LOCUS       NM_000567               2015 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens C-reactive protein (CRP), transcript variant 2, mRNA.
ACCESSION   NM_000567
VERSION     NM_000567.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2015)
  AUTHORS   Noone,D.P., Isendoorn,M.M.E., Hamers,S.M.W.R., Keizer,M.E.,
            Wulffele,J., van der Velden,T.T., Dijkstra,D.J., Trouw,L.A.,
            Filippov,D.V. and Sharp,T.H.
  TITLE     Structural basis for surface activation of the classical complement
            cascade by the short pentraxin C-reactive protein
  JOURNAL   Proc Natl Acad Sci U S A 121 (37), e2404542121 (2024)
   PUBMED   39240968
  REMARK    GeneRIF: Structural basis for surface activation of the classical
            complement cascade by the short pentraxin C-reactive protein.
REFERENCE   2  (bases 1 to 2015)
  AUTHORS   Siregar,M.F., Terauchi,M., Tobing,I.D., Lubis,R.B., Azmeila,S.,
            Pasaribu,H.P., Prabudi,O., Ardiansyah,E. and Effendi,I.H.
  TITLE     Role of estradiol and C-reactive protein levels on genitourinary
            syndrome in menopausal women
  JOURNAL   Narra J 4 (2), e626 (2024)
   PUBMED   39280318
  REMARK    GeneRIF: Role of estradiol and C-reactive protein levels on
            genitourinary syndrome in menopausal women.
REFERENCE   3  (bases 1 to 2015)
  AUTHORS   Zhou,H.H., Tang,Y.L., Xu,T.H. and Cheng,B.
  TITLE     C-reactive protein: structure, function, regulation, and role in
            clinical diseases
  JOURNAL   Front Immunol 15, 1425168 (2024)
   PUBMED   38947332
  REMARK    GeneRIF: C-reactive protein: structure, function, regulation, and
            role in clinical diseases.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2015)
  AUTHORS   Ma,Y.J. and Garred,P.
  TITLE     Pentraxins in Complement Activation and Regulation
  JOURNAL   Front Immunol 9, 3046 (2018)
   PUBMED   30619374
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2015)
  AUTHORS   Lu,J., Mold,C., Du Clos,T.W. and Sun,P.D.
  TITLE     Pentraxins and Fc Receptor-Mediated Immune Responses
  JOURNAL   Front Immunol 9, 2607 (2018)
   PUBMED   30483265
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2015)
  AUTHORS   Pepys,M.B.
  TITLE     The Pentraxins 1975-2018: Serendipity, Diagnostics and Drugs
  JOURNAL   Front Immunol 9, 2382 (2018)
   PUBMED   30459761
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2015)
  AUTHORS   Badimon,L., Pena,E., Arderiu,G., Padro,T., Slevin,M., Vilahur,G.
            and Chiva-Blanch,G.
  TITLE     C-Reactive Protein in Atherothrombosis and Angiogenesis
  JOURNAL   Front Immunol 9, 430 (2018)
   PUBMED   29552019
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2015)
  AUTHORS   Oliveira,E.B., Gotschlich,C. and Liu,T.Y.
  TITLE     Primary structure of human C-reactive protein
  JOURNAL   J Biol Chem 254 (2), 489-502 (1979)
   PUBMED   762075
REFERENCE   9  (bases 1 to 2015)
  AUTHORS   Osmand,A.P., Gerwurz,H. and Friedenson,B.
  TITLE     Partial amino-acid sequences of human and rabbit C-reactive
            proteins: homology with immunoglobulins and histocompatibility
            antigens
  JOURNAL   Proc Natl Acad Sci U S A 74 (3), 1214-1218 (1977)
   PUBMED   403526
REFERENCE   10 (bases 1 to 2015)
  AUTHORS   Osmand,A.P., Friedenson,B., Gewurz,H., Painter,R.H., Hofmann,T. and
            Shelton,E.
  TITLE     Characterization of C-reactive protein and the complement
            subcomponent C1t as homologous proteins displaying cyclic
            pentameric symmetry (pentraxins)
  JOURNAL   Proc Natl Acad Sci U S A 74 (2), 739-743 (1977)
   PUBMED   265538
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG533281.1, X56214.1, X56692.1,
            BG618967.1 and AI609949.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000567.2.
            
            Summary: The protein encoded by this gene belongs to the pentraxin
            family which also includes serum amyloid P component protein and
            pentraxin 3. Pentraxins are involved in complement activation and
            amplification via communication with complement initiation pattern
            recognition molecules, but also complement regulation via
            recruitment of complement regulators. The encoded protein has a
            calcium dependent ligand binding domain with a distinctive
            flattened beta-jellyroll structure. It exists in two forms as
            either a pentamer in circulation or as a nonsoluble monomer in
            tissues. It is involved in several host defense related functions
            based on its ability to recognize foreign pathogens and damaged
            cells of the host and to initiate their elimination by interacting
            with humoral and cellular effector systems in the blood.
            Consequently, the level of this protein in plasma increases greatly
            during acute phase response to tissue injury, infection, or other
            inflammatory stimuli. Elevated expression of the encoded protein is
            associated with severe acute respiratory syndrome coronavirus 2
            (SARS&#8208;CoV&#8208;2) infection. [provided by RefSeq, Aug 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.209230.1,
                                           SRR5189658.167882.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in cytokine storm inflammatory
                                      response
            MANE Ensembl match     :: ENST00000255030.9/ ENSP00000255030.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-523               BG533281.1         2-524
            524-1206            X56214.1           509-1191
            1207-1645           X56692.1           1192-1630
            1646-2011           BG618967.1         255-620
            2012-2015           AI609949.1         10-13               c
FEATURES             Location/Qualifiers
     source          1..2015
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.2"
     gene            1..2015
                     /gene="CRP"
                     /gene_synonym="PTX1"
                     /note="C-reactive protein"
                     /db_xref="GeneID:1401"
                     /db_xref="HGNC:HGNC:2367"
                     /db_xref="MIM:123260"
     exon            1..165
                     /gene="CRP"
                     /gene_synonym="PTX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..779
                     /gene="CRP"
                     /gene_synonym="PTX1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2; pentraxin 1; C-reactive protein,
                     pentraxin-related"
                     /codon_start=1
                     /product="C-reactive protein isoform 1 precursor"
                     /protein_id="NP_000558.2"
                     /db_xref="CCDS:CCDS30911.1"
                     /db_xref="GeneID:1401"
                     /db_xref="HGNC:HGNC:2367"
                     /db_xref="MIM:123260"
                     /translation="MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPL
                     TKPLKAFTVCLHFYTELSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILF
                     EVPEVTVAPVHICTSWESASGIVEFWVDGKPRVRKSLKKGYTVGAEASIILGQEQDSF
                     GGNFEGSQSLVGDIGNVNMWDFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFT
                     KPQLWP"
     exon            166..2015
                     /gene="CRP"
                     /gene_synonym="PTX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1994..1999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRP"
                     /gene_synonym="PTX1"
                     /note="hexamer: AATAAA"
     polyA_site      2015
                     /gene="CRP"
                     /gene_synonym="PTX1"
                     /note="major polyA site"
ORIGIN      
        1 aaggcaagag atctaggact tctagcccct gaactttcag ccgaatacat cttttccaaa
       61 ggagtgaatt caggcccttg tatcactggc agcaggacgt gaccatggag aagctgttgt
      121 gtttcttggt cttgaccagc ctctctcatg cttttggcca gacagacatg tcgaggaagg
      181 cttttgtgtt tcccaaagag tcggatactt cctatgtatc cctcaaagca ccgttaacga
      241 agcctctcaa agccttcact gtgtgcctcc acttctacac ggaactgtcc tcgacccgtg
      301 ggtacagtat tttctcgtat gccaccaaga gacaagacaa tgagattctc atattttggt
      361 ctaaggatat aggatacagt tttacagtgg gtgggtctga aatattattc gaggttcctg
      421 aagtcacagt agctccagta cacatttgta caagctggga gtccgcctca gggatcgtgg
      481 agttctgggt agatgggaag cccagggtga ggaagagtct gaagaaggga tacactgtgg
      541 gggcagaagc aagcatcatc ttggggcagg agcaggattc cttcggtggg aactttgaag
      601 gaagccagtc cctggtggga gacattggaa atgtgaacat gtgggacttt gtgctgtcac
      661 cagatgagat taacaccatc tatcttggcg ggcccttcag tcctaatgtc ctgaactggc
      721 gggcactgaa gtatgaagtg caaggcgaag tgttcaccaa accccagctg tggccctgag
      781 gcccagctgt gggtcctgaa ggtacctccc ggttttttac accgcatggg ccccacgtct
      841 ctgtctctgg tacctcccgc ttttttacac tgcatggttc ccacgtctct gtctctgggc
      901 ctttgttccc ctatatgcat tgcaggcctg ctccaccctc ctcagcgcct gagaatggag
      961 gtaaagtgtc tggtctggga gctcgttaac tatgctggga aacggtccaa aagaatcaga
     1021 atttgaggtg ttttgttttc atttttattt caagttggac agatcttgga gataatttct
     1081 tacctcacat agatgagaaa actaacaccc agaaaggaga aatgatgtta taaaaaactc
     1141 ataaggcaag agctgagaag gaagcgctga tcttctattt aattccccac ccatgacccc
     1201 cagaaagcag gagggcattg cccacattca cagggctctt cagtctcaga atcaggacac
     1261 tggccaggtg tctggtttgg gtccagagtg ctcatcatca tgtcatagaa ctgctgggcc
     1321 caggtctcct gaaatgggaa gcccagcaat accacgcagt ccctccactt tctcaaagca
     1381 cactggaaag gccattagaa ttgccccagc agagcagatc tgcttttttt ccagagcaaa
     1441 atgaagcact aggtataaat atgttgttac tgccaagaac ttaaatgact ggtttttgtt
     1501 tgcttgcagt gctttcttaa ttttatggct cttctgggaa actcctcccc ttttccacac
     1561 gaaccttgtg gggctgtgaa ttctttcttc atccccgcat tcccaatata cccaggccac
     1621 aagagtggac gtgaaccaca gggtgtcctg tcagaggagc ccatctccca tctccccagc
     1681 tccctatctg gaggatagtt ggatagttac gtgttcctag caggaccaac tacagtcttc
     1741 ccaaggattg agttatggac tttgggagtg agacatcttc ttgctgctgg atttccaagc
     1801 tgagaggacg tgaacctggg accaccagta gccatcttgt ttgccacatg gagagagact
     1861 gtgaggacag aagccaaact ggaagtggag gagccaaggg attgacaaac aacagagcct
     1921 tgaccacgtg gagtctctga atcagccttg tctggaacca gatctacacc tggactgccc
     1981 aggtctataa gccaataaag cccctgttta cttga
//
