LOCUS       NM_001882               1645 bp    mRNA    linear   PRI 07-MAY-2024
DEFINITION  Homo sapiens corticotropin releasing hormone binding protein
            (CRHBP), mRNA.
ACCESSION   NM_001882
VERSION     NM_001882.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1645)
  AUTHORS   Zeng,S., Liu,C. and Wang,Z.
  TITLE     The Effect of CRHBP rs10062367 Polymorphism and Parenting Styles on
            Internalizing Problems in Preschoolers: The Moderating Effect of
            Sensory Processing Sensitivity
  JOURNAL   Child Psychiatry Hum Dev 55 (3), 644-654 (2024)
   PUBMED   36114994
  REMARK    GeneRIF: The Effect of CRHBP rs10062367 Polymorphism and Parenting
            Styles on Internalizing Problems in Preschoolers: The Moderating
            Effect of Sensory Processing Sensitivity.
REFERENCE   2  (bases 1 to 1645)
  AUTHORS   Ersig,A.L., Young,E.E., Brown,R.L. and Malecki,K.
  TITLE     Genetic Variation, Stress, and Physiological Stress Response in
            Adults With Food Allergy or Celiac Disease
  JOURNAL   Biol Res Nurs 25 (2), 300-309 (2023)
   PUBMED   36280595
  REMARK    GeneRIF: Genetic Variation, Stress, and Physiological Stress
            Response in Adults With Food Allergy or Celiac Disease.
REFERENCE   3  (bases 1 to 1645)
  AUTHORS   Chen,Y., Hu,L.P., Liu,L.L., Zhang,X.F., Ji,A.C., Li,J.J. and
            Nie,S.J.
  TITLE     [Analysis of Correlation between Gene Polymorphisms of CRHBP in
            Yunnan Han Population and Schizophrenia and Aggressive Behavior]
  JOURNAL   Fa Yi Xue Za Zhi 36 (5), 672-676 (2020)
   PUBMED   33295169
  REMARK    GeneRIF: [Analysis of Correlation between Gene Polymorphisms of
            CRHBP in Yunnan Han Population and Schizophrenia and Aggressive
            Behavior].
REFERENCE   4  (bases 1 to 1645)
  AUTHORS   Yang,K., Xiao,Y., Xu,T., Yu,W., Ruan,Y., Luo,P. and Cheng,F.
  TITLE     Integrative analysis reveals CRHBP inhibits renal cell carcinoma
            progression by regulating inflammation and apoptosis
  JOURNAL   Cancer Gene Ther 27 (7-8), 607-618 (2020)
   PUBMED   31570754
  REMARK    GeneRIF: Integrative analysis reveals CRHBP inhibits renal cell
            carcinoma progression by regulating inflammation and apoptosis.
REFERENCE   5  (bases 1 to 1645)
  AUTHORS   Tang,L., Chen,Y., Xiang,Q., Xiang,J., Tang,Y. and Li,J.
  TITLE     The GCAG Haplotype of the CRHBP Gene May Decrease the Risk for
            Robbery Behavior Among the Han Chinese
  JOURNAL   Genet Test Mol Biomarkers 24 (7), 436-442 (2020)
   PUBMED   32551975
  REMARK    GeneRIF: The GCAG Haplotype of the CRHBP Gene May Decrease the Risk
            for Robbery Behavior Among the Han Chinese.
REFERENCE   6  (bases 1 to 1645)
  AUTHORS   Behan,D.P., Heinrichs,S.C., Troncoso,J.C., Liu,X.J., Kawas,C.H.,
            Ling,N. and De Souza,E.B.
  TITLE     Displacement of corticotropin releasing factor from its binding
            protein as a possible treatment for Alzheimer's disease
  JOURNAL   Nature 378 (6554), 284-287 (1995)
   PUBMED   7477348
REFERENCE   7  (bases 1 to 1645)
  AUTHORS   Vamvakopoulos,N.C., Sioutopoulou,T.O., Durkin,S.A., Nierman,W.C.,
            Wasmuth,J.J. and McPherson,J.D.
  TITLE     Mapping the human corticotropin releasing hormone binding protein
            gene (CRHBP) to the long arm of chromosome 5 (5q11.2-q13.3)
  JOURNAL   Genomics 25 (1), 325-327 (1995)
   PUBMED   7774945
REFERENCE   8  (bases 1 to 1645)
  AUTHORS   Behan,D.P., Potter,E., Lewis,K.A., Jenkins,N.A., Copeland,N.,
            Lowry,P.J. and Vale,W.W.
  TITLE     Cloning and structure of the human corticotrophin releasing
            factor-binding protein gene (CRHBP)
  JOURNAL   Genomics 16 (1), 63-68 (1993)
   PUBMED   8198617
  REMARK    Erratum:[Genomics 1994 Jan 1;19(1):198]
REFERENCE   9  (bases 1 to 1645)
  AUTHORS   Potter,E., Behan,D.P., Fischer,W.H., Linton,E.A., Lowry,P.J. and
            Vale,W.W.
  TITLE     Cloning and characterization of the cDNAs for human and rat
            corticotropin releasing factor-binding proteins
  JOURNAL   Nature 349 (6308), 423-426 (1991)
   PUBMED   1846945
REFERENCE   10 (bases 1 to 1645)
  AUTHORS   Behan,D.P., Linton,E.A. and Lowry,P.J.
  TITLE     Isolation of the human plasma corticotrophin-releasing
            factor-binding protein
  JOURNAL   J Endocrinol 122 (1), 23-31 (1989)
   PUBMED   2549150
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB959505.1, BC018038.1 and
            AW451896.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001882.3.
            
            Summary: Corticotropin-releasing hormone is a potent stimulator of
            synthesis and secretion of preopiomelanocortin-derived peptides.
            Although CRH concentrations in the human peripheral circulation are
            normally low, they increase throughout pregnancy and fall rapidly
            after parturition. Maternal plasma CRH probably originates from the
            placenta. Human plasma contains a CRH-binding protein which
            inactivates CRH and which may prevent inappropriate
            pituitary-adrenal stimulation in pregnancy. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018038.1, SRR1660809.14523.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274368.9/ ENSP00000274368.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 CB959505.1         218-221
            5-1330              BC018038.1         5-1330
            1331-1645           AW451896.1         20-334              c
FEATURES             Location/Qualifiers
     source          1..1645
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.3"
     gene            1..1645
                     /gene="CRHBP"
                     /gene_synonym="CRF-BP; CRFBP"
                     /note="corticotropin releasing hormone binding protein"
                     /db_xref="GeneID:1393"
                     /db_xref="HGNC:HGNC:2356"
                     /db_xref="MIM:122559"
     exon            1..171
                     /gene="CRHBP"
                     /gene_synonym="CRF-BP; CRFBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1059
                     /gene="CRHBP"
                     /gene_synonym="CRF-BP; CRFBP"
                     /note="CRH-BP; CRF-binding protein"
                     /codon_start=1
                     /product="corticotropin-releasing factor-binding protein"
                     /protein_id="NP_001873.2"
                     /db_xref="CCDS:CCDS4034.1"
                     /db_xref="GeneID:1393"
                     /db_xref="HGNC:HGNC:2356"
                     /db_xref="MIM:122559"
                     /translation="MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANL
                     KRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSI
                     DCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIF
                     FRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKIS
                     DLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVG
                     CDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL"
     exon            172..265
                     /gene="CRHBP"
                     /gene_synonym="CRF-BP; CRFBP"
                     /inference="alignment:Splign:2.1.0"
     exon            266..423
                     /gene="CRHBP"
                     /gene_synonym="CRF-BP; CRFBP"
                     /inference="alignment:Splign:2.1.0"
     exon            424..634
                     /gene="CRHBP"
                     /gene_synonym="CRF-BP; CRFBP"
                     /inference="alignment:Splign:2.1.0"
     exon            635..783
                     /gene="CRHBP"
                     /gene_synonym="CRF-BP; CRFBP"
                     /inference="alignment:Splign:2.1.0"
     exon            784..901
                     /gene="CRHBP"
                     /gene_synonym="CRF-BP; CRFBP"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1645
                     /gene="CRHBP"
                     /gene_synonym="CRF-BP; CRFBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1622..1627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRHBP"
                     /gene_synonym="CRF-BP; CRFBP"
                     /note="hexamer: AATACA"
     polyA_site      1645
                     /gene="CRHBP"
                     /gene_synonym="CRF-BP; CRFBP"
                     /note="major polyA site"
ORIGIN      
        1 agcttctagc tctcagtctg cgcgagggtg taggaaggaa agcccaggac ctccggagca
       61 gagcacagca gctgcagagg caaggccagc atgtcgccca acttcaaact tcagtgtcac
      121 ttcattctca tcttcctgac ggctctaaga ggggaaagcc ggtacctaga gctgagggaa
      181 gcggcggact acgatccttt cctgctcttc agcgccaacc tgaagcggga gctggctggg
      241 gagcagccgt accgccgcgc tctgcggtgc ctggacatgc tgagcctcca gggccagttc
      301 accttcaccg ccgaccggcc gcagctgcac tgcgcagcct tcttcatcag cgagcccgag
      361 gagttcatta ccatccacta cgaccaggtc tccatcgact gtcagggcgg cgacttcctg
      421 aaggtatttg atggttggat tctcaagggg gagaagttcc ccagttccca ggatcatcct
      481 ctcccctcag ctgagcggta catagatttc tgtgagagtg gtcttagcag gaggagcatc
      541 agatcttccc agaatgtggc catgatcttc ttccgagtcc atgaaccagg aaatggattc
      601 acattaacca taaagacaga ccccaacctc tttccttgca atgtcatttc tcagactcca
      661 aatggaaagt ttaccctggt agttccacac cagcatcgaa actgcagctt ctccataatt
      721 tatcctgtgg tgatcaaaat atctgatctt accctgggac acgtaaatgg tcttcagtta
      781 aagaaatcct cagcaggttg cgagggaata ggagactttg tggagctgct gggaggaact
      841 ggattggacc cttccaagat gacgccttta gctgatctct gctacccctt tcatggcccg
      901 gcccagatga aagttggctg tgacaacact gtggtgcgca tggtctccag tggaaaacac
      961 gtaaatcgtg tgacttttga gtatcgtcag ctggagccgt acgagctgga aaacccaaat
     1021 ggaaacagta tcggggaatt ctgtttgtct ggtctttgaa taaccaaccc agtgatttac
     1081 atgctgatag ctaagtgagt ttttaatggc cattgtgtat gattttgatg cacaactagt
     1141 taaaagcctt tcataccagt cagtattccc agccttgagc gcacgcgcgc acacacacac
     1201 acacatacac acacgcatta atttttgtac tttgcttctt ttatgtttgt aatctgtaaa
     1261 tgaacacatg gcagaaaata acccctgatt ggtaggatca tagttctaaa tggaaatgtt
     1321 tgtaattctt tgatgtgcta caaacctgaa actggtaaga caagcacaaa gcaacgtgca
     1381 atacaaaaat cgtatctcaa gggaaaatac tcaaagaaag aaaagtggca gcacttatat
     1441 tagttttata acaggataaa gtcttgtgta tagcaaagta gttgcatctg tttattttct
     1501 atttattatt gttacaatag gtaatagtta tagcaattat ttattgattt gtaacaactt
     1561 gtttttaacc aaactttgta gcatggaaaa aattttccat ccacaaatac aaacatgaat
     1621 aaatacattc agaatgttgg cacca
//
