LOCUS       NM_016190               1902 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens cornulin (CRNN), mRNA.
ACCESSION   NM_016190
VERSION     NM_016190.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1902)
  AUTHORS   Hong,F., Wan,X. and Bai,Y.
  TITLE     Identification of Down-Expressed CRNN Associated with Cancer
            Progression and Poor Prognosis in Laryngeal Squamous Cell Carcinoma
  JOURNAL   Front Biosci (Landmark Ed) 29 (3), 125 (2024)
   PUBMED   38538265
  REMARK    GeneRIF: Identification of Down-Expressed CRNN Associated with
            Cancer Progression and Poor Prognosis in Laryngeal Squamous Cell
            Carcinoma.
REFERENCE   2  (bases 1 to 1902)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1902)
  AUTHORS   Li,C., Xiao,L., Jia,J., Li,F., Wang,X., Duan,Q., Jing,H., Yang,P.,
            Chen,C., Wang,Q., Liu,J., Shao,Y., Wang,N. and Zheng,Y.
  TITLE     Cornulin Is Induced in Psoriasis Lesions and Promotes Keratinocyte
            Proliferation via Phosphoinositide 3-Kinase/Akt Pathways
  JOURNAL   J Invest Dermatol 139 (1), 71-80 (2019)
   PUBMED   30009832
  REMARK    GeneRIF: knockdown of CRNN by small interfering RNA suppressed G1/S
            transition and attenuated the M5-induced proliferation. In
            addition, CRNN overexpression increased the phosphorylation and
            activation of phosphoinositide 3-kinase and Akt. Inactivation of
            the phosphoinositide 3-kinase and Akt pathways using small
            interfering RNA or selective inhibitors (LY294002 and MK2206)
            reduced the proliferative effects of CRNN
REFERENCE   4  (bases 1 to 1902)
  AUTHORS   Trzeciak,M., Sakowicz-Burkiewicz,M., Wesserling,M., Glen,J.,
            Dobaczewska,D., Bandurski,T., Nowicki,R. and Pawelczyk,T.
  TITLE     Altered Expression of Genes Encoding Cornulin and Repetin in Atopic
            Dermatitis
  JOURNAL   Int Arch Allergy Immunol 172 (1), 11-19 (2017)
   PUBMED   28219068
  REMARK    GeneRIF: The single-nucleotide polymorphisms of CRNN (rs941934) and
            RPTN (rs3001978, rs28441202) may contribute to Atopic Dermatitis
            development, but further studies on a larger group of Atopic
            Dermatitis patients are needed to verify this assumption.
REFERENCE   5  (bases 1 to 1902)
  AUTHORS   Salahshourifar,I., Vincent-Chong,V.K., Chang,H.Y., Ser,H.L.,
            Ramanathan,A., Kallarakkal,T.G., Rahman,Z.A., Ismail,S.M.,
            Prepageran,N., Mustafa,W.M., Abraham,M.T., Tay,K.K. and Zain,R.B.
  TITLE     Downregulation of CRNN gene and genomic instability at 1q21.3 in
            oral squamous cell carcinoma
  JOURNAL   Clin Oral Investig 19 (9), 2273-2283 (2015)
   PUBMED   25846277
  REMARK    GeneRIF: This study showed a significant correlation between
            LOH/MSI at 1q21.3 with clinical outcomes and that downregulation of
            CRNN gene could be considered as a prognostic marker of OSCC.
REFERENCE   6  (bases 1 to 1902)
  AUTHORS   Pohler,E., Craig,A.L., Cotton,J., Lawrie,L., Dillon,J.F., Ross,P.,
            Kernohan,N. and Hupp,T.R.
  TITLE     The Barrett's antigen anterior gradient-2 silences the p53
            transcriptional response to DNA damage
  JOURNAL   Mol Cell Proteomics 3 (6), 534-547 (2004)
   PUBMED   14967811
REFERENCE   7  (bases 1 to 1902)
  AUTHORS   Yagui-Beltran,A., Craig,A.L., Lawrie,L., Thompson,D.,
            Pospisilova,S., Johnston,D., Kernohan,N., Hopwood,D., Dillon,J.F.
            and Hupp,T.R.
  TITLE     The human oesophageal squamous epithelium exhibits a novel type of
            heat shock protein response
  JOURNAL   Eur J Biochem 268 (20), 5343-5355 (2001)
   PUBMED   11606197
REFERENCE   8  (bases 1 to 1902)
  AUTHORS   Xu,Z., Wang,M.R., Xu,X., Cai,Y., Han,Y.L., Wu,K.M., Wang,J.,
            Chen,B.S., Wang,X.Q. and Wu,M.
  TITLE     Novel human esophagus-specific gene c1orf10: cDNA cloning, gene
            structure, and frequent loss of expression in esophageal cancer
  JOURNAL   Genomics 69 (3), 322-330 (2000)
   PUBMED   11056050
REFERENCE   9  (bases 1 to 1902)
  AUTHORS   Louis,E., Philippet,B., Cardos,B., Heinen,E., Cormann,N.,
            Kinet-Denoel,C., Braum,M. and Simar,L.J.
  TITLE     Intercellular contacts between germinal center cells. Mechanisms of
            adhesion between lymphoid cells and follicular dendritic cells
  JOURNAL   Acta Otorhinolaryngol Belg 43 (4), 297-320 (1989)
   PUBMED   2631556
REFERENCE   10 (bases 1 to 1902)
  AUTHORS   Masuda,A.
  TITLE     Immunohistochemical study of Warthin's tumour with special regard
            to the germinal centre
  JOURNAL   Histol Histopathol 3 (1), 81-91 (1988)
   PUBMED   2980212
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA420219.1, AF077831.1 and
            BC030807.1.
            
            On May 17, 2019 this sequence version replaced NM_016190.2.
            
            Summary: This gene encodes a member of the 'fused gene' family of
            proteins, which contain N-terminus EF-hand domains and multiple
            tandem peptide repeats. The encoded protein contains two EF-hand
            Ca2+ binding domains in its N-terminus and two glutamine- and
            threonine-rich 60 amino acid repeats in its C-terminus. This gene,
            also known as squamous epithelial heat shock protein 53, may play a
            role in the mucosal/epithelial immune response and epidermal
            differentiation. [provided by RefSeq, Jan 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030807.1, AF077831.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2156670 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000271835.3/ ENSP00000271835.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DA420219.1         12-22
            12-1897             AF077831.1         1-1886
            1898-1902           BC030807.1         1898-1902
FEATURES             Location/Qualifiers
     source          1..1902
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..1902
                     /gene="CRNN"
                     /gene_synonym="C1orf10; DRC1; PDRC1; SEP53"
                     /note="cornulin"
                     /db_xref="GeneID:49860"
                     /db_xref="HGNC:HGNC:1230"
                     /db_xref="MIM:611312"
     exon            1..50
                     /gene="CRNN"
                     /gene_synonym="C1orf10; DRC1; PDRC1; SEP53"
                     /inference="alignment:Splign:2.1.0"
     exon            51..201
                     /gene="CRNN"
                     /gene_synonym="C1orf10; DRC1; PDRC1; SEP53"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1551
                     /gene="CRNN"
                     /gene_synonym="C1orf10; DRC1; PDRC1; SEP53"
                     /note="tumor-related protein; squamous epithelial heat
                     shock protein 53; 53 kDa squamous epithelial-induced
                     stress protein; 58 kDa heat shock protein; 53 kDa putative
                     calcium-binding protein"
                     /codon_start=1
                     /product="cornulin"
                     /protein_id="NP_057274.1"
                     /db_xref="CCDS:CCDS1010.1"
                     /db_xref="GeneID:49860"
                     /db_xref="HGNC:HGNC:1230"
                     /db_xref="MIM:611312"
                     /translation="MPQLLQNINGIIEAFRRYARTEGNCTALTRGELKRLLEQEFADV
                     IVKPHDPATVDEVLRLLDEDHTGTVEFKEFLVLVFKVAQACFKTLSESAEGACGSQES
                     GSLHSGASQELGEGQRSGTEVGRAGKGQHYEGSSHRQSQQGSRGQNRPGVQTQGQATG
                     SAWVSSYDRQAESQSQERISPQIQLSGQTEQTQKAGEGKRNQTTEMRPERQPQTREQD
                     RAHQTGETVTGSGTQTQAGATQTVEQDSSHQTGRTSKQTQEATNDQNRGTETHGQGRS
                     QTSQAVTGGHAQIQAGTHTQTPTQTVEQDSSHQTGSTSTQTQESTNGQNRGTEIHGQG
                     RSQTSQAVTGGHTQIQAGSHTETVEQDRSQTVSHGGAREQGQTQTQPGSGQRWMQVSN
                     PEAGETVPGGQAQTGASTESGRQEWSSTHPRRCVTEGQGDRQPTVVGEEWVDDHSRET
                     VILRLDQGNLHTSVSSAQGQDAAQSEEKRGITARELYSYLRSTKP"
     exon            202..1902
                     /gene="CRNN"
                     /gene_synonym="C1orf10; DRC1; PDRC1; SEP53"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcctcaca ccacttaaca gccacttgtt tcatcccacc tgggcattag gttgacttca
       61 aagatgcctc agttactgca aaacattaat gggatcatcg aggccttcag gcgctatgca
      121 aggacggagg gcaactgcac agcgctcacc cgaggggagc tgaaaagact cttggagcaa
      181 gagtttgccg atgtgattgt gaaaccccac gatccagcaa ctgtggatga ggtcctgcgt
      241 ctgctggatg aagaccacac agggactgtg gaattcaagg aattcctggt cttagtgttt
      301 aaagttgccc aggcctgttt caagacactg agcgagagtg ctgagggagc ctgcggctct
      361 caagagtctg gaagcctcca ctctggggcc tcgcaggagc tgggcgaagg acagagaagt
      421 ggcactgaag tgggaagggc ggggaaaggg cagcattatg aggggagcag ccacagacag
      481 agccagcagg gttccagagg gcagaacagg cctggggttc agacccaggg tcaggccact
      541 ggctctgcgt gggtcagcag ctatgacagg caagctgagt cccagagcca ggaaagaata
      601 agcccgcaga tacaactctc tgggcagaca gagcagaccc agaaagctgg agaaggcaag
      661 aggaatcaga caacagagat gaggccagag agacagccac agaccaggga acaggacaga
      721 gcccaccaga caggtgagac tgtgactgga tctggaactc agacccaggc aggtgccacc
      781 cagactgtgg agcaggacag cagccaccag acaggaagaa ccagcaagca gacacaggag
      841 gccaccaatg accagaacag agggactgag acccacggtc aaggcaggag ccagaccagc
      901 caggctgtga caggaggaca tgctcagata caggcaggga cacacaccca gacacccacc
      961 cagaccgtgg agcaggacag cagccaccag acaggaagca ccagcaccca gacacaggag
     1021 tccaccaatg gccagaacag agggactgag atccacggtc aaggcaggag ccagaccagc
     1081 caggctgtga caggaggaca cactcagata caggcagggt cacacaccga gactgtggag
     1141 caggacagaa gccaaactgt aagccacgga ggggctagag aacagggaca gacccagacg
     1201 cagccaggca gtggtcaaag atggatgcaa gtgagcaacc ctgaggcagg agagacagta
     1261 ccgggaggac aggcccagac tggggcaagc actgagtcag gaaggcagga gtggagcagc
     1321 actcacccaa ggcgctgtgt gacagaaggg cagggagaca gacagcccac agtggttggt
     1381 gaggaatggg ttgatgacca ctcaagggag acagtgatcc tcaggctgga ccagggcaac
     1441 ttgcatacca gtgtttcctc agcacagggc caggatgcag cccagtcaga agagaagcga
     1501 ggcatcacag ctagagagct gtattcctac ttgagaagca ccaagccatg acttccccga
     1561 ctccaatgtc cagtactgga agaagacagc tggagagagt ttggcttgtc ctgcatggcc
     1621 aatccagtgg gtgcatccct ggacatcagc tcttcattat gcagcttccc ttttaggtct
     1681 ttctcaatga gataatttct gcaaggagct ttctatcctg aactcttctt tcttacctgc
     1741 tttgcggtgc agaccctctc aggagcagga agactcagag caagtcaccc ctttgtactg
     1801 aattgtcctc atcttgtggg gggtttcagg actattttta tctctgacat ctctctattg
     1861 ccccatctac cctaatgcat caataaaacc ttaagccact gg
//
