LOCUS       NM_001014809            3174 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens collapsin response mediator protein 1 (CRMP1),
            transcript variant 1, mRNA.
ACCESSION   NM_001014809
VERSION     NM_001014809.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3174)
  AUTHORS   Ravindran,E., Arashiki,N., Becker,L.L., Takizawa,K., Levy,J.,
            Rambaud,T., Makridis,K.L., Goshima,Y., Li,N., Vreeburg,M.,
            Demeer,B., Dickmanns,A., Stegmann,A.P.A., Hu,H., Nakamura,F. and
            Kaindl,A.M.
  TITLE     Monoallelic CRMP1 gene variants cause neurodevelopmental disorder
  JOURNAL   Elife 11, e80793 (2022)
   PUBMED   36511780
  REMARK    GeneRIF: Monoallelic CRMP1 gene variants cause neurodevelopmental
            disorder.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3174)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3174)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3174)
  AUTHORS   Huang,L., Li,Y., Wang,C., Li,N., Hou,Y., Chang,R., Sun,M., Wang,R.,
            Zhu,L. and Qiao,C.
  TITLE     Overexpression of Collapsin Response Mediator Protein 1 Inhibits
            Human Trophoblast Cells Proliferation, Migration, and Invasion
  JOURNAL   Reprod Sci 26 (7), 954-960 (2019)
   PUBMED   30466368
  REMARK    GeneRIF: CRMP-1 might have implications for the pathogenesis of
            preeclampsia by regulating the biological behavior of trophoblast
            cells.
REFERENCE   5  (bases 1 to 3174)
  AUTHORS   McLean,C.K., Narayan,S., Lin,S.Y., Rai,N., Chung,Y., Hipolito,M.S.,
            Cascella,N.G., Nurnberger,J.I. Jr., Ishizuka,K., Sawa,A.S. and
            Nwulia,E.A.
  TITLE     Lithium-associated transcriptional regulation of CRMP1 in
            patient-derived olfactory neurons and symptom changes in bipolar
            disorder
  JOURNAL   Transl Psychiatry 8 (1), 81 (2018)
   PUBMED   29666369
  REMARK    GeneRIF: Study provides a novel insight into the relevance of
            collapsin response mediator protein 1, a key molecule in
            semaphorin-3A signaling during neurodevelopment, in the molecular
            mechanism of action of lithium, and in the pathophysiology of
            bipolar disorder.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3174)
  AUTHORS   Shih,J.Y., Lee,Y.C., Yang,S.C., Hong,T.M., Huang,C.Y. and Yang,P.C.
  TITLE     Collapsin response mediator protein-1: a novel invasion-suppressor
            gene
  JOURNAL   Clin Exp Metastasis 20 (1), 69-76 (2003)
   PUBMED   12650609
  REMARK    GeneRIF: Collapsin response mediator protein-1: a novel
            invasion-suppressor gene.
            Review article
REFERENCE   7  (bases 1 to 3174)
  AUTHORS   Leung,T., Ng,Y., Cheong,A., Ng,C.H., Tan,I., Hall,C. and Lim,L.
  TITLE     p80 ROKalpha binding protein is a novel splice variant of CRMP-1
            which associates with CRMP-2 and modulates RhoA-induced neuronal
            morphology
  JOURNAL   FEBS Lett 532 (3), 445-449 (2002)
   PUBMED   12482610
  REMARK    GeneRIF: CRMP-1 and CRMP-2 have a role in RhoA-dependent signaling,
            through interaction with and regulation of ROKalpha
REFERENCE   8  (bases 1 to 3174)
  AUTHORS   Shih,J.Y., Yang,S.C., Hong,T.M., Yuan,A., Chen,J.J., Yu,C.J.,
            Chang,Y.L., Lee,Y.C., Peck,K., Wu,C.W. and Yang,P.C.
  TITLE     Collapsin response mediator protein-1 and the invasion and
            metastasis of cancer cells
  JOURNAL   J Natl Cancer Inst 93 (18), 1392-1400 (2001)
   PUBMED   11562390
REFERENCE   9  (bases 1 to 3174)
  AUTHORS   Torres,R. and Polymeropoulos,M.H.
  TITLE     Genomic organization and localization of the human CRMP-1 gene
  JOURNAL   DNA Res 5 (6), 393-395 (1998)
   PUBMED   10048489
REFERENCE   10 (bases 1 to 3174)
  AUTHORS   Hamajima,N., Matsuda,K., Sakata,S., Tamaki,N., Sasaki,M. and
            Nonaka,M.
  TITLE     A novel gene family defined by human dihydropyrimidinase and three
            related proteins with differential tissue distribution
  JOURNAL   Gene 180 (1-2), 157-163 (1996)
   PUBMED   8973361
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC105915.5, DB498528.1,
            AK094725.1 and BC007898.2.
            
            On May 17, 2019 this sequence version replaced NM_001014809.2.
            
            Summary: This gene encodes a member of a family of cytosolic
            phosphoproteins expressed exclusively in the nervous system. The
            encoded protein is thought to be a part of the semaphorin signal
            transduction pathway implicated in semaphorin-induced growth cone
            collapse during neural development. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest protein
            (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK094725.1, SRR1803612.258146.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324989.12/ ENSP00000321606.7
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC105915.5         162761-162763       c
            4-132               DB498528.1         2-130
            133-344             AC105915.5         162420-162631       c
            345-2802            AK094725.1         1-2458
            2803-3174           BC007898.2         1842-2213
FEATURES             Location/Qualifiers
     source          1..3174
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.2"
     gene            1..3174
                     /gene="CRMP1"
                     /gene_synonym="CRMP-1; DPYSL1; DRP-1; DRP1; ULIP-3"
                     /note="collapsin response mediator protein 1"
                     /db_xref="GeneID:1400"
                     /db_xref="HGNC:HGNC:2365"
                     /db_xref="MIM:602462"
     exon            1..498
                     /gene="CRMP1"
                     /gene_synonym="CRMP-1; DPYSL1; DRP-1; DRP1; ULIP-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..2178
                     /gene="CRMP1"
                     /gene_synonym="CRMP-1; DPYSL1; DRP-1; DRP1; ULIP-3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dihydropyrimidinase-like 1; dihydropyrimidinase-related
                     protein 1; unc-33-like phosphoprotein 3; inactive
                     dihydropyrimidinase"
                     /codon_start=1
                     /product="dihydropyrimidinase-related protein 1 isoform 1"
                     /protein_id="NP_001014809.1"
                     /db_xref="CCDS:CCDS33950.1"
                     /db_xref="GeneID:1400"
                     /db_xref="HGNC:HGNC:2365"
                     /db_xref="MIM:602462"
                     /translation="MADRRRAWNTEDDLPVYLARPGSAAQTPRQKYGGMFAAVEGAYE
                     NKTIDFDAYSVGRRGSARTPRSAGRPDAVGLPGPGGSEDTASDVSEPSGSAVSSPGER
                     DERPPTLRIRRPAPRDLPLGRDNGQSDRLLIKGGRIINDDQSLYADVYLEDGLIKQIG
                     ENLIVPGGVKTIEANGRMVIPGGIDVNTYLQKPSQGMTAADDFFQGTRAALVGGTTMI
                     IDHVVPEPGSSLLTSFEKWHEAADTKSCCDYSLHVDITSWYDGVREELEVLVQDKGVN
                     SFQVYMAYKDVYQMSDSQLYEAFTFLKGLGAVILVHAENGDLIAQEQKRILEMGITGP
                     EGHALSRPEELEAEAVFRAITIAGRINCPVYITKVMSKSAADIIALARKKGPLVFGEP
                     IAASLGTDGTHYWSKNWAKAAAFVTSPPLSPDPTTPDYLTSLLACGDLQVTGSGHCPY
                     STAQKAVGKDNFTLIPEGVNGIEERMTVVWDKAVATGKMDENQFVAVTSTNAAKIFNL
                     YPRKGRIAVGSDADVVIWDPDKLKTITAKSHKSAVEYNIFEGMECHGSPLVVISQGKI
                     VFEDGNINVNKGMGRFIPRKAFPEHLYQRVKIRNKVFGLQGVSRGMYDGPVYEVPATP
                     KYATPAPSAKSSPSKHQPPPIRNLHQSNFSLSGAQIDDNNPRRTGHRIVAPPGGRSNI
                     TSLG"
     exon            499..587
                     /gene="CRMP1"
                     /gene_synonym="CRMP-1; DPYSL1; DRP-1; DRP1; ULIP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            588..772
                     /gene="CRMP1"
                     /gene_synonym="CRMP-1; DPYSL1; DRP-1; DRP1; ULIP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            773..937
                     /gene="CRMP1"
                     /gene_synonym="CRMP-1; DPYSL1; DRP-1; DRP1; ULIP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            938..999
                     /gene="CRMP1"
                     /gene_synonym="CRMP-1; DPYSL1; DRP-1; DRP1; ULIP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1080
                     /gene="CRMP1"
                     /gene_synonym="CRMP-1; DPYSL1; DRP-1; DRP1; ULIP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1149
                     /gene="CRMP1"
                     /gene_synonym="CRMP-1; DPYSL1; DRP-1; DRP1; ULIP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1270
                     /gene="CRMP1"
                     /gene_synonym="CRMP-1; DPYSL1; DRP-1; DRP1; ULIP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1427
                     /gene="CRMP1"
                     /gene_synonym="CRMP-1; DPYSL1; DRP-1; DRP1; ULIP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1569
                     /gene="CRMP1"
                     /gene_synonym="CRMP-1; DPYSL1; DRP-1; DRP1; ULIP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1740
                     /gene="CRMP1"
                     /gene_synonym="CRMP-1; DPYSL1; DRP-1; DRP1; ULIP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1920
                     /gene="CRMP1"
                     /gene_synonym="CRMP-1; DPYSL1; DRP-1; DRP1; ULIP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2086
                     /gene="CRMP1"
                     /gene_synonym="CRMP-1; DPYSL1; DRP-1; DRP1; ULIP-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..3174
                     /gene="CRMP1"
                     /gene_synonym="CRMP-1; DPYSL1; DRP-1; DRP1; ULIP-3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3124
                     /gene="CRMP1"
                     /gene_synonym="CRMP-1; DPYSL1; DRP-1; DRP1; ULIP-3"
                     /note="major polyA site"
     regulatory      3139..3144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRMP1"
                     /gene_synonym="CRMP-1; DPYSL1; DRP-1; DRP1; ULIP-3"
                     /note="hexamer: AATGAA"
     polyA_site      3174
                     /gene="CRMP1"
                     /gene_synonym="CRMP-1; DPYSL1; DRP-1; DRP1; ULIP-3"
                     /note="major polyA site"
ORIGIN      
        1 gcagtcgcgc ccgggccgcc gcaggcccgc accgaggcgc ggagcgcggc gcacggcggt
       61 gcccagggcc gcgggcgggc aggcgggagc gcggtgggtg gccggccttg gacgggtatg
      121 gcggaccggc ggcgcgcgtg gaacaccgag gacgacctgc ccgtgtacct ggcgcggccg
      181 ggcagcgcgg cgcagacccc gcgccagaag tacggcggca tgttcgccgc ggtggagggc
      241 gcctacgaga acaagaccat cgacttcgac gcctacagtg tgggccgccg cggctcggcg
      301 cgcacgccgc gcagcgctgg ccggcccgac gcggtcgggc tgccagggcc gggaggcagc
      361 gaggacacgg ccagcgacgt gagcgagccc tcgggctccg cggtcagctc tcccggagag
      421 cgcgacgagc ggccgccgac gctgcgcatc cgccgccccg cgccccgcga cctgcccctc
      481 ggccgggaca atggccagag tgaccgactc ctcatcaaag gtggacggat catcaacgat
      541 gaccaatccc tttatgctga cgtctacctg gaggatggac ttatcaaaca aataggagag
      601 aacttaatcg ttcctggtgg agtgaagacc attgaagcca acgggcggat ggttattccc
      661 ggaggtattg atgtcaacac gtacctgcag aagccctccc aggggatgac tgcggctgat
      721 gacttcttcc aagggaccag ggcggcactg gtgggcggga ccacgatgat cattgaccat
      781 gttgttcctg aacctgggtc cagcctactg acctctttcg agaagtggca cgaagcagct
      841 gacaccaaat cctgctgtga ttactccctc cacgtggaca tcacaagctg gtacgatggc
      901 gttcgggagg agctggaggt gctggtgcag gacaaaggcg tcaattcctt ccaagtctac
      961 atggcctata aggatgtcta ccaaatgtcc gacagccagc tctatgaagc ctttaccttc
     1021 cttaagggcc tgggagctgt gatcttggtc catgcagaaa atggagattt gatagctcag
     1081 gaacaaaagc ggatcctgga gatgggcatc acgggtcccg agggccatgc cctgagcaga
     1141 cctgaagagc tggaggccga ggcggtgttc cgggccatca ccattgcggg ccggatcaac
     1201 tgccctgtgt acatcaccaa ggtcatgagc aagagtgcag ccgacatcat cgctctggcc
     1261 aggaagaaag ggcccctagt ttttggagag cccattgccg ccagcctggg gaccgatggc
     1321 acccattact ggagcaagaa ctgggccaag gctgcggcgt tcgtgacttc ccctcccctg
     1381 agcccggacc ctaccacgcc cgactacttg acctccctac tggcctgtgg ggacttgcag
     1441 gtcacaggca gcggccactg tccctacagc actgcccaga aggcggtggg caaggacaac
     1501 tttaccctga tccccgaggg tgtcaacggg atagaggagc ggatgacggt cgtctgggac
     1561 aaggcggtgg ctactggcaa aatggatgag aaccagtttg tcgctgtcac cagcaccaat
     1621 gcagccaaga tctttaacct gtacccaagg aaagggcgga ttgccgtggg ctcggatgcc
     1681 gacgtggtca tctgggaccc cgacaagttg aagaccataa cagccaaaag tcacaagtcg
     1741 gcggtggagt acaacatctt cgagggtatg gagtgccacg gctccccact agtggtcatc
     1801 agccagggca agatcgtctt tgaagacgga aacatcaacg tcaacaaggg catgggccgc
     1861 ttcattccgc ggaaggcgtt cccggagcac ctgtaccagc gcgtcaaaat caggaataag
     1921 gtttttggat tgcaaggggt ttccaggggc atgtatgacg gtcctgtgta cgaggtacca
     1981 gctacaccca aatatgcaac tcccgctcct tcagccaaat cttcgccttc taaacaccag
     2041 cccccaccca tcagaaacct ccaccagtcc aacttcagct tatcaggtgc ccagatagat
     2101 gacaacaatc ccaggcgcac cggccaccgc atcgtggcgc cccctggtgg ccgctccaac
     2161 atcaccagcc tcggttgaac gtggatgcgc ggaggagcta gcctgaagga ttctgggaat
     2221 catgtccatc ccttttcctg tcagtgtttt tgaaacccac agttttagtt ggtgctgatg
     2281 gagggagggg gaagtcgaag gatgctcttt cccttttctg tttaggaaga agtggtacta
     2341 gtgtggtgtg tttgcttgga aattccttgc cccacagttg tgttcatgct gaatccacct
     2401 cggagcatgg tgttttcatt cccccttcct agtgaaccac aggttttagc attgtcttgt
     2461 tctgtccctt ccacttctaa ctccactggc tccatgattc tctgagtggt ggttcctttg
     2521 caccctgtag atgttctagg atagttgatg catgttacta aattacgtat gcaagtctgt
     2581 gagtgcgtct gaggggacat cgccaaggac tgactgagac acgatgccga gacctcaagc
     2641 cctgaggggc agtcccaaaa cccttacagt gaagatgttt actcattgcc cccacctctg
     2701 gtccacacta gaaagaagct cgccccacct ccacctgtga gatccgtgaa ttctcggaat
     2761 ggcaggggaa gccttgcact aggttgcaga gaagcatcct ccacatcctg tgtcagaaac
     2821 cctggtctcc gtggcacttg taactcaccg tgctgtcttc tggtctgtgt gtgttcttca
     2881 agccagctct aggcttcagg ccgagccagg ttcacactca gaaagaggtc tccccatccc
     2941 cattcggggc tgacgatggg gggctgatgg ctgcccctgc gtggcctgag tcctggtccc
     3001 tctgaggcag ttgacggggc agtcagattt ttaaagtttt gtacaaagtt ttcctttgta
     3061 atcactccca tttttactta acaaccaact tgttgtggct cttatttctg aattcaaagc
     3121 ttgtgaaaaa ataaagaaaa tgaactgccc actgacctga ctagggcact ttca
//
