LOCUS       NM_001145148            2495 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens corticotropin releasing hormone receptor 1 (CRHR1),
            transcript variant 1d, mRNA.
ACCESSION   NM_001145148 XM_003403613 XM_003403614
VERSION     NM_001145148.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2495)
  AUTHORS   Zhao,W., Lan,Q., Zhou,M., Liang,W., Yang,Y. and Gong,P.
  TITLE     Genetic Contributions to Attachment Stability Over Time: the Roles
            of CRHR1 Polymorphisms
  JOURNAL   J Youth Adolesc 53 (2), 273-283 (2024)
   PUBMED   37891393
  REMARK    GeneRIF: Genetic Contributions to Attachment Stability Over Time:
            the Roles of CRHR1 Polymorphisms.
REFERENCE   2  (bases 1 to 2495)
  AUTHORS   Wu,S.V., Yuan,P.Q., Lai,J., Wong,K., Chen,M.C., Ohning,G.V. and
            Tache,Y.
  TITLE     Activation of Type 1 CRH receptor isoforms induces serotonin
            release from human carcinoid BON-1N cells: an enterochromaffin cell
            model
  JOURNAL   Endocrinology 152 (1), 126-137 (2011)
   PUBMED   21123435
  REMARK    GeneRIF: These findings define the expression of enterochromaffin
            cell-specific CRH(1) isoforms and activation of CRH(1)-dependent
            pathways leading to serotonin release and synthesis.
REFERENCE   3  (bases 1 to 2495)
  AUTHORS   Hillhouse,E.W. and Grammatopoulos,D.K.
  TITLE     The molecular mechanisms underlying the regulation of the
            biological activity of corticotropin-releasing hormone receptors:
            implications for physiology and pathophysiology
  JOURNAL   Endocr Rev 27 (3), 260-286 (2006)
   PUBMED   16484629
  REMARK    Review article
REFERENCE   4  (bases 1 to 2495)
  AUTHORS   Parham,K.L., Zervou,S., Karteris,E., Catalano,R.D., Old,R.W. and
            Hillhouse,E.W.
  TITLE     Promoter analysis of human corticotropin-releasing factor (CRF)
            type 1 receptor and regulation by CRF and urocortin
  JOURNAL   Endocrinology 145 (8), 3971-3983 (2004)
   PUBMED   15142984
REFERENCE   5  (bases 1 to 2495)
  AUTHORS   Pisarchik,A. and Slominski,A.T.
  TITLE     Alternative splicing of CRH-R1 receptors in human and mouse skin:
            identification of new variants and their differential expression
  JOURNAL   FASEB J 15 (14), 2754-2756 (2001)
   PUBMED   11606483
REFERENCE   6  (bases 1 to 2495)
  AUTHORS   Grammatopoulos,D.K., Dai,Y., Randeva,H.S., Levine,M.A.,
            Karteris,E., Easton,A.J. and Hillhouse,E.W.
  TITLE     A novel spliced variant of the type 1 corticotropin-releasing
            hormone receptor with a deletion in the seventh transmembrane
            domain present in the human pregnant term myometrium and fetal
            membranes
  JOURNAL   Mol Endocrinol 13 (12), 2189-2202 (1999)
   PUBMED   10598591
REFERENCE   7  (bases 1 to 2495)
  AUTHORS   McLean,M., Bisits,A., Davies,J., Woods,R., Lowry,P. and Smith,R.
  TITLE     A placental clock controlling the length of human pregnancy
  JOURNAL   Nat Med 1 (5), 460-463 (1995)
   PUBMED   7585095
REFERENCE   8  (bases 1 to 2495)
  AUTHORS   Ross,P.C., Kostas,C.M. and Ramabhadran,T.V.
  TITLE     A variant of the human corticotropin-releasing factor (CRF)
            receptor: cloning, expression and pharmacology
  JOURNAL   Biochem Biophys Res Commun 205 (3), 1836-1842 (1994)
   PUBMED   7811272
REFERENCE   9  (bases 1 to 2495)
  AUTHORS   Vita,N., Laurent,P., Lefort,S., Chalon,P., Lelias,J.M., Kaghad,M.,
            Le Fur,G., Caput,D. and Ferrara,P.
  TITLE     Primary structure and functional expression of mouse pituitary and
            human brain corticotrophin releasing factor receptors
  JOURNAL   FEBS Lett 335 (1), 1-5 (1993)
   PUBMED   8243652
REFERENCE   10 (bases 1 to 2495)
  AUTHORS   Chen,R., Lewis,K.A., Perrin,M.H. and Vale,W.W.
  TITLE     Expression cloning of a human corticotropin-releasing-factor
            receptor
  JOURNAL   Proc Natl Acad Sci U S A 90 (19), 8967-8971 (1993)
   PUBMED   7692441
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF488558.1, AF180301.1,
            X72304.1 and CK299669.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001145148.1.
            
            Summary: This gene encodes a G-protein coupled receptor that binds
            neuropeptides of the corticotropin releasing hormone family that
            are major regulators of the hypothalamic-pituitary-adrenal pathway.
            The encoded protein is essential for the activation of signal
            transduction pathways that regulate diverse physiological processes
            including stress, reproduction, immune response and obesity.
            Alternative splicing results in multiple transcript variants.
            Naturally-occurring readthrough transcription between this gene and
            upstream GeneID:147081 results in transcripts that encode isoforms
            that share similarity with the products of this gene. [provided by
            RefSeq, Aug 2016].
            
            Transcript Variant: This variant (1d, also known as CRH-R1d), lacks
            an alternate in-frame exon in both the central and 3' coding
            regions, compared to variant. The encoded isoform (4) is shorter
            than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF180301.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               AF488558.1         2229-2453
            226-1431            AF180301.1         1-1206
            1432-2493           X72304.1           1475-2536
            2494-2495           CK299669.1         18-19               c
FEATURES             Location/Qualifiers
     source          1..2495
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..2495
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /note="corticotropin releasing hormone receptor 1"
                     /db_xref="GeneID:1394"
                     /db_xref="HGNC:HGNC:2357"
                     /db_xref="MIM:122561"
     exon            1..258
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1431
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 1d; corticotropin-releasing factor type 1
                     receptor; seven transmembrane helix receptor"
                     /codon_start=1
                     /product="corticotropin-releasing factor receptor 1
                     isoform 4 precursor"
                     /protein_id="NP_001138620.1"
                     /db_xref="CCDS:CCDS45713.1"
                     /db_xref="GeneID:1394"
                     /db_xref="HGNC:HGNC:2357"
                     /db_xref="MIM:122561"
                     /translation="MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQC
                     NASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSEC
                     QEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLIS
                     AFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIV
                     LTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPM
                     ILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNP
                     GEDEVSRVVFIYFNSFLESFQVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSF
                     HSIKQSTAV"
     exon            259..346
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            347..466
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            467..552
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            553..659
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            660..780
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            781..934
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            935..995
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1068
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1154
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1290
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..2495
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2470..2475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /note="hexamer: AATAAT"
     polyA_site      2495
                     /gene="CRHR1"
                     /gene_synonym="CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1;
                     CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1L"
                     /note="major polyA site"
ORIGIN      
        1 gggaaacggc ggccagactt ccccgggaag gggcgagcga gagccgggcc gggccgggcc
       61 gggccgcggg gccgggaagc gccgagccgg gcatctcctc accaggcagc gaccgaggag
      121 cccggccgcc caccccgtgc cgcccgagcc cgcagccgcc cgccggtccc tctgggatgt
      181 ccgtaggacc cgggcattca ggacggtagc cgagcgagcc cgaggatggg agggcacccg
      241 cagctccgtc tcgtcaaggc ccttctcctt ctggggctga accccgtctc tgcctccctc
      301 caggaccagc actgcgagag cctgtccctg gccagcaaca tctcaggact gcagtgcaac
      361 gcatccgtgg acctcattgg cacctgctgg ccccgcagcc ctgcggggca gctagtggtt
      421 cggccctgcc ctgccttttt ctatggtgtc cgctacaata ccacaaacaa tggctaccgg
      481 gagtgcctgg ccaatggcag ctgggccgcc cgcgtgaatt actccgagtg ccaggagatc
      541 ctcaatgagg agaaaaaaag caaggtgcac taccatgtcg cagtcatcat caactacctg
      601 ggccactgta tctccctggt ggccctcctg gtggcctttg tcctctttct gcggctcagg
      661 agcatccggt gcctgcgaaa catcatccac tggaacctca tctccgcctt catcctgcgc
      721 aacgccacct ggttcgtggt ccagctaacc atgagccccg aggtccacca gagcaacgtg
      781 ggctggtgca ggttggtgac agccgcctac aactacttcc atgtgaccaa cttcttctgg
      841 atgttcggcg agggctgcta cctgcacaca gccatcgtgc tcacctactc cactgaccgg
      901 ctgcgcaaat ggatgttcat ctgcattggc tggggtgtgc ccttccccat cattgtggcc
      961 tgggccattg ggaagctgta ctacgacaat gagaagtgct ggtttggcaa aaggcctggg
     1021 gtgtacaccg actacatcta ccagggcccc atgatcctgg tcctgctgat caatttcatc
     1081 ttccttttca acatcgtccg catcctcatg accaagctcc gggcatccac cacgtctgag
     1141 accattcagt acaggaaggc tgtgaaagcc actctggtgc tgctgcccct cctgggcatc
     1201 acctacatgc tgttcttcgt caatcccggg gaggatgagg tctcccgggt cgtcttcatc
     1261 tacttcaact ccttcctgga atccttccag gtccgttctg ccatccggaa gaggtggcac
     1321 cggtggcagg acaagcactc gatccgtgcc cgagtggccc gtgccatgtc catccccacc
     1381 tccccaaccc gtgtcagctt tcacagcatc aagcagtcca cagcagtctg agctggcagg
     1441 tcatggagca gcccccaaag agctgtggct ggggggatga cggccaggct ccctgaccac
     1501 cctgcctgtg gaggtgacct gttaggtctc atgcccactc ccccaggagc agctggcact
     1561 gacagcctgg gggggccgct ctccccctgc agccgtgcag gactctagct catgagtgga
     1621 aagtcaccta caggactggg ccgggcccag ggcctctggc ttccctgccc aatcctccct
     1681 ggagaaggga catgggaatg aattgaaatg gggcgctgga cacctacagc agcacgcatg
     1741 tccctccaag gctgtcttct cccagagcac aagaaggcca gcccactggg ccctggggct
     1801 gccctcggca accgtgggga ggccatttgc tgccctgggg catcatgggc aactcgtgac
     1861 agcctctgac tcaccacgat gacgcctctg gacctcggtg atgccttccg acaccactgg
     1921 gaaccaaggg ccctcactca ggaaccctgg agacagaagt caggtgtcat catcagactt
     1981 gcggccacag cactagagtc acccccccag gcctccagaa ccttactggc actgtggcac
     2041 tgccaccagc aatgccctgc cttgctgcct tcaccctgaa catttagtac cctgcaggcc
     2101 aggccagctt cccctcactt aaccacccca taccagtcac ctcctgctcc ttttcctctt
     2161 ttgtgagaag atgggggctg gagggggcag agtggcctgt gagcaagagc caggggtgtc
     2221 ccagtcccag cctctggggc agagcttgta gccctggatg gcctctgggg caggaccact
     2281 agctaagcaa gccaggagaa gacccctgcc caagtggctc ttgggacaac gtgctgctta
     2341 cactccaggt gtggaccggc cgcagccccc actgacctgc ccatgtccag agggactgga
     2401 cagccagggc agggctttgg ggggcactag aagatgaggg tgtcggctgt gaggcgggtg
     2461 gctggtataa ataatattta tcttttcaac cagca
//
