LOCUS       NM_183011               2857 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens cAMP responsive element modulator (CREM), transcript
            variant 21, mRNA.
ACCESSION   NM_183011 XM_006717379
VERSION     NM_183011.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2857)
  AUTHORS   Karami Hezarcheshmeh,F., Yaghmaei,P., Hayati Roodbari,N. and
            Yari,K.
  TITLE     Methylation Status of cAMP-responsive Element Modulator (CREM) Gene
            in Infertile Men and Its Association with Sperm Parameters
  JOURNAL   Reprod Sci 31 (7), 2001-2008 (2024)
   PUBMED   38499948
  REMARK    GeneRIF: Methylation Status of cAMP-responsive Element Modulator
            (CREM) Gene in Infertile Men and Its Association with Sperm
            Parameters.
REFERENCE   2  (bases 1 to 2857)
  AUTHORS   Chen,J., Qin,H., Hao,J., Wang,Q., Chen,S., Yang,G., Li,M., Zhu,X.,
            Wang,D., Chen,H., Cui,C. and Chen,M.
  TITLE     Cardiac-specific overexpression of CREM-IbDeltaC-X via CRISPR/Cas9
            in mice presents a new model of atrial cardiomyopathy with
            spontaneous atrial fibrillation
  JOURNAL   Transl Res 267, 54-66 (2024)
   PUBMED   38199433
  REMARK    GeneRIF: Cardiac-specific overexpression of CREM-IbDeltaC-X via
            CRISPR/Cas9 in mice presents a new model of atrial cardiomyopathy
            with spontaneous atrial fibrillation.
REFERENCE   3  (bases 1 to 2857)
  AUTHORS   Sanchez-Jasso,D.E., Lopez-Guzman,S.F., Bermudez-Cruz,R.M. and
            Oviedo,N.
  TITLE     Novel Aspects of cAMP-Response Element Modulator (CREM) Role in
            Spermatogenesis and Male Fertility
  JOURNAL   Int J Mol Sci 24 (16), 12558 (2023)
   PUBMED   37628737
  REMARK    GeneRIF: Novel Aspects of cAMP-Response Element Modulator (CREM)
            Role in Spermatogenesis and Male Fertility.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2857)
  AUTHORS   Luo,S., Zhang,H., Xie,Y., Huang,J., Luo,D. and Zhang,Q.
  TITLE     Decreased SUV39H1 at the promoter region leads to increased
            CREMalpha and accelerates autoimmune response in CD4+ T cells from
            patients with systemic lupus erythematosus
  JOURNAL   Clin Epigenetics 14 (1), 181 (2022)
   PUBMED   36536372
  REMARK    GeneRIF: Decreased SUV39H1 at the promoter region leads to
            increased CREMalpha and accelerates autoimmune response in CD4[+] T
            cells from patients with systemic lupus erythematosus.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2857)
  AUTHORS   Abofoul-Azab,M., Lunenfeld,E., Kleiman,S., Barda,S., Hauser,R. and
            Huleihel,M.
  TITLE     Determining the expression levels of CSF-1 and OCT4, CREM-1, and
            protamine in testicular biopsies of adult Klinefelter patients:
            Their possible correlation with spermatogenesis
  JOURNAL   Andrologia 54 (10), e14558 (2022)
   PUBMED   36177809
  REMARK    GeneRIF: Determining the expression levels of CSF-1 and OCT4,
            CREM-1, and protamine in testicular biopsies of adult Klinefelter
            patients: Their possible correlation with spermatogenesis.
REFERENCE   6  (bases 1 to 2857)
  AUTHORS   Pongubala,J.M. and Atchison,M.L.
  TITLE     Activating transcription factor 1 and cyclic AMP response element
            modulator can modulate the activity of the immunoglobulin kappa 3'
            enhancer
  JOURNAL   J Biol Chem 270 (17), 10304-10313 (1995)
   PUBMED   7730336
REFERENCE   7  (bases 1 to 2857)
  AUTHORS   Walker,W.H., Sanborn,B.M. and Habener,J.F.
  TITLE     An isoform of transcription factor CREM expressed during
            spermatogenesis lacks the phosphorylation domain and represses
            cAMP-induced transcription
  JOURNAL   Proc Natl Acad Sci U S A 91 (26), 12423-12427 (1994)
   PUBMED   7809053
REFERENCE   8  (bases 1 to 2857)
  AUTHORS   Fujimoto,T., Fujisawa,J. and Yoshida,M.
  TITLE     Novel isoforms of human cyclic AMP-responsive element modulator
            (hCREM) mRNA
  JOURNAL   J Biochem 115 (2), 298-303 (1994)
   PUBMED   8206879
REFERENCE   9  (bases 1 to 2857)
  AUTHORS   Masquilier,D., Foulkes,N.S., Mattei,M.G. and Sassone-Corsi,P.
  TITLE     Human CREM gene: evolutionary conservation, chromosomal
            localization, and inducibility of the transcript
  JOURNAL   Cell Growth Differ 4 (11), 931-937 (1993)
   PUBMED   7916662
REFERENCE   10 (bases 1 to 2857)
  AUTHORS   Meyer,T.E. and Habener,J.F.
  TITLE     Cyclic AMP response element binding protein CREB and modulator
            protein CREM are products of distinct genes
  JOURNAL   Nucleic Acids Res 20 (22), 6106 (1992)
   PUBMED   1461747
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL157783.15 and AL117336.22.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Apr 28, 2021 this sequence version replaced
            XM_006717379.3, NM_183011.1.
            
            Summary: This gene encodes a bZIP transcription factor that binds
            to the cAMP responsive element found in many viral and cellular
            promoters. It is an important component of cAMP-mediated signal
            transduction during the spermatogenetic cycle, as well as other
            complex processes. Alternative promoter and translation initiation
            site usage allows this gene to exert spatial and temporal
            specificity to cAMP responsiveness. Multiple alternatively spliced
            transcript variants encoding several different isoforms have been
            found for this gene, with some of them functioning as activators
            and some as repressors of transcription. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (21), also known as CREM 10,
            differs in the 5' UTR, 3' UTR, and contains an additional segment
            in the coding region, compared to variant 1. This results in a
            shorter isoform (21, also known as u) with a distinct C-terminus,
            compared to isoform 1. This isoform represents the tau2 activator
            isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.1737104.1,
                                           SRR1660807.91062.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000685392.1/ ENSP00000509489.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-348               AL157783.15        15636-15983
            349-446             AL157783.15        26572-26669
            447-570             AL157783.15        37158-37281
            571-668             AL157783.15        67679-67776
            669-811             AL157783.15        67924-68066
            812-1000            AL157783.15        76990-77178
            1001-1157           AL157783.15        95685-95841
            1158-2857           AL117336.22        4401-6100
FEATURES             Location/Qualifiers
     source          1..2857
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p11.21"
     gene            1..2857
                     /gene="CREM"
                     /gene_synonym="CREM-2; hCREM-2; ICER"
                     /note="cAMP responsive element modulator"
                     /db_xref="GeneID:1390"
                     /db_xref="HGNC:HGNC:2352"
                     /db_xref="MIM:123812"
     exon            1..348
                     /gene="CREM"
                     /gene_synonym="CREM-2; hCREM-2; ICER"
                     /inference="alignment:Splign:2.1.0"
     exon            349..446
                     /gene="CREM"
                     /gene_synonym="CREM-2; hCREM-2; ICER"
                     /inference="alignment:Splign:2.1.0"
     CDS             403..1302
                     /gene="CREM"
                     /gene_synonym="CREM-2; hCREM-2; ICER"
                     /note="isoform 21 is encoded by transcript variant 21;
                     inducible cAMP early repressor ICER; CREM 2beta-a protein;
                     CREM 2alpha-b protein; cAMP response element modulator"
                     /codon_start=1
                     /product="cAMP-responsive element modulator isoform 21"
                     /protein_id="NP_898829.1"
                     /db_xref="CCDS:CCDS7181.1"
                     /db_xref="GeneID:1390"
                     /db_xref="HGNC:HGNC:2352"
                     /db_xref="MIM:123812"
                     /translation="MSKCARKKYIKTNPRQMTMETVESQHDGSITASLTESKSAHVQT
                     QTGQNSIPALAQVAAIAETDESAESEGVIDSHKRREILSRRPSYRKILNELSSDVPGV
                     PKIEEERSEEEGTPPSIATMAVPTSIYQTSTGQYIAIAQGGTIQISNPGSDGVQGLQA
                     LTMTNSGAPPPGATIVQYAAQSADGTQQFFVPGSQVVVQAATGDMPTYQIRAPTAALP
                     QGVVMAASPGSLHSPQQLAEEATRKRELRLMKNREAARECRRKKKEYVKCLENRVAVL
                     ENQNKTLIEELKALKDLYCHKVE"
     exon            447..570
                     /gene="CREM"
                     /gene_synonym="CREM-2; hCREM-2; ICER"
                     /inference="alignment:Splign:2.1.0"
     exon            571..668
                     /gene="CREM"
                     /gene_synonym="CREM-2; hCREM-2; ICER"
                     /inference="alignment:Splign:2.1.0"
     exon            669..811
                     /gene="CREM"
                     /gene_synonym="CREM-2; hCREM-2; ICER"
                     /inference="alignment:Splign:2.1.0"
     exon            812..1000
                     /gene="CREM"
                     /gene_synonym="CREM-2; hCREM-2; ICER"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1157
                     /gene="CREM"
                     /gene_synonym="CREM-2; hCREM-2; ICER"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..2857
                     /gene="CREM"
                     /gene_synonym="CREM-2; hCREM-2; ICER"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1762..1767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CREM"
                     /gene_synonym="CREM-2; hCREM-2; ICER"
                     /note="hexamer: AATATA"
     polyA_site      1780
                     /gene="CREM"
                     /gene_synonym="CREM-2; hCREM-2; ICER"
                     /note="major polyA site"
     regulatory      2004..2009
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CREM"
                     /gene_synonym="CREM-2; hCREM-2; ICER"
                     /note="hexamer: AATAAA"
     polyA_site      2029
                     /gene="CREM"
                     /gene_synonym="CREM-2; hCREM-2; ICER"
     regulatory      2263..2268
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CREM"
                     /gene_synonym="CREM-2; hCREM-2; ICER"
                     /note="hexamer: AATAGA"
     polyA_site      2283
                     /gene="CREM"
                     /gene_synonym="CREM-2; hCREM-2; ICER"
     regulatory      2351..2356
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CREM"
                     /gene_synonym="CREM-2; hCREM-2; ICER"
                     /note="hexamer: TATAAA"
     polyA_site      2369
                     /gene="CREM"
                     /gene_synonym="CREM-2; hCREM-2; ICER"
                     /note="major polyA site"
     regulatory      2822..2827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CREM"
                     /gene_synonym="CREM-2; hCREM-2; ICER"
                     /note="hexamer: AATAAA"
     polyA_site      2857
                     /gene="CREM"
                     /gene_synonym="CREM-2; hCREM-2; ICER"
ORIGIN      
        1 attgttggat tgtggcgctt cactcctgct ggcggccggc agggggcgga gttcgagcct
       61 ggattttttt cctcggggcc tcccccggga ggccgtcccg gcgtggggga ggggaggacg
      121 gggcgggagg acgcggttcg gtcggctgca gcgctacttt tggtccgggg tcggcaggga
      181 ggccgcggct accgcatcac agctgacgtg aggactacgt ggggccgctg ccggctccgg
      241 gttgctgggc ggcggcgccg ctgctgagcg gcggtcgggc tcgccgtctc cacctcctcg
      301 cgtccgtaat cagtgacgag gtccgctacg taaatccctt tgcggcggga taaataaaga
      361 aaacaggaaa ggaggaaagc attgattaca aatatcttaa caatgagcaa atgtgcaagg
      421 aaaaaatata ttaagacaaa tccaagacaa atgaccatgg aaacagttga atcccagcat
      481 gatggaagta taacagcttc tttgacagag agcaagtctg ctcatgtgca gactcagact
      541 ggccaaaatt caatccctgc tttagctcag gtagcagcaa ttgcagagac agatgaatct
      601 gcagaatcag aaggtgtaat tgattctcat aaacgtagag aaatcctttc acgaagaccc
      661 tcttatagga aaatactgaa tgaactgtcc tctgatgtgc ctggtgttcc caagattgaa
      721 gaagagagat cagaggaaga aggaacacca cctagtattg ctaccatggc agtaccaact
      781 agcatatatc agactagcac ggggcaatac attgctatag cccaaggtgg aacaatccag
      841 atttctaacc caggatctga tggtgttcag ggactgcagg cattaacaat gacaaattca
      901 ggagctcctc caccaggtgc tacaattgta cagtacgcag cacaatcagc tgatggcaca
      961 cagcagttct ttgtcccagg cagccaggtt gttgttcaag ctgccactgg tgacatgcca
     1021 acttaccaga tccgagctcc tactgctgct ttgccacagg gagtggtgat ggctgcatcg
     1081 cccggaagtt tgcacagtcc ccagcagctg gcagaagaag caacacgcaa acgagagctg
     1141 aggctaatga aaaacaggga agctgcccgg gagtgtcgca ggaagaagaa agaatatgtc
     1201 aaatgtcttg aaaatcgtgt ggctgtgctt gaaaaccaaa acaagactct cattgaggaa
     1261 ctcaaggccc tcaaagatct ttattgccat aaagtagagt aactgtcttt gacttggacc
     1321 ttgtttactc taatcaaggc aggagatgca gcagtcctac ttattgccat gtggacttgt
     1381 gggaaggaca cgtgtgaccc ttaagaatcc agtttggatt agtgtttgaa attgaattgg
     1441 gaatgttgtt ccaggatgtg gaatgcagcc gtgatcacac ttaccgagct tactttgatc
     1501 tgtttgtcaa tagcatgcaa aaaatgcttt gtttgccctt tgcttctgct ttttttcagg
     1561 gaagctgcca aagaatgtcg acgtcgaaag aaagaatatg taaaatgtct ggagagccga
     1621 gttgcagtgc tggaagtcca gaacaagaag cttatagagg aacttgaaac cttgaaagac
     1681 atttgttctc ccaaaacaga ttactagaaa tatttaacta tgaactgaag gcagcatgta
     1741 tagttgcttt tgaaggaata caatatatag ctggcaagaa tggtggcttc ttttctttgt
     1801 atcattcatc ttcttcttta atcacttaac attcctaaaa tgcttcactg tacgtagtta
     1861 agtcgtagct ataacttcaa attttttaaa agagacaaac tgtaaaaaat gtgtgtattc
     1921 ttaaaatgca atatttgtaa ggcttgttcc aatgccacat acttgcagct cccattctat
     1981 gtgtcatcaa tagtgtccta tgcaataaaa ttatttgcag gtctttaaat cattttagga
     2041 aaggatgatc aaaaataatg catccagcag tacaataaaa gtaaaccaca aaaaaatacc
     2101 tcaggaaaga atagaaagaa agtctatcta atgacatgcc tatatgagaa gaatagccta
     2161 gatatgaata tatggcattt gcagattttt atattagttg ctttgttaaa aaaaaaaaga
     2221 ttgtattgct gtccttgaat gccatagtca aagagagttt ttaatagaac catgttggtt
     2281 gcactttgta gtgtttggtg ctcatttaaa tatctgaaca tttactacag tttttaactc
     2341 tactgtgtaa tataaaagat cttgcagaag ttcttagtgt tggtttaata ttacctaatg
     2401 aaagtgatga catatttttt atatctggaa tgagcctgtt gggatcgcat tgcatacctt
     2461 cggggtacaa gtcagtttct acactgggtg ctgatccttg cacgcgccct ttctaccatc
     2521 tcacggtggg gatggccgca gggctgtgca cccagaagaa gatggctgtt agcgtttcgg
     2581 ccttcataat ggcctgagac tttctttctg taggtggtct ggagctgtcc ggctggtggc
     2641 cccctatttt gccatttagc gaacaaccac aggaatttta aaaacaaaaa catcccaaga
     2701 ttttttcatt tcaaaatgct tcaaagtcca cattagatca gatactccgc tgtcggcaca
     2761 ttcagctgag gttcattaca atcgagactg caatgtgatc tatgtttcat cttgttttta
     2821 taataaaaag cttcagggaa caagcccaaa gccctca
//
