LOCUS       NM_019604               2473 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cytotoxic and regulatory T cell molecule (CRTAM),
            transcript variant 1, mRNA.
ACCESSION   NM_019604
VERSION     NM_019604.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2473)
  AUTHORS   Zheng,S., Yang,B., Li,L., Chen,M., Zhang,L., Chi,W., Shao,Z.M.,
            Xiu,B., Chi,Y. and Wu,J.
  TITLE     CRTAM promotes antitumor immune response in triple negative breast
            cancer by enhancing CD8+ T cell infiltration
  JOURNAL   Int Immunopharmacol 129, 111625 (2024)
   PUBMED   38354509
  REMARK    GeneRIF: CRTAM promotes antitumor immune response in triple
            negative breast cancer by enhancing CD8+ T cell infiltration.
REFERENCE   2  (bases 1 to 2473)
  AUTHORS   Barragan-Galvez,J.C., Gonzalez-Orozco,M., Hernandez-Flores,A.,
            Maravillas-Montero,J.L., Chavez-Guerrero,Y. and Ortiz-Navarrete,V.
  TITLE     Prokaryotic Expression of the Immunoglobulin's Domains of CRTAM to
            Characterize a Monoclonal Antibody
  JOURNAL   Protein J 39 (3), 224-231 (2020)
   PUBMED   32300914
  REMARK    GeneRIF: Prokaryotic Expression of the Immunoglobulin's Domains of
            CRTAM to Characterize a Monoclonal Antibody.
REFERENCE   3  (bases 1 to 2473)
  AUTHORS   Ramirez-Ramirez,D., Padilla-Castaneda,S., Galan-Enriquez,C.S.,
            Vadillo,E., Prieto-Chavez,J.L., Jimenez-Hernandez,E.,
            Vilchis-Ordonez,A., Sandoval,A., Balandran,J.C., Perez-Tapia,S.M.,
            Ortiz-Navarrete,V. and Pelayo,R.
  TITLE     CRTAM+ NK cells endowed with suppressor properties arise in
            leukemic bone marrow
  JOURNAL   J Leukoc Biol 105 (5), 999-1013 (2019)
   PUBMED   30791148
  REMARK    GeneRIF: The findings suggest, for the first time, that the tumor
            microenvironment in acute lymphoblastic leukemia directly
            contribute to exhaustion of NK cell functions by the CRTAM/Necl-2
            interaction, and that the potential regulatory role of
            exhausted-like NK cells may favor malignant progression at the
            expense of anti-tumor responses.
REFERENCE   4  (bases 1 to 2473)
  AUTHORS   Takeuchi,A., Badr Mel,S., Miyauchi,K., Ishihara,C., Onishi,R.,
            Guo,Z., Sasaki,Y., Ike,H., Takumi,A., Tsuji,N.M., Murakami,Y.,
            Katakai,T., Kubo,M. and Saito,T.
  TITLE     CRTAM determines the CD4+ cytotoxic T lymphocyte lineage
  JOURNAL   J Exp Med 213 (1), 123-138 (2016)
   PUBMED   26694968
  REMARK    GeneRIF: These results reveal that CRTAM is critical to instruct
            the differentiation of CD4(+)CTL through the induction of Eomes and
            CTL-related gene.
REFERENCE   5  (bases 1 to 2473)
  AUTHORS   Rojas-Marquez,C., Valle-Rios,R., Lopez-Bayghen,E. and
            Ortiz-Navarrete,V.
  TITLE     CRTAM is negatively regulated by ZEB1 in T cells
  JOURNAL   Mol Immunol 66 (2), 290-298 (2015)
   PUBMED   25910959
  REMARK    GeneRIF: CRTAM is negatively regulated by ZEB1 in T cells.
REFERENCE   6  (bases 1 to 2473)
  AUTHORS   Yeh,J.H., Sidhu,S.S. and Chan,A.C.
  TITLE     Regulation of a late phase of T cell polarity and effector
            functions by Crtam
  JOURNAL   Cell 132 (5), 846-859 (2008)
   PUBMED   18329370
REFERENCE   7  (bases 1 to 2473)
  AUTHORS   Patino-Lopez,G., Hevezi,P., Lee,J., Willhite,D., Verge,G.M.,
            Lechner,S.M., Ortiz-Navarrete,V. and Zlotnik,A.
  TITLE     Human class-I restricted T cell associated molecule is highly
            expressed in the cerebellum and is a marker for activated NKT and
            CD8+ T lymphocytes
  JOURNAL   J Neuroimmunol 171 (1-2), 145-155 (2006)
   PUBMED   16300832
REFERENCE   8  (bases 1 to 2473)
  AUTHORS   Boles,K.S., Barchet,W., Diacovo,T., Cella,M. and Colonna,M.
  TITLE     The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell
            responses through the cell-surface receptor CRTAM
  JOURNAL   Blood 106 (3), 779-786 (2005)
   PUBMED   15811952
  REMARK    GeneRIF: NK cells and T8 cells recognize Necl-2 through CRTAM,
            expressed only on activated cells. CRTAM-Necl-2 interactions
            promote cytotoxicity of NK cells and IFN-gamma secretion of T8
            cells as well as NK cell-mediated rejection of tumors expressing
            Necl-2
REFERENCE   9  (bases 1 to 2473)
  AUTHORS   Galibert,L., Diemer,G.S., Liu,Z., Johnson,R.S., Smith,J.L.,
            Walzer,T., Comeau,M.R., Rauch,C.T., Wolfson,M.F., Sorensen,R.A.,
            Van der Vuurst de Vries,A.R., Branstetter,D.G., Koelling,R.M.,
            Scholler,J., Fanslow,W.C., Baum,P.R., Derry,J.M. and Yan,W.
  TITLE     Nectin-like protein 2 defines a subset of T-cell zone dendritic
            cells and is a ligand for class-I-restricted T-cell-associated
            molecule
  JOURNAL   J Biol Chem 280 (23), 21955-21964 (2005)
   PUBMED   15781451
  REMARK    GeneRIF: Necl2/CRTAM molecular pair could regulate a large panel of
            cell/cell interactions both within and outside of the immune system
REFERENCE   10 (bases 1 to 2473)
  AUTHORS   Kennedy,J., Vicari,A.P., Saylor,V., Zurawski,S.M., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A. and Zlotnik,A.
  TITLE     A molecular analysis of NKT cells: identification of a class-I
            restricted T cell-associated molecule (CRTAM)
  JOURNAL   J Leukoc Biol 67 (5), 725-734 (2000)
   PUBMED   10811014
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC070266.1, AF001622.1, AB209830.1 and AP004318.2.
            
            On Nov 23, 2018 this sequence version replaced NM_019604.3.
            
            Summary: The CRTAM gene is upregulated in CD4 (see MIM
            186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells
            and encodes a type I transmembrane protein with V and C1-like Ig
            domains (Yeh et al., 2008 [PubMed 18329370]).[supplied by OMIM, Feb
            2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK313578.1, BC070266.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000227348.9/ ENSP00000227348.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-240               BC070266.1         3-242
            241-1008            AF001622.1         194-961
            1009-1149           BC070266.1         1011-1151
            1150-1581           AF001622.1         1103-1534
            1582-1943           AB209830.1         945-1306
            1944-2473           AP004318.2         36366-36895
FEATURES             Location/Qualifiers
     source          1..2473
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.1"
     gene            1..2473
                     /gene="CRTAM"
                     /gene_synonym="CD355"
                     /note="cytotoxic and regulatory T cell molecule"
                     /db_xref="GeneID:56253"
                     /db_xref="HGNC:HGNC:24313"
                     /db_xref="MIM:612597"
     exon            1..93
                     /gene="CRTAM"
                     /gene_synonym="CD355"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1229
                     /gene="CRTAM"
                     /gene_synonym="CD355"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; class-I MHC-restricted T-cell-associated
                     molecule"
                     /codon_start=1
                     /product="cytotoxic and regulatory T-cell molecule isoform
                     1 precursor"
                     /protein_id="NP_062550.2"
                     /db_xref="CCDS:CCDS8437.1"
                     /db_xref="GeneID:56253"
                     /db_xref="HGNC:HGNC:24313"
                     /db_xref="MIM:612597"
                     /translation="MWWRVLSLLAWFPLQEASLTNHTETITVEEGQTLTLKCVTSLRK
                     NSSLQWLTPSGFTIFLNEYPALKNSKYQLLHHSANQLSITVPNVTLQDEGVYKCLHYS
                     DSVSTKEVKVIVLATPFKPILEASVIRKQNGEEHVVLMCSTMRSKPPPQITWLLGNSM
                     EVSGGTLHEFETDGKKCNTTSTLIIHTYGKNSTVDCIIRHRGLQGRKLVAPFRFEDLV
                     TDEETASDALERNSLSSQDPQQPTSTVSVTEDSSTSEIDKEEKEQTTQDPDLTTEANP
                     QYLGLARKKSGILLLTLVSFLIFILFIIVQLFIMKLRKAHVIWKKENEVSEHTLESYR
                     SRSNNEETSSEEKNGQSSHPMRCMNYITKLYSEAKTKRKENVQHSKLEEKHIQVPESI
                     V"
     exon            94..240
                     /gene="CRTAM"
                     /gene_synonym="CD355"
                     /inference="alignment:Splign:2.1.0"
     exon            241..393
                     /gene="CRTAM"
                     /gene_synonym="CD355"
                     /inference="alignment:Splign:2.1.0"
     exon            394..537
                     /gene="CRTAM"
                     /gene_synonym="CD355"
                     /inference="alignment:Splign:2.1.0"
     exon            538..699
                     /gene="CRTAM"
                     /gene_synonym="CD355"
                     /inference="alignment:Splign:2.1.0"
     exon            700..780
                     /gene="CRTAM"
                     /gene_synonym="CD355"
                     /inference="alignment:Splign:2.1.0"
     exon            781..864
                     /gene="CRTAM"
                     /gene_synonym="CD355"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1011
                     /gene="CRTAM"
                     /gene_synonym="CD355"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1098
                     /gene="CRTAM"
                     /gene_synonym="CD355"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..2473
                     /gene="CRTAM"
                     /gene_synonym="CD355"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2449..2454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRTAM"
                     /gene_synonym="CD355"
                     /note="hexamer: AATAAA"
     polyA_site      2473
                     /gene="CRTAM"
                     /gene_synonym="CD355"
                     /note="major polyA site"
ORIGIN      
        1 agaatctaga ggaagttgac aaaggtgcca cagcagcaca gcacagtatg tggtggagag
       61 ttctcagctt gctggcatgg ttccccttgc aagaggcctc tctgactaac cacacagaaa
      121 ccatcaccgt ggaggaaggc cagacgctca ctctaaagtg tgtcacttct ctgaggaaga
      181 actcctccct ccagtggctg accccctcag ggttcaccat ttttttaaat gagtatcctg
      241 ctttaaaaaa ttccaaatac cagcttcttc atcactcggc caatcagctc tccatcactg
      301 tgcctaacgt aaccctgcaa gatgaaggcg tgtacaagtg cttacattac agcgactctg
      361 taagcacaaa ggaagtgaaa gtgattgtgc tggcaactcc tttcaagcca atcctggaag
      421 cttcagttat cagaaagcaa aatggagaag aacatgttgt actcatgtgc tccaccatga
      481 gaagcaagcc ccctccgcag ataacctggc tacttgggaa tagcatggaa gtgtccggtg
      541 gaacgctcca tgaatttgaa actgatggga agaaatgtaa tactaccagc actctcataa
      601 tccacactta tggcaaaaat tcaacggtgg actgcattat ccgacacaga ggcctgcaag
      661 ggagaaaact agtagcaccc ttccggtttg aagatttggt tactgatgaa gagacagctt
      721 cagatgctct ggagagaaac tctctatcct ctcaagaccc acagcagccc accagtactg
      781 tctcagtaac ggaagattct agtacatcgg agattgacaa ggaagagaaa gaacaaacca
      841 ctcaagatcc tgacttgacc accgaagcaa atcctcagta tttaggactg gcaagaaaga
      901 aaagtggcat cctgctgctc acgctggtgt ccttcctcat tttcatactc ttcatcatag
      961 tccagctctt catcatgaag ctgaggaaag cacatgtgat atggaagaaa gaaaacgaag
     1021 tttcagaaca cacactagaa agttacagat caaggtcaaa taatgaagaa acatcatctg
     1081 aagagaaaaa tggccaatct tcccacccta tgcgttgcat gaactacatc acaaagttgt
     1141 actcagaagc aaaaacaaag aggaaggaaa atgtacaaca ttcaaaatta gaagaaaagc
     1201 acatccaagt accagagagt attgtgtagt gctctctgca atggaacatg tgatttcagg
     1261 gttgccgcag tgtcacctca gtggaccagc ctgggggaag gagcttaatt gctgagacat
     1321 taataatgac ctcttagtgc aatgcaagat ggtgtcctcg gataatgatc tgccccggag
     1381 ctagggcagc aacatgagga ccaaaccatg cacataaagc ttgtagttta aaaaagaaaa
     1441 gcaaaaaaat aattatgcct gacactactt cagagcagga ggattctacg aagccttggg
     1501 gatcagggtc agtgtgagca gctaacatcc tacctcaaat ggaacaggat tttttgatgc
     1561 tttgctctaa tggaactgtt taaaaaattt ttttttcttt ttaatatttt cttctggtca
     1621 caaaataaag aaatttggga tgcaaagtac ctaaagatct ctgatcctaa gaagttactt
     1681 ctggccaggc gcggtggctc atgcctgtaa tcctagcact ttgggaggct gaggtaggca
     1741 gatcacttga ggtcaggagt tggagaccag cctggccaac atagtgaaac cccgtctcta
     1801 ctaaaaatgc aaaaattagc caggcgtagt ggtgcgcacc tgtagtctca gatacttggg
     1861 aggctgaggg tggagaatcg cttgaacctg ggaggtggag attgcagtga gtcaagatct
     1921 caccactgca ctccagcctg ggcaacagag ggagactctg tctcaaaaaa aaagaagtta
     1981 cttccaagac agacttttaa gatgtaacca gcacaaagca atgtcaggga ggagtgatac
     2041 atgacaataa atgagtcaga tgagcaagaa ggccccagaa cccatgcccc aaggcacaaa
     2101 gaggagctca gggtaggccc aaagattcga attccttaga ttactaaatc acatgagcgg
     2161 accttgtctg tcagataaga tttttacctg gaaattccat gaccaataca tgtgcaaaag
     2221 aaaatgatgg gttgaattta ctgattattg acctaatgga tggcttttta aaatgtttta
     2281 ataaaaagca gaatagatgt ttgtttttct agtggttata ccaagttata cttcctgttt
     2341 tcacgtgtga aagtaacatg ggacatgcct ttcttttccg atcagtttat ttaagctata
     2401 cagcaaactt tggcatttat gtggagcatt tctcattgtt ggaatctgaa taaaccaatt
     2461 acaaaataac ata
//
