LOCUS       NM_001101426            5742 bp    mRNA    linear   PRI 07-OCT-2024
DEFINITION  Homo sapiens CDP-L-ribitol pyrophosphorylase A (CRPPA), transcript
            variant 1, mRNA.
ACCESSION   NM_001101426 XM_001126777 XM_001131763 XM_001132057
VERSION     NM_001101426.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5742)
  AUTHORS   Hu,Q., Gu,Y., Chen,S., Tian,Y. and Yang,S.
  TITLE     Hsa_circ_0079480 promotes tumor progression in acute myeloid
            leukemia via miR-654-3p/HDGF axis
  JOURNAL   Aging (Albany NY) 13 (1), 1120-1131 (2020)
   PUBMED   33290265
  REMARK    GeneRIF: Hsa_circ_0079480 promotes tumor progression in acute
            myeloid leukemia via miR-654-3p/HDGF axis.
REFERENCE   2  (bases 1 to 5742)
  AUTHORS   Song,D., Fu,X., Ge,L., Chang,X., Wei,C., Liu,J., Yang,H., Qu,S.,
            Bao,X., Toda,T., Wu,X. and Xiong,H.
  TITLE     A splice site mutation c.1251G>A of ISPD gene is a common cause of
            congenital muscular dystrophy in Chinese patients
  JOURNAL   Clin Genet 97 (5), 789-790 (2020)
   PUBMED   31909476
  REMARK    GeneRIF: A splice site mutation c.1251G>A of ISPD gene is a common
            cause of congenital muscular dystrophy in Chinese patients.
REFERENCE   3  (bases 1 to 5742)
  AUTHORS   Sheikh,M.O., Halmo,S.M. and Wells,L.
  TITLE     Recent advancements in understanding mammalian O-mannosylation
  JOURNAL   Glycobiology 27 (9), 806-819 (2017)
   PUBMED   28810660
  REMARK    Review article
REFERENCE   4  (bases 1 to 5742)
  AUTHORS   Gerin,I., Ury,B., Breloy,I., Bouchet-Seraphin,C., Bolsee,J.,
            Halbout,M., Graff,J., Vertommen,D., Muccioli,G.G., Seta,N.,
            Cuisset,J.M., Dabaj,I., Quijano-Roy,S., Grahn,A., Van
            Schaftingen,E. and Bommer,G.T.
  TITLE     ISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol
            phosphate onto alpha-dystroglycan
  JOURNAL   Nat Commun 7, 11534 (2016)
   PUBMED   27194101
  REMARK    GeneRIF: ISPD and FKTN are essential for the incorporation of
            ribitol into alpha-dystroglycan.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5742)
  AUTHORS   Takata,R., Matsuda,K., Sugimura,J., Obara,W., Fujioka,T.,
            Okihara,K., Takaha,N., Miki,T., Ashida,S., Inoue,K., Tanikawa,C.,
            Shuin,T., Sasaki,S., Kojima,Y., Kohri,K., Kubo,M., Yamaguchi,M.,
            Ohnishi,Y. and Nakamura,Y.
  TITLE     Impact of four loci on serum tamsulosin hydrochloride concentration
  JOURNAL   J Hum Genet 58 (1), 21-26 (2013)
   PUBMED   23151678
REFERENCE   6  (bases 1 to 5742)
  AUTHORS   Vuillaumier-Barrot,S., Bouchet-Seraphin,C., Chelbi,M., Devisme,L.,
            Quentin,S., Gazal,S., Laquerriere,A., Fallet-Bianco,C., Loget,P.,
            Odent,S., Carles,D., Bazin,A., Aziza,J., Clemenson,A., Guimiot,F.,
            Bonniere,M., Monnot,S., Bole-Feysot,C., Bernard,J.P., Loeuillet,L.,
            Gonzales,M., Socha,K., Grandchamp,B., Attie-Bitach,T.,
            Encha-Razavi,F. and Seta,N.
  TITLE     Identification of mutations in TMEM5 and ISPD as a cause of severe
            cobblestone lissencephaly
  JOURNAL   Am J Hum Genet 91 (6), 1135-1143 (2012)
   PUBMED   23217329
  REMARK    GeneRIF: TMEM5 mutations were frequently associated with gonadal
            dysgenesis and neural tube defects, and ISPD mutations were
            frequently associated with brain vascular anomalies.
REFERENCE   7  (bases 1 to 5742)
  AUTHORS   Roscioli,T., Kamsteeg,E.J., Buysse,K., Maystadt,I., van
            Reeuwijk,J., van den Elzen,C., van Beusekom,E., Riemersma,M.,
            Pfundt,R., Vissers,L.E., Schraders,M., Altunoglu,U., Buckley,M.F.,
            Brunner,H.G., Grisart,B., Zhou,H., Veltman,J.A., Gilissen,C.,
            Mancini,G.M., Delree,P., Willemsen,M.A., Ramadza,D.P., Chitayat,D.,
            Bennett,C., Sheridan,E., Peeters,E.A., Tan-Sindhunata,G.M., de
            Die-Smulders,C.E., Devriendt,K., Kayserili,H., El-Hashash,O.A.,
            Stemple,D.L., Lefeber,D.J., Lin,Y.Y. and van Bokhoven,H.
  TITLE     Mutations in ISPD cause Walker-Warburg syndrome and defective
            glycosylation of alpha-dystroglycan
  JOURNAL   Nat Genet 44 (5), 581-585 (2012)
   PUBMED   22522421
  REMARK    GeneRIF: Mutations in ISPD cause Walker-Warburg syndrome and
            defective glycosylation of alpha-dystroglycan.
REFERENCE   8  (bases 1 to 5742)
  AUTHORS   Willer,T., Lee,H., Lommel,M., Yoshida-Moriguchi,T., de
            Bernabe,D.B., Venzke,D., Cirak,S., Schachter,H., Vajsar,J.,
            Voit,T., Muntoni,F., Loder,A.S., Dobyns,W.B., Winder,T.L.,
            Strahl,S., Mathews,K.D., Nelson,S.F., Moore,S.A. and Campbell,K.P.
  TITLE     ISPD loss-of-function mutations disrupt dystroglycan
            O-mannosylation and cause Walker-Warburg syndrome
  JOURNAL   Nat Genet 44 (5), 575-580 (2012)
   PUBMED   22522420
  REMARK    GeneRIF: ISPD loss-of-function mutations disrupt dystroglycan
            O-mannosylation and cause Walker-Warburg syndrome.
REFERENCE   9  (bases 1 to 5742)
  AUTHORS   Sparks,S.E., Quijano-Roy,S., Harper,A., Rutkowski,A., Gordon,E.,
            Hoffman,E.P. and Pegoraro,E.
  TITLE     Congenital Muscular Dystrophy Overview - RETIRED CHAPTER, FOR
            HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301468
REFERENCE   10 (bases 1 to 5742)
  AUTHORS   Wylam,M.E., Samsel,R.W., Umans,J.G., Mitchell,R.W., Leff,A.R. and
            Schumacker,P.T.
  TITLE     Endotoxin in vivo impairs endothelium-dependent relaxation of
            canine arteries in vitro
  JOURNAL   Am Rev Respir Dis 142 (6 Pt 1), 1263-1267 (1990)
   PUBMED   2252242
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC079155.7, AC004741.2,
            AC073629.6 and AC006035.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001101426.3.
            
            Summary: This gene encodes a 2-C-methyl-D-erythritol 4-phosphate
            cytidylyltransferase-like protein. Mutations in this gene are the
            cause of Walker-Warburg syndrome. Alternate splicing results in
            multiple transcript variants. [provided by RefSeq, May 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longest isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. The full extent of this transcript
            is supported by and orthologous data in mouse (NM_178629.5).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.77161.1,
                                           SRR1660807.174457.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000407010.7/ ENSP00000385478.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-473               AC079155.7         77608-78080         c
            474-750             AC079155.7         62603-62879         c
            751-900             AC079155.7         32634-32783         c
            901-1005            AC004741.2         75327-75431         c
            1006-1051           AC004741.2         68225-68270         c
            1052-1149           AC004741.2         44933-45030         c
            1150-1242           AC004741.2         25724-25816         c
            1243-1335           AC004741.2         25194-25286         c
            1336-1467           AC073629.6         16751-16882         c
            1468-5742           AC006035.2         70382-74656         c
FEATURES             Location/Qualifiers
     source          1..5742
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p21.2"
     gene            1..5742
                     /gene="CRPPA"
                     /gene_synonym="hISPD; ISPD; LGMDR20; MDDGA7; MDDGC7; Nip"
                     /note="CDP-L-ribitol pyrophosphorylase A"
                     /db_xref="GeneID:729920"
                     /db_xref="HGNC:HGNC:37276"
                     /db_xref="MIM:614631"
     exon            1..473
                     /gene="CRPPA"
                     /gene_synonym="hISPD; ISPD; LGMDR20; MDDGA7; MDDGC7; Nip"
                     /inference="alignment:Splign:2.1.0"
     CDS             217..1572
                     /gene="CRPPA"
                     /gene_synonym="hISPD; ISPD; LGMDR20; MDDGA7; MDDGC7; Nip"
                     /EC_number="2.7.7.40"
                     /note="isoform a is encoded by transcript variant 1;
                     4-diphosphocytidyl-2C-methyl-D-erythritol synthase
                     homolog; notch1-induced protein; 2-C-methyl-D-erythritol
                     4-phosphate cytidylyltransferase-like protein; testicular
                     tissue protein Li 97; D-ribitol-5-phosphate
                     cytidylyltransferase; isoprenoid synthase domain
                     containing"
                     /codon_start=1
                     /product="D-ribitol-5-phosphate cytidylyltransferase
                     isoform a"
                     /protein_id="NP_001094896.1"
                     /db_xref="GeneID:729920"
                     /db_xref="HGNC:HGNC:37276"
                     /db_xref="MIM:614631"
                     /translation="MEAGPPGSARPAEPGPCLSGQRGADHTASASLQSVAGTEPGRHP
                     QAVAAVLPAGGCGERMGVPTPKQFCPILERPLISYTLQALERVCWIKDIVVAVTGENM
                     EVMKSIIQKYQHKRISLVEAGVTRHRSIFNGLKALAEDQINSKLSKPEVVIIHDAVRP
                     FVEEGVLLKVVTAAKEHGAAGAIRPLVSTVVSPSADGCLDYSLERARHRASEMPQAFL
                     FDVIYEAYQQCSDYDLEFGTECLQLALKYCCTKAKLVEGSPDLWKVTYKRDLYAAESI
                     IKERISQEICVVMDTEEDNKHVGHLLEEVLKSELNHVKVTSEALGHAGRHLQQIILDQ
                     CYNFVCVNVTTSDFQETQKLLSMLEESSLCILYPVVVVSVHFLDFKLVPPSQKMENLM
                     QIREFAKEVKERNILLYGLLISYPQDDQKLQESLRQGAIIIASLIKERNSGLIGQLLI
                     A"
     exon            474..750
                     /gene="CRPPA"
                     /gene_synonym="hISPD; ISPD; LGMDR20; MDDGA7; MDDGC7; Nip"
                     /inference="alignment:Splign:2.1.0"
     exon            751..900
                     /gene="CRPPA"
                     /gene_synonym="hISPD; ISPD; LGMDR20; MDDGA7; MDDGC7; Nip"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1005
                     /gene="CRPPA"
                     /gene_synonym="hISPD; ISPD; LGMDR20; MDDGA7; MDDGC7; Nip"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1051
                     /gene="CRPPA"
                     /gene_synonym="hISPD; ISPD; LGMDR20; MDDGA7; MDDGC7; Nip"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1149
                     /gene="CRPPA"
                     /gene_synonym="hISPD; ISPD; LGMDR20; MDDGA7; MDDGC7; Nip"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1242
                     /gene="CRPPA"
                     /gene_synonym="hISPD; ISPD; LGMDR20; MDDGA7; MDDGC7; Nip"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1335
                     /gene="CRPPA"
                     /gene_synonym="hISPD; ISPD; LGMDR20; MDDGA7; MDDGC7; Nip"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1467
                     /gene="CRPPA"
                     /gene_synonym="hISPD; ISPD; LGMDR20; MDDGA7; MDDGC7; Nip"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..5742
                     /gene="CRPPA"
                     /gene_synonym="hISPD; ISPD; LGMDR20; MDDGA7; MDDGC7; Nip"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1744..1749
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRPPA"
                     /gene_synonym="hISPD; ISPD; LGMDR20; MDDGA7; MDDGC7; Nip"
                     /note="hexamer: AATAAA"
     polyA_site      1771
                     /gene="CRPPA"
                     /gene_synonym="hISPD; ISPD; LGMDR20; MDDGA7; MDDGC7; Nip"
     regulatory      2061..2066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRPPA"
                     /gene_synonym="hISPD; ISPD; LGMDR20; MDDGA7; MDDGC7; Nip"
                     /note="hexamer: AATAAA"
     polyA_site      2081
                     /gene="CRPPA"
                     /gene_synonym="hISPD; ISPD; LGMDR20; MDDGA7; MDDGC7; Nip"
                     /note="major polyA site"
     regulatory      5718..5723
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRPPA"
                     /gene_synonym="hISPD; ISPD; LGMDR20; MDDGA7; MDDGC7; Nip"
                     /note="hexamer: AATAAA"
     polyA_site      5742
                     /gene="CRPPA"
                     /gene_synonym="hISPD; ISPD; LGMDR20; MDDGA7; MDDGC7; Nip"
                     /note="major polyA site"
ORIGIN      
        1 agatcggcag cctcagctgc tgccgtagct gtcgggatcg tcccctgcgg ggcagcaaca
       61 gcggggctcc gacggctgag gggggcgcct tctgcttgcg cgctctgcgt ccctctccgt
      121 ggtctgccct tcgccccgcg accccggccg agggtgggag cagcgcgggg tcgcatcggc
      181 ccgaggctag cggggctcgc cgttccgccc gcagccatgg aggccgggcc gccgggcagc
      241 gccaggccgg cggagccggg tccttgcctg agtggtcagc gcggcgcgga ccacacggct
      301 tccgcctccc tgcagagcgt ggccgggacc gagcccgggc gccacccgca agccgtggca
      361 gctgtgttgc ctgccggggg gtgcggggag aggatggggg tccccacccc gaagcaattc
      421 tgccccatcc tggagaggcc gctcatcagc tacaccctac aggccctgga gagagtatgt
      481 tggataaagg acattgttgt ggcagtaact ggagagaaca tggaagtaat gaaaagtatt
      541 attcagaagt atcagcataa acgcatctca ctggtcgaag ctggagtgac ccgccacagg
      601 tcaattttca atggactaaa agcactggca gaagatcaga tcaactctaa actctctaag
      661 ccagaagtag tgattatcca tgatgctgtg agaccatttg ttgaggaagg tgtccttctt
      721 aaagttgtca cagctgctaa ggaacacggg gcagcaggag ccattcgacc tcttgtatct
      781 actgtcgtca gtccatctgc tgatggttgc ttagactact cgctagaacg tgccagacac
      841 agagcaagtg aaatgcccca agcttttcta tttgatgtga tttatgaagc atatcagcag
      901 tgtagtgact atgacttgga atttggaact gagtgtttgc aattggccct aaaatactgt
      961 tgcactaaag ccaaacttgt agaaggatca cctgacctct ggaaggtgac ctacaaacga
     1021 gatctctatg cggctgaatc gattattaag gagagaattt cccaagagat ttgtgtagtt
     1081 atggatacag aagaagataa caaacatgta ggtcatcttc ttgaagaagt gctgaaaagt
     1141 gaattaaatc atgtaaaagt cacatctgag gctctgggtc atgctggcag acatcttcag
     1201 caaatcatct tagatcaatg ctacaatttt gtttgtgtga atgttacaac ctctgatttt
     1261 caagaaaccc agaagttact gagcatgctt gaagagagta gtctttgcat tttatatcct
     1321 gttgttgttg tttcagttca ttttcttgat tttaaattag tacctcccag tcagaaaatg
     1381 gaaaacctaa tgcagattag agaatttgca aaggaagtaa aagaaagaaa tattttgtta
     1441 tatgggcttc tcatatctta cccacaggat gatcagaagc tacaggagag tttaaggcaa
     1501 ggtgctatca ttattgcttc attaatcaag gaaagaaatt ctggactcat tggtcagctt
     1561 ctgatagcat gaagaacaca aaaaattacc tattttctaa aacatctatt tgcgtatctt
     1621 aattgtgctt tgtgcccccg ctgctgtgtg tggtagaatg tttcagttgt cttttatatc
     1681 ttctctataa tttgtaggat gtgatgctta gattataaag cagattaatg tttatatctg
     1741 tgaaataaag aatacttttg tgtatgacaa atattaattg cctgaaccag aaaaaaatag
     1801 tagataagtg gaaaataata gccttcaaat gaatctttcc acagagacat gaacggtcaa
     1861 atagaaataa tgatggggtg agctattctt tcaaggaatg agaatttaga aaacttcagt
     1921 tattatccta actgttaatt aataatttac actattatga agctaatgga taaacttcag
     1981 aattattctc acttctataa ttgtcctgtc accaggtgat attttgtctt tttgtcttgt
     2041 gttaaaaatg tctacacttt aataaaaaag ggtgagtggg ataccaggga acggaactgt
     2101 ttgtttctag cattttcccc atttgccaca tattactcaa gatccctaaa acagatgtca
     2161 tttccttctt ttctgttttt aaattgtatg ttatttttgg tttatgaact ataattatga
     2221 cttacattat tttaaagggt ctctagtttt tctgaatgaa cttaaaagtg tctggaaagt
     2281 ttcgtaggtg attctggtca atccctggtt agttatcttc tataaggtag agaatctatt
     2341 gtacatcata gagttaaatt agttatttca attcagatac tgctaccttt taaaatcaag
     2401 ttcttatttc cagttttcat tggtatatac atctgaaata ttaatatttt cccttgcatg
     2461 ttataattat gggtgtcctt taattcatta gaggtgactt ttaatctata catacactta
     2521 ctctatttat tttatttttt attgttttga aatgcagtcg ccctctgtca ggctggagtg
     2581 cagtggcaca atctcagctg actgcaacct ctgcctcctg ggtttaagca attatcctcc
     2641 ctcagcctcc cgagtagctg ggattacagg cacctgccac cacacctggc taattttttt
     2701 tttttttttt tttttttgta tttttagtag agaagggttt tcgccatgta ggccaggctg
     2761 gtcttgaact cctgacctca agtgatctgc ctgcctcggc ctcccaaaat gctgggatta
     2821 taggtgtgag ccaccatacc cagccaacat acatttattt tattgaaaca gattagggct
     2881 taggctgcac gtggaaacta taaaagttgc atgaagtgtt ttcagttaaa gatacactat
     2941 acaatatcta ccttgtggaa tttttattta acatgttggg tgattttccc tctagtgttc
     3001 aagtatatat atagtaggag agtttatatt ttacattctc ctaattgaaa tgtgttattt
     3061 gaatgtaggc ttgtatctaa attcctgggc ctgccctttt tctctctcta ggaatattaa
     3121 gaaatttaaa atccattaat ttaagttttt gaggatggaa ataggtaagc aatgtgtgga
     3181 ttgtggttag gaatgtctgt gcctttgttc agatgtcggc tgtgtgtgtg acgaaaacca
     3241 cagctgccaa gtccccaaca tgcacctgtt gaagtcatca ggtgaaaatg tttaagactt
     3301 tgaaagtgct cataaaggaa gaaggggaaa tgttatcaag gctttaaaga gagggtaagt
     3361 gccttgaaga agaatgcagt aaactgggca tatttgtggc acagcaaaat caccctgatc
     3421 gctggagtgc tggctgagtt aacatagact tcagcttaag gaatcctaca gcagacaaga
     3481 atttatctca gagtacttac tatgacatta ccctaggcaa ctggtaacat ttagtataat
     3541 ttagttaata aaatattaag ttgtgcctgg aaaaaatagc atttggtcct tcatagcagg
     3601 caaagcaatt cacagcattg ggaaaaaaaa atacatacat acatatacat gtatgtatac
     3661 ccatatatat gtatatacat gcatgtatac ccatatatat gtatatactt acatgtatat
     3721 acatatatat gtatgtacgt acatatatac ccatatctat gtatgtacgt acatatatac
     3781 ccgtatatat gtacgtacat atatacacat atatgtatgc acgtacatat atacacatat
     3841 atgtatgtac gtacatatat acacattatg tacatacata tatacgtata tatgtacatg
     3901 catgtatgta tgtatatacg tacgcataca cacatatatt tatatacgta cgcatacaca
     3961 catatatgta tatacgtacg catacacaca tatatgtata tacgtacgca tacacacata
     4021 tatgtatata cgtacgcata cacacatata tgtatatacg tacgtatata cacacatata
     4081 tgtatatacg tacgtatata tgtattttta tgttttatgt atatgtattt tatatgtata
     4141 tatatctgca catccttcac tattttcatg aggaaattgg agctcaggga tcttagttac
     4201 cttgccaaaa tcatgtgact gaatagtaac aaaagtttgg gcttaaaata aggaagactg
     4261 ataataagtg ttaagcttat attcctgtct aacaatgacc cctggcaaag acatctgata
     4321 tataagccac gtctgatata taagacgtga tatataagcc agaggcactg aatgaacatt
     4381 ggcgaaatgg acaagaaggg tgggacactt atgtccaggg actaggtgaa agtcctggag
     4441 cttttggctt tccagccacc ttcccagcat aaagaaattg tagctaaagt taagggaatg
     4501 aatagaagta ttggccaaaa gagaaattat tttgttgttt aagagatctg gccgggcgcg
     4561 atggctcacg cctgaaatcc cagcactttg ggaggccgag gcaggcagat tacgaggtca
     4621 ggagatccag accatcctgg ctaatgcggt gaaaccccgt ctctagtaaa aatacaaaaa
     4681 aaatagccag gcatcgtggc gggcgcctgt agtcccagct actcaggagg cttaggcagg
     4741 agaatggcgt caacctggga ggcggagctt gcagtgagcc gacatagcgc cactgcactc
     4801 cagcctgggc aacagagcaa gactccgtct caaaaaaaaa aaaaaaaaaa aaaagagaga
     4861 tccagaggta actttacagt tacattttca tcactgcttc tgtaaattta ctttagtaaa
     4921 agctgtctat tctcacttta ttttccaaaa tctcttaaaa aataatagtg attatgcttc
     4981 aaggtttctg aaaatgcttc cacttgtggg aaattttgtt gcaaaatggt tttctttcta
     5041 aacttacgct agttagttaa atgcaaatta aagttagtcg tcttaggagt tcatcatagc
     5101 gtgagtaatg gtttgattaa tgacattttg gtagaggtcc tatttttttt cataaaagtg
     5161 ctcaatttga gatgacttgt tgcaagtata ctcatttaca ggtaagagtc agctccctat
     5221 attctctcag agtcattgtt atggttatta ttgtaagtat tttacattaa tttaacagaa
     5281 attttttctt ccctaactta taactcaact ttatgtaaat acagtgatca tcttataaaa
     5341 atcaaattac agaatgtctt aaaatctgta aatttgactt tgttttaatg ttgaaactac
     5401 aaattcacag aggcataaat ctaacatctt aattaaaatg tcaaccatat gcaagaagaa
     5461 agatagaagt tatttagaaa gtttaatttg aaaacagaat aatgaagcat tttaattgat
     5521 ataggatttg ttagtatggc ttaaaatcag tggactagaa gtagctgtgt aggtggtggt
     5581 tggcattata gttgcattta tatatgttct tattaatttc agtttcaaaa ttgtaagaag
     5641 catatgcata tttttaaggt gacattgaaa agtactataa agattctaaa tatgttgttt
     5701 ttacaaaaca aaatgtaaat aaattattga tttaaaatct aa
//
