LOCUS       NM_001278628            4015 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens crooked neck pre-mRNA splicing factor 1 (CRNKL1),
            transcript variant 5, mRNA.
ACCESSION   NM_001278628
VERSION     NM_001278628.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4015)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4015)
  AUTHORS   Xiao,H., Wyler,E., Milek,M., Grewe,B., Kirchner,P., Ekici,A.,
            Silva,A.B.O.V., Jungnickl,D., Full,F., Thomas,M., Landthaler,M.,
            Ensser,A. and Uberla,K.
  TITLE     CRNKL1 Is a Highly Selective Regulator of Intron-Retaining HIV-1
            and Cellular mRNAs
  JOURNAL   mBio 12 (1), e02525-20 (2021)
   PUBMED   33468685
  REMARK    GeneRIF: CRNKL1 Is a Highly Selective Regulator of Intron-Retaining
            HIV-1 and Cellular mRNAs.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4015)
  AUTHORS   Bertram,K., Agafonov,D.E., Liu,W.T., Dybkov,O., Will,C.L.,
            Hartmuth,K., Urlaub,H., Kastner,B., Stark,H. and Luhrmann,R.
  TITLE     Cryo-EM structure of a human spliceosome activated for step 2 of
            splicing
  JOURNAL   Nature 542 (7641), 318-323 (2017)
   PUBMED   28076346
REFERENCE   4  (bases 1 to 4015)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 4015)
  AUTHORS   Hegele,A., Kamburov,A., Grossmann,A., Sourlis,C., Wowro,S.,
            Weimann,M., Will,C.L., Pena,V., Luhrmann,R. and Stelzl,U.
  TITLE     Dynamic protein-protein interaction wiring of the human spliceosome
  JOURNAL   Mol Cell 45 (4), 567-580 (2012)
   PUBMED   22365833
REFERENCE   6  (bases 1 to 4015)
  AUTHORS   Hillman,R.T., Green,R.E. and Brenner,S.E.
  TITLE     An unappreciated role for RNA surveillance
  JOURNAL   Genome Biol 5 (2), R8 (2004)
   PUBMED   14759258
REFERENCE   7  (bases 1 to 4015)
  AUTHORS   Chung,S., Zhou,Z., Huddleston,K.A., Harrison,D.A., Reed,R.,
            Coleman,T.A. and Rymond,B.C.
  TITLE     Crooked neck is a component of the human spliceosome and implicated
            in the splicing process
  JOURNAL   Biochim Biophys Acta 1576 (3), 287-297 (2002)
   PUBMED   12084575
  REMARK    GeneRIF: Data show that crooked neck activity appears essential as
            extracts depleted of hcrn fail to splice pre-mRNA. These and
            related data support the view that crooked neck is a
            phylogenetically conserved pre-mRNA splicing factor.
REFERENCE   8  (bases 1 to 4015)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   9  (bases 1 to 4015)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   10 (bases 1 to 4015)
  AUTHORS   Lai,C.H., Chiu,J.Y. and Lin,W.
  TITLE     Identification of the human crooked neck gene by comparative gene
            identification
  JOURNAL   Biochim Biophys Acta 1517 (3), 449-454 (2001)
   PUBMED   11342225
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB040881.1, BI550198.1,
            AL832435.1 and AA255987.1.
            
            On Feb 27, 2020 this sequence version replaced NM_001278628.1.
            
            Summary: The crooked neck (crn) gene of Drosophila is essential for
            embryogenesis and is thought to be involved in cell cycle
            progression and pre-mRNA splicing. A protein encoded by this human
            locus has been found to localize to pre-mRNA splicing complexes in
            the nucleus and is necessary for pre-mRNA splicing. Alternatively
            spliced transcript variants have been described. [provided by
            RefSeq, Jul 2013].
            
            Transcript Variant: This variant (5) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream start codon, compared to variant 1. This variant
            represents use of an alternate promoter, compared to variant 1. The
            encoded isoform (d) is shorter than isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832435.1, AF111802.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000536226.2/ ENSP00000440733.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                DB040881.1         29-59
            32-113              BI550198.1         50-131
            114-3834            AL832435.1         114-3834
            3835-4015           AA255987.1         13-193              c
FEATURES             Location/Qualifiers
     source          1..4015
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.23"
     gene            1..4015
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /note="crooked neck pre-mRNA splicing factor 1"
                     /db_xref="GeneID:51340"
                     /db_xref="HGNC:HGNC:15762"
                     /db_xref="MIM:610952"
     exon            1..175
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..2188
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /note="isoform d is encoded by transcript variant 5;
                     crooked neck-like 1; crooked neck-like protein 1; crooked
                     neck homolog; Crn, crooked neck-like 1; SYF3
                     pre-mRNA-splicing factor; crooked neck pre-mRNA splicing
                     factor-like 1"
                     /codon_start=1
                     /product="crooked neck-like protein 1 isoform d"
                     /protein_id="NP_001265557.1"
                     /db_xref="CCDS:CCDS63238.1"
                     /db_xref="GeneID:51340"
                     /db_xref="HGNC:HGNC:15762"
                     /db_xref="MIM:610952"
                     /translation="MAASTAAGKQRIPKVAKVKNKAPAEVQITAEQLLREAKERELEL
                     LPPPPQQKITDEEELNDYKLRKRKTFEDNIRKNRTVISNWIKYAQWEESLKEIQRARS
                     IYERALDVDYRNITLWLKYAEMEMKNRQVNHARNIWDRAITTLPRVNQFWYKYTYMEE
                     MLGNVAGARQVFERWMEWQPEEQAWHSYINFELRYKEVDRARTIYERFVLVHPDVKNW
                     IKYARFEEKHAYFAHARKVYERAVEFFGDEHMDEHLYVAFAKFEENQKEFERVRVIYK
                     YALDRISKQDAQELFKNYTIFEKKFGDRRGIEDIIVSKRRFQYEEEVKANPHNYDAWF
                     DYLRLVESDAEAEAVREVYERAIANVPPIQEKRHWKRYIYLWINYALYEELEAKDPER
                     TRQVYQASLELIPHKKFTFAKMWILYAQFEIRQKNLSLARRALGTSIGKCPKNKLFKV
                     YIELELQLREFDRCRKLYEKFLEFGPENCTSWIKFAELETILGDIDRARAIYELAISQ
                     PRLDMPEVLWKSYIDFEIEQEETERTRNLYRRLLQRTQHVKVWISFAQFELSSGKEGS
                     LTKCRQIYEEANKTMRNCEEKEERLMLLESWRSFEEEFGTASDKERVDKLMPEKVKKR
                     RKVQTDDGSDAGWEEYFDYIFPEDAANQPNLKLLAMAKLWKKQQQEKEDAEHHPDEDV
                     DESES"
     exon            176..328
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /inference="alignment:Splign:2.1.0"
     exon            329..420
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /inference="alignment:Splign:2.1.0"
     exon            421..579
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /inference="alignment:Splign:2.1.0"
     exon            580..746
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /inference="alignment:Splign:2.1.0"
     exon            747..925
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1096
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1288
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1348
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1429
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1669
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1771
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..2020
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..4015
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2222..2227
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /note="hexamer: TATAAA"
     polyA_site      2241
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /note="major polyA site"
     regulatory      3017..3022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /note="hexamer: CATAAA"
     polyA_site      3038
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
     regulatory      3576..3581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /note="hexamer: AATAAA"
     polyA_site      3606
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
     regulatory      3987..3992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
                     /note="hexamer: AGTAAA"
     polyA_site      4015
                     /gene="CRNKL1"
                     /gene_synonym="CLF; Clf1; CRN; HCRN; MSTP021; SYF3"
ORIGIN      
        1 agttccgctt ccggttccga gatcctgttt gttttctgaa agctttgtgg tttcggtgag
       61 ctctcagagc cgatttctag cgtccgtgcc ggggacaggt gtccagaggt cgactgctgc
      121 agacatggcg gcctccaccg cggccgggaa gcagcggatt cccaaagtgg ccaaggtgaa
      181 aaacaaagcc ccggctgagg tacagataac tgctgaacaa ctcttaagag aggctaaaga
      241 aagagaactt gagcttcttc cacctccacc tcaacagaag atcacagatg aagaagaatt
      301 aaatgattat aaactaagga aaaggaagac ttttgaagat aatataagaa aaaacaggac
      361 tgtgattagt aactggataa aatacgcaca atgggaagaa agcctaaagg agattcaaag
      421 ggctcgatcc atatacgagc gtgctttaga tgtagactac cgaaatatta cactctggct
      481 gaaatacgca gaaatggaaa tgaagaatcg ccaagtcaac catgctcgaa atatctggga
      541 ccgggccata acaacgctgc ctcgagttaa tcagttctgg tacaagtaca cgtacatgga
      601 ggaaatgttg ggaaacgttg ccggtgcccg gcaggtgttt gagcgctgga tggagtggca
      661 gcctgaggag caagcctggc actcctacat caactttgag ctgagataca aagaggtgga
      721 tcgggcccgc accatttatg agcgatttgt cctcgtgcac cctgatgtta agaactggat
      781 caagtatgcc cgctttgaag aaaaacatgc ttattttgcc catgcacgga aagtgtatga
      841 gagagctgtg gaattctttg gagatgaaca tatggatgag cacctttatg ttgcctttgc
      901 caagtttgaa gaaaatcaga aagagtttga aagggtacga gtgatttaca agtatgccct
      961 ggacagaatt tcaaaacaag atgcccaaga actctttaaa aattatacca tctttgagaa
     1021 gaagtttggt gataggcggg gtattgaaga tatcattgtg agcaaacgga gattccagta
     1081 cgaagaagaa gtgaaggcga atccacacaa ttatgatgca tggtttgatt acttgcgctt
     1141 ggtagaaagt gacgcagaag ctgaagccgt gagagaagtc tatgaaaggg ccattgccaa
     1201 tgtcccaccc attcaggaga agaggcactg gaagcgctac atttatcttt ggatcaacta
     1261 tgcactctat gaagaattgg aggcaaagga tcctgagagg acaagacagg tgtatcaagc
     1321 ctctttggaa ctaattcctc acaaaaagtt cacatttgcc aaaatgtgga tactgtatgc
     1381 acagtttgaa atacgacaga agaatctgtc attagccaga agagcattgg gaacttccat
     1441 aggcaaatgt ccaaagaaca aattatttaa agtttacata gaattggagc tacagcttcg
     1501 agaatttgac agatgccgga agctttatga aaagttcctg gaatttggac ctgaaaattg
     1561 tacctcatgg attaaattcg ctgaattaga gacaatcctt ggtgatattg acagagcacg
     1621 ggcaatctat gaattagcca tcagtcagcc acgtttagac atgccagagg tgctttggaa
     1681 atcatatatt gattttgaaa ttgagcagga agaaacagaa agaacacgaa acctttaccg
     1741 gcggttgctt caacggacgc agcatgtcaa ggtatggatc agctttgctc agtttgagtt
     1801 gtcttcagga aaagaaggaa gtttgactaa atgcagacaa atttatgaag aagctaacaa
     1861 aaccatgcga aactgtgaag aaaaggaaga gagacttatg ctgctggaat cttggcgaag
     1921 ttttgaagaa gaatttggaa cagcttcaga taaggagaga gtagacaaac tcatgccaga
     1981 gaaagtcaag aagagaagaa aggtccagac tgatgatggg tctgatgcag gctgggaaga
     2041 atactttgat tacatctttc cagaagatgc tgccaaccaa cctaacctca aactcctggc
     2101 catggccaaa ctgtggaaga aacagcagca ggaaaaggag gatgctgagc accatccaga
     2161 tgaggacgtc gatgagagtg aatcctgatc tttttttcat agacaaatgt tttgttattt
     2221 ttataaatta attgtttgga actcttgtga ctcctggaag ttcttatata tttcaccagt
     2281 aagaaattga ttggtatctt tgatggctac tttttaagtt attttttaaa tgctcttggg
     2341 ttagctaggg gtagggattg caagtaaagg acttttttaa ctgctggatt tgtttttcca
     2401 actgagtcca aacttttcta atgtctgtcc acatcatgca ttaggaaatg taattaaggt
     2461 aacattctac agttactttt catgtcatac ccataaagat agtttatgca ttcatctgaa
     2521 atgtgtaact ttttcatgtc ttcagagtca cagacttgag ttcatttccc agctctgcca
     2581 ctcatgatta tataacttaa ttttcatttt cctcattcac aaaatgggcc aatagtttga
     2641 cagctcattt tgaagattac attataaaag gaatatacct ggtgggtgca tagtaagtgc
     2701 tcagtaaatt gtttgttcta agccactttt aaaaatggtt tcattccttg tagaattgaa
     2761 tgcgagtgga ttaataattt accttacttt cttactagtg tccagttata ttgtttttta
     2821 gaacaacact tggaaaataa tttgcagtga ttatatttct gaacaaggtt cagaaaacat
     2881 tgtttactaa gaatttagtc taataatttc agttaggcgc tcatcagttc tccagagtgg
     2941 ttgagtttgt aataccttgt ttaaagaata atggcttgtt cacgtgtgtg ctatgaaaaa
     3001 tgatgtccca tgttcacata aatttgggaa attctggact aagacttaag tctcgttaat
     3061 caaatctctt tatagttagg cttctgtaca ttatgtatct ccagtagcaa tgttgccata
     3121 ttatttattt cccaaactta gtggacaatg gagtcatttc tacctagagt accagtaaac
     3181 atctcccagt gtgctatagt agaaaatgtc tactcctcac tgctgacatg ttaaacttac
     3241 tcttggttta gagcatgtgt agaaacacct aaggtagctc tatgctaaat aatgaagagt
     3301 agcacaagaa tgaatgtatt tgctgatacg ttgctcacat tctcaagcaa aaattcaact
     3361 gcattaaccg atctgagagt tttcctttaa cctggactgt gtttctcaag cacatttttt
     3421 ctttgttcac tgcccaagga ctagaactgt atttttaagg ttgttttccc ctaaaaggac
     3481 ctttagtaag caaatttatt attaaatgtg cacatcttat tcacccaagg gaataaaagc
     3541 tacttcgtaa tgttgttact aaattttatc ttgaaaataa ataacagtgt ttgaggacag
     3601 aagaaactag gactgttgtt gagataaaat ctgttttcag cctgactgct ttagtcactg
     3661 gacgagcatc agctactgcg gtgtcagatc acttctcgag tagaggtctg cctagtgagt
     3721 gagcaggaga acatcatctt aatagccttt ggctcaccca gagtcaggga gagatgaaaa
     3781 taataggtca gaatgcaagt gacttaatca cagtcttcct agaattatct gtttatgttg
     3841 catgaatgca taagaaaaaa attctgtcat gttcccaagg tagaattgta ataagcatgt
     3901 gccagtgtga aagctggaag gaaaaaagct attctctaac aggagaacat aaagattcat
     3961 ttctctccca ccctcaactc caccaaagta aatcctttcg atagtaaaag tttaa
//
