LOCUS       NM_016441               6060 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cysteine rich transmembrane BMP regulator 1 (CRIM1),
            mRNA.
ACCESSION   NM_016441
VERSION     NM_016441.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6060)
  AUTHORS   Dai,N., Ma,H. and Feng,Y.
  TITLE     Silencing of long non-coding RNA SDCBP2-AS1/microRNA-656-3p/CRIM1
            axis promotes ferroptosis of lung cancer cells
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (9), 189-194 (2023)
   PUBMED   37807311
  REMARK    GeneRIF: Silencing of long non-coding RNA
            SDCBP2-AS1/microRNA-656-3p/CRIM1 axis promotes ferroptosis of lung
            cancer cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6060)
  AUTHORS   Yu,F., Xing,J., Li,L. and Xiang,M.
  TITLE     CircCRIM1 mediates proliferation, migration, and invasion of
            trophoblast cell through regulating miR-942-5p/IL1RAP axis
  JOURNAL   Am J Reprod Immunol 90 (1), e13699 (2023)
   PUBMED   37382169
  REMARK    GeneRIF: CircCRIM1 mediates proliferation, migration, and invasion
            of trophoblast cell through regulating miR-942-5p/IL1RAP axis.
REFERENCE   3  (bases 1 to 6060)
  AUTHORS   Park,Y., Kim,H., Seo,H., Choi,J.Y., Ma,Y., Yun,S., Min,B.J.,
            Seo,M.E., Yoo,K.H., Kang,H.J., Im,H.J. and Kim,J.H.
  TITLE     Homozygote CRIM1 variant is associated with thiopurine-induced
            neutropenia in leukemic patients with both wildtype NUDT15 and TPMT
  JOURNAL   J Transl Med 18 (1), 265 (2020)
   PUBMED   32611418
  REMARK    GeneRIF: Homozygote CRIM1 variant is associated with
            thiopurine-induced neutropenia in leukemic patients with both
            wildtype NUDT15 and TPMT.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6060)
  AUTHORS   Maurizi,E., Schiroli,D., Atkinson,S.D., Mairs,L., Courtney,D.G.,
            O'Hagan,B., McGilligan,V.E., Pagnamenta,A.T., Taylor,J.C.,
            Vasquez,J.J.D., Illanes-Velarde,D.E., Goldsmith,D., Gouws,P.,
            Moore,J.E., Nesbit,M.A. and Moore,C.B.T.
  TITLE     A novel role for CRIM1 in the corneal response to UV and pterygium
            development
  JOURNAL   Exp Eye Res 179, 75-92 (2019)
   PUBMED   30365943
  REMARK    GeneRIF: We propose here a series of intracellular events where
            CRIM1 regulation of the ERK pathway prevents UV-induced cell
            proliferation and may play an important role in the in the
            pathogenesis of pterygium.
REFERENCE   5  (bases 1 to 6060)
  AUTHORS   Ogasawara,N., Kudo,T., Sato,M., Kawasaki,Y., Yonezawa,S.,
            Takahashi,S., Miyagi,Y., Natori,Y. and Sugiyama,A.
  TITLE     Reduction of Membrane Protein CRIM1 Decreases E-Cadherin and
            Increases Claudin-1 and MMPs, Enhancing the Migration and Invasion
            of Renal Carcinoma Cells
  JOURNAL   Biol Pharm Bull 41 (4), 604-611 (2018)
   PUBMED   29607933
  REMARK    GeneRIF: CRIM1 regulates the expression of several
            epithelial-mesenchymal transition (EMT) related factors and appears
            to play a role in suppressing migration and invasion through
            control of EMT.
REFERENCE   6  (bases 1 to 6060)
  AUTHORS   Polasek,O., Marusic,A., Rotim,K., Hayward,C., Vitart,V.,
            Huffman,J., Campbell,S., Jankovic,S., Boban,M., Biloglav,Z.,
            Kolcic,I., Krzelj,V., Terzic,J., Matec,L., Tometic,G., Nonkovic,D.,
            Nincevic,J., Pehlic,M., Zedelj,J., Velagic,V., Juricic,D.,
            Kirac,I., Belak Kovacevic,S., Wright,A.F., Campbell,H. and Rudan,I.
  TITLE     Genome-wide association study of anthropometric traits in Korcula
            Island, Croatia
  JOURNAL   Croat Med J 50 (1), 7-16 (2009)
   PUBMED   19260139
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   7  (bases 1 to 6060)
  AUTHORS   Wilkinson,L., Kolle,G., Wen,D., Piper,M., Scott,J. and Little,M.
  TITLE     CRIM1 regulates the rate of processing and delivery of bone
            morphogenetic proteins to the cell surface
  JOURNAL   J Biol Chem 278 (36), 34181-34188 (2003)
   PUBMED   12805376
  REMARK    GeneRIF: CRIM1 modulates BMP activity by affecting its processing
            and delivery to the cell surface
REFERENCE   8  (bases 1 to 6060)
  AUTHORS   Glienke,J., Sturz,A., Menrad,A. and Thierauch,K.H.
  TITLE     CRIM1 is involved in endothelial cell capillary formation in vitro
            and is expressed in blood vessels in vivo
  JOURNAL   Mech Dev 119 (2), 165-175 (2002)
   PUBMED   12464430
  REMARK    GeneRIF: CRIM1 has a role in capillary formation and maintenance
            during angiogenesis
REFERENCE   9  (bases 1 to 6060)
  AUTHORS   Georgas,K., Bowles,J., Yamada,T., Koopman,P. and Little,M.H.
  TITLE     Characterisation of Crim1 expression in the developing mouse
            urogenital tract reveals a sexually dimorphic gonadal expression
            pattern
  JOURNAL   Dev Dyn 219 (4), 582-587 (2000)
   PUBMED   11084657
REFERENCE   10 (bases 1 to 6060)
  AUTHORS   Kolle,G., Georgas,K., Holmes,G.P., Little,M.H. and Yamada,T.
  TITLE     CRIM1, a novel gene encoding a cysteine-rich repeat protein, is
            developmentally regulated and implicated in vertebrate CNS
            development and organogenesis
  JOURNAL   Mech Dev 90 (2), 181-193 (2000)
   PUBMED   10642437
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009414.4, AB209139.1 and
            AF167706.1.
            
            On Nov 23, 2018 this sequence version replaced NM_016441.2.
            
            Summary: This gene encodes a transmembrane protein containing six
            cysteine-rich repeat domains and an insulin-like growth
            factor-binding domain. The encoded protein may play a role in
            tissue development though interactions with members of the
            transforming growth factor beta family, such as bone morphogenetic
            proteins. [provided by RefSeq, Nov 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF167706.1, SRR1660809.144038.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000280527.7/ ENSP00000280527.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-449               AC009414.4         7290-7738           c
            450-1812            AB209139.1         1-1363
            1813-6060           AF167706.1         1337-5584
FEATURES             Location/Qualifiers
     source          1..6060
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.2"
     gene            1..6060
                     /gene="CRIM1"
                     /gene_synonym="CRIM-1; S52"
                     /note="cysteine rich transmembrane BMP regulator 1"
                     /db_xref="GeneID:51232"
                     /db_xref="HGNC:HGNC:2359"
                     /db_xref="MIM:606189"
     exon            1..846
                     /gene="CRIM1"
                     /gene_synonym="CRIM-1; S52"
                     /inference="alignment:Splign:2.1.0"
     CDS             516..3626
                     /gene="CRIM1"
                     /gene_synonym="CRIM-1; S52"
                     /note="cysteine-rich repeat-containing protein S52;
                     cysteine-rich motor neuron 1 protein; cysteine rich
                     transmembrane BMP regulator 1 (chordin-like)"
                     /codon_start=1
                     /product="cysteine-rich motor neuron 1 protein precursor"
                     /protein_id="NP_057525.1"
                     /db_xref="CCDS:CCDS1783.1"
                     /db_xref="GeneID:51232"
                     /db_xref="HGNC:HGNC:2359"
                     /db_xref="MIM:606189"
                     /translation="MYLVAGDRGLAGCGHLLVSLLGLLLLLARSGTRALVCLPCDESK
                     CEEPRNCPGSIVQGVCGCCYTCASQRNESCGGTFGIYGTCDRGLRCVIRPPLNGDSLT
                     EYEAGVCEDENWTDDQLLGFKPCNENLIAGCNIINGKCECNTIRTCSNPFEFPSQDMC
                     LSALKRIEEEKPDCSKARCEVQFSPRCPEDSVLIEGYAPPGECCPLPSRCVCNPAGCL
                     RKVCQPGNLNILVSKASGKPGECCDLYECKPVFGVDCRTVECPPVQQTACPPDSYETQ
                     VRLTADGCCTLPTRCECLSGLCGFPVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKP
                     ACVFNNVEYYDGDMFRMDNCRFCRCQGGVAICFTAQCGEINCERYYVPEGECCPVCED
                     PVYPFNNPAGCYANGLILAHGDRWREDDCTFCQCVNGERHCVATVCGQTCTNPVKVPG
                     ECCPVCEEPTIITVDPPACGELSNCTLTGKDCINGFKRDHNGCRTCQCINTEELCSER
                     KQGCTLNCPFGFLTDAQNCEICECRPRPKKCRPIICDKYCPLGLLKNKHGCDICRCKK
                     CPELSCSKICPLGFQQDSHGCLICKCREASASAGPPILSGTCLTVDGHHHKNEESWHD
                     GCRECYCLNGREMCALITCPVPACGNPTIHPGQCCPSCADDFVVQKPELSTPSICHAP
                     GGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLCQNPSRTQDSCCPQCTDQPFR
                     PSLSRNNSVPNYCKNDEGDIFLAAESWKPDVCTSCICIDSVISCFSESCPSVSCERPV
                     LRKGQCCPYCIEDTIPKKVVCHFSGKAYADEERWDLDSCTHCYCLQGQTLCSTVSCPP
                     LPCVEPINVEGSCCPMCPEMYVPEPTNIPIEKTNHRGEVDLEVPLWPTPSENDIVHLP
                     RDMGHLQVDYRDNRLHPSEDSSLDSIASVVVPIIICLSIIIAFLFINQKKQWIPLLCW
                     YRTPTKPSSLNNQLVSVDCKKGTRVQVDSSQRMLRIAEPDARFSGFYSMQKQNHLQAD
                     NFYQTV"
     exon            847..1020
                     /gene="CRIM1"
                     /gene_synonym="CRIM-1; S52"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1263
                     /gene="CRIM1"
                     /gene_synonym="CRIM-1; S52"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1384
                     /gene="CRIM1"
                     /gene_synonym="CRIM-1; S52"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1506
                     /gene="CRIM1"
                     /gene_synonym="CRIM-1; S52"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1689
                     /gene="CRIM1"
                     /gene_synonym="CRIM-1; S52"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1887
                     /gene="CRIM1"
                     /gene_synonym="CRIM-1; S52"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2016
                     /gene="CRIM1"
                     /gene_synonym="CRIM-1; S52"
                     /inference="alignment:Splign:2.1.0"
     exon            2017..2173
                     /gene="CRIM1"
                     /gene_synonym="CRIM-1; S52"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2295
                     /gene="CRIM1"
                     /gene_synonym="CRIM-1; S52"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2505
                     /gene="CRIM1"
                     /gene_synonym="CRIM-1; S52"
                     /inference="alignment:Splign:2.1.0"
     exon            2506..2721
                     /gene="CRIM1"
                     /gene_synonym="CRIM-1; S52"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..2943
                     /gene="CRIM1"
                     /gene_synonym="CRIM-1; S52"
                     /inference="alignment:Splign:2.1.0"
     exon            2944..3138
                     /gene="CRIM1"
                     /gene_synonym="CRIM-1; S52"
                     /inference="alignment:Splign:2.1.0"
     exon            3139..3261
                     /gene="CRIM1"
                     /gene_synonym="CRIM-1; S52"
                     /inference="alignment:Splign:2.1.0"
     exon            3262..3449
                     /gene="CRIM1"
                     /gene_synonym="CRIM-1; S52"
                     /inference="alignment:Splign:2.1.0"
     exon            3450..6060
                     /gene="CRIM1"
                     /gene_synonym="CRIM-1; S52"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5929..5934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRIM1"
                     /gene_synonym="CRIM-1; S52"
                     /note="hexamer: AATAAA"
     polyA_site      5959
                     /gene="CRIM1"
                     /gene_synonym="CRIM-1; S52"
                     /note="major polyA site"
     regulatory      6037..6042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRIM1"
                     /gene_synonym="CRIM-1; S52"
                     /note="hexamer: AATAAA"
     polyA_site      6060
                     /gene="CRIM1"
                     /gene_synonym="CRIM-1; S52"
                     /note="major polyA site"
ORIGIN      
        1 aggagtgagg cgagcggggc gcgcggagcg gacgccgcgg atcttgtgct gcgccaccgc
       61 gcccactcgg cagctcggga ggcggggacc ggcccggagg ctgcgccgct gcggggccgg
      121 ccgactcgga ggaggagagg gaggaggcgc cgccggcccg ggctggagcc gagcgcagca
      181 gccaccgccg ccgccgcgcc agaagtttgg gttgaaccgg agctgccggg aggaaacttt
      241 tttctttttt ccccctccct cccgggagga ggaggaggag gaggagggga agctgccgcc
      301 ggcgccaagg ctcgtgggct cggggtcggc gcggcccgca gaaggggcgg gggcctcgcc
      361 ccgcgagggg aggcgcgccc cgggggcccc gagaggggcg gtgaggaccg cgggctgctg
      421 gtgcggcggc ggcggcgcgt gtgccccgcg caggggaggg cgcccgcccc gctcccggcc
      481 cggctgcgag gaggaggcgg cggcggcgca ggaggatgta cttggtggcg ggggacaggg
      541 ggttggccgg ctgcgggcac ctcctggtct cgctgctggg gctgctgctg ctgctggcgc
      601 gctccggcac ccgggcgctg gtctgcctgc cctgtgacga gtccaagtgc gaggagccca
      661 ggaactgccc ggggagcatc gtgcagggcg tctgcggctg ctgctacacg tgcgccagcc
      721 agaggaacga gagctgcggc ggcaccttcg ggatttacgg aacctgcgac cgggggctgc
      781 gttgtgtcat ccgccccccg ctcaatggcg actccctcac cgagtacgaa gcgggcgttt
      841 gcgaagatga gaactggact gatgaccaac tgcttggttt taaaccatgc aatgaaaacc
      901 ttattgctgg ctgcaatata atcaatggga aatgtgaatg taacaccatt cgaacctgca
      961 gcaatccctt tgagtttcca agtcaggata tgtgcctttc agctttaaag agaattgaag
     1021 aagagaagcc agattgctcc aaggcccgct gtgaagtcca gttctctcca cgttgtcctg
     1081 aagattctgt tctgatcgag ggttatgctc ctcctgggga gtgctgtccc ttacccagcc
     1141 gctgcgtgtg caaccccgca ggctgtctgc gcaaagtctg ccagccggga aacctgaaca
     1201 tactagtgtc aaaagcctca gggaagccgg gagagtgctg tgacctctat gagtgcaaac
     1261 cagttttcgg cgtggactgc aggactgtgg aatgccctcc tgttcagcag accgcgtgtc
     1321 ccccggacag ctatgaaact caagtcagac taactgcaga tggttgctgt actttgccaa
     1381 caagatgcga gtgtctctct ggcttatgtg gtttccccgt gtgtgaggtg ggatccactc
     1441 cccgcatagt ctctcgtggc gatgggacac ctggaaagtg ctgtgatgtc tttgaatgtg
     1501 ttaatgatac aaagccagcc tgcgtattta acaatgtgga atattatgat ggagacatgt
     1561 ttcgaatgga caactgtcgg ttctgtcgat gccaaggggg cgttgccatc tgcttcaccg
     1621 cccagtgtgg tgagataaac tgcgagaggt actacgtgcc cgaaggagag tgctgcccag
     1681 tgtgtgaaga tccagtgtat ccttttaata atcccgctgg ctgctatgcc aatggcctga
     1741 tccttgccca cggagaccgg tggcgggaag acgactgcac attctgccag tgcgtcaacg
     1801 gtgaacgcca ctgcgttgcg accgtctgcg gacagacctg cacaaaccct gtgaaagtgc
     1861 ctggggagtg ttgccctgtg tgcgaagaac caaccatcat cacagttgat ccacctgcat
     1921 gtggggagtt atcaaactgc actctgacag ggaaggactg cattaatggt ttcaaacgcg
     1981 atcacaatgg ttgtcggacc tgtcagtgca taaacaccga ggaactatgt tcagaacgta
     2041 aacaaggctg caccttgaac tgtcccttcg gtttccttac tgatgcccaa aactgtgaga
     2101 tctgtgagtg ccgcccaagg cccaagaagt gcagacccat aatctgtgac aagtattgtc
     2161 cacttggatt gctgaagaat aagcacggct gtgacatctg tcgctgtaag aaatgtccag
     2221 agctctcatg cagtaagatc tgccccttgg gtttccagca ggacagtcac ggctgtctta
     2281 tctgcaagtg cagagaggcc tctgcttcag ctgggccacc catcctgtcg ggcacttgtc
     2341 tcaccgtgga tggtcatcat cataaaaatg aggagagctg gcacgatggg tgccgggaat
     2401 gctactgtct caatggacgg gaaatgtgtg ccctgatcac ctgcccggtg cctgcctgtg
     2461 gcaaccccac cattcaccct ggacagtgct gcccatcatg tgcagatgac tttgtggtgc
     2521 agaagccaga gctcagtact ccctccattt gccacgcccc tggaggagaa tactttgtgg
     2581 aaggagaaac gtggaacatt gactcctgta ctcagtgcac ctgccacagc ggacgggtgc
     2641 tgtgtgagac agaggtgtgc ccaccgctgc tctgccagaa cccctcacgc acccaggatt
     2701 cctgctgccc acagtgtaca gatcaacctt ttcggccttc cttgtcccgc aataacagcg
     2761 tacctaatta ctgcaaaaat gatgaagggg atatattcct ggcagctgag tcctggaagc
     2821 ctgacgtttg taccagctgc atctgcattg atagcgtaat tagctgtttc tctgagtcct
     2881 gcccttctgt atcctgtgaa agacctgtct tgagaaaagg ccagtgttgt ccctactgca
     2941 tagaagacac aattccaaag aaggtggtgt gccacttcag tgggaaggcc tatgccgacg
     3001 aggagcggtg ggaccttgac agctgcaccc actgctactg cctgcagggc cagaccctct
     3061 gctcgaccgt cagctgcccc cctctgccct gtgttgagcc catcaacgtg gaaggaagtt
     3121 gctgcccaat gtgtccagaa atgtatgtcc cagaaccaac caatataccc attgagaaga
     3181 caaaccatcg aggagaggtt gacctggagg ttcccctgtg gcccacgcct agtgaaaatg
     3241 atatcgtcca tctccctaga gatatgggtc acctccaggt agattacaga gataacaggc
     3301 tgcacccaag tgaagattct tcactggact ccattgcctc agttgtggtt cccataatta
     3361 tatgcctctc tattataata gcattcctat tcatcaatca gaagaaacag tggataccac
     3421 tgctttgctg gtatcgaaca ccaactaagc cttcttcctt aaataatcag ctagtatctg
     3481 tggactgcaa gaaaggaacc agagtccagg tggacagttc ccagagaatg ctaagaattg
     3541 cagaaccaga tgcaagattc agtggcttct acagcatgca aaaacagaac catctacagg
     3601 cagacaattt ctaccaaaca gtgtgaagaa aggcaactag gatgaggttt caaaagacgg
     3661 aagacgacta aatctgctct aaaaagtaaa ctagaatttg tgcacttgct tagtggattg
     3721 tattggattg tgacttgatg tacagcgcta agaccttact gggatgggct ctgtctacag
     3781 caatgtgcag aacaagcatt cccacttttc ctcaagataa ctgaccaagt gttttcttag
     3841 aaccaaagtt tttaaagttg ctaagatata tttgcctgta agatagctgt agagatattt
     3901 ggggtgggga cagtgagttt ggatggggaa atgggtggga gggtggtgtt gggaagaaaa
     3961 attggtcagc ttggctcggg gagaaacctg gtaacataaa agcagttcag tggcccagag
     4021 gttatttttt tcctattgct ctgaagactg cactggttgc tgcaaagctc aggcctgaat
     4081 gagcaggaaa caaaaaaggc cttgcgaccc agctgccata accaccttag aactaccaga
     4141 cgagcacatc agaacccttt gacagccatc ccaggtctaa agccacaagt ttcttttcta
     4201 tacagtcaca actgcagtag gcagtgagga agccagagaa atgcgatagc ggcatttctc
     4261 taaagcgggt tattaaggat atatacagtt acactttttg ctgcttttat tttcttccaa
     4321 gccaatcaat cagccagttc ctagcagagt cagcacatga acaagatcta agtcatttct
     4381 tgatgtgagc actggagctt tttttttttt acaacgtgac aggaagagga gggagagggt
     4441 gacgaacacc aggcatttcc aggggctata tttcactgtt tgttgttgct ttgttctgtt
     4501 atattgttgg ttgttcatag tttttgttga agctctagct taagaagaaa ctttttttaa
     4561 aaagactgtt tggggattct ttttccttat tatatactga ttctacaaaa tagaaactac
     4621 ttcattttaa ttgtatatta ttcaagcacc tttgttgaag ctcaaaaaaa atgatgcctc
     4681 tttaaacttt agcaattata ggagtattta tgtaactatc ttatgcttca aaaaacaaaa
     4741 gtatttgtgt gcatgtgtat ataatatata tatatacata tatatttata cacatacaat
     4801 ttatgttttc ctgttgaatg tatttttatg agattttaac cagaacaaag gcagataaac
     4861 aggcattcca tagcagtgct tttgatcact tacaaatttt ttgaataaca caaaatctca
     4921 ttctacctgc agtttaattg gaaagatgtg tgtgtgagag tatgtatgtg tgtgtgtgtg
     4981 tgtgtgtgtg tgcgcgcgca cgcacgcctt gagcagtcag cattgcacct gctatggaga
     5041 agggtattcc tttattaaaa tcttcctcat ttggatttgc tttcagttgg ttttcaattt
     5101 gctcactggc cagagacatt gatggcagtt cttatctgca tcactaatca gctcctggat
     5161 tttttttttt tttttttcaa acaatggttt gaaacaacta ctggaatatt gtccacaata
     5221 agctggaagt ttgttgtagt atgcctcaaa tataactgac tgtatactat agtggtaact
     5281 tttcaaacag cccttagcac ttttatacta attaacccat ttgtgcattg agttttcttt
     5341 taaaaatgct tgttgtgaaa gacacagata cccagtatgc ttaacgtgaa aagaaaatgt
     5401 gttctgtttt gtaaaggaac tttcaagtat tgttgtaaat acttggacag aggttgctga
     5461 actttaaaaa aaattaattt attattataa tgacctaatt tattaatctg aagattaacc
     5521 atttttttgt cttagaatat caaaaagaaa aagaaaaagg tgttctagct gtttgcatca
     5581 aaggaaaaaa agatttatta tcaaggggca atatttttat cttttccaaa ataaatttgt
     5641 taatgataca ttacaaaaat agattgacat cagcctgatt agtataaatt ttgttggtaa
     5701 ttaatccatt cctggcataa aaagtcttta tcaaaaaaaa ttgtagatgc ttgctttttg
     5761 ttttttcaat catggccata ttatgaaaat actaacagga tataggacaa ggtgtaaatt
     5821 tttttattat tattttaaag atatgattta tcctgagtgc tgtatctatt actcttttac
     5881 tttggttcct gttgtgctct tgtaaaagaa aaatataatt tcctgaagaa taaaatagat
     5941 atatggcact tggagtgcat catagttcta cagtttgttt ttgttttctt caaaaaagct
     6001 gtaagagaat tatctgcaac ttgattcttg gcaggaaata aacattttga gttgaaatca
//
