LOCUS       NM_004750               1741 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens cytokine receptor like factor 1 (CRLF1), mRNA.
ACCESSION   NM_004750
VERSION     NM_004750.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1741)
  AUTHORS   Lu,Z., Wang,D., Sun,Y. and Dai,Y.
  TITLE     ENO1 regulates IL-1beta-induced chondrocyte inflammation, apoptosis
            and matrix degradation possibly through the potential binding to
            CRLF1
  JOURNAL   Tissue Cell 90, 102504 (2024)
   PUBMED   39116531
  REMARK    GeneRIF: ENO1 regulates IL-1beta-induced chondrocyte inflammation,
            apoptosis and matrix degradation possibly through the potential
            binding to CRLF1.
REFERENCE   2  (bases 1 to 1741)
  AUTHORS   Xiang,C., Chen,L., Zhu,S., Chen,Y., Huang,H., Yang,C., Chi,Y.,
            Wang,Y., Lei,Y. and Cai,X.
  TITLE     CRLF1 bridges AKT and mTORC2 through SIN1 to inhibit pyroptosis and
            enhance chemo-resistance in ovarian cancer
  JOURNAL   Cell Death Dis 15 (9), 662 (2024)
   PUBMED   39256356
  REMARK    GeneRIF: CRLF1 bridges AKT and mTORC2 through SIN1 to inhibit
            pyroptosis and enhance chemo-resistance in ovarian cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1741)
  AUTHORS   Yu,B., Cao,Y., Li,S., Bai,R., Zhou,G., Fu,Q., Liang,L., Gu,W.,
            Zhang,L. and Chen,M.
  TITLE     Identification and validation of CRLF1 and NRG1 as immune-related
            signatures in hypertrophic scar
  JOURNAL   Genomics 116 (2), 110797 (2024)
   PUBMED   38262564
  REMARK    GeneRIF: Identification and validation of CRLF1 and NRG1 as
            immune-related signatures in hypertrophic scar.
REFERENCE   4  (bases 1 to 1741)
  AUTHORS   Guo,J., Ye,W., Wu,X., Huang,H., Li,B., Ren,Z. and Yang,Z.
  TITLE     Long non-coding RNA MIR22HG suppresses the chondrogenic
            differentiation of human adipose-derived stem cells by interacting
            with CTCF to upregulate CRLF1
  JOURNAL   Funct Integr Genomics 23 (4), 329 (2023)
   PUBMED   37910254
  REMARK    GeneRIF: Long non-coding RNA MIR22HG suppresses the chondrogenic
            differentiation of human adipose-derived stem cells by interacting
            with CTCF to upregulate CRLF1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1741)
  AUTHORS   A,R., Chandran,S., Ghatak,A.R., Thomas,N. and Danda,S.
  TITLE     Novel Mutations in CRLF1: Case Reports with Crisponi Syndrome
  JOURNAL   Indian J Pediatr 89 (11), 1148-1150 (2022)
   PUBMED   35984556
  REMARK    GeneRIF: Novel Mutations in CRLF1: Case Reports with Crisponi
            Syndrome.
            Review article
REFERENCE   6  (bases 1 to 1741)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   7  (bases 1 to 1741)
  AUTHORS   Knappskog,P.M., Majewski,J., Livneh,A., Nilsen,P.T., Bringsli,J.S.,
            Ott,J. and Boman,H.
  TITLE     Cold-induced sweating syndrome is caused by mutations in the CRLF1
            gene
  JOURNAL   Am J Hum Genet 72 (2), 375-383 (2003)
   PUBMED   12509788
REFERENCE   8  (bases 1 to 1741)
  AUTHORS   Elson,G.C., Lelievre,E., Guillet,C., Chevalier,S., Plun-Favreau,H.,
            Froger,J., Suard,I., de Coignac,A.B., Delneste,Y., Bonnefoy,J.Y.,
            Gauchat,J.F. and Gascan,H.
  TITLE     CLF associates with CLC to form a functional heteromeric ligand for
            the CNTF receptor complex
  JOURNAL   Nat Neurosci 3 (9), 867-872 (2000)
   PUBMED   10966616
REFERENCE   9  (bases 1 to 1741)
  AUTHORS   Elson,G.C., Graber,P., Losberger,C., Herren,S., Gretener,D.,
            Menoud,L.N., Wells,T.N., Kosco-Vilbois,M.H. and Gauchat,J.F.
  TITLE     Cytokine-like factor-1, a novel soluble protein, shares homology
            with members of the cytokine type I receptor family
  JOURNAL   J Immunol 161 (3), 1371-1379 (1998)
   PUBMED   9686600
REFERENCE   10 (bases 1 to 1741)
  AUTHORS   Hahn,A.F. and Knappskog,P.M.
  TITLE     Cold-Induced Sweating Syndrome Including Crisponi Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   21370513
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF073515.1 and AY358291.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004750.4.
            
            Summary: This gene encodes a member of the cytokine type I receptor
            family. The protein forms a secreted complex with
            cardiotrophin-like cytokine factor 1 and acts on cells expressing
            ciliary neurotrophic factor receptors. The complex can promote
            survival of neuronal cells. Mutations in this gene result in
            Crisponi syndrome and cold-induced sweating syndrome. [provided by
            RefSeq, Oct 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF073515.1, AY358291.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392386.8/ ENSP00000376188.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AF073515.1         52-64
            14-1741             AY358291.1         1-1728
FEATURES             Location/Qualifiers
     source          1..1741
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..1741
                     /gene="CRLF1"
                     /gene_synonym="CISS; CISS1; CLF; CLF-1; NR6; zcytor5"
                     /note="cytokine receptor like factor 1"
                     /db_xref="GeneID:9244"
                     /db_xref="HGNC:HGNC:2364"
                     /db_xref="MIM:604237"
     exon            1..258
                     /gene="CRLF1"
                     /gene_synonym="CISS; CISS1; CLF; CLF-1; NR6; zcytor5"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..1412
                     /gene="CRLF1"
                     /gene_synonym="CISS; CISS1; CLF; CLF-1; NR6; zcytor5"
                     /note="cytokine type 1 receptor CRLP-1; class I cytokine
                     receptor; cytokine-like factor 1"
                     /codon_start=1
                     /product="cytokine receptor-like factor 1 precursor"
                     /protein_id="NP_004741.1"
                     /db_xref="CCDS:CCDS32962.1"
                     /db_xref="GeneID:9244"
                     /db_xref="HGNC:HGNC:2364"
                     /db_xref="MIM:604237"
                     /translation="MPAGRRGPAAQSARRPPPLLPLLLLLCVLGAPRAGSGAHTAVIS
                     PQDPTLLIGSSLLATCSVHGDPPGATAEGLYWTLNGRRLPPELSRVLNASTLALALAN
                     LNGSRQRSGDNLVCHARDGSILAGSCLYVGLPPEKPVNISCWSKNMKDLTCRWTPGAH
                     GETFLHTNYSLKYKLRWYGQDNTCEEYHTVGPHSCHIPKDLALFTPYEIWVEATNRLG
                     SARSDVLTLDILDVVTTDPPPDVHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQIRY
                     RVEDSVDWKVVDDVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYGSKKAGIWSEWSHPT
                     AASTPRSERPGPGGGACEPRGGEPSSGPVRRELKQFLGWLKKHAYCSNLSFRLYDQWR
                     AWMQKSHKTRNQDEGILPSGRRGTARGPAR"
     exon            259..540
                     /gene="CRLF1"
                     /gene_synonym="CISS; CISS1; CLF; CLF-1; NR6; zcytor5"
                     /inference="alignment:Splign:2.1.0"
     exon            541..670
                     /gene="CRLF1"
                     /gene_synonym="CISS; CISS1; CLF; CLF-1; NR6; zcytor5"
                     /inference="alignment:Splign:2.1.0"
     exon            671..840
                     /gene="CRLF1"
                     /gene_synonym="CISS; CISS1; CLF; CLF-1; NR6; zcytor5"
                     /inference="alignment:Splign:2.1.0"
     exon            841..998
                     /gene="CRLF1"
                     /gene_synonym="CISS; CISS1; CLF; CLF-1; NR6; zcytor5"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1167
                     /gene="CRLF1"
                     /gene_synonym="CISS; CISS1; CLF; CLF-1; NR6; zcytor5"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1355
                     /gene="CRLF1"
                     /gene_synonym="CISS; CISS1; CLF; CLF-1; NR6; zcytor5"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1398
                     /gene="CRLF1"
                     /gene_synonym="CISS; CISS1; CLF; CLF-1; NR6; zcytor5"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1741
                     /gene="CRLF1"
                     /gene_synonym="CISS; CISS1; CLF; CLF-1; NR6; zcytor5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1720..1725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRLF1"
                     /gene_synonym="CISS; CISS1; CLF; CLF-1; NR6; zcytor5"
                     /note="hexamer: AATAAA"
     polyA_site      1741
                     /gene="CRLF1"
                     /gene_synonym="CISS; CISS1; CLF; CLF-1; NR6; zcytor5"
                     /note="major polyA site"
ORIGIN      
        1 agacttgctc cggcctccgc gtccgcgccc agcgacgtgc gggcggcctg gcccgcgccc
       61 tcccgcgccc ggcctgcgtc ccgcgccctg cgccaccgcc gccgagccgc agcccgccgc
      121 gcgcccccgg cagcgccggc cccatgcccg ccggccgccg gggccccgcc gcccaatccg
      181 cgcggcggcc gccgccgttg ctgcccctgc tgctgctgct ctgcgtcctc ggggcgccgc
      241 gagccggatc aggagcccac acagctgtga tcagtcccca ggatcccacg cttctcatcg
      301 gctcctccct gctggccacc tgctcagtgc acggagaccc accaggagcc accgccgagg
      361 gcctctactg gaccctcaac gggcgccgcc tgccccctga gctctcccgt gtactcaacg
      421 cctccacctt ggctctggcc ctggccaacc tcaatgggtc caggcagcgg tcgggggaca
      481 acctcgtgtg ccacgcccgt gacggcagca tcctggctgg ctcctgcctc tatgttggcc
      541 tgcccccaga gaaacccgtc aacatcagct gctggtccaa gaacatgaag gacttgacct
      601 gccgctggac gccaggggcc cacggggaga ccttcctcca caccaactac tccctcaagt
      661 acaagcttag gtggtatggc caggacaaca catgtgagga gtaccacaca gtggggcccc
      721 actcctgcca catccccaag gacctggctc tctttacgcc ctatgagatc tgggtggagg
      781 ccaccaaccg cctgggctct gcccgctccg atgtactcac gctggatatc ctggatgtgg
      841 tgaccacgga ccccccgccc gacgtgcacg tgagccgcgt cgggggcctg gaggaccagc
      901 tgagcgtgcg ctgggtgtcg ccacccgccc tcaaggattt cctctttcaa gccaaatacc
      961 agatccgcta ccgagtggag gacagtgtgg actggaaggt ggtggacgat gtgagcaacc
     1021 agacctcctg ccgcctggcc ggcctgaaac ccggcaccgt gtacttcgtg caagtgcgct
     1081 gcaacccctt tggcatctat ggctccaaga aagccgggat ctggagtgag tggagccacc
     1141 ccacagccgc ctccactccc cgcagtgagc gcccgggccc gggcggcggg gcgtgcgaac
     1201 cgcggggcgg agagccgagc tcggggccgg tgcggcgcga gctcaagcag ttcctgggct
     1261 ggctcaagaa gcacgcgtac tgctccaacc tcagcttccg cctctacgac cagtggcgag
     1321 cctggatgca gaagtcgcac aagacccgca accaggacga ggggatcctg ccctcgggca
     1381 gacggggcac ggcgagaggt cctgccagat aagctgtagg ggctcaggcc accctccctg
     1441 ccacgtggag acgcagaggc cgaacccaaa ctggggccac ctctgtaccc tcacttcagg
     1501 gcacctgagc caccctcagc aggagctggg gtggcccctg agctccaacg gccataacag
     1561 ctctgactcc cacgtgaggc cacctttggg tgcaccccag tgggtgtgtg tgtgtgtgtg
     1621 agggttggtt gagttgccta gaacccctgc cagggctggg ggtgagaagg ggagtcatta
     1681 ctccccatta cctagggccc ctccaaaaga gtccttttaa ataaatgagc tatttaggtg
     1741 c
//
