LOCUS       NM_014675               6660 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens ciliary rootlet coiled-coil, rootletin (CROCC), mRNA.
ACCESSION   NM_014675 XM_371227
VERSION     NM_014675.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6660)
  AUTHORS   Ko,D., Kim,J., Rhee,K. and Choi,H.J.
  TITLE     Identification of a Structurally Dynamic Domain for Oligomer
            Formation in Rootletin
  JOURNAL   J Mol Biol 432 (13), 3915-3932 (2020)
   PUBMED   32325071
  REMARK    GeneRIF: Identification of a Structurally Dynamic Domain for
            Oligomer Formation in Rootletin.
REFERENCE   2  (bases 1 to 6660)
  AUTHORS   Hossain,D., Shih,S.Y., Xiao,X., White,J. and Tsang,W.Y.
  TITLE     Cep44 functions in centrosome cohesion by stabilizing rootletin
  JOURNAL   J Cell Sci 133 (4) (2020)
   PUBMED   31974111
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6660)
  AUTHORS   Xu,G., Wei,X., Tu,Q. and Zhou,C.
  TITLE     Up-regulated microRNA-33b inhibits epithelial-mesenchymal
            transition in gallbladder cancer through down-regulating CROCC
  JOURNAL   Biosci Rep 40 (1) (2020)
   PUBMED   31799620
  REMARK    GeneRIF: Up-regulated microRNA-33b inhibits epithelial-mesenchymal
            transition in gallbladder cancer through down-regulating CROCC.
REFERENCE   4  (bases 1 to 6660)
  AUTHORS   Xia,Y., Huang,N., Chen,Z., Li,F., Fan,G., Ma,D., Chen,J. and
            Teng,J.
  TITLE     CCDC102B functions in centrosome linker assembly and centrosome
            cohesion
  JOURNAL   J Cell Sci 131 (23) (2018)
   PUBMED   30404835
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6660)
  AUTHORS   Mahen,R.
  TITLE     Stable centrosomal roots disentangle to allow interphase centriole
            independence
  JOURNAL   PLoS Biol 16 (4), e2003998 (2018)
   PUBMED   29649211
  REMARK    GeneRIF: Rootletin forms large, diffusionally stable bifurcating
            fibers, which amass slowly on mature centrioles over many hours
            from anaphase. Nascent centrioles (procentrioles), in contrast, do
            not form roots and must be licensed to do so through PLK1 activity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6660)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   7  (bases 1 to 6660)
  AUTHORS   Bahmanyar,S., Kaplan,D.D., Deluca,J.G., Giddings,T.H. Jr.,
            O'Toole,E.T., Winey,M., Salmon,E.D., Casey,P.J., Nelson,W.J. and
            Barth,A.I.
  TITLE     beta-Catenin is a Nek2 substrate involved in centrosome separation
  JOURNAL   Genes Dev 22 (1), 91-105 (2008)
   PUBMED   18086858
REFERENCE   8  (bases 1 to 6660)
  AUTHORS   Ching,Y.P., Chan,S.F., Jeang,K.T. and Jin,D.Y.
  TITLE     The retroviral oncoprotein Tax targets the coiled-coil centrosomal
            protein TAX1BP2 to induce centrosome overduplication
  JOURNAL   Nat Cell Biol 8 (7), 717-724 (2006)
   PUBMED   16767081
  REMARK    GeneRIF: Our findings suggest that the HTLV-I Tax oncoprotein
            targets TAX1BP2 causing genomic instability and aneuploidy.
REFERENCE   9  (bases 1 to 6660)
  AUTHORS   Bahe,S., Stierhof,Y.D., Wilkinson,C.J., Leiss,F. and Nigg,E.A.
  TITLE     Rootletin forms centriole-associated filaments and functions in
            centrosome cohesion
  JOURNAL   J Cell Biol 171 (1), 27-33 (2005)
   PUBMED   16203858
REFERENCE   10 (bases 1 to 6660)
  AUTHORS   Yang,J., Liu,X., Yue,G., Adamian,M., Bulgakov,O. and Li,T.
  TITLE     Rootletin, a novel coiled-coil protein, is a structural component
            of the ciliary rootlet
  JOURNAL   J Cell Biol 159 (3), 431-440 (2002)
   PUBMED   12427867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            KF495875.1, BK005505.1, BX284668.4 and AL049569.13.
            
            On Nov 22, 2018 this sequence version replaced NM_014675.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BK005505.1, SRR14038191.3338298.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155371 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375541.10/ ENSP00000364691.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                KF495875.1         87-105
            20-300              BK005505.1         1-281
            301-301             BX284668.4         75178-75178
            302-4281            BK005505.1         283-4262
            4282-4282           AL049569.13        196568-196568       c
            4283-5232           BK005505.1         4264-5213
            5233-5233           AL049569.13        188303-188303       c
            5234-6214           BK005505.1         5215-6195
            6215-6215           AL049569.13        184968-184968       c
            6216-6660           BK005505.1         6197-6641
FEATURES             Location/Qualifiers
     source          1..6660
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..6660
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /note="ciliary rootlet coiled-coil, rootletin"
                     /db_xref="GeneID:9696"
                     /db_xref="HGNC:HGNC:21299"
                     /db_xref="MIM:615776"
     exon            1..148
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..6142
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /note="rootletin, ciliary rootlet protein; Tax1-binding
                     protein 2; ciliary rootlet coiled-coil protein"
                     /codon_start=1
                     /product="rootletin"
                     /protein_id="NP_055490.4"
                     /db_xref="CCDS:CCDS30616.1"
                     /db_xref="GeneID:9696"
                     /db_xref="HGNC:HGNC:21299"
                     /db_xref="MIM:615776"
                     /translation="MSLGLAGAQEVELTLETVIQTLESSVLCQEKGLGARDLAQDAQI
                     TSLPALIREIVTRNLSQPESPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQSRA
                     ERDELAIKYNAVSERLEQALRLEPGELETQEPRGLVRQSVELRRQLQEEQASYRRKLQ
                     AYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHSQDLESA
                     LIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREA
                     AWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRA
                     VQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDK
                     ADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQ
                     QTLRDLAQAVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPR
                     RGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRAL
                     EEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQ
                     EREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKEL
                     VEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSK
                     LSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQE
                     VARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARRE
                     AQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLF
                     EVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQK
                     LVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQEELLAR
                     LEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLATI
                     SLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRLQEQARDLG
                     KQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRS
                     LGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAG
                     ELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKES
                     RRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEK
                     QQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGL
                     RSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPA
                     TSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSR
                     ARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVATLERSLQ
                     ATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRS
                     RLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRD
                     KVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQS
                     SSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDERRL
                     LQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLS
                     AEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEV
                     ERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRSSAPFSPPSGPPE
                     K"
     exon            149..284
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            285..439
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            440..625
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            626..709
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            710..771
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            772..937
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1044
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1281
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1378
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1462
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1696
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1896
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2079
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2224
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2371
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2602
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..2796
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2797..2924
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2925..3094
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3095..3274
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3275..3409
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3410..3553
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3554..3792
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3793..3952
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3953..4120
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4121..4493
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4494..4663
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4664..4784
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4785..4948
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4949..5164
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            5165..5389
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            5390..5539
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            5540..5740
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            5741..5872
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            5873..6055
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            6056..6660
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6638..6643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /note="hexamer: AACAAA"
     polyA_site      6660
                     /gene="CROCC"
                     /gene_synonym="CROCC1; ROLT; TAX1BP2"
                     /note="major polyA site"
ORIGIN      
        1 acagcatcct ggctgtggcg cgtgctgact gagctagtct tggggtcctg gagaaggggg
       61 ctggaggcat gcccacagcc tcccccccat gagcttgggg ctggcggggg cacaggaggt
      121 ggagctgaca ctagagacgg ttatccagac actggagagc agcgtcctgt gccaggagaa
      181 aggcttgggc gcgcgggacc tggcccagga cgctcagatc accagcctgc ctgcccttat
      241 cagggagatt gtcacccgca acctctccca gcctgagagc ccagtcctgc tgccggccac
      301 agagatggca tcgctgctgt cgctgcagga ggagaaccag ctgctgcagc aggagctgtc
      361 ccgcgtggag gacctgctgg cccagagccg tgccgagcgc gatgagctcg ccattaagta
      421 caatgcggtc agcgagaggc tggagcaggc tctgcggctg gagcctgggg agctggagac
      481 gcaggagccc agggggctgg tacggcagag cgtggagttg cggaggcagc tgcaggagga
      541 gcaggcctcc taccggcgca agctgcaggc ctaccaggag ggccagcagc ggcaggccca
      601 gcttgtgcag cggctgcagg gcaagattct ccagtacaag aagaggtgct cggagctgga
      661 gcagcagctg ctggagagat ccggagagct ggagcagcag cggctgaggg acacagagca
      721 cagccaagac ctggaaagcg ccctcatccg gctggaggag gagcagcaga ggagtgccag
      781 cctggcccag gtgaatgcca tgctccgaga acagctggac caggcaggct cggccaacca
      841 ggctctgagt gaggacatac gaaaggtgac caatgactgg acacgctgcc gcaaggagct
      901 ggagcaccgg gaggcggcgt ggaggcgcga ggaggagtcc ttcaacgcct acttcagcaa
      961 cgagcacagt cgcctgctcc tcctctggag gcaggtggtg gggttccggc ggctggtcag
     1021 cgaggtgaag atgttcactg agagggacct gctgcagctg ggaggggagc tggcccggac
     1081 atcacgagct gtccaggagg cgggcctggg actgagcacg ggcctacggc tggcagagag
     1141 ccgggccgag gcagccctgg agaaacaggc cctgctgcag gcccagctgg aggagcagct
     1201 gcgggacaag gtgctccgcg agaaggacct ggcgcagcag cagatgcaaa gcgacctgga
     1261 caaggctgac ctcagtgcca gagtgacaga gctgggcctg gcagtgaagc gtcttgagaa
     1321 gcagaatctg gagaaggatc aggtcaacaa ggacctcact gagaagcttg aggccctgga
     1381 atccctgcgg ctacaggagc aggcggccct ggagacagag gatggagagg ggctacagca
     1441 gaccctaagg gacctggcac aggccgtctt gtcagactct gagagcggcg tccagctgag
     1501 cggctctgag cgcaccgcgg atgcttccaa cggcagcctg cgggggctct cgggccagcg
     1561 gaccccgtcc ccaccgcggc gctcctcgcc cggccgaggc cgttcacccc gccgaggccc
     1621 ctccccggcc tgctcagact cctccacgct cgccctgatc cactccgccc tgcacaagcg
     1681 ccagctgcag gtccaggaca tgcgtgggcg ctatgaggca agccaggacc tactgggcac
     1741 cctgcggaag cagcttagcg acagcgagag cgagcggcgg gccctagagg aacagctgca
     1801 gcgcctgcgg gacaagaccg acggcgccat gcaggcccac gaggacgccc agcgcgaggt
     1861 gcagcggctg cggagcgcca acgagctcct gagcagggag aagagcaacc tggcccacag
     1921 cctgcaggtg gcccagcagc aggccgagga gctgcggcag gagcgggaga agctgcaggc
     1981 tgcccaggag gagctgcggc gccagcggga ccggctggag gaagagcagg aggacgcagt
     2041 gcaggatggc gcgcgggtgc gccgggagct tgagcgcagc catagacaac tagagcagct
     2101 ggaagggaag cgctcagtcc tggccaagga gctggtggag gtgagggagg cgctgagccg
     2161 cgccacactg caacgggaca tgctgcaggc cgagaaggcc gaggtggccg aggcgctgac
     2221 caaggctgag gctggccgcg tggagctcga gctctccatg accaagctga gggcagagga
     2281 ggcctccctg caggactccc tgtccaagct gagcgccctc aacgagagcc ttgctcagga
     2341 caagttggat ctgaaccgcc ttgtcgccca gctggaggaa gaaaagtccg ccctgcaggg
     2401 ccggcaacgg caggcagagc aggaggccac agtggcgcgg gaagagcagg aacggctaga
     2461 ggagctgcgg ttggagcagg aggtggcgcg gcagggcctg gagggctccc tacgagtggc
     2521 ggagcaggcc caggaggcat tggagcagca gctccccacg ctgcgccatg agcgcagcca
     2581 gctgcaggag cagctagcgc agctctcccg gcagctgagc gggcgggagc aggagctgga
     2641 gcaggcccgg cgggaggccc agcggcaagt ggaggcgctg gagcgagcgg cccgtgagaa
     2701 ggaggcgcta gccaaggagc acgctggcct ggctgtgcag ctggtggctg cggagcgtga
     2761 aggcaggacc ctgtcagagg aggccacacg cctgcgcttg gagaaggaag ccctggaggg
     2821 cagcctgttt gaggtgcaac ggcagctggc ccagcttgag gcccgccggg agcagctgga
     2881 agccgagggg caggccctgc tgctggccaa ggagaccctg actggggagt tggcgggcct
     2941 gcggcagcaa ataatagcta cacaggagaa agccagtcta gacaaggagc tgatggccca
     3001 gaagctggtg caggctgagc gggaggccca ggcctctctg cgggagcagc gggcagctca
     3061 cgaggaggac ttacagcgac tccagcgtga aaaggaggca gcatggcggg agctggaggc
     3121 cgagcgggcc cagctgcaga gtcagctgca gcgtgagcag gaggagctgc tggcccggct
     3181 ggaggctgag aaggaagagc tgagtgagga gattgctgcc ctgcagcagg agcgcgacga
     3241 gggcctcctc ctagcagaga gtgagaagca gcaggccttg tctctgaagg agtctgagaa
     3301 gacggcgctg tcagagaagt tgatgggtac acggcacagc ctggccacca tctccctgga
     3361 gatggagcgg cagaaacgag atgcccagag ccggcaggag caggaccgga gcaccgtgaa
     3421 cgctctgacg tctgagctgc gggacctacg ggcccagcgg gaggaggctg ctgcggccca
     3481 cgcccaggag gtgaggaggc tgcaagagca ggcccgagac ctgggcaagc agcgggactc
     3541 ctgtcttcgc gaggcagaag agcttcggac ccagctgcgt ctgctggagg atgcccgtga
     3601 cgggctgcgg cgggagctgc tggaggccca gcgcaagctg cgtgagagcc aggagggccg
     3661 ggaggtgcag cgccaggagg caggcgagct gcgacgcagc ctgggcgagg gtgccaagga
     3721 gcgcgaggcc ctgcggcgtt ccaatgagga gcttcggtct gctgtgaaga aggcagagag
     3781 cgagcgcatc agcctgaagc ttgccaatga ggacaaggag cagaagctgg cactcctaga
     3841 ggaggcacgg acagctgtgg gcaaggaggc cggggagctg cgaactgggc tgcaggaggt
     3901 ggagcgctca cggctggagg ctcggcggga gctgcaggag ctccggcgtc agatgaagat
     3961 gctggacagt gagaacacca gactgggccg ggagctggcg gagctgcagg gccgcctggc
     4021 gctgggcgag cgggcagaga aggagagcag gcgggagacc ctgggcctcc ggcagaggct
     4081 gctgaagggc gaggccagcc tggaggtgat gcggcaggag ctccaggtag cccagcggaa
     4141 gctgcaggaa caagaaggcg agttccggac ccgcgagcga cgcctgctgg gctccctgga
     4201 ggaggcgcgt ggcactgaaa agcagcagct ggaccacgcc cgcggcctgg agctgaagct
     4261 ggaggcggcg cgggccgagg ctgcagagct gggcctgcgg ctgagcgcag ccgagggccg
     4321 ggcacaaggc ctggaggccg agctggcccg cgtggaggtg cagcggcgcg cggcggaggc
     4381 ccagctgggt ggcctgcgct cggctctgcg ccggggcctc ggcctcggtc gcgcgcccag
     4441 cccagccccg cggccagtgc ccggttcccc tgcccgggac gcacccgcag aaggaagcgg
     4501 ggaagggctc aacagcccca gcaccttaga atgcagccct gggtcccagc caccatctcc
     4561 aggacctgcc acctccccag cctctccaga cctggacccg gaggcagtgc gcggggccct
     4621 ccgggaattc ctgcaagagc tgcggagtgc ccagagagaa cgggacgaac ttcggaccca
     4681 gaccagtgcc ctgaatcgcc agctggccga gatggaggct gagagggaca gcgcaacctc
     4741 gagggccagg cagctgcaga aggcggtggc tgagagtgag gaagcccggc gcagtgtgga
     4801 tgggcggctg agcggggtcc aggcggagct ggcgctgcag gaggagagtg tgcggcgcag
     4861 tgagcgggag cgccgggcca cgctggacca ggtggccaca ctggagagga gcctgcaggc
     4921 caccgagagc gagctccggg ccagccagga gaagatcagc aagatgaagg ccaatgagac
     4981 aaagctggag ggcgacaagc ggcgcctgaa ggaggttctg gacgcctccg agagccgcac
     5041 tgtcaagctg gagctgcagc ggcgctcgct tgagggggag ctgcagcgca gccgcctggg
     5101 cctcagtgac cgcgaggccc aagcccaggc cctccaggat cgggtggatt ccctgcagag
     5161 acaggtggcc gacagcgagg tgaaggcagg gaccctgcag ctgaccgtgg agcggctgaa
     5221 tggggccctg gctaaggtgg aggaaagcga gggggccctg cgggacaagg tgcggggcct
     5281 gacagaggcc ctggcccaga gcagtgccag cctcaacagc acccgggaca agaacctgca
     5341 tctgcagaag gctctgaccg cctgtgaaca tgaccgccaa gtactccagg aacggctgga
     5401 tgccgcccgg caggcattat ctgaggcacg gaagcagagc agctccctgg gcgagcaggt
     5461 gcagacgttg cgaggcgagg tggctgacct ggaactgcag cgggtggagg ccgagggcca
     5521 gctacaacag ctacgggagg tgctgcggca gcggcaggag ggtgaggctg cagccctgaa
     5581 caccgtccag aagctgcaag acgagcggcg gctgctgcag gagcgcctgg gaagcctgca
     5641 gcgcgccctg gctcagctgg aagctgagaa gcgggaggtg gagcgctcag ccctgcggct
     5701 ggagaaggac cgtgtagccc tcaggaggac gctggacaag gtggagcggg agaagcttcg
     5761 tagccatgag gacacagtgc ggctgagcgc agagaagggc cgcctggacc gcaccctcac
     5821 gggggctgag ctggagctgg cagaggcgca gaggcagatc cagcagctgg aggcgcaggt
     5881 ggtggtgctg gagcagagcc acagcccggc ccagctggag gtggatgcgc agcagcagca
     5941 gctggagctg cagcaggagg tggagcggct gcgcagcgcc caggcgcaga ctgagcgcac
     6001 cctggaggct cgggagcggg cccaccgcca gagggtgcgt gggctggagg agcaggtgtc
     6061 cacactgaag ggccagctgc agcaggagct tcgaaggagc tcagcaccct tctccccacc
     6121 ctccggcccc ccagagaaat gagctcctgc tggcatctgg agaacacccc tgtgcctggg
     6181 acaggggagg acccttcttt tggacagccc ccccacccag agcccggtcc cttgggggcc
     6241 tcaagctggg gtgggatgag gaggcgctct gctggcagtg ctgaggacgg gtactccagc
     6301 tccaggcctg gagaggcttc ccagcaacac ctgcagtcca gcccccctct tctaggatga
     6361 gccactgtag atcattaaag ttcctccttg agaggctgag ccgtagccag gattggggag
     6421 agcccttgtc tctggtcagc cctggagcat gggatcgtgg gaaagaggag ggggaccagg
     6481 cccagggcag gggtcagagg cccaggccct gacttcggct tcccagagat ctctccgcct
     6541 tagttaagag catgtgtcgg gaaattcctc agagtgctca gagtccctgt atttttatac
     6601 ctttttacaa tgttaactgt tcagaactgt tttttgtaac aaaaccttgt ttttaaaaaa
//
