LOCUS       NM_001883               2930 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens corticotropin releasing hormone receptor 2 (CRHR2),
            transcript variant 1, mRNA.
ACCESSION   NM_001883
VERSION     NM_001883.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2930)
  AUTHORS   Amin,M., Horst,N., Wu,R. and Gragnoli,C.
  TITLE     Novel corticotropin-releasing hormone receptor genes (CRHR1 and
            CRHR2) linkage to and association with polycystic ovary syndrome
  JOURNAL   J Ovarian Res 16 (1), 155 (2023)
   PUBMED   37543650
  REMARK    GeneRIF: Novel corticotropin-releasing hormone receptor genes
            (CRHR1 and CRHR2) linkage to and association with polycystic ovary
            syndrome.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2930)
  AUTHORS   Amin,M., Ott,J., Gordon,D., Wu,R., Postolache,T.T., Vergare,M. and
            Gragnoli,C.
  TITLE     Comorbidity of Novel CRHR2 Gene Variants in Type 2 Diabetes and
            Depression
  JOURNAL   Int J Mol Sci 23 (17), 9819 (2022)
   PUBMED   36077219
  REMARK    GeneRIF: Comorbidity of Novel CRHR2 Gene Variants in Type 2
            Diabetes and Depression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2930)
  AUTHORS   Ramirez-Guerrero,A.A., Gonzalez-Villasenor,C.O., Leal-Ugarte,E.,
            Gutierrez-Angulo,M., Ramirez-Flores,M., Delgado-Enciso,I. and
            Macias-Gomez,N.M.
  TITLE     Association between genetic variant rs2267716 of CRHR2 gene with
            colorectal cancer
  JOURNAL   J Investig Med 70 (4), 947-952 (2022)
   PUBMED   34969780
  REMARK    GeneRIF: Association between genetic variant rs2267716 of CRHR2
            gene with colorectal cancer.
REFERENCE   4  (bases 1 to 2930)
  AUTHORS   Bruce,J.K., Burns,G.L., Sinn Soh,W., Nair,P.M., Sherwin,S., Fan,K.,
            Dowling,L.R., Goggins,B.J., Koloski,N., Potter,M., Bollipo,S.,
            Foster,R., Gan,L.T., Veysey,M., Philpott,D.J., Girardin,S.E.,
            Holtmann,G., Kaiko,G.E., Walker,M.M., Talley,N.J. and Keely,S.
  TITLE     Defects in NLRP6, autophagy and goblet cell homeostasis are
            associated with reduced duodenal CRH receptor 2 expression in
            patients with functional dyspepsia
  JOURNAL   Brain Behav Immun 101, 335-345 (2022)
   PUBMED   35093492
  REMARK    GeneRIF: Defects in NLRP6, autophagy and goblet cell homeostasis
            are associated with reduced duodenal CRH receptor 2 expression in
            patients with functional dyspepsia.
REFERENCE   5  (bases 1 to 2930)
  AUTHORS   Grammatopoulos,D.K., Randeva,H.S., Levine,M.A., Katsanou,E.S. and
            Hillhouse,E.W.
  TITLE     Urocortin, but not corticotropin-releasing hormone (CRH), activates
            the mitogen-activated protein kinase signal transduction pathway in
            human pregnant myometrium: an effect mediated via R1alpha and
            R2beta CRH receptor subtypes and stimulation of Gq-proteins
  JOURNAL   Mol Endocrinol 14 (12), 2076-2091 (2000)
   PUBMED   11117536
REFERENCE   6  (bases 1 to 2930)
  AUTHORS   Kostich,W.A., Chen,A., Sperle,K. and Largent,B.L.
  TITLE     Molecular identification and analysis of a novel human
            corticotropin-releasing factor (CRF) receptor: the CRF2gamma
            receptor
  JOURNAL   Mol Endocrinol 12 (8), 1077-1085 (1998)
   PUBMED   9717834
REFERENCE   7  (bases 1 to 2930)
  AUTHORS   Meyer,A.H., Ullmer,C., Schmuck,K., Morel,C., Wishart,W., Lubbert,H.
            and Engels,P.
  TITLE     Localization of the human CRF2 receptor to 7p21-p15 by radiation
            hybrid mapping and FISH analysis
  JOURNAL   Genomics 40 (1), 189-190 (1997)
   PUBMED   9070940
REFERENCE   8  (bases 1 to 2930)
  AUTHORS   Donaldson,C.J., Sutton,S.W., Perrin,M.H., Corrigan,A.Z.,
            Lewis,K.A., Rivier,J.E., Vaughan,J.M. and Vale,W.W.
  TITLE     Cloning and characterization of human urocortin
  JOURNAL   Endocrinology 137 (5), 2167-2170 (1996)
   PUBMED   8612563
  REMARK    Erratum:[Endocrinology. 1996 Sep;137(9):3896. doi:
            10.1210/endo.137.9.8756563. PMID: 8756563]
REFERENCE   9  (bases 1 to 2930)
  AUTHORS   Liaw,C.W., Lovenberg,T.W., Barry,G., Oltersdorf,T.,
            Grigoriadis,D.E. and de Souza,E.B.
  TITLE     Cloning and characterization of the human corticotropin-releasing
            factor-2 receptor complementary deoxyribonucleic acid
  JOURNAL   Endocrinology 137 (1), 72-77 (1996)
   PUBMED   8536644
REFERENCE   10 (bases 1 to 2930)
  AUTHORS   Perrin,M.H., Donaldson,C.J., Chen,R., Lewis,K.A. and Vale,W.W.
  TITLE     Cloning and functional expression of a rat brain corticotropin
            releasing factor (CRF) receptor
  JOURNAL   Endocrinology 133 (6), 3058-3061 (1993)
   PUBMED   8243338
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA808296.1, AK313661.1,
            U34587.1, AC004976.1, CN367944.1 and DB308619.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001883.4.
            
            Summary: The protein encoded by this gene belongs to the G-protein
            coupled receptor 2 family, and the subfamily of corticotropin
            releasing hormone receptor. This receptor shows high affinity for
            corticotropin releasing hormone (CRH), and also binds CRH-related
            peptides such as urocortin. CRH is synthesized in the hypothalamus,
            and plays an important role in coordinating the endocrine,
            autonomic, and behavioral responses to stress and immune challenge.
            Studies in mice suggest that this receptor maybe involved in
            mediating cardiovascular homeostasis. Alternatively spliced
            transcript variants encoding different isoforms have been described
            for this gene.[provided by RefSeq, Jan 2011].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript, and encodes isoform 1 (also known as alpha isoform).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.360.1, SRR1803614.6688.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03465404 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000471646.6/ ENSP00000418722.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-331               DA808296.1         243-573
            332-1222            AK313661.1         362-1252
            1223-1833           U34587.1           1047-1657
            1834-1978           AC004976.1         38645-38789         c
            1979-2181           U34587.1           1803-2005
            2182-2657           CN367944.1         91-566
            2658-2929           DB308619.1         1-272               c
            2930-2930           AC004976.1         37693-37693         c
FEATURES             Location/Qualifiers
     source          1..2930
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.3"
     gene            1..2930
                     /gene="CRHR2"
                     /gene_synonym="CRF-RB; CRF2; CRFR2; HM-CRF"
                     /note="corticotropin releasing hormone receptor 2"
                     /db_xref="GeneID:1395"
                     /db_xref="HGNC:HGNC:2358"
                     /db_xref="MIM:602034"
     exon            1..279
                     /gene="CRHR2"
                     /gene_synonym="CRF-RB; CRF2; CRFR2; HM-CRF"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..1412
                     /gene="CRHR2"
                     /gene_synonym="CRF-RB; CRF2; CRFR2; HM-CRF"
                     /note="isoform 1 is encoded by transcript variant 1;
                     corticotropin-releasing factor receptor 2; CRH-R2"
                     /codon_start=1
                     /product="corticotropin-releasing factor receptor 2
                     isoform 1"
                     /protein_id="NP_001874.2"
                     /db_xref="CCDS:CCDS5429.1"
                     /db_xref="GeneID:1395"
                     /db_xref="HGNC:HGNC:2358"
                     /db_xref="MIM:602034"
                     /translation="MDAALLHSLLEANCSLALAEELLLDGWGPPLDPEGPYSYCNTTL
                     DQIGTCWPRSAAGALVERPCPEYFNGVKYNTTRNAYRECLENGTWASKINYSQCEPIL
                     DDKQRKYDLHYRIALVVNYLGHCVSVAALVAAFLLFLALRSIRCLRNVIHWNLITTFI
                     LRNVMWFLLQLVDHEVHESNEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYS
                     TERLRKCLFLFIGWCIPFPIIVAWAIGKLYYENEQCWFGKEPGDLVDYIYQGPIILVL
                     LINFVFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDD
                     LSQIMFIYFNSFLQSFQGFFVSVFYCFFNGEVRSAVRKRWHRWQDHHSLRVPMARAMS
                     IPTSPTRISFHSIKQTAAV"
     exon            280..405
                     /gene="CRHR2"
                     /gene_synonym="CRF-RB; CRF2; CRFR2; HM-CRF"
                     /inference="alignment:Splign:2.1.0"
     exon            406..491
                     /gene="CRHR2"
                     /gene_synonym="CRF-RB; CRF2; CRFR2; HM-CRF"
                     /inference="alignment:Splign:2.1.0"
     exon            492..601
                     /gene="CRHR2"
                     /gene_synonym="CRF-RB; CRF2; CRFR2; HM-CRF"
                     /inference="alignment:Splign:2.1.0"
     exon            602..719
                     /gene="CRHR2"
                     /gene_synonym="CRF-RB; CRF2; CRFR2; HM-CRF"
                     /inference="alignment:Splign:2.1.0"
     exon            720..873
                     /gene="CRHR2"
                     /gene_synonym="CRF-RB; CRF2; CRFR2; HM-CRF"
                     /inference="alignment:Splign:2.1.0"
     exon            874..934
                     /gene="CRHR2"
                     /gene_synonym="CRF-RB; CRF2; CRFR2; HM-CRF"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1007
                     /gene="CRHR2"
                     /gene_synonym="CRF-RB; CRF2; CRFR2; HM-CRF"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1093
                     /gene="CRHR2"
                     /gene_synonym="CRF-RB; CRF2; CRFR2; HM-CRF"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1229
                     /gene="CRHR2"
                     /gene_synonym="CRF-RB; CRF2; CRFR2; HM-CRF"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1271
                     /gene="CRHR2"
                     /gene_synonym="CRF-RB; CRF2; CRFR2; HM-CRF"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..2930
                     /gene="CRHR2"
                     /gene_synonym="CRF-RB; CRF2; CRFR2; HM-CRF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2270..2275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRHR2"
                     /gene_synonym="CRF-RB; CRF2; CRFR2; HM-CRF"
                     /note="hexamer: AATAAA"
     polyA_site      2290
                     /gene="CRHR2"
                     /gene_synonym="CRF-RB; CRF2; CRFR2; HM-CRF"
     regulatory      2901..2906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRHR2"
                     /gene_synonym="CRF-RB; CRF2; CRFR2; HM-CRF"
                     /note="hexamer: AATAAA"
     polyA_site      2930
                     /gene="CRHR2"
                     /gene_synonym="CRF-RB; CRF2; CRFR2; HM-CRF"
                     /note="major polyA site"
ORIGIN      
        1 acttgacagc tctgggcgac cggaggtggc gcccaaaggc tgcccgggag atcggggctg
       61 ggctggcggg ggccaggacc ccgcgccctc tcggccgctc actctcgcgt ccactccctc
      121 gcagtcacgc cgggcgcgca ctcccactcc ctctccgcac gcggctgcgg gacgcgatgg
      181 acgcggcact gctccacagc ctgctggagg ccaactgcag cctggcgctg gctgaagagc
      241 tgctcttgga cggctggggg ccacccctgg accccgaggg tccctactcc tactgcaaca
      301 cgaccttgga ccagatcgga acgtgctggc cccgcagcgc tgccggagcc ctcgtggaga
      361 ggccgtgccc cgagtacttc aacggcgtca agtacaacac gacccggaat gcctatcgag
      421 aatgcttgga gaatgggacg tgggcctcaa agatcaacta ctcacagtgt gagcccattt
      481 tggatgacaa gcagaggaag tatgacctgc actaccgcat cgcccttgtc gtcaactacc
      541 tgggccactg cgtatctgtg gcagccctgg tggccgcctt cctgcttttc ctggccctgc
      601 ggagcattcg ctgtctgcgg aatgtgattc actggaacct catcaccacc tttatcctgc
      661 gaaatgtcat gtggttcctg ctgcagctcg ttgaccatga agtgcacgag agcaatgagg
      721 tctggtgccg ctgcatcacc accatcttca actacttcgt ggtgaccaac ttcttctgga
      781 tgtttgtgga aggctgctac ctgcacacgg ccattgtcat gacctactcc actgagcgcc
      841 tgcgcaagtg cctcttcctc ttcatcggat ggtgcatccc cttccccatc atcgtcgcct
      901 gggccatcgg caagctctac tatgagaatg aacagtgctg gtttggcaag gagcctggcg
      961 acctggtgga ctacatctac caaggcccca tcattctcgt gctcctgatc aatttcgtat
     1021 ttctgttcaa catcgtcagg atcctaatga caaagttacg cgcgtccacc acatccgaga
     1081 caatccagta caggaaggca gtgaaggcca ccctggtgct cctgcccctc ctgggcatca
     1141 cctacatgct cttcttcgtc aatcccgggg aggacgacct gtcacagatc atgttcatct
     1201 atttcaactc cttcctgcag tcgttccagg gtttcttcgt gtctgtcttc tactgcttct
     1261 tcaatggaga ggtgcgctca gccgtgagga agaggtggca ccgctggcag gaccatcact
     1321 cccttcgagt ccccatggcc cgggccatgt ccatccctac atcacccaca cggatcagct
     1381 tccacagcat caagcagacg gccgctgtgt gacccctcgg tcgcccacct gcacagctcc
     1441 cctgtcctcc tccaccttct tcctctgggt tctctgtgct gggcaggctc tcgtggggca
     1501 ggagatggga ggggagagac cagctctcca gcctggcagg aaagaggggg tgcggcagcc
     1561 aagggggact gcaagggaca gggatgagtg ggggccacca ggctcagcgc aagaggaagc
     1621 agagggaatt cacaggaccc cctgagaaga gccagtcaga tgtctgcagg catttgccca
     1681 tcccagcctc tctggccagg gccttactgg gcccagagca gagaaggacc tgtccaacac
     1741 acacagctat ttatagtagc agacacaggg ctcccctgcc ctactcatgg agccagcagc
     1801 caggcaatgg tgtggccctg cactggccct tggcctccac actcagtggt gcccctgcag
     1861 ttgggtgggg tacgccagca aaggatcagt ttggctgcct tatcccaggg gctgtcacct
     1921 agagaggctc acttgtaccc cacccttgtt cctgtgtccc ctccccagcc atcctcccgc
     1981 cttgggggct ccatgaagga tgcaggcttc caggcctggc ttcctctctt gggagacccc
     2041 ttctctgcct agtccacaga ttaggcaatc aaggaagacg ccatcaggga agccacatcc
     2101 ttagtcaacc agttgcatcg tgcggggcaa aatgaggagc agaggcatgg aggagggagg
     2161 cgtgggatgg gaatagcaga aaccaaccat gtcttcagtg attgaaactc ataccccatt
     2221 gccctttgcc ctccagtctc cccttcagaa acatctctgc tctctgtgaa ataaaccatg
     2281 cctcttggaa gtggcctccc ctcaggtcaa gtcacccagg cacccgaaga gtggtgtggg
     2341 ccaaggatcg tggctgggtc tgagggggcc acatccatct tccttagtgg gctcgggccc
     2401 tggcctcggg ccagttctct ctctctctga cctctggtag gtttggagtc tttatggtca
     2461 aagcacctgc aggcgggtct gtcccttatc actccaacca ggctaatacc tggccccagc
     2521 ccccaaccaa gggcagcttg attcagcctg gaggaggtgt gcagctcatc cagcaagcca
     2581 gggcctgtcc caaaggccaa ggctctggaa tctggtgggc agggtagaca tggcccctca
     2641 gttgaccacc agggcagctt ccaggcttgg cttccgtccc tgtgtccctg cagcggagcc
     2701 gcaggagtca gggagagaga agcatcaggc catttcttcc aaaagaaacc aatgctctag
     2761 gtacccccta caaaaataag ttttgaaaaa tcatgtatcc cgtcttgcac atttttaagt
     2821 tgacatgtag tattttttac ttaagtttta aatccttcaa aggtgtgatt tctgccattt
     2881 tgtaaatatt tacattttta aataaaactg ctgcaacaat ttaaaataca
//
