LOCUS       NM_001312               1178 bp    mRNA    linear   PRI 29-APR-2025
DEFINITION  Homo sapiens cysteine rich protein 2 (CRIP2), transcript variant 1,
            mRNA.
ACCESSION   NM_001312
VERSION     NM_001312.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1178)
  AUTHORS   Li,F., Bing,Z., Chen,W., Ye,F., Liu,Y., Ding,L. and Jin,X.
  TITLE     Prognosis biomarker and potential therapeutic target CRIP2
            associated with radiosensitivity in NSCLC cells
  JOURNAL   Biochem Biophys Res Commun 584, 73-79 (2021)
   PUBMED   34773852
  REMARK    GeneRIF: Prognosis biomarker and potential therapeutic target CRIP2
            associated with radiosensitivity in NSCLC cells.
REFERENCE   2  (bases 1 to 1178)
  AUTHORS   Chen,L., Li,N., Zhang,M., Sun,M., Bian,J., Yang,B., Li,Z., Wang,J.,
            Li,F., Shi,X., Wang,Y., Yuan,F., Zou,P., Shan,C. and Wang,J.
  TITLE     APEX2-based Proximity Labeling of Atox1 Identifies CRIP2 as a
            Nuclear Copper-binding Protein that Regulates Autophagy Activation
  JOURNAL   Angew Chem Int Ed Engl 60 (48), 25346-25355 (2021)
   PUBMED   34550632
  REMARK    GeneRIF: APEX2-based Proximity Labeling of Atox1 Identifies CRIP2
            as a Nuclear Copper-binding Protein that Regulates Autophagy
            Activation.
REFERENCE   3  (bases 1 to 1178)
  AUTHORS   Zhou,L., Wang,Y., Zhou,M., Zhang,Y., Wang,P., Li,X., Yang,J.,
            Wang,H. and Ding,Z.
  TITLE     HOXA9 inhibits HIF-1alpha-mediated glycolysis through interacting
            with CRIP2 to repress cutaneous squamous cell carcinoma development
  JOURNAL   Nat Commun 9 (1), 1480 (2018)
   PUBMED   29662084
  REMARK    GeneRIF: HOXA9 inhibits HIF1A-mediated glycolysis through
            interacting with CRIP2 to repress cutaneous squamous cell carcinoma
            development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1178)
  AUTHORS   Hoffmann,C., Mao,X., Dieterle,M., Moreau,F., Al Absi,A.,
            Steinmetz,A., Oudin,A., Berchem,G., Janji,B. and Thomas,C.
  TITLE     CRP2, a new invadopodia actin bundling factor critically promotes
            breast cancer cell invasion and metastasis
  JOURNAL   Oncotarget 7 (12), 13688-13705 (2016)
   PUBMED   26883198
  REMARK    GeneRIF: High CRP2 expression is associated with breast cancer cell
            invasion and metastasis.
REFERENCE   5  (bases 1 to 1178)
  AUTHORS   Tanabe,C., Hotoda,N., Sasagawa,N., Futai,E., Komano,H. and
            Ishiura,S.
  TITLE     ADAM19 autolysis is activated by LPS and promotes non-classical
            secretion of cysteine-rich protein 2
  JOURNAL   Biochem Biophys Res Commun 396 (4), 927-932 (2010)
   PUBMED   20460109
  REMARK    GeneRIF: These findings suggest that ADAM19 autolysis is activated
            by lipopolysaccharide and that ADAM19 promotes the secretion of
            CRIP2.
REFERENCE   6  (bases 1 to 1178)
  AUTHORS   Weiskirchen,R. and Gunther,K.
  TITLE     The CRP/MLP/TLP family of LIM domain proteins: acting by connecting
  JOURNAL   Bioessays 25 (2), 152-162 (2003)
   PUBMED   12539241
  REMARK    Review article
REFERENCE   7  (bases 1 to 1178)
  AUTHORS   Chang,D.F., Belaguli,N.S., Iyer,D., Roberts,W.B., Wu,S.P.,
            Dong,X.R., Marx,J.G., Moore,M.S., Beckerle,M.C., Majesky,M.W. and
            Schwartz,R.J.
  TITLE     Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth
            muscle differentiation cofactors
  JOURNAL   Dev Cell 4 (1), 107-118 (2003)
   PUBMED   12530967
  REMARK    GeneRIF: Function of avian CRIP2 in smooth muscle differentiation
REFERENCE   8  (bases 1 to 1178)
  AUTHORS   Weiskirchen,R. and Gressner,A.M.
  TITLE     The cysteine- and glycine-rich LIM domain protein CRP2 specifically
            interacts with a novel human protein (CRP2BP)
  JOURNAL   Biochem Biophys Res Commun 274 (3), 655-663 (2000)
   PUBMED   10924333
REFERENCE   9  (bases 1 to 1178)
  AUTHORS   Tsui,S.K., Chan,P.P., Cheuk,C.W., Liew,C.C., Waye,M.M., Fung,K.P.
            and Lee,C.Y.
  TITLE     A novel cDNA encoding for a LIM domain protein located at human
            chromosome 14q32 as a candidate for leukemic translocation
  JOURNAL   Biochem Mol Biol Int 39 (4), 747-754 (1996)
   PUBMED   8843343
REFERENCE   10 (bases 1 to 1178)
  AUTHORS   Karim,M.A., Ohta,K., Egashira,M., Jinno,Y., Niikawa,N., Matsuda,I.
            and Indo,Y.
  TITLE     Human ESP1/CRP2, a member of the LIM domain protein family:
            characterization of the cDNA and assignment of the gene locus to
            chromosome 14q32.3
  JOURNAL   Genomics 31 (2), 167-176 (1996)
   PUBMED   8824798
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC034151.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001312.3.
            
            Summary: This gene encodes a putative transcription factor with two
            LIM zinc-binding domains. The encoded protein may participate in
            the differentiation of smooth muscle tissue. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Aug
            2012].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.86327.1,
                                           SRR7346977.589896.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329146.9/ ENSP00000328521.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1178              BC034151.1         28-1205
FEATURES             Location/Qualifiers
     source          1..1178
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.33"
     gene            1..1178
                     /gene="CRIP2"
                     /gene_synonym="CRIP; CRP2; ESP1"
                     /note="cysteine rich protein 2"
                     /db_xref="GeneID:1397"
                     /db_xref="HGNC:HGNC:2361"
                     /db_xref="MIM:601183"
     exon            1..85
                     /gene="CRIP2"
                     /gene_synonym="CRIP; CRP2; ESP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..669
                     /gene="CRIP2"
                     /gene_synonym="CRIP; CRP2; ESP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Cysteine-rich intestinal protein; LIM domain protein
                     ESP1/CRP2"
                     /codon_start=1
                     /product="cysteine-rich protein 2 isoform 1"
                     /protein_id="NP_001303.1"
                     /db_xref="CCDS:CCDS10003.1"
                     /db_xref="GeneID:1397"
                     /db_xref="HGNC:HGNC:2361"
                     /db_xref="MIM:601183"
                     /translation="MASKCPKCDKTVYFAEKVSSLGKDWHKFCLKCERCSKTLTPGGH
                     AEHDGKPFCHKPCYATLFGPKGVNIGGAGSYIYEKPLAEGPQVTGPIEVPAARAEERK
                     ASGPPKGPSRASSVTTFTGEPNTCPRCSKKVYFAEKVTSLGKDWHRPCLRCERCGKTL
                     TPGGHAEHDGQPYCHKPCYGILFGPKGVNTGAVGSYIYDRDPEGKVQP"
     exon            86..180
                     /gene="CRIP2"
                     /gene_synonym="CRIP; CRP2; ESP1"
                     /inference="alignment:Splign:2.1.0"
     exon            181..238
                     /gene="CRIP2"
                     /gene_synonym="CRIP; CRP2; ESP1"
                     /inference="alignment:Splign:2.1.0"
     exon            239..379
                     /gene="CRIP2"
                     /gene_synonym="CRIP; CRP2; ESP1"
                     /inference="alignment:Splign:2.1.0"
     exon            380..448
                     /gene="CRIP2"
                     /gene_synonym="CRIP; CRP2; ESP1"
                     /inference="alignment:Splign:2.1.0"
     exon            449..543
                     /gene="CRIP2"
                     /gene_synonym="CRIP; CRP2; ESP1"
                     /inference="alignment:Splign:2.1.0"
     exon            544..601
                     /gene="CRIP2"
                     /gene_synonym="CRIP; CRP2; ESP1"
                     /inference="alignment:Splign:2.1.0"
     exon            602..1178
                     /gene="CRIP2"
                     /gene_synonym="CRIP; CRP2; ESP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1157..1162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRIP2"
                     /gene_synonym="CRIP; CRP2; ESP1"
                     /note="hexamer: AATAAA"
     polyA_site      1178
                     /gene="CRIP2"
                     /gene_synonym="CRIP; CRP2; ESP1"
                     /note="major polyA site"
ORIGIN      
        1 ggagaacggg cggagggcgc gggccgaccg ggcgcaccga ccatggcctc caaatgcccc
       61 aagtgcgaca agaccgtgta cttcgccgag aaggtgagct ccctggggaa ggactggcac
      121 aagttctgcc tcaagtgcga gcgctgcagc aagacgctga cgcccggggg ccacgccgag
      181 catgacggga agccgttctg ccacaagccg tgctacgcca ccctgttcgg acccaaaggc
      241 gtgaacatcg ggggcgcggg ctcctacatc tacgagaagc ccctggcgga ggggccgcag
      301 gtcaccggcc ccatcgaggt ccccgcggcc cgagcagagg agcggaaggc gagcggcccc
      361 ccgaaggggc ccagcagagc ctccagtgtc accactttca ccggggagcc caacacgtgc
      421 ccgcgctgca gcaagaaggt gtacttcgct gagaaggtga cgtctctggg caaggattgg
      481 caccggccct gcctgcgctg cgagcgctgc gggaagacac tgacccccgg cgggcacgcg
      541 gagcacgacg gccagcccta ctgccacaag ccctgctatg gaatcctctt cggacccaag
      601 ggagtgaaca ccggtgcggt gggcagctac atctatgacc gggaccccga aggcaaggtc
      661 cagccctagg ctacagcggc tctcatgatg tgggctcacc tgcgccccag accctgcagg
      721 ggcccccctg cttggctctg ctgggagagt gctcagccgc ccagtcctgc ctgcaagccc
      781 agggcgagta ttggaggagg ggcagccacg ggcagagcac catgcccatc cccgagtctc
      841 tggtgtgtct gccccctctg gcatcctctg ggcgtcccat gatcccttct gtgtctgcgt
      901 gtccgaatcc ccgtgtgacc ctgtcccagc attttcccgc cgaccctgcg tgtccccgtg
      961 gcgctgtccg ctctccctct cctgctgccc acccacctgc cagtgttatt tatgctccct
     1021 tcgtgggtga tggccacgcc ctcaccatgt ccctggcaga gggcttccct ccgggatccc
     1081 ctgcctggtg cccacactgc ctcgcaagcg ctcgccaccc tcacgtggct cacctgctgt
     1141 tgagccttgt gctgtcaata aacggtttga ggattgca
//
