LOCUS       NM_022148               1538 bp    mRNA    linear   PRI 10-OCT-2024
DEFINITION  Homo sapiens cytokine receptor like factor 2 (CRLF2), transcript
            variant 1, mRNA.
ACCESSION   NM_022148 XM_351944
VERSION     NM_022148.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1538)
  AUTHORS   Yamamoto,R., Segawa,R., Kato,H., Niino,Y., Sato,T., Hiratsuka,M.
            and Hirasawa,N.
  TITLE     Identification of amino acids in transmembrane domains of mutated
            cytokine receptor-like factor 2 and interleukin-7 receptor alpha
            required for constitutive signal transduction
  JOURNAL   Biochim Biophys Acta Biomembr 1866 (7), 184359 (2024)
   PUBMED   38862034
  REMARK    GeneRIF: Identification of amino acids in transmembrane domains of
            mutated cytokine receptor-like factor 2 and interleukin-7 receptor
            alpha required for constitutive signal transduction.
REFERENCE   2  (bases 1 to 1538)
  AUTHORS   Wang,D., Wang,F., Huang,Y., Wang,J., Luo,H., Zhang,P., Peng,J.,
            Tang,G., Wang,Y., Yu,L. and Ni,D.
  TITLE     TSLP/TSLPR promotes renal fibrosis by activating STAT3 in renal
            fibroblasts
  JOURNAL   Int Immunopharmacol 121, 110430 (2023)
   PUBMED   37364323
  REMARK    GeneRIF: TSLP/TSLPR promotes renal fibrosis by activating STAT3 in
            renal fibroblasts.
REFERENCE   3  (bases 1 to 1538)
  AUTHORS   Wang,J., Sun,K., Chen,W.M., Wang,X., Li,L.D., Hao,Y., Xu,N.,
            Jiang,H., Xu,L.P., Wang,Y., Zhang,X.H., Huang,X.J., Jiang,Q. and
            Qin,Y.Z.
  TITLE     The prognostic significance of CRLF2 expression at diagnosis in
            adult Ph-negative B-cell precursor acute lymphoblastic leukemia
  JOURNAL   Leuk Lymphoma 64 (3), 698-706 (2023)
   PUBMED   36642937
  REMARK    GeneRIF: The prognostic significance of CRLF2 expression at
            diagnosis in adult Ph-negative B-cell precursor acute lymphoblastic
            leukemia.
REFERENCE   4  (bases 1 to 1538)
  AUTHORS   Juarez-Velazquez,M.D.R., Moreno-Lorenzana,D.L., Martinez
            Anaya,D.A., Hernandez Monterde,E.A., Aguilar-Hernandez,M.M.,
            Reyes-Leon,A., Chavez-Gonzalez,M.A., Lopez Santiago,N., Zapata
            Tarres,M., Juarez Villegas,L., Rivera Sanchez,N., Soto Lerma,O.,
            Vega-Vega,L., Rivera Luna,R. and Perez-Vera,P.
  TITLE     High occurrence of CRLF2 abnormalities in Mexican children with
            B-cell acute lymphoblastic leukemia
  JOURNAL   Cytokine 155, 155896 (2022)
   PUBMED   35537330
  REMARK    GeneRIF: High occurrence of CRLF2 abnormalities in Mexican children
            with B-cell acute lymphoblastic leukemia.
REFERENCE   5  (bases 1 to 1538)
  AUTHORS   Junco,J.J., Zorman,B., Gant,V.U. Jr., Munoz,J., Lacorazza,H.D.,
            Sumazin,P. and Rabin,K.R.
  TITLE     CRLF2 overexpression results in reduced B-cell differentiation and
            upregulated E2F signaling in the Dp16 mouse model of Down syndrome
  JOURNAL   Exp Hematol 110, 34-38 (2022)
   PUBMED   35306048
  REMARK    GeneRIF: CRLF2 overexpression results in reduced B-cell
            differentiation and upregulated E2F signaling in the Dp16 mouse
            model of Down syndrome.
REFERENCE   6  (bases 1 to 1538)
  AUTHORS   Blagoev,B., Nielsen,M.M., Angrist,M., Chakravarti,A. and Pandey,A.
  TITLE     Cloning of rat thymic stromal lymphopoietin receptor (TSLPR) and
            characterization of genomic structure of murine Tslpr gene
  JOURNAL   Gene 284 (1-2), 161-168 (2002)
   PUBMED   11891057
REFERENCE   7  (bases 1 to 1538)
  AUTHORS   Reche,P.A., Soumelis,V., Gorman,D.M., Clifford,T., Liu,Mr.,
            Travis,M., Zurawski,S.M., Johnston,J., Liu,Y.J., Spits,H., de Waal
            Malefyt,R., Kastelein,R.A. and Bazan,J.F.
  TITLE     Human thymic stromal lymphopoietin preferentially stimulates
            myeloid cells
  JOURNAL   J Immunol 167 (1), 336-343 (2001)
   PUBMED   11418668
REFERENCE   8  (bases 1 to 1538)
  AUTHORS   Zhang,W., Wang,J., Wang,Q., Chen,G., Zhang,J., Chen,T., Wan,T.,
            Zhang,Y. and Cao,X.
  TITLE     Identification of a novel type I cytokine receptor CRL2
            preferentially expressed by human dendritic cells and activated
            monocytes
  JOURNAL   Biochem Biophys Res Commun 281 (4), 878-883 (2001)
   PUBMED   11237741
REFERENCE   9  (bases 1 to 1538)
  AUTHORS   Tonozuka,Y., Fujio,K., Sugiyama,T., Nosaka,T., Hirai,M. and
            Kitamura,T.
  TITLE     Molecular cloning of a human novel type I cytokine receptor related
            to delta1/TSLPR
  JOURNAL   Cytogenet Cell Genet 93 (1-2), 23-25 (2001)
   PUBMED   11474172
REFERENCE   10 (bases 1 to 1538)
  AUTHORS   Hiroyama,T., Iwama,A., Morita,Y., Nakamura,Y., Shibuya,A. and
            Nakauchi,H.
  TITLE     Molecular cloning and characterization of CRLM-2, a novel type I
            cytokine receptor preferentially expressed in hematopoietic cells
  JOURNAL   Biochem Biophys Res Commun 272 (1), 224-229 (2000)
   PUBMED   10872831
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK026800.1, AF142570.1 and
            AC188046.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_022148.3.
            
            Summary: This gene encodes a member of the type I cytokine receptor
            family. The encoded protein is a receptor for thymic stromal
            lymphopoietin (TSLP). Together with the interleukin 7 receptor
            (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and
            JAK2 pathways, which control processes such as cell proliferation
            and development of the hematopoietic system. Rearrangement of this
            gene with immunoglobulin heavy chain gene (IGH) on chromosome 14,
            or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y
            chromosomes is associated with B-progenitor acute lymphoblastic
            leukemia (ALL) and Down syndrome ALL. Alternatively spliced
            transcript variants have been found for this gene. [provided by
            RefSeq, Sep 2014].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB052639.1, AF338733.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000400841.8/ ENSP00000383641.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AK026800.1         77-89
            14-1490             AF142570.1         15-1491
            1491-1532           AK026800.1         1746-1787
            1533-1538           AC188046.2         16095-16100
FEATURES             Location/Qualifiers
     source          1..1538
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /chromosome="Y"
                     /map="X"
                     /map="Y"
     gene            1..1538
                     /gene="CRLF2"
                     /gene_synonym="CRL2; CRLF2Y; TSLPR"
                     /note="cytokine receptor like factor 2"
                     /db_xref="GeneID:64109"
                     /db_xref="HGNC:HGNC:14281"
                     /db_xref="MIM:300357"
                     /db_xref="MIM:400023"
     exon            1..94
                     /gene="CRLF2"
                     /gene_synonym="CRL2; CRLF2Y; TSLPR"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1131
                     /gene="CRLF2"
                     /gene_synonym="CRL2; CRLF2Y; TSLPR"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cytokine receptor CRL2 precusor; thymic
                     stromal-derived lymphopoietin receptor; IL-XR; TSLP
                     receptor; thymic stromal lymphopoietin protein receptor"
                     /codon_start=1
                     /product="cytokine receptor-like factor 2 isoform 1
                     precursor"
                     /protein_id="NP_071431.2"
                     /db_xref="CCDS:CCDS75945.1"
                     /db_xref="GeneID:64109"
                     /db_xref="HGNC:HGNC:14281"
                     /db_xref="MIM:300357"
                     /db_xref="MIM:400023"
                     /translation="MGRLVLLWGAAVFLLGGWMALGQGGAAEGVQIQIIYFNLETVQV
                     TWNASKYSRTNLTFHYRFNGDEAYDQCTNYLLQEGHTSGCLLDAEQRDDILYFSIRNG
                     THPVFTASRWMVYYLKPSSPKHVRFSWHQDAVTVTCSDLSYGDLLYEVQYRSPFDTEW
                     QSKQENTCNVTIEGLDAEKCYSFWVRVKAMEDVYGPDTYPSDWSEVTCWQRGEIRDAC
                     AETPTPPKPKLSKFILISSLAILLMVSLLLLSLWKLWRVKKFLIPSVPDPKSIFPGLF
                     EIHQGNFQEWITDTQNVAHLHKMAGAEQESGPEEPLVVQLAKTEAESPRMLDPQTEEK
                     EASGGSLQLPHQPLQGGDVVTIGGFTFVMNDRSYVAL"
     exon            95..197
                     /gene="CRLF2"
                     /gene_synonym="CRL2; CRLF2Y; TSLPR"
                     /inference="alignment:Splign:2.1.0"
     exon            198..364
                     /gene="CRLF2"
                     /gene_synonym="CRL2; CRLF2Y; TSLPR"
                     /inference="alignment:Splign:2.1.0"
     exon            365..498
                     /gene="CRLF2"
                     /gene_synonym="CRL2; CRLF2Y; TSLPR"
                     /inference="alignment:Splign:2.1.0"
     exon            499..661
                     /gene="CRLF2"
                     /gene_synonym="CRL2; CRLF2Y; TSLPR"
                     /inference="alignment:Splign:2.1.0"
     exon            662..782
                     /gene="CRLF2"
                     /gene_synonym="CRL2; CRLF2Y; TSLPR"
                     /inference="alignment:Splign:2.1.0"
     exon            783..867
                     /gene="CRLF2"
                     /gene_synonym="CRL2; CRLF2Y; TSLPR"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1538
                     /gene="CRLF2"
                     /gene_synonym="CRL2; CRLF2Y; TSLPR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actcctgttt caggcatggg gcggctggtt ctgctgtggg gagctgccgt ctttctgctg
       61 ggaggctgga tggctttggg gcaaggagga gcagcagaag gagtacagat tcagatcatc
      121 tacttcaatt tagaaaccgt gcaggtgaca tggaatgcca gcaaatactc caggaccaac
      181 ctgactttcc actacagatt caacggtgat gaggcctatg accagtgcac caactacctt
      241 ctccaggaag gtcacacttc ggggtgcctc ctagacgcag agcagcgaga cgacattctc
      301 tatttctcca tcaggaatgg gacgcacccc gttttcaccg caagtcgctg gatggtttat
      361 tacctgaaac ccagttcccc gaagcacgtg agattttcgt ggcatcagga tgcagtgacg
      421 gtgacgtgtt ctgacctgtc ctacggggat ctcctctatg aggttcagta ccggagcccc
      481 ttcgacaccg agtggcagtc caaacaggaa aatacctgca acgtcaccat agaaggcttg
      541 gatgccgaga agtgttactc tttctgggtc agggtgaagg ctatggagga tgtatatggg
      601 ccagacacat acccaagcga ctggtcagag gtgacatgct ggcagagagg cgagattcgg
      661 gatgcctgtg cagagacacc aacgcctccc aaaccaaagc tgtccaaatt tattttaatt
      721 tccagcctgg ccatccttct gatggtgtct ctcctccttc tgtctttatg gaaattatgg
      781 agagtgaaga agtttctcat tcccagcgtg ccagacccga aatccatctt ccccgggctc
      841 tttgagatac accaagggaa cttccaggag tggatcacag acacccagaa cgtggcccac
      901 ctccacaaga tggcaggtgc agagcaagaa agtggccccg aggagcccct ggtagtccag
      961 ttggccaaga ctgaagccga gtctcccagg atgctggacc cacagaccga ggagaaagag
     1021 gcctctgggg gatccctcca gcttccccac cagcccctcc aaggcggtga tgtggtcaca
     1081 atcgggggct tcacctttgt gatgaatgac cgctcctacg tggcgttgtg atggacacac
     1141 cactgtcaaa gtcaacgtca ggatccacgt tgacatttaa agacagaggg gactgtcccg
     1201 gggactccac accaccatgg atgggaagtc tccacgccaa tgatggtagg actaggagac
     1261 tctgaagacc cagcctcacc gcctaatgcg gccactgccc tgctaacttt cccccacatg
     1321 agtctctgtg ttcaaaggct tgatggcaga tgggagccaa ttgctccagg agatttactc
     1381 ccagttcctt ttcgtgcctg aacgttgtca cataaacccc aaggcagcac gtccaaaatg
     1441 ctgtaaaacc atcttcccac tctgtgagtc cccagttccg tccatgtacc attcccatag
     1501 cattggattc tcggaggatt ttttgtctgt tttgagac
//
