LOCUS       NM_005207               5342 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens CRK like proto-oncogene, adaptor protein (CRKL),
            transcript variant 1, mRNA.
ACCESSION   NM_005207
VERSION     NM_005207.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5342)
  AUTHORS   Wesener,M.C., Weiler,S.M.E., Bissinger,M., Klessinger,T.F.,
            Rose,F., Merker,S., Luzarowski,M., Ruppert,T., Helm,B.,
            Klingmuller,U., Schirmacher,P. and Breuhahn,K.
  TITLE     CRKL Enhances YAP Signaling through Binding and JNK/JUN Pathway
            Activation in Liver Cancer
  JOURNAL   Int J Mol Sci 25 (15), 8549 (2024)
   PUBMED   39126118
  REMARK    GeneRIF: CRKL Enhances YAP Signaling through Binding and JNK/JUN
            Pathway Activation in Liver Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5342)
  AUTHORS   Xie,P., Yu,M., Zhang,B., Yu,Q., Zhao,Y., Wu,M., Jin,L., Yan,J.,
            Zhou,B., Liu,S., Li,X., Zhou,C., Zhu,X., Huang,C., Xu,Y., Xiao,Y.,
            Zhou,J., Fan,J., Hung,M.C., Ye,Q., Guo,L. and Li,H.
  TITLE     CRKL dictates anti-PD-1 resistance by mediating tumor-associated
            neutrophil infiltration in hepatocellular carcinoma
  JOURNAL   J Hepatol 81 (1), 93-107 (2024)
   PUBMED   38403027
  REMARK    GeneRIF: CRKL dictates anti-PD-1 resistance by mediating
            tumor-associated neutrophil infiltration in hepatocellular
            carcinoma.
REFERENCE   3  (bases 1 to 5342)
  AUTHORS   Guo,C., Lv,X., Zhang,Q., Yi,L., Ren,Y., Li,Z., Yan,J., Zheng,S.,
            Sun,M.Z. and Liu,S.
  TITLE     CRKL but not CRKII contributes to hemin-induced erythroid
            differentiation of CML
  JOURNAL   J Cell Mol Med 28 (9), e18308 (2024)
   PUBMED   38683131
  REMARK    GeneRIF: CRKL but not CRKII contributes to hemin-induced erythroid
            differentiation of CML.
REFERENCE   4  (bases 1 to 5342)
  AUTHORS   Pagano,L., Simonetti,L., Pennacchietti,V., Toto,A., Malagrino,F.,
            Ivarsson,Y. and Gianni,S.
  TITLE     Exploring the short linear motif-mediated protein-protein
            interactions of CrkL through ProP-PD
  JOURNAL   Biochem Biophys Res Commun 703, 149658 (2024)
   PUBMED   38387229
  REMARK    GeneRIF: Exploring the short linear motif-mediated protein-protein
            interactions of CrkL through ProP-PD.
REFERENCE   5  (bases 1 to 5342)
  AUTHORS   Hu,J.H., Tang,H.N. and Wang,Y.H.
  TITLE     Cancer-associated fibroblast exosome LINC00355 promotes
            epithelial-mesenchymal transition and chemoresistance in colorectal
            cancer through the miR-34b-5p/CRKL axis
  JOURNAL   Cancer Gene Ther 31 (2), 259-272 (2024)
   PUBMED   38052858
  REMARK    GeneRIF: Cancer-associated fibroblast exosome LINC00355 promotes
            epithelial-mesenchymal transition and chemoresistance in colorectal
            cancer through the miR-34b-5p/CRKL axis.
REFERENCE   6  (bases 1 to 5342)
  AUTHORS   Fukazawa,T., Miyake,S., Band,V. and Band,H.
  TITLE     Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF)
            stimulation and its association with EGF receptor and downstream
            signaling proteins
  JOURNAL   J Biol Chem 271 (24), 14554-14559 (1996)
   PUBMED   8662998
REFERENCE   7  (bases 1 to 5342)
  AUTHORS   Smit,L., van der Horst,G. and Borst,J.
  TITLE     Sos, Vav, and C3G participate in B cell receptor-induced signaling
            pathways and differentially associate with Shc-Grb2, Crk, and Crk-L
            adaptors
  JOURNAL   J Biol Chem 271 (15), 8564-8569 (1996)
   PUBMED   8621483
REFERENCE   8  (bases 1 to 5342)
  AUTHORS   Reedquist,K.A., Fukazawa,T., Panchamoorthy,G., Langdon,W.Y.,
            Shoelson,S.E., Druker,B.J. and Band,H.
  TITLE     Stimulation through the T cell receptor induces Cbl association
            with Crk proteins and the guanine nucleotide exchange protein C3G
  JOURNAL   J Biol Chem 271 (14), 8435-8442 (1996)
   PUBMED   8626543
REFERENCE   9  (bases 1 to 5342)
  AUTHORS   Salgia,R., Uemura,N., Okuda,K., Li,J.L., Pisick,E., Sattler,M., de
            Jong,R., Druker,B., Heisterkamp,N., Chen,L.B. et al.
  TITLE     CRKL links p210BCR/ABL with paxillin in chronic myelogenous
            leukemia cells
  JOURNAL   J Biol Chem 270 (49), 29145-29150 (1995)
   PUBMED   7493940
REFERENCE   10 (bases 1 to 5342)
  AUTHORS   ten Hoeve,J., Morris,C., Heisterkamp,N. and Groffen,J.
  TITLE     Isolation and chromosomal localization of CRKL, a human crk-like
            gene
  JOURNAL   Oncogene 8 (9), 2469-2474 (1993)
   PUBMED   8361759
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC002470.17, X59656.1,
            BC043500.1 and AA844269.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005207.3.
            
            Summary: This gene encodes a protein kinase containing SH2 and SH3
            (src homology) domains which has been shown to activate the RAS and
            JUN kinase signaling pathways and transform fibroblasts in a
            RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine
            kinase, plays a role in fibroblast transformation by BCR-ABL, and
            may be oncogenic.[provided by RefSeq, Jan 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.144276.1,
                                           SRR1803615.104356.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354336.8/ ENSP00000346300.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC002470.17        153084-153102
            20-713              X59656.1           1-694
            714-1714            BC043500.1         636-1636
            1715-5074           AC002470.17        185797-189156
            5075-5342           AA844269.1         14-281              c
FEATURES             Location/Qualifiers
     source          1..5342
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.21"
     gene            1..5342
                     /gene="CRKL"
                     /note="CRK like proto-oncogene, adaptor protein"
                     /db_xref="GeneID:1399"
                     /db_xref="HGNC:HGNC:2363"
                     /db_xref="MIM:602007"
     exon            1..839
                     /gene="CRKL"
                     /inference="alignment:Splign:2.1.0"
     CDS             529..1440
                     /gene="CRKL"
                     /note="v-crk avian sarcoma virus CT10 oncogene
                     homolog-like"
                     /codon_start=1
                     /product="crk-like protein"
                     /protein_id="NP_005198.1"
                     /db_xref="CCDS:CCDS13785.1"
                     /db_xref="GeneID:1399"
                     /db_xref="HGNC:HGNC:2363"
                     /db_xref="MIM:602007"
                     /translation="MSSARFDSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTC
                     PGDYVLSVSENSRVSHYIINSLPNRRFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPA
                     PRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQW
                     WSARNKDGRVGMIPVPYVEKLVRSSPHGKHGNRNSNSYGIPEPAHAYAQPQTTTPLPA
                     VSGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQWE
                     GEVNGRKGLFPFTHVKIFDPQNPDENE"
     exon            840..1305
                     /gene="CRKL"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..5342
                     /gene="CRKL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5172..5177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRKL"
                     /note="hexamer: ATTAAA"
     polyA_site      5197
                     /gene="CRKL"
                     /note="major polyA site"
     regulatory      5311..5316
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRKL"
                     /note="hexamer: AATAAA"
     polyA_site      5342
                     /gene="CRKL"
                     /note="major polyA site"
ORIGIN      
        1 gcagacggag cgcgctgagc ggagggggag gtggctgccg cttctcccgc gtccgccatt
       61 ttgttgctgt ggctattggg aacaagctgg gcaaaagcac cccggaggcg cgacgctcct
      121 tcgagttcgg tgcctcgtgt gacggcgggg gtcggtgaag acccgtcgag ctgcggcgcc
      181 ggcgcgttcc aggccgggag tcactggagg cacccctggg acgccgagca gcccgagaac
      241 cccggggtgg cctccgctgc ggctcgggtt tgcctgcccc gaccccccgg ctctgccgtg
      301 cattcccggg cggctctctc cgtgtggcgg ccccggagca ggcgggcggc gtcggaggat
      361 gctgcgggcc cggagccgag aggaaagtgc tggcccagcc ctctgagcgc tcctcgaggt
      421 gtgcgagagg cccttcctcg gccccaaagc cgtctgccgg gctaaggcgt gcagagcagg
      481 cgaggacagc cgccgcccct accgccgcag agtccccggt ccaacaccat gtcctccgcc
      541 aggttcgact cctcggaccg ctccgcctgg tatatggggc cggtgtctcg ccaggaggcg
      601 cagacccggc tccagggcca gcgccacggt atgttcctcg tccgcgattc ttccacctgc
      661 cctggggact atgtgctgtc ggtgtccgag aactcgcggg tctcccacta catcatcaac
      721 tcgctgccca accgccgttt taagatcggg gaccaggaat ttgaccattt gccggccctg
      781 ctggagtttt acaagatcca ctacctggac accaccaccc tcatcgagcc tgcgcccagg
      841 tatccaagcc caccaatggg atctgtctca gcacccaacc tgcctacagc agaagataac
      901 ctggaatatg tacggactct gtatgatttt cctgggaatg atgccgaaga cctgcccttt
      961 aaaaagggtg agatcctagt gataatagag aagcctgaag aacagtggtg gagtgcccgg
     1021 aacaaggatg gccgggttgg gatgattcct gtcccttatg tcgaaaagct tgtgagatcc
     1081 tcaccacacg gaaagcatgg aaataggaat tccaacagtt atgggatccc agaacctgct
     1141 catgcatacg ctcaacctca gaccacaact cctctacctg cagtttccgg ttctcctggg
     1201 gcagcaatca cccctttgcc atccacacag aatggacctg tctttgcgaa agcaatccag
     1261 aaaagagtac cctgtgctta tgacaagact gccttggcat tagaggttgg tgacatcgtg
     1321 aaagtcacaa ggatgaatat aaatggccag tgggaaggcg aagtgaacgg gcgcaaaggg
     1381 cttttcccct ttacgcacgt caaaatcttt gaccctcaaa acccagatga aaacgagtga
     1441 ttgctgttgc cctgtttcct gctgctttgt tgttctgcct gtcctagtct cctttgaagt
     1501 gggaaagcat tttctctcat aggcaagtca cactgcattg ccgaagtcca gctttctgca
     1561 gactggcagt cgcacacaca tttggaatgc acacagcggc tgcctcctga tgtttgtatc
     1621 atagtcgtat tgtcaaagag tagccgattt tagagttctt ttggatcata aactggaaat
     1681 actgatggaa gcacacaagt ggagagaagt tgacatggaa agggtcttcc ttctcattgc
     1741 tgcccgtttg tacatgggac tgattctgtt gtgttcacca gagaaagctt gaggccatgg
     1801 cgagatactg catgtttgct gttccacaaa gcagtggctt agctgccatc ttgcttttct
     1861 ttggacaaca ggaagtgaac cttaaggaag agagaattct gttctaaaac tccaaaatct
     1921 ggcttttttt tttcttttgt tttggtttgg ttttggaaaa ctaattaatt agacttgtgt
     1981 gggggttttt ttttgttttg ttttgtttgt tttgttttgt ttttttgaga cggtgtctcg
     2041 ctgcatcacc caggctggag tgcagtggcg caatctcgcc ttcctgcagt ctccgcctcc
     2101 tgagttcaag cgattctcct gcctcagcct cccaagtagc tgggactgca ggcgcgcaca
     2161 ccacgcccag ctaatttttg tatttttagt agagacgggg tttcatcatg ttgaccaggc
     2221 tggtctcaaa ctcctgactt caggtgatcc acccgccttc agcctcccaa cgtgctggga
     2281 ttacagccgt gagccgccgc gcctggccta gacttgtgtg ttctaaacag gttaagtagc
     2341 aggttgggtt tttatgatag tgcaaggaat gactcatgcc tctgagcttc taaactgaag
     2401 ctgctgtaac taaaggaatc tgaaaagaac aaccctgaag cagaggcctt tattgtcttg
     2461 gttgccagta gtaccttgtt ttgccatgta gcagacaaca cacaaaataa tgcagttgtg
     2521 gtgtgccatg ctatgtgcac agccccttgg attactttgt tttaaaaagc atcagagttg
     2581 ggggtacttt agggaaacct ttgcttacct tgttttgcca gtgataagag cagtgggttg
     2641 gagggcactt ggccagtttt ctgttcagct tttcagtgaa tgtacccctt taaggttcag
     2701 acttaaactt ccttaaaaag tggcgttgtt catagaatcg ttggactcat taatgaatcg
     2761 ttcaactcca ctcactgaag cccagacctc cgtgcccagg cccaatctcg tcaggctgcc
     2821 agagaaagtt ggtgctgctc atactggtct cacagtctaa gtaagtgtct gtgatgctcc
     2881 caagcaaagg aaatgcaagc tctggaaatt cgttaatgta tttgatgtct tagtgtttta
     2941 gtgactaggg agaccattaa ctagtttatc attaaccact tatcagtgta ttgatgttaa
     3001 agcatttccc tgttagctaa aagaggcctg ttcatacaag ccaactggta tatacgtgtg
     3061 gttcatccat catctgctgc acatagcaga ctagaattct gggaaccctg tgcaattcag
     3121 tctgctctcc cttgtggacc ctggtaaaga aaagcctcag ctcatagtga acacagcaga
     3181 cctagaaatg tagcagcagc ctactgagta gctttcattt actgatcatc tgctgtgact
     3241 gtggccctgt ctggaggttc ctaggttttg agatttagag caatgcattc tggagacaga
     3301 accagcagaa cagccatttt tcaatttttc tttaaatcag tattccatca ggcagataac
     3361 tgctgtattc atgaatcttg agagtgttcc tgagacagaa ttaatggtca tttgggaaaa
     3421 ctatcgccat ggcttcccat ctgtggtttt cctctaaaag ccttggagat tagcccttcc
     3481 ttgccagtga gaacggtgac cgcctcctgc tctgcacggt ctgcggcagt tgccgcttct
     3541 ggttaggtgt gtcaggttgg cttattttgg gttcaggcct ggcgtagcac ccacaagtgg
     3601 cagacatatc acaagagtcc ccagactctg cctagaaaca gtgtttgccc tttggccagt
     3661 gacgtggttc atcccggccc atgttgagcc atgagtggag tttccaacag agggaggaat
     3721 gtgtgccttg ttcaaggagg gcacgaccct taggcctttt tcaaccagat ttagctgaag
     3781 ggcttgacac ctttgaatta cagcagttga ctcagagtgc aagaagtctg gccattttgg
     3841 aaagcaaggt ttcctttcag ccctgtctac tgaccaatac cccgactcac cttgtgtggc
     3901 gcacttcaga atcagatata cctagagtat acctgtggtt tggttttata attaatcagc
     3961 tcgttacttc agcccatgaa aatggcatcc agggctgcca ggagattcag agctcaaaac
     4021 aaggcgagct tgagttctgc actccagata tgtgccaaaa ctagtaaaac ttaacggact
     4081 tacaaccttg tcagtttttt taatgaggca gggatactct gtttttcaca ctaaacatat
     4141 gaatgcagca ctgctgcctc agctcagctt cgtgcctggg ttccccactg gtctgggaag
     4201 actgttgtgc tccatagagc agtgcacatc tgacccagag ggtgggtgtt cataactgct
     4261 acttgctctg ctctaccatg tttaaagaaa tatttggatg ttaaattaac tcactatggt
     4321 ttttcacctg ggaaggaaac aaattacgta ctagagggca ttgactggtt aaaaacttgt
     4381 gtatcccggg aaggacctgc ggtacaggag tcagccatgt ctgtgctgtg tggaaccacc
     4441 tgatgacatg gttaacgagg aagacgatgt gttgaccggc tgccgtttga ggactttggt
     4501 cacccagact agacaccttc tgtgctcatg tttggaaagc tgaaagggaa ggacagctgt
     4561 gccctcctgg gagctcatgt gtccctggcg ctgtgctagc tttcctttac agctgtttac
     4621 agacaaggca ggcctgaggc agatggccac tgctcttgtg atgtttgctc agaggaatat
     4681 gaacatttta tttttgaaaa gggatgatgt ggttttttgc caggtgttta taattaatcc
     4741 tttaatatta tggttattaa cctcttaaac atgaatgaat tcttgattgt tttaacacag
     4801 tacctaagac taatgctttc tgtggacacc actgagctct gcctcaactc caccctctgc
     4861 gaccggagga ctatgcccct agtaactgct gtcggtgtgg acgctgtgct ggttctgttt
     4921 tctaaaggag cagaaggaca ggtctctgag acaggatcgt tgtccctaca ggaggaacag
     4981 tggccttgct tcttagacgg tcttcactgt gtgttttaaa acaacaacaa caacaacaac
     5041 aacaacataa aactcttttg acctgtaact taaagatcat aaacttcagg caataatatt
     5101 ttctgtgtaa gcttttaaaa ttatttttgg ggatcatagc ttgttttatt ttgtgctata
     5161 aaattaacag tattaaatga cttatattct tagaatacat cgagtgtctt ttcttaacag
     5221 attagtgcct ttttattttt gtattccgtt ttacgttact ggtcccagca tcaaaaccct
     5281 tgtttccatg gcctgtttgt atattgtctc aataaaactt gcatcagccg gtggtggcgg
     5341 ca
//
