LOCUS       NM_001311                672 bp    mRNA    linear   PRI 27-APR-2025
DEFINITION  Homo sapiens cysteine rich protein 1 (CRIP1), mRNA.
ACCESSION   NM_001311
VERSION     NM_001311.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 672)
  AUTHORS   Tang,P., Yu,Z., Sun,H., Liu,L., Gong,L., Fang,T., Sun,X., Xie,S.,
            An,G., Xu,Z., Qiu,L. and Hao,M.
  TITLE     CRIP1 involves the pathogenesis of multiple myeloma via
            dual-regulation of proteasome and autophagy
  JOURNAL   EBioMedicine 100, 104961 (2024)
   PUBMED   38199044
  REMARK    GeneRIF: CRIP1 involves the pathogenesis of multiple myeloma via
            dual-regulation of proteasome and autophagy.
REFERENCE   2  (bases 1 to 672)
  AUTHORS   Liu,X., Tang,R., Xu,J., Tan,Z., Liang,C., Meng,Q., Lei,Y., Hua,J.,
            Zhang,Y., Liu,J., Zhang,B., Wang,W., Yu,X. and Shi,S.
  TITLE     CRIP1 fosters MDSC trafficking and resets tumour microenvironment
            via facilitating NF-kappaB/p65 nuclear translocation in pancreatic
            ductal adenocarcinoma
  JOURNAL   Gut 72 (12), 2329-2343 (2023)
   PUBMED   37541772
  REMARK    GeneRIF: CRIP1 fosters MDSC trafficking and resets tumour
            microenvironment via facilitating NF-kappaB/p65 nuclear
            translocation in pancreatic ductal adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 672)
  AUTHORS   Deng,X., Zeng,Y., Qiu,X., Zhong,M., Xiong,X., Luo,M., Zhang,J. and
            Chen,X.
  TITLE     CRIP1 supports the growth and migration of AML-M5 subtype cells by
            activating Wnt/beta-catenin pathway
  JOURNAL   Leuk Res 130, 107312 (2023)
   PUBMED   37224580
  REMARK    GeneRIF: CRIP1 supports the growth and migration of AML-M5 subtype
            cells by activating Wnt/beta-catenin pathway.
REFERENCE   4  (bases 1 to 672)
  AUTHORS   Wang,J., Zhou,Y., Zhang,D., Zhao,W., Lu,Y., Liu,C., Lin,W.,
            Zhang,Y., Chen,K., Wang,H. and Zhao,L.
  TITLE     CRIP1 suppresses BBOX1-mediated carnitine metabolism to promote
            stemness in hepatocellular carcinoma
  JOURNAL   EMBO J 41 (15), e110218 (2022)
   PUBMED   35775648
  REMARK    GeneRIF: CRIP1 suppresses BBOX1-mediated carnitine metabolism to
            promote stemness in hepatocellular carcinoma.
REFERENCE   5  (bases 1 to 672)
  AUTHORS   Qi,B., Liu,S., Liu,D., Yao,H. and Yan,R.
  TITLE     Comprehensive Analysis of CRIP1 in Patients with Ovarian Cancer,
            including ceRNA Network, Immune-Infiltration Pattern, and Clinical
            Benefit
  JOURNAL   Dis Markers 2022, 2687867 (2022)
   PUBMED   35140819
  REMARK    GeneRIF: Comprehensive Analysis of CRIP1 in Patients with Ovarian
            Cancer, including ceRNA Network, Immune-Infiltration Pattern, and
            Clinical Benefit.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 672)
  AUTHORS   Dube,J.Y., Chapdelaine,P., Trahan,P.L., Deperthes,D., Frenette,G.
            and Tremblay,R.R.
  TITLE     Abundant cysteine-rich protein-1 is localized in the stromal
            compartment of the human prostate
  JOURNAL   Arch Androl 40 (2), 109-115 (1998)
   PUBMED   9507743
REFERENCE   7  (bases 1 to 672)
  AUTHORS   Garcia-Barcelo,M., Tsui,S.K., Chim,S.S., Fung,K.P., Lee,C.Y. and
            Waye,M.M.
  TITLE     Mapping of the human cysteine-rich intestinal protein gene CRIP1 to
            the human chromosomal segment 7q11.23
  JOURNAL   Genomics 47 (3), 419-422 (1998)
   PUBMED   9480758
REFERENCE   8  (bases 1 to 672)
  AUTHORS   Khoo,C., Blanchard,R.K., Sullivan,V.K. and Cousins,R.J.
  TITLE     Human cysteine-rich intestinal protein: cDNA cloning and expression
            of recombinant protein and identification in human peripheral blood
            mononuclear cells
  JOURNAL   Protein Expr Purif 9 (3), 379-387 (1997)
   PUBMED   9126610
REFERENCE   9  (bases 1 to 672)
  AUTHORS   Tsui,S.K., Yam,N.Y., Lee,C.Y. and Waye,M.M.
  TITLE     Isolation and characterization of a cDNA that codes for a
            LIM-containing protein which is developmentally regulated in heart
  JOURNAL   Biochem Biophys Res Commun 205 (1), 497-505 (1994)
   PUBMED   7999070
REFERENCE   10 (bases 1 to 672)
  AUTHORS   Hempe,J.M. and Cousins,R.J.
  TITLE     Cysteine-rich intestinal protein binds zinc during transmucosal
            zinc transport
  JOURNAL   Proc Natl Acad Sci U S A 88 (21), 9671-9674 (1991)
   PUBMED   1946385
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928654.1, BQ128075.1, BU500642.1 and BC002738.2.
            
            On May 17, 2019 this sequence version replaced NM_001311.4.
            
            Summary: Cysteine-rich intestinal protein (CRIP) belongs to the
            LIM/double zinc finger protein family, members of which include
            cysteine- and glycine-rich protein-1 (CSRP1; MIM 123876),
            rhombotin-1 (RBTN1; MIM 186921), rhombotin-2 (RBTN2; MIM 180385),
            and rhombotin-3 (RBTN3; MIM 180386). CRIP may be involved in
            intestinal zinc transport (Hempe and Cousins, 1991 [PubMed
            1946385]).[supplied by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.517542.1,
                                           SRR1163658.398610.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392531.4/ ENSP00000376315.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AL928654.1         165304-165337
            35-146              BQ128075.1         6-117
            147-297             BU500642.1         57-207
            298-510             BQ128075.1         269-481
            511-514             BC002738.2         411-414
            515-672             AL928654.1         167208-167365
FEATURES             Location/Qualifiers
     source          1..672
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.33"
     gene            1..672
                     /gene="CRIP1"
                     /gene_synonym="CRHP; CRIP; CRP-1; CRP1"
                     /note="cysteine rich protein 1"
                     /db_xref="GeneID:1396"
                     /db_xref="HGNC:HGNC:2360"
                     /db_xref="MIM:123875"
     exon            1..87
                     /gene="CRIP1"
                     /gene_synonym="CRHP; CRIP; CRP-1; CRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            88..188
                     /gene="CRIP1"
                     /gene_synonym="CRHP; CRIP; CRP-1; CRP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..382
                     /gene="CRIP1"
                     /gene_synonym="CRHP; CRIP; CRP-1; CRP1"
                     /note="cysteine-rich heart protein; cysteine-rich
                     intestinal protein; cysteine-rich protein 1 (intestinal)"
                     /codon_start=1
                     /product="cysteine-rich protein 1"
                     /protein_id="NP_001302.1"
                     /db_xref="CCDS:CCDS10004.1"
                     /db_xref="GeneID:1396"
                     /db_xref="HGNC:HGNC:2360"
                     /db_xref="MIM:123875"
                     /translation="MPKCPKCNKEVYFAERVTSLGKDWHRPCLKCEKCGKTLTSGGHA
                     EHEGKPYCNHPCYAAMFGPKGFGRGGAESHTFK"
     exon            189..283
                     /gene="CRIP1"
                     /gene_synonym="CRHP; CRIP; CRP-1; CRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            284..341
                     /gene="CRIP1"
                     /gene_synonym="CRHP; CRIP; CRP-1; CRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            342..387
                     /gene="CRIP1"
                     /gene_synonym="CRHP; CRIP; CRP-1; CRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            388..672
                     /gene="CRIP1"
                     /gene_synonym="CRHP; CRIP; CRP-1; CRP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      492..497
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRIP1"
                     /gene_synonym="CRHP; CRIP; CRP-1; CRP1"
                     /note="hexamer: AGTAAA"
     polyA_site      514
                     /gene="CRIP1"
                     /gene_synonym="CRHP; CRIP; CRP-1; CRP1"
                     /note="major polyA site"
ORIGIN      
        1 cttttgcctc ggaactggac ccgggagaca tcacagcgct gggctagggg cgcggcttga
       61 actcgcctaa agagctgcgc cctctcatct cgcgcctgca gcccgtgccg ccccagccgc
      121 tgccgcctgc accggacccg gagccgtcat gcccaagtgt cccaagtgca acaaggaggt
      181 gtacttcgcc gagagggtga cctctctggg caaggactgg catcggccct gcctgaagtg
      241 cgagaaatgt gggaagacgc tgacctctgg gggccacgct gagcacgaag gcaaacccta
      301 ctgcaaccac ccctgctacg cagccatgtt tgggcctaaa ggctttgggc ggggcggagc
      361 cgagagccac actttcaagt aaaccaggtg gtggagaccc catccttggc tgcttgcagg
      421 gccactgtcc aggcaaatgc caggccttgt ccccagatgc ccagggctcc cttgttgccc
      481 ctaatgctct cagtaaacct gaacacttgg aaaacctgtg tgtgtacatg cgcgtgtgtg
      541 ctggggagtg ccaagggagc tgcagtgggg tcctggcagc aggctctgcc accggcgcct
      601 gctcttctgc tgcccattgc cctccccagg gggccgttcc agggtctcat aggcgagggc
      661 tccctgtgca gg
//
