LOCUS       NM_000756               1288 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens corticotropin releasing hormone (CRH), mRNA.
ACCESSION   NM_000756
VERSION     NM_000756.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1288)
  AUTHORS   Zhu,C. and Li,S.
  TITLE     Role of CRH in colitis and colitis-associated cancer: a combinative
            result of central and peripheral effects?
  JOURNAL   Front Endocrinol (Lausanne) 15, 1363748 (2024)
   PUBMED   38616821
  REMARK    GeneRIF: Role of CRH in colitis and colitis-associated cancer: a
            combinative result of central and peripheral effects?
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1288)
  AUTHORS   Zhu,C. and Li,S.
  TITLE     The peripheral corticotropin releasing factor family's role in
            vasculitis
  JOURNAL   Vascul Pharmacol 154, 107275 (2024)
   PUBMED   38184094
  REMARK    GeneRIF: The peripheral corticotropin releasing factor family's
            role in vasculitis.
            Review article
REFERENCE   3  (bases 1 to 1288)
  AUTHORS   Qing,L., Xiong,P., Lu,Y., Jiang,H. and Nie,S.
  TITLE     Sex-dependent association of DNA methylation in the coding region
            of the corticotropin-releasing hormone gene and schizophrenia
            spectrum disorder
  JOURNAL   Ann Hum Biol 50 (1), 1-8 (2023)
   PUBMED   37401376
  REMARK    GeneRIF: Sex-dependent association of DNA methylation in the coding
            region of the corticotropin-releasing hormone gene and
            schizophrenia spectrum disorder.
REFERENCE   4  (bases 1 to 1288)
  AUTHORS   Contoreggi,C.
  TITLE     Corticotropin releasing hormone and imaging, rethinking the stress
            axis
  JOURNAL   Nucl Med Biol 42 (4), 323-339 (2015)
   PUBMED   25573209
  REMARK    Review article
REFERENCE   5  (bases 1 to 1288)
  AUTHORS   Kurahashi,H. and Hirose,S.
  TITLE     Autosomal Dominant Sleep-Related Hypermotor (Hyperkinetic) Epilepsy
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301348
REFERENCE   6  (bases 1 to 1288)
  AUTHORS   Vamvakopoulos,N.C., Karl,M., Mayol,V., Gomez,T., Stratakis,C.A.,
            Margioris,A. and Chrousos,G.P.
  TITLE     Structural analysis of the regulatory region of the human
            corticotropin releasing hormone gene
  JOURNAL   FEBS Lett 267 (1), 1-5 (1990)
   PUBMED   2365075
REFERENCE   7  (bases 1 to 1288)
  AUTHORS   Robinson,B.G., D'Angio,L.A. Jr., Pasieka,K.B. and Majzoub,J.A.
  TITLE     Preprocorticotropin releasing hormone: cDNA sequence and in vitro
            processing
  JOURNAL   Mol Cell Endocrinol 61 (2), 175-180 (1989)
   PUBMED   2783917
REFERENCE   8  (bases 1 to 1288)
  AUTHORS   Sasaki,A., Tempst,P., Liotta,A.S., Margioris,A.N., Hood,L.E.,
            Kent,S.B., Sato,S., Shinkawa,O., Yoshinaga,K. and Krieger,D.T.
  TITLE     Isolation and characterization of a corticotropin-releasing
            hormone-like peptide from human placenta
  JOURNAL   J Clin Endocrinol Metab 67 (4), 768-773 (1988)
   PUBMED   3262120
REFERENCE   9  (bases 1 to 1288)
  AUTHORS   Arbiser,J.L., Morton,C.C., Bruns,G.A. and Majzoub,J.A.
  TITLE     Human corticotropin releasing hormone gene is located on the long
            arm of chromosome 8
  JOURNAL   Cytogenet Cell Genet 47 (3), 113-116 (1988)
   PUBMED   3259914
REFERENCE   10 (bases 1 to 1288)
  AUTHORS   Shibahara,S., Morimoto,Y., Furutani,Y., Notake,M., Takahashi,H.,
            Shimizu,S., Horikawa,S. and Numa,S.
  TITLE     Isolation and sequence analysis of the human
            corticotropin-releasing factor precursor gene
  JOURNAL   EMBO J 2 (5), 775-779 (1983)
   PUBMED   6605851
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK075431.1 and AC090195.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000756.3.
            
            Summary: This gene encodes a member of the corticotropin-releasing
            factor family. The encoded preproprotein is proteolytically
            processed to generate the mature neuropeptide hormone. In response
            to stress, this hormone is secreted by the paraventricular nucleus
            (PVN) of the hypothalamus, binds to corticotropin releasing hormone
            receptors and stimulates the release of adrenocorticotropic hormone
            from the pituitary gland. Marked reduction in this protein has been
            observed in association with Alzheimer's disease. Autosomal
            recessive hypothalamic corticotropin deficiency has multiple and
            potentially fatal metabolic consequences including hypoglycemia and
            hepatitis. In addition to production in the hypothalamus, this
            protein is also synthesized in peripheral tissues, such as T
            lymphocytes, and is highly expressed in the placenta. In the
            placenta it is a marker that determines the length of gestation and
            the timing of parturition and delivery. A rapid increase in
            circulating levels of the hormone occurs at the onset of
            parturition, suggesting that, in addition to its metabolic
            functions, this protein may act as a trigger for parturition.
            [provided by RefSeq, Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG573303.1, AK075431.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000276571.5/ ENSP00000276571.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1287              AK075431.1         128-1414
            1288-1288           AC090195.5         72191-72191         c
FEATURES             Location/Qualifiers
     source          1..1288
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q13.1"
     gene            1..1288
                     /gene="CRH"
                     /gene_synonym="CRF; CRH1"
                     /note="corticotropin releasing hormone"
                     /db_xref="GeneID:1392"
                     /db_xref="HGNC:HGNC:2355"
                     /db_xref="MIM:122560"
     exon            1..172
                     /gene="CRH"
                     /gene_synonym="CRF; CRH1"
                     /inference="alignment:Splign:2.1.0"
     exon            173..1288
                     /gene="CRH"
                     /gene_synonym="CRF; CRH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..777
                     /gene="CRH"
                     /gene_synonym="CRF; CRH1"
                     /note="corticotropin-releasing factor; corticoliberin"
                     /codon_start=1
                     /product="corticoliberin preproprotein"
                     /protein_id="NP_000747.1"
                     /db_xref="CCDS:CCDS6188.1"
                     /db_xref="GeneID:1392"
                     /db_xref="HGNC:HGNC:2355"
                     /db_xref="MIM:122560"
                     /translation="MRLPLLVSAGVLLVALLPCPPCRALLSRGPVPGARQAPQHPQPL
                     DFFQPPPQSEQPQQPQARPVLLRMGEEYFLRLGNLNKSPAAPLSPASSLLAGGSGSRP
                     SPEQATANFFRVLLQQLLLPRRSLDSPAALAERGARNALGGHQEAPERERRSEEPPIS
                     LDLTFHLLREVLEMARAEQLAQQAHSNRKLMEIIGK"
     regulatory      1196..1201
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRH"
                     /gene_synonym="CRF; CRH1"
                     /note="hexamer: AATAAA"
     polyA_site      1215
                     /gene="CRH"
                     /gene_synonym="CRF; CRH1"
                     /note="major polyA site"
     regulatory      1263..1268
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRH"
                     /gene_synonym="CRF; CRH1"
                     /note="hexamer: AATAAA"
     polyA_site      1288
                     /gene="CRH"
                     /gene_synonym="CRF; CRH1"
                     /note="major polyA site"
ORIGIN      
        1 gagaaactca gagaccaagt ccattgagag actgagggga aagagaggag agaaagaaaa
       61 agagagtggg aacagtaaag agaaaggaag acaacctcca gagaaagccc ccggagacgt
      121 ctctctgcag agaggcggca gcacccggct cacctgcgaa gcgcctggga agcgagtgcc
      181 cctaacatgc ggctgccgct gcttgtgtcc gcgggagtcc tgctggtggc tctcctgccc
      241 tgcccgccat gcagggcgct cctgagccgc gggccggtcc cgggagctcg gcaggcgccg
      301 cagcaccctc agcccttgga tttcttccag ccgccgccgc agtccgagca gccccagcag
      361 ccgcaggctc ggccggtcct gctccgcatg ggagaggagt acttcctccg cctggggaac
      421 ctcaacaaga gcccggccgc tcccctttcg cccgcctcct cgctcctcgc cggaggcagc
      481 ggcagccgcc cttcgccgga acaggcgacc gccaactttt tccgcgtgtt gctgcagcag
      541 ctgctgctgc ctcggcgctc gctcgacagc cccgcggctc tcgcggagcg cggcgctagg
      601 aatgccctcg gcggccacca ggaggcaccg gagagagaaa ggcggtccga ggagcctccc
      661 atctccctgg atctcacctt ccacctcctc cgggaagtct tggaaatggc cagggccgag
      721 cagttagcac agcaagctca cagcaacagg aaactcatgg agattattgg gaaataaaac
      781 ggtgcgtttg gccaaaaaga atctgcattt agcacaaaaa aaatttaaaa aaatacagta
      841 ttctgtacca tagcgctgct cttatgccat ttgtttattt ttatatagct tgaaacatag
      901 agggagagag ggagagagcc tatacccctt acttagcatg cacaaagtgt attcacgtgc
      961 agcagcaaca caatgttatt cgttttgtct acgtttagtt tccgtttcca ggtgtttata
     1021 gtggtgtttt aaagagaatg tagacctgtg agaaaacgtt ttgtttgaaa aagcagacag
     1081 aagtcactca attgtttttg ttgtggtctg agccaaagag aatgccattc tcttgggtgg
     1141 gtaagactaa atctgtaagc tctttgaaac aactttctct tgtaaacgtt tcagtaataa
     1201 aacatctttc cagtccttgg tcagtttggt tgtgtaagag aatgttgaat acttatattt
     1261 ttaataaaag ttgcaaaggt aatcatga
//
