LOCUS       NM_004382               2537 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens corticotropin releasing hormone receptor 1 (CRHR1),
            transcript variant 1a, mRNA.
ACCESSION   NM_004382 XM_938107
VERSION     NM_004382.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2537)
  AUTHORS   Zhao,W., Lan,Q., Zhou,M., Liang,W., Yang,Y. and Gong,P.
  TITLE     Genetic Contributions to Attachment Stability Over Time: the Roles
            of CRHR1 Polymorphisms
  JOURNAL   J Youth Adolesc 53 (2), 273-283 (2024)
   PUBMED   37891393
  REMARK    GeneRIF: Genetic Contributions to Attachment Stability Over Time:
            the Roles of CRHR1 Polymorphisms.
REFERENCE   2  (bases 1 to 2537)
  AUTHORS   Wu,S.V., Yuan,P.Q., Lai,J., Wong,K., Chen,M.C., Ohning,G.V. and
            Tache,Y.
  TITLE     Activation of Type 1 CRH receptor isoforms induces serotonin
            release from human carcinoid BON-1N cells: an enterochromaffin cell
            model
  JOURNAL   Endocrinology 152 (1), 126-137 (2011)
   PUBMED   21123435
  REMARK    GeneRIF: These findings define the expression of enterochromaffin
            cell-specific CRH(1) isoforms and activation of CRH(1)-dependent
            pathways leading to serotonin release and synthesis.
REFERENCE   3  (bases 1 to 2537)
  AUTHORS   Hillhouse,E.W. and Grammatopoulos,D.K.
  TITLE     The molecular mechanisms underlying the regulation of the
            biological activity of corticotropin-releasing hormone receptors:
            implications for physiology and pathophysiology
  JOURNAL   Endocr Rev 27 (3), 260-286 (2006)
   PUBMED   16484629
  REMARK    Review article
REFERENCE   4  (bases 1 to 2537)
  AUTHORS   Parham,K.L., Zervou,S., Karteris,E., Catalano,R.D., Old,R.W. and
            Hillhouse,E.W.
  TITLE     Promoter analysis of human corticotropin-releasing factor (CRF)
            type 1 receptor and regulation by CRF and urocortin
  JOURNAL   Endocrinology 145 (8), 3971-3983 (2004)
   PUBMED   15142984
REFERENCE   5  (bases 1 to 2537)
  AUTHORS   Pisarchik,A. and Slominski,A.T.
  TITLE     Alternative splicing of CRH-R1 receptors in human and mouse skin:
            identification of new variants and their differential expression
  JOURNAL   FASEB J 15 (14), 2754-2756 (2001)
   PUBMED   11606483
REFERENCE   6  (bases 1 to 2537)
  AUTHORS   Grammatopoulos,D.K., Dai,Y., Randeva,H.S., Levine,M.A.,
            Karteris,E., Easton,A.J. and Hillhouse,E.W.
  TITLE     A novel spliced variant of the type 1 corticotropin-releasing
            hormone receptor with a deletion in the seventh transmembrane
            domain present in the human pregnant term myometrium and fetal
            membranes
  JOURNAL   Mol Endocrinol 13 (12), 2189-2202 (1999)
   PUBMED   10598591
REFERENCE   7  (bases 1 to 2537)
  AUTHORS   McLean,M., Bisits,A., Davies,J., Woods,R., Lowry,P. and Smith,R.
  TITLE     A placental clock controlling the length of human pregnancy
  JOURNAL   Nat Med 1 (5), 460-463 (1995)
   PUBMED   7585095
REFERENCE   8  (bases 1 to 2537)
  AUTHORS   Ross,P.C., Kostas,C.M. and Ramabhadran,T.V.
  TITLE     A variant of the human corticotropin-releasing factor (CRF)
            receptor: cloning, expression and pharmacology
  JOURNAL   Biochem Biophys Res Commun 205 (3), 1836-1842 (1994)
   PUBMED   7811272
REFERENCE   9  (bases 1 to 2537)
  AUTHORS   Vita,N., Laurent,P., Lefort,S., Chalon,P., Lelias,J.M., Kaghad,M.,
            Le Fur,G., Caput,D. and Ferrara,P.
  TITLE     Primary structure and functional expression of mouse pituitary and
            human brain corticotrophin releasing factor receptors
  JOURNAL   FEBS Lett 335 (1), 1-5 (1993)
   PUBMED   8243652
REFERENCE   10 (bases 1 to 2537)
  AUTHORS   Chen,R., Lewis,K.A., Perrin,M.H. and Vale,W.W.
  TITLE     Expression cloning of a human corticotropin-releasing-factor
            receptor
  JOURNAL   Proc Natl Acad Sci U S A 90 (19), 8967-8971 (1993)
   PUBMED   7692441
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X72304.1 and CK299669.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_004382.4.
            
            Summary: This gene encodes a G-protein coupled receptor that binds
            neuropeptides of the corticotropin releasing hormone family that
            are major regulators of the hypothalamic-pituitary-adrenal pathway.
            The encoded protein is essential for the activation of signal
            transduction pathways that regulate diverse physiological processes
            including stress, reproduction, immune response and obesity.
            Alternative splicing results in multiple transcript variants.
            Naturally-occurring readthrough transcription between this gene and
            upstream GeneID:147081 results in transcripts that encode isoforms
            that share similarity with the products of this gene. [provided by
            RefSeq, Aug 2016].
            
            Transcript Variant: This variant (1a, also known as CRHR1alpha),
            lacks an alternate in-frame exon in the central coding region,
            compared to variant 1b, resulting in an isoform (2) that is shorter
            than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X72304.1, SRR1803614.85299.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000314537.10/ ENSP00000326060.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2535              X72304.1           2-2536
            2536-2537           CK299669.1         18-19               c
FEATURES             Location/Qualifiers
     source          1..2537
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..2537
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /note="corticotropin releasing hormone receptor 1"
                     /db_xref="GeneID:1394"
                     /db_xref="HGNC:HGNC:2357"
                     /db_xref="MIM:122561"
     exon            1..258
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1473
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 1a; corticotropin-releasing factor type 1
                     receptor; seven transmembrane helix receptor"
                     /codon_start=1
                     /product="corticotropin-releasing factor receptor 1
                     isoform 2 precursor"
                     /protein_id="NP_004373.2"
                     /db_xref="CCDS:CCDS42350.1"
                     /db_xref="GeneID:1394"
                     /db_xref="HGNC:HGNC:2357"
                     /db_xref="MIM:122561"
                     /translation="MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQC
                     NASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSEC
                     QEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLIS
                     AFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIV
                     LTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPM
                     ILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNP
                     GEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVA
                     RAMSIPTSPTRVSFHSIKQSTAV"
     exon            259..346
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            347..466
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            467..552
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            553..659
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            660..780
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            781..934
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            935..995
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1068
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1154
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1290
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1332
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..2537
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2512..2517
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /note="hexamer: AATAAT"
     polyA_site      2537
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /note="major polyA site"
ORIGIN      
        1 gggaaacggc ggccagactt ccccgggaag gggcgagcga gagccgggcc gggccgggcc
       61 gggccgcggg gccgggaagc gccgagccgg gcatctcctc accaggcagc gaccgaggag
      121 cccggccgcc caccccgtgc cgcccgagcc cgcagccgcc cgccggtccc tctgggatgt
      181 ccgtaggacc cgggcattca ggacggtagc cgagcgagcc cgaggatggg agggcacccg
      241 cagctccgtc tcgtcaaggc ccttctcctt ctggggctga accccgtctc tgcctccctc
      301 caggaccagc actgcgagag cctgtccctg gccagcaaca tctcaggact gcagtgcaac
      361 gcatccgtgg acctcattgg cacctgctgg ccccgcagcc ctgcggggca gctagtggtt
      421 cggccctgcc ctgccttttt ctatggtgtc cgctacaata ccacaaacaa tggctaccgg
      481 gagtgcctgg ccaatggcag ctgggccgcc cgcgtgaatt actccgagtg ccaggagatc
      541 ctcaatgagg agaaaaaaag caaggtgcac taccatgtcg cagtcatcat caactacctg
      601 ggccactgta tctccctggt ggccctcctg gtggcctttg tcctctttct gcggctcagg
      661 agcatccggt gcctgcgaaa catcatccac tggaacctca tctccgcctt catcctgcgc
      721 aacgccacct ggttcgtggt ccagctaacc atgagccccg aggtccacca gagcaacgtg
      781 ggctggtgca ggttggtgac agccgcctac aactacttcc atgtgaccaa cttcttctgg
      841 atgttcggcg agggctgcta cctgcacaca gccatcgtgc tcacctactc cactgaccgg
      901 ctgcgcaaat ggatgttcat ctgcattggc tggggtgtgc ccttccccat cattgtggcc
      961 tgggccattg ggaagctgta ctacgacaat gagaagtgct ggtttggcaa aaggcctggg
     1021 gtgtacaccg actacatcta ccagggcccc atgatcctgg tcctgctgat caatttcatc
     1081 ttccttttca acatcgtccg catcctcatg accaagctcc gggcatccac cacgtctgag
     1141 accattcagt acaggaaggc tgtgaaagcc actctggtgc tgctgcccct cctgggcatc
     1201 acctacatgc tgttcttcgt caatcccggg gaggatgagg tctcccgggt cgtcttcatc
     1261 tacttcaact ccttcctgga atccttccag ggcttctttg tgtctgtgtt ctactgtttc
     1321 ctcaatagtg aggtccgttc tgccatccgg aagaggtggc accggtggca ggacaagcac
     1381 tcgatccgtg cccgagtggc ccgtgccatg tccatcccca cctccccaac ccgtgtcagc
     1441 tttcacagca tcaagcagtc cacagcagtc tgagctggca ggtcatggag cagcccccaa
     1501 agagctgtgg ctggggggat gacggccagg ctccctgacc accctgcctg tggaggtgac
     1561 ctgttaggtc tcatgcccac tcccccagga gcagctggca ctgacagcct gggggggccg
     1621 ctctccccct gcagccgtgc aggactctag ctcatgagtg gaaagtcacc tacaggactg
     1681 ggccgggccc agggcctctg gcttccctgc ccaatcctcc ctggagaagg gacatgggaa
     1741 tgaattgaaa tggggcgctg gacacctaca gcagcacgca tgtccctcca aggctgtctt
     1801 ctcccagagc acaagaaggc cagcccactg ggccctgggg ctgccctcgg caaccgtggg
     1861 gaggccattt gctgccctgg ggcatcatgg gcaactcgtg acagcctctg actcaccacg
     1921 atgacgcctc tggacctcgg tgatgccttc cgacaccact gggaaccaag ggccctcact
     1981 caggaaccct ggagacagaa gtcaggtgtc atcatcagac ttgcggccac agcactagag
     2041 tcaccccccc aggcctccag aaccttactg gcactgtggc actgccacca gcaatgccct
     2101 gccttgctgc cttcaccctg aacatttagt accctgcagg ccaggccagc ttcccctcac
     2161 ttaaccaccc cataccagtc acctcctgct ccttttcctc ttttgtgaga agatgggggc
     2221 tggagggggc agagtggcct gtgagcaaga gccaggggtg tcccagtccc agcctctggg
     2281 gcagagcttg tagccctgga tggcctctgg ggcaggacca ctagctaagc aagccaggag
     2341 aagacccctg cccaagtggc tcttgggaca acgtgctgct tacactccag gtgtggaccg
     2401 gccgcagccc ccactgacct gcccatgtcc agagggactg gacagccagg gcagggcttt
     2461 ggggggcact agaagatgag ggtgtcggct gtgaggcggg tggctggtat aaataatatt
     2521 tatcttttca accagca
//
