LOCUS       NM_206922                991 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens cysteine rich protein 3 (CRIP3), transcript variant 1,
            mRNA.
ACCESSION   NM_206922 XM_376501
VERSION     NM_206922.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 991)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 991)
  AUTHORS   Suzuki,H., Okamoto-Katsuyama,M., Suwa,T., Maeda,R., Tamura,T.A. and
            Yamaguchi,Y.
  TITLE     TLP-mediated global transcriptional repression after double-strand
            DNA breaks slows down DNA repair and induces apoptosis
  JOURNAL   Sci Rep 9 (1), 4868 (2019)
   PUBMED   30890736
  REMARK    GeneRIF: TLP-mediated global transcriptional repression after
            double-strand DNA breaks slows down DNA repair and induces
            apoptosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 991)
  AUTHORS   Casrouge,A., Veitia,R., Kirchner,J., Bevan,M.J. and
            Kanellopoulos,J.
  TITLE     The human and mouse orthologous LIM-only proteins respectively
            encoded in chromosome 6 and 17 show a different expression pattern
  JOURNAL   Microbes Infect 6 (12), 1063-1072 (2004)
   PUBMED   15380775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR976447.1, AY555741.1, CN282994.1, AI042209.1 and AA813350.1.
            
            On Sep 21, 2018 this sequence version replaced NM_206922.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY555741.1, SRR5189664.40153.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372569.8/ ENSP00000361650.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                CR976447.1         46-79
            35-441              AY555741.1         1-407
            442-640             CN282994.1         355-553
            641-649             AY555741.1         607-615
            650-990             AI042209.1         1-341               c
            991-991             AA813350.1         8-8                 c
FEATURES             Location/Qualifiers
     source          1..991
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..991
                     /gene="CRIP3"
                     /gene_synonym="CRP-3; h6LIMo; TLP; TLP-A"
                     /note="cysteine rich protein 3"
                     /db_xref="GeneID:401262"
                     /db_xref="HGNC:HGNC:17751"
     exon            1..77
                     /gene="CRIP3"
                     /gene_synonym="CRP-3; h6LIMo; TLP; TLP-A"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..649
                     /gene="CRIP3"
                     /gene_synonym="CRP-3; h6LIMo; TLP; TLP-A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     thymus LIM protein TLP-A; chromosome 6 LIM domain only
                     protein"
                     /codon_start=1
                     /product="cysteine-rich protein 3 isoform 1"
                     /protein_id="NP_996805.2"
                     /db_xref="CCDS:CCDS4894.2"
                     /db_xref="GeneID:401262"
                     /db_xref="HGNC:HGNC:17751"
                     /translation="MSWTCPRCQQPVFFAEKVSSLGKNWHRFCLKCERCHSILSPGGH
                     AEHNGRPYCHKPCYGALFGPRGVNIGGVGSYLYNPPTPSPGCTTPLSPSSFSPPRPRT
                     GLPQGKKSPPHMKTFTGETSLCPGCGEPVYFAEKVMSLGRNWHRPCLRCQRCHKTLTA
                     GSHAEHDGVPYCHVPCYGYLFGPKGVNIGDVGCYIYDPVKIKFK"
     exon            78..172
                     /gene="CRIP3"
                     /gene_synonym="CRP-3; h6LIMo; TLP; TLP-A"
                     /inference="alignment:Splign:2.1.0"
     exon            173..230
                     /gene="CRIP3"
                     /gene_synonym="CRP-3; h6LIMo; TLP; TLP-A"
                     /inference="alignment:Splign:2.1.0"
     exon            231..362
                     /gene="CRIP3"
                     /gene_synonym="CRP-3; h6LIMo; TLP; TLP-A"
                     /inference="alignment:Splign:2.1.0"
     exon            363..434
                     /gene="CRIP3"
                     /gene_synonym="CRP-3; h6LIMo; TLP; TLP-A"
                     /inference="alignment:Splign:2.1.0"
     exon            435..529
                     /gene="CRIP3"
                     /gene_synonym="CRP-3; h6LIMo; TLP; TLP-A"
                     /inference="alignment:Splign:2.1.0"
     exon            530..587
                     /gene="CRIP3"
                     /gene_synonym="CRP-3; h6LIMo; TLP; TLP-A"
                     /inference="alignment:Splign:2.1.0"
     exon            588..991
                     /gene="CRIP3"
                     /gene_synonym="CRP-3; h6LIMo; TLP; TLP-A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      929..934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRIP3"
                     /gene_synonym="CRP-3; h6LIMo; TLP; TLP-A"
                     /note="hexamer: CATAAA"
     polyA_site      950
                     /gene="CRIP3"
                     /gene_synonym="CRP-3; h6LIMo; TLP; TLP-A"
     regulatory      973..978
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRIP3"
                     /gene_synonym="CRP-3; h6LIMo; TLP; TLP-A"
                     /note="hexamer: AATAAA"
     polyA_site      991
                     /gene="CRIP3"
                     /gene_synonym="CRP-3; h6LIMo; TLP; TLP-A"
                     /note="major polyA site"
ORIGIN      
        1 actgtgtgcc gcgtgcgctg cctggagcgg agctatgagc tggacctgtc cgcgttgcca
       61 gcaacctgtt ttcttcgctg agaaggtgag ctccctgggc aagaactggc accgcttctg
      121 cctgaaatgt gagcgctgcc acagcatcct gtcccctggc gggcatgcag agcacaatgg
      181 gaggccatac tgccacaagc catgctatgg ggctctcttt ggacccaggg gggtgaacat
      241 tggtggtgta ggctcctact tgtacaatcc ccccactccc agccctggct gcaccactcc
      301 tctcagcccc agcagcttca gccctcccag gccaaggact ggcctccccc aaggcaagaa
      361 aagccctccc catatgaaga cattcactgg ggagacctcg ctgtgccctg gctgtgggga
      421 gcccgtctat tttgctgaga aggtgatgtc attaggcaga aattggcacc gaccgtgtct
      481 gaggtgccag cgttgccaca agaccctgac tgctgggagt catgctgagc atgatggagt
      541 cccctactgc cacgtcccct gctacggcta cctgtttggc cccaaaggtg tgaacattgg
      601 cgatgtgggc tgctacatct atgacccagt gaagataaaa ttcaaatgag acgctcacaa
      661 aaaaggtcac cctaactcag gcctcccatc atgcccctca tggtccaatg gaagctacaa
      721 aaatctccag tcccatgggg gttggggaag gtgggatctt gggggcctgg gcctaggctc
      781 catggtaggc cagagagtct agactttctc tgccaatttt ttccctttcc catttctatc
      841 tggttaggga acagcccgtt ttgaagggta tcctcctcct ggccatcaca acccctttcc
      901 ccagcacatt ctggagcttc aaggtactca taaaacttgt gtttattgaa tttcagcctc
      961 tgtggcttct tcaataaaat gttggctccc a
//
