDFKDFYLSIADHYVEVLECKIQ
                     CEENLTPVIGGYPVEKFVATMYHYLQFAYYKLNDLKNAAPCAVSYLLFDQNDKVMQQN
                     LVYYQYHRDTWGLSDEHFQPRPEAVQFFNVTTLQKELYDFAKENIMDDDEGEVVEYVD
                     DLLELEETS"
     exon            536..685
                     /gene="CRTAP"
                     /gene_synonym="CASP; LEPREL3; OI7; P3H5"
                     /inference="alignment:Splign:2.1.0"
     exon            686..857
                     /gene="CRTAP"
                     /gene_synonym="CASP; LEPREL3; OI7; P3H5"
                     /inference="alignment:Splign:2.1.0"
     exon            858..986
                     /gene="CRTAP"
                     /gene_synonym="CASP; LEPREL3; OI7; P3H5"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1132
                     /gene="CRTAP"
                     /gene_synonym="CASP; LEPREL3; OI7; P3H5"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1216
                     /gene="CRTAP"
                     /gene_synonym="CASP; LEPREL3; OI7; P3H5"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..6595
                     /gene="CRTAP"
                     /gene_synonym="CASP; LEPREL3; OI7; P3H5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1964..1969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRTAP"
                     /gene_synonym="CASP; LEPREL3; OI7; P3H5"
                     /note="hexamer: AAGAAA"
     polyA_site      1987
                     /gene="CRTAP"
                     /gene_synonym="CASP; LEPREL3; OI7; P3H5"
                     /note="major polyA site"
     regulatory      3834..3839
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRTAP"
                     /gene_synonym="CASP; LEPREL3; OI7; P3H5"
                     /note="hexamer: AATAAA"
     polyA_site      3852
                     /gene="CRTAP"
                     /gene_synonym="CASP; LEPREL3; OI7; P3H5"
                     /note="major polyA site"
     regulatory      5627..5632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRTAP"
                     /gene_synonym="CASP; LEPREL3; OI7; P3H5"
                     /note="hexamer: AATAAA"
     polyA_site      5652
                     /gene="CRTAP"
                     /gene_synonym="CASP; LEPREL3; OI7; P3H5"
     polyA_site      6547
                     /gene="CRTAP"
                     /gene_synonym="CASP; LEPREL3; OI7; P3H5"
     regulatory      6574..6579
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRTAP"
                     /gene_synonym="CASP; LEPREL3; OI7; P3H5"
                     /note="hexamer: ATTAAA"
     polyA_site      6595
                     /gene="CRTAP"
                     /gene_synonym="CASP; LEPREL3; OI7; P3H5"
ORIGIN      
        1 cctttccttc tccctcccct tttcccttcc ttcgtccctt ccttccttcc tttcgccggg
       61 cgcgatggag ccggggcgcc ggggggccgc ggcgctgcta gcgctgctgt gcgtggcctg
      121 cgcgctgcgc gccgggcgcg cccaatacga acgctacagc ttccgcagct tcccacggga
      181 cgagctgatg ccgctcgagt cggcctaccg gcacgcgctg gacaagtaca gcggcgagca
      241 ctgggccgag agcgtgggct acctggagat cagcctgcgg ctgcaccgct tgctgcgcga
      301 cagcgaggcc ttctgccacc gcaactgcag cgccgcgccg cagcccgagc ccgccgccgg
      361 cctcgccagc tatcccgagc tgcgcctctt cgggggcctg ctgcgccgcg cgcactgcct
      421 caagcgctgc aagcagggcc tgccagcctt ccgccagtcc cagcccagcc gcgaggtgct
      481 ggcggacttc cagcgccgcg agccctacaa gttcctgcag ttcgcttact tcaaggcaaa
      541 taatctcccc aaagccatcg ccgctgctca cacctttcta ctgaagcatc ctgatgacga
      601 aatgatgaag aggaacatgg catattataa gagcctgcct ggtgccgagg actacattaa
      661 agacctggaa accaagtcat atgaaagcct gttcatccga gcagtgcggg catacaacgg
      721 tgagaactgg agaacatcca tcacagacat ggagctggcc cttcccgact tcttcaaagc
      781 cttttacgag tgtctcgcag cctgcgaggg ttccagggag atcaaggact tcaaggattt
      841 ctacctttcc atagcagatc attatgtaga agttctggaa tgcaaaatac agtgtgaaga
      901 gaacctcacc ccagttatag gaggctatcc ggttgagaaa tttgtggcta ccatgtatca
      961 ttacttgcag tttgcctatt ataagttgaa cgacctgaag aatgcagccc cctgtgcagt
     1021 cagctatctg ctctttgatc agaatgacaa ggtcatgcag cagaacctgg tgtattacca
     1081 gtaccacagg gacacttggg gcctctcgga tgagcacttc cagcccagac ctgaagcagt
     1141 tcagttcttt aatgtgacca cactccagaa ggagctgtat gactttgcta aggaaaatat
     1201 aatggatgat gatgagggag aagttgtgga atatgtggat gacctcttgg aactggagga
     1261 gaccagctag cccacagcaa ccaaagagac ttcctcttgg cgttcaggaa acacagattc
     1321 tttgtccttt tcccaacagc ccaggctgtt gatacctcag agccttctct ttactctcca
     1381 aagtgaaagg gaagcccccg tctctctaac tgcatgtcat caggggtgag cctgcctttc
     1441 ctatcttcac acctgccacc tcatgttcac acctatcttt ctcacctttt ttttgagatg
     1501 gagtctcgct ctcttgccca ggctggagtg caatggcacg ttctcagctc actgcaacct
     1561 ccgcctcttg ggttcaagca attctgctgc atcagcctcc cgagtacctg ggattacagg
     1621 catgtgccac cacgcccggc taattttgta tttttagtag agacggggtt ttgccatgtt
     1681 ggccaggctg gtctcgaact cttgacttca gatgatccat ctgccttggc ctcccacagt
     1741 gctgggatta caggcgtgag ccaccatgcc cggcctcttt ctcaccttta cacctgtctt
     1801 cttatcctca catctgtttt cacaccttca tccctgtctt cctcatgttc acacttgtct
     1861 tccccatgtt catagctgcc tttcttacca ttttggtttg aagggcagtc ttctctggct
     1921 tgtttttttg tttttcccag aaaatcagta ttatttttta aataagaaaa acattcctag
     1981 aagatgataa ttgtgaaaac ctcctttggc ttatttgctt ttccagattt tagtctcctt
     2041 tctccccatc cgggaaagat ggtggaagac ataggctaaa tttctccagc ctcacaatgg
     2101 tcttcacttg gtctgacttg taccaattct agcacccact gaaaaacaag ttgagtagag
     2161 agtgtagagt gcagaaatgt ggcttttgcc ccactttgca tctccaaaat tacaacggtt
     2221 ggccgatccc atttgaggac aatgcttagt tataagtctc cgagttggaa aaggaagaaa
     2281 gccagagctg tctagtttca ttcattcttt cagtaaatat ttattgagta cctactgtgt
     2341 gctaggcatt gacctgggaa ctagagatac ttcacagaat aacagggaaa gttccctgtg
     2401 ctcatggagc ttacattcta cagggagaaa gagatagcca atacatagga ataaatatat
     2461 acaaggtatc atgtagtgat aattgctgtg gagaaaaata aagcagggga gggagtaaga
     2521 aatcctggag atgaggctgc agttttaaat ggggcctcac tgggaatgtg acgttgagca
     2581 gagacgttag ggaagtggat cctggacaag gcattccagg cagaggaaca ggatgtgcac
     2641 tgccccaaag tgagaacttg ctctacgtgg tcaggaaaga gcagggagac caagcagagt
     2701 cgtgggcagg ggtagaatgg aaggagaggc ggctggggag gacaggtggt ggagggcctt
     2761 ggcttctgct aagtgagatg ggaaccactg gagggtttga acagaggagt gccttgattg
     2821 atttatattt tgcaagggtc attctagctg ccatattgtg aaaaacttta gtggacaagg
     2881 gcagaaggaa gagggaagac ctgttaggaa gctactgcaa ggttccaggc ttgggcctgg
     2941 gccacagcaa cagcagtggt caaatatcta gatttatttt gaaaagagcc aataggattt
     3001 gctgagagtt tgaatgtgga gtgtaagaga aggaagagtt aatgatgaca ttaaggtttt
     3061 tggcctgaat agcaggaaag atggagttac cagttactga aatagggaag gatgggctgg
     3121 gtaagtatgg aatttggtgc aaagcaggct gtctgtggtt ggaatgggag gttctggctg
     3181 caaatcaaag tggagagttc tctcaggtca ggtctgcagc agagctcgag acagggatct
     3241 gaatgcactt ggtttattgt tgggggtgct ctcagaagga acctgtgaaa gcctttatca
     3301 gtcatttatt ggctgtgaga agttctctgg gagtgtgggt acatttgaag gcaagtgact
     3361 tcagttgagg gcaagtctct ggaaaagagg ctgtaggcat ctggcagcta ccatgcatgg
     3421 tagtgtgttg ggggtggggg tcctgggcac tggctgtgtg aagggatctg gcagggcacc
     3481 acagcgcccc ctactgaacc atcagcatgt cagtggcatt taaagccatg cagctggagg
     3541 ggccactgag attgtctctg agtattactg agaagcaaca gaaaagagcc atggatggag
     3601 cccttgggct ctctgggaaa tgggaaatca gccaaaggac tgagaaggag ttaccttaag
     3661 gtcagagaaa accaagagag tgtggtgttc tggaagctga gctttcttta ttcaacctca
     3721 ttcccttctc caaataagcc acttgtgtag ttgggcccct ccagggttga aggcaagagg
     3781 agaaaggcac agcgtttggg aaacaagact tttcctgcaa tagcctggga aggaataaaa
     3841 ggatagagtg tttgggtttt tgtgtaatgg tggttaattg gggtggaaca ctcacacgtt
     3901 gtgctttttc tgggcttccc ttatccccca gaacactcta ccaacctcgg ggaactcggg
     3961 cacatccttc tgtttctcct tcagctctat cctgctttcc tcatcccttc tgacaccacg
     4021 tcctcactca cctgcacaag aatccctgca tcaggttctc ctttgagggt acccacccag
     4081 gacagtcccc taccacttct gtcttgggct gaagttgccc acgtccacaa aatctgtact
     4141 cccagcgggg gtgtttggcc cgaggagtca gtgttattac tggtggatgc accgtgtcca
     4201 cagcagcccc caatcccagc gatgcgtcag atcttacgtg gcttcctgct gggggagatg
     4261 gccttcaccc acgggatgcc gggttctcct ttctttcctc accccaacct ttactccacc
     4321 agagaaactt ccttttgaac tcagtgggga agagggtgat gagacaggac tagaaagtag
     4381 tgggggaccc agcgagtgga cgccctgctc cgggattcct gagtctgtaa atagtgtgcc
     4441 cagcagctgt gaactcccct tatagcctca ggctgcagtg tccttcccag ctgtgtgaga
     4501 aaatgaaagc cgacgtccac agggacccag gcagggttgg gtgttgtgac tcactccacc
     4561 tctgtgccct gcagaggtac tgttgggtcc ttgtcttgtg agcctggggt gagctctctg
     4621 tacatgttgt tgttccacgt atgggttgac ttggcatgct ggggggtcct cgttcactct
     4681 ctgaagttgg cctcctttca ctggggattg aaaagcacct ccacccctac cctagtgatg
     4741 tcccctgagg acccgggtga tagtacagtc aatattgtca gtactttgct ttgattgaag
     4801 gctgtagagc tgagttacca aaatttctat ttcaaaggaa accaaacctt aaaaaaaaaa
     4861 aacaaaaact gggctgggtc ttccaaacct accatgaaac cctggtgtgc aggctgcact
     4921 caatgacctc aacccaacac ctccctgagt gtgcttcttg gaagagccta gaagattcct
     4981 ggatggagac cccattggtt cagcctcaag tctggcccgt cttcgaaaaa acaaacacat
     5041 ttgtaagctt tgtgggagct tccaggcctg ctctaagatg ccttgcttgt cctttgaccc
     5101 atcagcatgg agctcagtgg ttgctgtttg gttctgcagg ctggtgggga ggccgcccat
     5161 cgtggtgggg catctgtcca gccccattgc cactcagggc atccaaacag gaggcacccg
     5221 ctgggaaggg tctaaagata ctccttgtgg ccactgctac tgttcacact tgacttgtgg
     5281 agaagcgaag ggctgagggg aggtttgtgt acacccatgt atttaaaagt gactgactga
     5341 ctgaaatgag cacataccga catatgcaac atactaatac cttcctgatt ttcgagactt
     5401 tctaattact acaactaacc tgttgtgctc acctctggaa ttcagaaaga gagccactgc
     5461 gagcactgac cacaagggct gccttaggaa ggaaatgtgt gctttcagga gttcttatta
     5521 ggggaatttt aagagcacaa aaattttatt gaacccacct tagtgacaaa cagaaaatga
     5581 tttgttagat tgtcagttgg aaggggttta ttatgactgc tggtgaaata aacagtgacc
     5641 agtttctgcc aacatttatg gaaataacgt ttctaggttt taaatgtgag ccgtaaactg
     5701 aagctacttc agttaaaaaa aaaaaaatca atacttaaac tgtagggaaa aggtggattg
     5761 gtgccagaga aaacattatt taatagtgtc agaacatgga actgcaacac agtttgtagc
     5821 aaggcactga gaaaaaccca caactaatcc ttcatcgcag ctgtctgaac tcttgatcat
     5881 ctgccatccc ccaaacagtg acttcttttt ttctggtgac tccaggcctg aatgacctag
     5941 tgtggagagt ttaaactatg tacaagggag gaaagaaaaa aaggaaagga accttaagta
     6001 agcctcagcc aaaggtttta tgcattggac ttcctgtgcc tgcccccagg ggcaagactg
     6061 atccccatgc ctgtgcccat gacatctccc tgaaagagga caccatgaca gcccggcttt
     6121 gccttgactg acccactgct accccagaaa taagaatcaa gagcagctat tgttatcctt
     6181 agagtgtttt ccgtctaggg ccggctcgtg aacagccaca tatccttgca cctgacactg
     6241 tccccacaca aatagctggc tttcgttgct tgttgaatga atgagtgagt tggctctata
     6301 tccccttgga gctggccggt aagatattag tgcctcattt tacaagaaga gaataggaag
     6361 gaattaagca atttggccaa cagatacaag atagattcca gagttttatc tcccacttta
     6421 gggtggcagc cagtaggcca aactccaaag accgttgctg atgtcttttt ctgcctcccc
     6481 tctttgggtt agtgtggtat gtacaagctc actcttgttg aaaattagaa aatagttgaa
     6541 aacaaaaggt ttttgttttt ctttttaaat cacattaaat gttttacatt gctta
//
