LOCUS       NM_018058               2683 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens cartilage acidic protein 1 (CRTAC1), transcript
            variant 1, mRNA.
ACCESSION   NM_018058
VERSION     NM_018058.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2683)
  AUTHORS   Beugelink,J.W., Hof,H. and Janssen,B.J.C.
  TITLE     CRTAC1 has a Compact beta-propeller-TTR Core Stabilized by
            Potassium Ions
  JOURNAL   J Mol Biol 436 (18), 168712 (2024)
   PUBMED   39029889
  REMARK    GeneRIF: CRTAC1 has a Compact beta-propeller-TTR Core Stabilized by
            Potassium Ions.
REFERENCE   2  (bases 1 to 2683)
  AUTHORS   Tan,L., Zhang,H., Ding,Y., Huang,Y. and Sun,D.
  TITLE     CRTAC1 identified as a promising diagnosis and prognostic biomarker
            in lung adenocarcinoma
  JOURNAL   Sci Rep 14 (1), 11223 (2024)
   PUBMED   38755183
  REMARK    GeneRIF: CRTAC1 identified as a promising diagnosis and prognostic
            biomarker in lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2683)
  AUTHORS   Hulme,C.H., Peffers,M.J., Roberts,S., Gallacher,P., Jermin,P. and
            Wright,K.T.
  TITLE     Proteomic Analyses of Autologous Chondrocyte Implantation Plasma
            Highlight Cartilage Acidic Protein 1 as a Candidate for Preclinical
            Screening
  JOURNAL   Am J Sports Med 51 (6), 1422-1433 (2023)
   PUBMED   37039559
  REMARK    GeneRIF: Proteomic Analyses of Autologous Chondrocyte Implantation
            Plasma Highlight Cartilage Acidic Protein 1 as a Candidate for
            Preclinical Screening.
REFERENCE   4  (bases 1 to 2683)
  AUTHORS   He,J., Dong,C., Zhang,H., Jiang,Y., Liu,T. and Man,X.
  TITLE     The oncogenic role of TFAP2A in bladder urothelial carcinoma via a
            novel long noncoding RNA TPRG1-AS1/DNMT3A/CRTAC1 axis
  JOURNAL   Cell Signal 102, 110527 (2023)
   PUBMED   36410635
  REMARK    GeneRIF: The oncogenic role of TFAP2A in bladder urothelial
            carcinoma via a novel long noncoding RNA TPRG1-AS1/DNMT3A/CRTAC1
            axis.
REFERENCE   5  (bases 1 to 2683)
  AUTHORS   Brems,H., Park,C., Maertens,O., Pemov,A., Messiaen,L.,
            Upadhyaya,M., Claes,K., Beert,E., Peeters,K., Mautner,V.,
            Sloan,J.L., Yao,L., Lee,C.C., Sciot,R., De Smet,L., Legius,E. and
            Stewart,D.R.
  TITLE     Glomus tumors in neurofibromatosis type 1: genetic, functional, and
            clinical evidence of a novel association
  JOURNAL   Cancer Res 69 (18), 7393-7401 (2009)
   PUBMED   19738042
  REMARK    Erratum:[Cancer Res. 2009 Oct 15;69(20):8216. Messia, Ludwine
            [corrected to Messiaen, Ludwine]]
REFERENCE   6  (bases 1 to 2683)
  AUTHORS   Turner,H.C., Budak,M.T., Akinci,M.A. and Wolosin,J.M.
  TITLE     Comparative analysis of human conjunctival and corneal epithelial
            gene expression with oligonucleotide microarrays
  JOURNAL   Invest Ophthalmol Vis Sci 48 (5), 2050-2061 (2007)
   PUBMED   17460260
REFERENCE   7  (bases 1 to 2683)
  AUTHORS   Steck,E., Braun,J., Pelttari,K., Kadel,S., Kalbacher,H. and
            Richter,W.
  TITLE     Chondrocyte secreted CRTAC1: a glycosylated extracellular matrix
            molecule of human articular cartilage
  JOURNAL   Matrix Biol 26 (1), 30-41 (2007)
   PUBMED   17074475
  REMARK    GeneRIF: CRTAC1 acquired an alternate last exon from the
            tail-to-tail oriented neighbouring gene in humans resulting in the
            glycosylated isoform CRTAC1-A which represents a new extracellular
            matrix molecule of articular cartilage.
REFERENCE   8  (bases 1 to 2683)
  AUTHORS   Warzecha,J., Gottig,S., Bruning,C., Lindhorst,E., Arabmothlagh,M.
            and Kurth,A.
  TITLE     Sonic hedgehog protein promotes proliferation and chondrogenic
            differentiation of bone marrow-derived mesenchymal stem cells in
            vitro
  JOURNAL   J Orthop Sci 11 (5), 491-496 (2006)
   PUBMED   17013738
REFERENCE   9  (bases 1 to 2683)
  AUTHORS   Benz,K., Breit,S., Lukoschek,M., Mau,H. and Richter,W.
  TITLE     Molecular analysis of expansion, differentiation, and growth factor
            treatment of human chondrocytes identifies differentiation markers
            and growth-related genes
  JOURNAL   Biochem Biophys Res Commun 293 (1), 284-292 (2002)
   PUBMED   12054597
REFERENCE   10 (bases 1 to 2683)
  AUTHORS   Steck,E., Benz,K., Lorenz,H., Loew,M., Gress,T. and Richter,W.
  TITLE     Chondrocyte expressed protein-68 (CEP-68), a novel human marker
            gene for cultured chondrocytes
  JOURNAL   Biochem J 353 (Pt 2), 169-174 (2001)
   PUBMED   11139377
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK057190.1, AJ276171.1 and
            AA485276.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_018058.6.
            
            Summary: This gene encodes a glycosylated extracellular matrix
            protein that is found in the interterritorial matrix of articular
            deep zone cartilage. This protein is used as a marker to
            distinguish chondrocytes from osteoblasts and mesenchymal stem
            cells in culture. The presence of FG-GAP motifs and an RGD
            integrin-binding motif suggests that this protein may be involved
            in cell-cell or cell-matrix interactions. Copy number alterations
            in this gene have been observed in neurofibromatosis type
            1-associated glomus tumors. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1, also known as CRTAC1-A)
            represents the longer transcript and encodes the longer isoform
            (A).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ276171.1, AK057190.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370597.8/ ENSP00000359629.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-880               AK057190.1         208-1087
            881-2681            AJ276171.1         881-2681
            2682-2683           AA485276.1         23-24               c
FEATURES             Location/Qualifiers
     source          1..2683
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.2"
     gene            1..2683
                     /gene="CRTAC1"
                     /gene_synonym="ASPIC; ASPIC1; CEP-68; CEP68; LOTUS"
                     /note="cartilage acidic protein 1"
                     /db_xref="GeneID:55118"
                     /db_xref="HGNC:HGNC:14882"
                     /db_xref="MIM:606276"
     exon            1..173
                     /gene="CRTAC1"
                     /gene_synonym="ASPIC; ASPIC1; CEP-68; CEP68; LOTUS"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..2135
                     /gene="CRTAC1"
                     /gene_synonym="ASPIC; ASPIC1; CEP-68; CEP68; LOTUS"
                     /note="isoform A precursor is encoded by transcript
                     variant 1; chondrocyte expressed protein 68 kDa CEP-68;
                     acidic secreted protein in cartilage"
                     /codon_start=1
                     /product="cartilage acidic protein 1 isoform A precursor"
                     /protein_id="NP_060528.3"
                     /db_xref="CCDS:CCDS31266.1"
                     /db_xref="GeneID:55118"
                     /db_xref="HGNC:HGNC:14882"
                     /db_xref="MIM:606276"
                     /translation="MAPSADPGMSRMLPFLLLLWFLPITEGSQRAEPMFTAVTNSVLP
                     PDYDSNPTQLNYGVAVTDVDHDGDFEIVVAGYNGPNLVLKYDRAQKRLVNIAVDERSS
                     PYYALRDRQGNAIGVTACDIDGDGREEIYFLNTNNAFSGVATYTDKLFKFRNNRWEDI
                     LSDEVNVARGVASLFAGRSVACVDRKGSGRYSIYIANYAYGNVGPDALIEMDPEASDL
                     SRGILALRDVAAEAGVSKYTGGRGVSVGPILSSSASDIFCDNENGPNFLFHNRGDGTF
                     VDAAASAGVDDPHQHGRGVALADFNRDGKVDIVYGNWNGPHRLYLQMSTHGKVRFRDI
                     ASPKFSMPSPVRTVITADFDNDQELEIFFNNIAYRSSSANRLFRVIRREHGDPLIEEL
                     NPGDALEPEGRGTGGVVTDFDGDGMLDLILSHGESMAQPLSVFRGNQGFNNNWLRVVP
                     RTRFGAFARGAKVVLYTKKSGAHLRIIDGGSGYLCEMEPVAHFGLGKDEASSVEVTWP
                     DGKMVSRNVASGEMNSVLEILYPRDEDTLQDPAPLECGQGFSQQENGHCMDTNECIQF
                     PFVCPRDKPVCVNTYGSYRCRTNKKCSRGYEPNEDGTACVGTLGQSPGPRPTTPTAAA
                     ATAAAAAAAGAATAAPVLVDGDLNLGSVVKESCEPSC"
     exon            174..373
                     /gene="CRTAC1"
                     /gene_synonym="ASPIC; ASPIC1; CEP-68; CEP68; LOTUS"
                     /inference="alignment:Splign:2.1.0"
     exon            374..570
                     /gene="CRTAC1"
                     /gene_synonym="ASPIC; ASPIC1; CEP-68; CEP68; LOTUS"
                     /inference="alignment:Splign:2.1.0"
     exon            571..707
                     /gene="CRTAC1"
                     /gene_synonym="ASPIC; ASPIC1; CEP-68; CEP68; LOTUS"
                     /inference="alignment:Splign:2.1.0"
     exon            708..864
                     /gene="CRTAC1"
                     /gene_synonym="ASPIC; ASPIC1; CEP-68; CEP68; LOTUS"
                     /inference="alignment:Splign:2.1.0"
     exon            865..999
                     /gene="CRTAC1"
                     /gene_synonym="ASPIC; ASPIC1; CEP-68; CEP68; LOTUS"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1145
                     /gene="CRTAC1"
                     /gene_synonym="ASPIC; ASPIC1; CEP-68; CEP68; LOTUS"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1282
                     /gene="CRTAC1"
                     /gene_synonym="ASPIC; ASPIC1; CEP-68; CEP68; LOTUS"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1365
                     /gene="CRTAC1"
                     /gene_synonym="ASPIC; ASPIC1; CEP-68; CEP68; LOTUS"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1466
                     /gene="CRTAC1"
                     /gene_synonym="ASPIC; ASPIC1; CEP-68; CEP68; LOTUS"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1635
                     /gene="CRTAC1"
                     /gene_synonym="ASPIC; ASPIC1; CEP-68; CEP68; LOTUS"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..1781
                     /gene="CRTAC1"
                     /gene_synonym="ASPIC; ASPIC1; CEP-68; CEP68; LOTUS"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1824
                     /gene="CRTAC1"
                     /gene_synonym="ASPIC; ASPIC1; CEP-68; CEP68; LOTUS"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1968
                     /gene="CRTAC1"
                     /gene_synonym="ASPIC; ASPIC1; CEP-68; CEP68; LOTUS"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2683
                     /gene="CRTAC1"
                     /gene_synonym="ASPIC; ASPIC1; CEP-68; CEP68; LOTUS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2648..2653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRTAC1"
                     /gene_synonym="ASPIC; ASPIC1; CEP-68; CEP68; LOTUS"
                     /note="hexamer: AACAAG"
     polyA_site      2683
                     /gene="CRTAC1"
                     /gene_synonym="ASPIC; ASPIC1; CEP-68; CEP68; LOTUS"
                     /note="major polyA site"
ORIGIN      
        1 gtataaagcg agcgcgcggc gtcggggcgg gaggctcgag gccagcccgg gaccggggct
       61 gggagcaagc aggcggcggc gccggcggca gaggcggcag cgagcgcccg cttcccacgc
      121 ccctaggcgg cggggccgag agcgggagga tggctccgag cgctgacccc ggcatgtcca
      181 ggatgttacc gttcctgctg ctgctctggt ttctgcccat cactgagggg tcccagcggg
      241 ctgaacccat gttcactgca gtcaccaact cagttctgcc tcctgactat gacagtaatc
      301 ccacccagct caactatggt gtggcagtta ctgatgtgga ccatgatggg gactttgaga
      361 tcgtcgtggc ggggtacaat ggacccaacc tggttctgaa gtatgaccgg gcccagaagc
      421 ggctggtgaa catcgcggtc gatgagcgca gctcacccta ctacgcgctg cgggaccggc
      481 aggggaacgc catcggggtc acagcctgcg acatcgacgg ggacggccgg gaggagatct
      541 acttcctcaa caccaataat gccttctcgg gggtggccac gtacaccgac aagttgttca
      601 agttccgcaa taaccggtgg gaagacatcc tgagcgatga ggtcaacgtg gcccgtggtg
      661 tggccagcct ctttgccgga cgctctgtgg cctgtgtgga cagaaagggc tctggacgct
      721 actctatcta cattgccaat tacgcctacg gtaatgtggg ccctgatgcc ctcattgaaa
      781 tggaccctga ggccagtgac ctctcccggg gcattctggc gctcagagat gtggctgctg
      841 aggctggggt cagcaaatat acagggggcc gaggcgtcag cgtgggcccc atcctcagca
      901 gcagtgcctc ggatatcttc tgcgacaatg agaatgggcc taacttcctt ttccacaacc
      961 ggggcgatgg cacctttgtg gacgctgcgg ccagtgctgg tgtggacgac ccccaccagc
     1021 atgggcgagg tgtcgccctg gctgacttca accgtgatgg caaagtggac atcgtctatg
     1081 gcaactggaa tggcccccac cgcctctatc tgcaaatgag cacccatggg aaggtccgct
     1141 tccgggacat cgcctcaccc aagttctcca tgccctcccc tgtccgcacg gtcatcaccg
     1201 ccgactttga caatgaccag gagctggaga tcttcttcaa caacattgcc taccgcagct
     1261 cctcagccaa ccgcctcttc cgcgtcatcc gtagagagca cggagacccc ctcatcgagg
     1321 agctcaatcc cggcgacgcc ttggagcctg agggccgggg cacagggggt gtggtgaccg
     1381 acttcgacgg agacgggatg ctggacctca tcttgtccca tggagagtcc atggctcagc
     1441 cgctgtccgt cttccggggc aatcagggct tcaacaacaa ctggctgcga gtggtgccac
     1501 gcacccggtt tggggccttt gccaggggag ctaaggtcgt gctctacacc aagaagagtg
     1561 gggcccacct gaggatcatc gacgggggct caggctacct gtgtgagatg gagcccgtgg
     1621 cacactttgg cctggggaag gatgaagcca gcagtgtgga ggtgacgtgg ccagatggca
     1681 agatggtgag ccggaacgtg gccagcgggg agatgaactc agtgctggag atcctctacc
     1741 cccgggatga ggacacactt caggacccag ccccactgga gtgtggccaa ggattctccc
     1801 agcaggaaaa tggccattgc atggacacca atgaatgcat ccagttccca ttcgtgtgcc
     1861 ctcgagacaa gcccgtatgt gtcaacacct atggaagcta caggtgccgg accaacaaga
     1921 agtgcagtcg gggctacgag cccaacgagg atggcacagc ctgcgtgggg actctcggcc
     1981 agtcaccggg cccccgcccc accaccccca ccgctgctgc tgccactgcc gctgctgctg
     2041 ccgctgctgg agctgccact gctgcaccgg tcctcgtaga tggagatctc aatctggggt
     2101 cggtggttaa ggagagctgc gagcccagct gctgagcagg ggtgggacat gaaccagcgg
     2161 atggagtcca gcaggggagt gggaaagtgg gcttgtgctg ctgcctagac agtagggatg
     2221 taaaggcctg ggagctagac cctccccaag cccatccatg cacattactt agctaacaat
     2281 tagggagact cgtaaggcca ggccctgtgc tgggcacata gctgtgatca cagcagacag
     2341 ggtcgctgcc ctgatggcgc ttacattcca gtgggtctaa tgaccatatc ttaggacaca
     2401 gatgtgccca gggaggtggt gtcactgcac aggaagtatg aggactttag tgtcctgagt
     2461 tcaaatcctg attcaggaac tcacaaagct atgtgacctt acaccagtca cttaacttgt
     2521 tagccatcca ttatcgcatc tgcaaaatgg ggattaagaa tagaatcttg gggttagtgt
     2581 ggagattaga ttaaatgtat gtaagacact tggcacaaaa cctggcacat agtaaaggct
     2641 caataaaaac aagtgcctct cactgggctt tgtcaacacg tga
//
