LOCUS       NM_003212               1956 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens cripto, EGF-CFC family member (CRIPTO), transcript
            variant 1, mRNA.
ACCESSION   NM_003212
VERSION     NM_003212.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1956)
  AUTHORS   Cabar,F.R., Pereira,P.P., Bandeira,C.L., Bevilacqua,E., Schultz,R.
            and Francisco,R.P.V.
  TITLE     CRIPTO-1 Is Immunolocalized in the Syncytiotrophoblast of Ampullary
            Pregnancies
  JOURNAL   Biomed Res Int 2022, 4769790 (2022)
   PUBMED   35434129
  REMARK    GeneRIF: CRIPTO-1 Is Immunolocalized in the Syncytiotrophoblast of
            Ampullary Pregnancies.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1956)
  AUTHORS   Karkampouna,S., van der Helm,D., Scarpa,M., van Hoek,B.,
            Verspaget,H.W., Goumans,M.J., Coenraad,M.J., Kruithof,B.P.T. and
            Kruithof-de Julio,M.
  TITLE     Oncofetal Protein CRIPTO Is Involved in Wound Healing and
            Fibrogenesis in the Regenerating Liver and Is Associated with the
            Initial Stages of Cardiac Fibrosis
  JOURNAL   Cells 10 (12), 3325 (2021)
   PUBMED   34943832
  REMARK    GeneRIF: Oncofetal Protein CRIPTO Is Involved in Wound Healing and
            Fibrogenesis in the Regenerating Liver and Is Associated with the
            Initial Stages of Cardiac Fibrosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1956)
  AUTHORS   Liu,Y., Li,Y.Q., Huang,S.H., Li,Y.L., Xia,J.W., Jia,J.S., Wei,F.,
            Wang,J.H., Dai,G.Q., Wang,Y.C., Li,X.Y., Han,L.X., Zhang,X.L.,
            Xiang,X.D., Zhao,W.T., Xiao,D. and Lin,X.L.
  TITLE     Liver-specific over-expression of Cripto-1 in transgenic mice
            promotes hepatocyte proliferation and deregulated expression of
            hepatocarcinogenesis-related genes and signaling pathways
  JOURNAL   Aging (Albany NY) 13 (17), 21155-21190 (2021)
   PUBMED   34517344
  REMARK    GeneRIF: Liver-specific over-expression of Cripto-1 in transgenic
            mice promotes hepatocyte proliferation and deregulated expression
            of hepatocarcinogenesis-related genes and signaling pathways.
REFERENCE   4  (bases 1 to 1956)
  AUTHORS   Arnouk,H., Yum,G. and Shah,D.
  TITLE     Cripto-1 as a Key Factor in Tumor Progression, Epithelial to
            Mesenchymal Transition and Cancer Stem Cells
  JOURNAL   Int J Mol Sci 22 (17), 9280 (2021)
   PUBMED   34502188
  REMARK    GeneRIF: Cripto-1 as a Key Factor in Tumor Progression, Epithelial
            to Mesenchymal Transition and Cancer Stem Cells.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1956)
  AUTHORS   Wang,Y., Li,X., Wang,S., Song,Z., Bao,Y., Zheng,L., Wang,G. and
            Sun,Y.
  TITLE     miR-3929 Inhibits Proliferation and Promotes Apoptosis by
            Downregulating Cripto-1 Expression in Cervical Cancer Cells
  JOURNAL   Cytogenet Genome Res 161 (8-9), 425-436 (2021)
   PUBMED   34569498
  REMARK    GeneRIF: miR-3929 Inhibits Proliferation and Promotes Apoptosis by
            Downregulating Cripto-1 Expression in Cervical Cancer Cells.
REFERENCE   6  (bases 1 to 1956)
  AUTHORS   Saccone,S., Rapisarda,A., Motta,S., Dono,R., Persico,G.M. and Della
            Valle,G.
  TITLE     Regional localization of the human EGF-like growth factor CRIPTO
            gene (TDGF-1) to chromosome 3p21
  JOURNAL   Hum Genet 95 (2), 229-230 (1995)
   PUBMED   7860072
REFERENCE   7  (bases 1 to 1956)
  AUTHORS   Brandt,R., Normanno,N., Gullick,W.J., Lin,J.H., Harkins,R.,
            Schneider,D., Jones,B.W., Ciardiello,F., Persico,M.G., Armenante,F.
            et al.
  TITLE     Identification and biological characterization of an epidermal
            growth factor-related protein: cripto-1
  JOURNAL   J Biol Chem 269 (25), 17320-17328 (1994)
   PUBMED   8006041
REFERENCE   8  (bases 1 to 1956)
  AUTHORS   Tekendo-Ngongang,C., Muenke,M. and Kruszka,P.
  TITLE     Holoprosencephaly Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301702
REFERENCE   9  (bases 1 to 1956)
  AUTHORS   Dono,R., Montuori,N., Rocchi,M., De Ponti-Zilli,L., Ciccodicola,A.
            and Persico,M.G.
  TITLE     Isolation and characterization of the CRIPTO autosomal gene and its
            X-linked related sequence
  JOURNAL   Am J Hum Genet 49 (3), 555-565 (1991)
   PUBMED   1882841
REFERENCE   10 (bases 1 to 1956)
  AUTHORS   Ciccodicola,A., Dono,R., Obici,S., Simeone,A., Zollo,M. and
            Persico,M.G.
  TITLE     Molecular characterization of a gene of the 'EGF family' expressed
            in undifferentiated human NTERA2 teratocarcinoma cells
  JOURNAL   EMBO J 8 (7), 1987-1991 (1989)
   PUBMED   2792079
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA941183.1, X14253.1 and
            AC104304.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003212.3.
            
            Summary: This gene encodes an epidermal growth factor-related
            protein that contains a cripto, FRL-1, and cryptic domain. The
            encoded protein is an extracellular, membrane-bound signaling
            protein that plays an essential role in embryonic development and
            tumor growth. Mutations in this gene are associated with forebrain
            defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6,
            8, 19 and X. Alternate splicing results in multiple transcript
            variants. [provided by RefSeq, Mar 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022393.1, SRR3476690.945295.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296145.6/ ENSP00000296145.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-246               DA941183.1         203-448
            247-877             X14253.1           312-942
            878-1272            AC104304.2         113721-114115
            1273-1956           X14253.1           1334-2017
FEATURES             Location/Qualifiers
     source          1..1956
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..1956
                     /gene="CRIPTO"
                     /gene_synonym="CR; CR-1; CRGF; TDGF1"
                     /note="cripto, EGF-CFC family member"
                     /db_xref="GeneID:6997"
                     /db_xref="HGNC:HGNC:11701"
                     /db_xref="MIM:187395"
     exon            1..217
                     /gene="CRIPTO"
                     /gene_synonym="CR; CR-1; CRGF; TDGF1"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..749
                     /gene="CRIPTO"
                     /gene_synonym="CR; CR-1; CRGF; TDGF1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cripto-1 growth factor; epidermal growth
                     factor-like cripto protein CR1; teratocarcinoma-derived
                     growth factor 1; protein Cripto"
                     /codon_start=1
                     /product="protein Cripto isoform 1 precursor"
                     /protein_id="NP_003203.1"
                     /db_xref="CCDS:CCDS2742.1"
                     /db_xref="GeneID:6997"
                     /db_xref="HGNC:HGNC:11701"
                     /db_xref="MIM:187395"
                     /translation="MDCRKMARFSYSVIWIMAISKVFELGLVAGLGHQEFARPSRGYL
                     AFRDDSIWPQEEPAIRPRSSQRVPPMGIQHSKELNRTCCLNGGTCMLGSFCACPPSFY
                     GRNCEHDVRKENCGSVPHDTWLPKKCSLCKCWHGQLRCFPQAFLPGCDGLVMDEHLVA
                     SRTPELPPSARTTTFMLVGICLSIQSYY"
     exon            218..270
                     /gene="CRIPTO"
                     /gene_synonym="CR; CR-1; CRGF; TDGF1"
                     /inference="alignment:Splign:2.1.0"
     exon            271..405
                     /gene="CRIPTO"
                     /gene_synonym="CR; CR-1; CRGF; TDGF1"
                     /inference="alignment:Splign:2.1.0"
     exon            406..520
                     /gene="CRIPTO"
                     /gene_synonym="CR; CR-1; CRGF; TDGF1"
                     /inference="alignment:Splign:2.1.0"
     exon            521..630
                     /gene="CRIPTO"
                     /gene_synonym="CR; CR-1; CRGF; TDGF1"
                     /inference="alignment:Splign:2.1.0"
     exon            631..1956
                     /gene="CRIPTO"
                     /gene_synonym="CR; CR-1; CRGF; TDGF1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtttcccct ggacgccttg ctcctgcttc tgctacgacc ttctggggaa aacgaatttc
       61 tcattttctt cttaaattgc cattttcgct ttaggagatg aatgttttcc tttggctgtt
      121 ttggcaatga ctctgaatta aagcgatgct aacgcctctt ttccccctaa ttgttaaaag
      181 ctatggactg caggaagatg gcccgcttct cttacagtgt gatttggatc atggccattt
      241 ctaaagtctt tgaactggga ttagttgccg ggctgggcca tcaggaattt gctcgtccat
      301 ctcggggata cctggccttc agagatgaca gcatttggcc ccaggaggag cctgcaattc
      361 ggcctcggtc ttcccagcgt gtgccgccca tggggataca gcacagtaag gagctaaaca
      421 gaacctgctg cctgaatggg ggaacctgca tgctggggtc cttttgtgcc tgccctccct
      481 ccttctacgg acggaactgt gagcacgatg tgcgcaaaga gaactgtggg tctgtgcccc
      541 atgacacctg gctgcccaag aagtgttccc tgtgtaaatg ctggcacggt cagctccgct
      601 gctttcctca ggcatttcta cccggctgtg atggccttgt gatggatgag cacctcgtgg
      661 cttccaggac tccagaacta ccaccgtctg cacgtactac cacttttatg ctagttggca
      721 tctgcctttc tatacaaagc tactattaat cgacattgac ctatttccag aaatacaatt
      781 ttagatatca tgcaaatttc atgaccagta aaggctgctg ctacaatgtc ctaactgaaa
      841 gatgatcatt tgtagttgcc ttaaaataat gaatacattt ccaaaatggt ctctaacatt
      901 tccttacaga actacttctt acttctttgc cctgccctct cccaaaaaac tacttctttt
      961 ttcaaaagaa agtcagccat atctccattg tgcctaagtc cagtgtttct tttttttttt
     1021 ttttttgaga cggagtctca ctctgtcacc caggctggac tgcaatgacg cgatcttggt
     1081 tcactgcaac ctccgcatcc ggggttcaag ccattctcct gcctcagcct cccaagtaac
     1141 tgggattaca ggcatgtgtc accatgccca gctaattttt ttgtattttt agtagagatg
     1201 ggggtttcac catattggcc agtctggtct cgaactcctg accttgtgat ccactcgcct
     1261 cagcctctcg aagtgctgag attacacacg tgagcaactg tgcaaggcct ggtgtttctt
     1321 gatacatgta attctaccaa ggtcttctta atatgttctt ttaaatgatt gaattatatg
     1381 ttcagattat tggagactaa ttctaatgtg gaccttagaa tacagttttg agtagagttg
     1441 atcaaaatca attaaaatag tctctttaaa aggaaagaaa acatctttaa ggggaggaac
     1501 cagagtgctg aaggaatgga agtccatctg cgtgtgtgca gggagactgg gtaggaaaga
     1561 ggaagcaaat agaagagaga ggttgaaaaa caaaatgggt tacttgattg gtgattaggt
     1621 ggtggtagag aagcaagtaa aaaggctaaa tggaagggca agtttccatc atctatagaa
     1681 agctatataa gacaagaact cccctttttt tcccaaaggc attataaaaa gaatgaagcc
     1741 tccttagaaa aaaaattata cctcaatgtc cccaacaaga ttgcttaata aattgtgttt
     1801 cctccaagct attcaattct tttaactgtt gtagaagaca aaatgttcac aatatattta
     1861 gttgtaaacc aagtgatcaa actacatatt gtaaagccca tttttaaaat acattgtata
     1921 tatgtgtatg cacagtaaaa atggaaacta tattga
//
