LOCUS       NM_001397362            2126 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens cripto, EGF-CFC family member 3 (CRIPTO3), mRNA.
ACCESSION   NM_001397362
VERSION     NM_001397362.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2126)
  AUTHORS   Ni,Q., An,M., Luo,S., Li,X., He,G., Shen,M., Xu,L., Huang,J.,
            Yan,M., Fan,Y. and Gao,Z.
  TITLE     Pseudogene TDGF1P3 regulates the proliferation and metastasis of
            colorectal cancer cells via the miR-338-3p-PKM2 axis
  JOURNAL   Biochem Biophys Res Commun 638, 7-13 (2023)
   PUBMED   36436343
  REMARK    GeneRIF: Pseudogene TDGF1P3 regulates the proliferation and
            metastasis of colorectal cancer cells via the miR-338-3p-PKM2 axis.
REFERENCE   2  (bases 1 to 2126)
  AUTHORS   Sun,C., Orozco,O., Olson,D.L., Choi,E., Garber,E., Tizard,R.,
            Szak,S., Sanicola,M. and Carulli,J.P.
  TITLE     CRIPTO3, a presumed pseudogene, is expressed in cancer
  JOURNAL   Biochem Biophys Res Commun 377 (1), 215-220 (2008)
   PUBMED   18835250
  REMARK    GeneRIF: These data indicate that CRIPTO3 is an expressed gene,
            particularly in certain cancers, and suggest a potentially novel
            mechanism of oncogenesis through activation of a retrogene.
REFERENCE   3  (bases 1 to 2126)
  AUTHORS   Hentschke,M., Kurth,I., Borgmeyer,U. and Hubner,C.A.
  TITLE     Germ cell nuclear factor is a repressor of CRIPTO-1 and CRIPTO-3
  JOURNAL   J Biol Chem 281 (44), 33497-33504 (2006)
   PUBMED   16954206
  REMARK    GeneRIF: CRIPTO-3, a processed pseudogene of CRIPTO-1 on the X
            chromosome, is expressed in undifferentiated NT2 cells and is
            regulated by germ cell nuclear factor in parallel to CRIPTO-1
REFERENCE   4  (bases 1 to 2126)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   5  (bases 1 to 2126)
  AUTHORS   Scognamiglio,B., Baldassarre,G., Cassano,C., Tucci,M., Montuori,N.,
            Dono,R., Lembo,G., Barra,A., Lago,C.T., Viglietto,G., Rocchi,M. and
            Persico,M.G.
  TITLE     Assignment of human teratocarcinoma derived growth factor (TDGF)
            sequences to chromosomes 2q37, 3q22, 6p25 and 19q13.1
  JOURNAL   Cytogenet Cell Genet 84 (3-4), 220-224 (1999)
   PUBMED   10393436
REFERENCE   6  (bases 1 to 2126)
  AUTHORS   Dono,R., Montuori,N., Rocchi,M., De Ponti-Zilli,L., Ciccodicola,A.
            and Persico,M.G.
  TITLE     Isolation and characterization of the CRIPTO autosomal gene and its
            X-linked related sequence
  JOURNAL   Am J Hum Genet 49 (3), 555-565 (1991)
   PUBMED   1882841
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC000113.1.
            
            Summary: The TDGF3 locus has characteristics of a retrotransposon,
            including lack of introns and a poly(A) sequence. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: M96956.1, BI598827.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000602699.2/ ENSP00000507999.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2126              AC000113.1         7906-10031          c
FEATURES             Location/Qualifiers
     source          1..2126
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq23"
     gene            1..2126
                     /gene="CRIPTO3"
                     /gene_synonym="CR-3; CRIPTO; CRIPTO-3; TDGF1P3; TDGF2;
                     TDGF3"
                     /note="cripto, EGF-CFC family member 3"
                     /db_xref="GeneID:6998"
                     /db_xref="HGNC:HGNC:11703"
     exon            1..2126
                     /gene="CRIPTO3"
                     /gene_synonym="CR-3; CRIPTO; CRIPTO-3; TDGF1P3; TDGF2;
                     TDGF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             235..801
                     /gene="CRIPTO3"
                     /gene_synonym="CR-3; CRIPTO; CRIPTO-3; TDGF1P3; TDGF2;
                     TDGF3"
                     /note="Teratocarcinoma-derived growth factor-2;
                     teratocarcinoma-derived growth factor 2 (retroposin,
                     possibly expressed); cripto-3 growth factor; epidermal
                     growth factor-like cripto protein CR3; putative
                     teratocarcinoma-derived growth factor 3;
                     teratocarcinoma-derived growth factor 1 pseudogene 3;
                     putative protein CRIPTO3"
                     /codon_start=1
                     /product="putative protein CRIPTO3 precursor"
                     /protein_id="NP_001384291.1"
                     /db_xref="CCDS:CCDS94651.1"
                     /db_xref="GeneID:6998"
                     /db_xref="HGNC:HGNC:11703"
                     /translation="MDCRKMVRFSYSVIWIMAISKAFELGLVAGLGHQEFARPSRGDL
                     AFRDDSIWPQEEPAIRPRSSQRVLPMGIQHSKELNRTCCLNGGTCMLESFCACPPSFY
                     GRNCEHDVRKENCGSVPHDTWLPKKCSLCKCWHGQLRCFPQAFLPGCDGLVMDEHLVA
                     SRTPELPPSARTTTFMLAGICLSIQSYY"
ORIGIN      
        1 aaaggctgag tctccagctc aaggtcaaaa cgtccaaggc cgaaagccct ccagtttccc
       61 ctggacacct tgctcctgct tctgctacga ccttctgggg aacgcgaatt tctcattttc
      121 ttcttaaatt gccattttcg ctttaggaga tgaatgtttt cctttggctg ttttggcaat
      181 gactctgaat taaagcgatg ctaacgcctc ttttccccct aattgttaaa agctatggac
      241 tgcaggaaga tggtccgctt ctcttacagt gtgatttgga tcatggccat ttctaaagcc
      301 tttgaactgg gattagttgc cgggctgggc catcaggaat ttgctcgtcc atctcgggga
      361 gacctggcct tcagagatga cagcatttgg ccccaggagg agcctgcaat tcggcctcgg
      421 tcttcccagc gtgtgctgcc catgggaata cagcacagta aggagctaaa cagaacctgc
      481 tgcctgaatg ggggaacctg catgctggag tccttttgtg cctgccctcc ctccttctac
      541 ggacggaact gtgagcacga tgtgcgcaaa gagaactgtg ggtctgtgcc ccatgacacc
      601 tggctgccca agaagtgttc cctgtgtaaa tgctggcacg gtcagctccg ctgctttcct
      661 caggcatttc tacccggctg tgatggcctt gtgatggatg agcacctcgt ggcttccagg
      721 actccagaac taccaccgtc tgcacgtact accactttta tgctagctgg catctgcctt
      781 tctatacaaa gctactatta atcgacattg acctatttcc agaaatacaa ttttagatat
      841 tatgcaaatt tcatgacccg taaaggctgc tgctacaatg tcctaactga aagatgatca
      901 tttgttagtt gccttaaaat aatgaataca tttccaaaac ggtctctaac atttccttac
      961 agaactaact acttcttacc tctttgccct gccctctccc aaaaaactac ttcttttttc
     1021 aaaagaaagt cagccatatc tccattgtgc ccaagtccag tgtttctttt ttttttttga
     1081 gacggagtct cactctgtca cccaggctgg actgcaatga cgcgatctcg gttcactgca
     1141 acctccgcat ccggggttca agccattctc ctgcctcagc ctcccaagta gctgggatta
     1201 caggcatgtg tcaccatgcc cggctaattt tttttgtatt tttagtagag acgggggttt
     1261 caccatattg gccagcctgg tctcgaactc ctgaccttgt gatccactcg cctcggcctc
     1321 tcgaagtgct gagattacac acgtgagcaa ctgtgcaagg cctggtgttt cttggtacat
     1381 gtaattctac caaggtcttc ttaatatgtt cttttaaatg attgaattac atcttcagat
     1441 tattaaagac taattctaat gtggacctta gaatacagtt ttgagtagag ttgatcaaaa
     1501 tcaattaaaa tagtctcttt taaaaggaaa gaaaacatct ttaaggggag gaaccagagt
     1561 gctgaaggaa tggaagtcca tctgcgtgtg tgcagggaga ctgggtagga aagaggaagc
     1621 aaatagaaga gagaggttga aaaacaaaat gggttacttg attggtgatt aggtggtggt
     1681 agagaagcaa gtaaaaaggc taaatggaag ggcaagtttc catcatctat agaaagctat
     1741 gtaagacaag gactcccctt tttttcccaa aggcattgta aaaagaatga agtctcctta
     1801 gaaaaaaaat tatacctcaa tgtccccaac aagattgctt aataaattgt gtttcctcca
     1861 agctattcaa ttcttttaac tgttgtagaa gagaaaatgt tcacaatata tttagttgta
     1921 aaccaagtga tcaaactaca tattgtaaag cccattttta aaatacattg tatatacgtg
     1981 tatgcacagt aaaaatggaa actatattga cctaaaaaaa aaaaaaaaaa gaaaacacct
     2041 agcaggcaag gaacatgctc ttcagaactc tgctcttcag agttccaaag aagggataaa
     2101 acatctttta tcaccatcaa aatagc
//
