LOCUS       NM_024324               1428 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens cysteine rich with EGF like domains 2 (CRELD2),
            transcript variant 2, mRNA.
ACCESSION   NM_024324
VERSION     NM_024324.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1428)
  AUTHORS   Hinaga,S., Kandeel,M. and Oh-Hashi,K.
  TITLE     Molecular characterization of the ER stress-inducible factor CRELD2
  JOURNAL   Cell Biochem Biophys 82 (2), 1463-1475 (2024)
   PUBMED   38753249
  REMARK    GeneRIF: Molecular characterization of the ER stress-inducible
            factor CRELD2.
REFERENCE   2  (bases 1 to 1428)
  AUTHORS   Tang,Q., Liu,Q., Li,Y., Mo,L. and He,J.
  TITLE     CRELD2, endoplasmic reticulum stress, and human diseases
  JOURNAL   Front Endocrinol (Lausanne) 14, 1117414 (2023)
   PUBMED   36936176
  REMARK    GeneRIF: CRELD2, endoplasmic reticulum stress, and human diseases.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1428)
  AUTHORS   Kern,P., Balzer,N.R., Blank,N., Cygon,C., Wunderling,K., Bender,F.,
            Frolov,A., Sowa,J.P., Bonaguro,L., Ulas,T., Homrich,M.,
            Kiermaier,E., Thiele,C., Schultze,J.L., Canbay,A., Bauer,R. and
            Mass,E.
  TITLE     Creld2 function during unfolded protein response is essential for
            liver metabolism homeostasis
  JOURNAL   FASEB J 35 (10), e21939 (2021)
   PUBMED   34549824
  REMARK    GeneRIF: Creld2 function during unfolded protein response is
            essential for liver metabolism homeostasis.
REFERENCE   4  (bases 1 to 1428)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1428)
  AUTHORS   Boyle,S.T., Poltavets,V., Kular,J., Pyne,N.T., Sandow,J.J.,
            Lewis,A.C., Murphy,K.J., Kolesnikoff,N., Moretti,P.A.B., Tea,M.N.,
            Tergaonkar,V., Timpson,P., Pitson,S.M., Webb,A.I., Whitfield,R.J.,
            Lopez,A.F., Kochetkova,M. and Samuel,M.S.
  TITLE     ROCK-mediated selective activation of PERK signalling causes
            fibroblast reprogramming and tumour progression through a
            CRELD2-dependent mechanism
  JOURNAL   Nat Cell Biol 22 (7), 882-895 (2020)
   PUBMED   32451439
  REMARK    GeneRIF: ROCK-mediated selective activation of PERK signalling
            causes fibroblast reprogramming and tumour progression through a
            CRELD2-dependent mechanism.
            Erratum:[Nat Cell Biol. 2020 Jul;22(7):908. doi:
            10.1038/s41556-020-0539-3.. PMID: 32499616]
REFERENCE   6  (bases 1 to 1428)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107.. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1428)
  AUTHORS   Maslen,C.L., Babcock,D., Redig,J.K., Kapeli,K., Akkari,Y.M. and
            Olson,S.B.
  TITLE     CRELD2: gene mapping, alternate splicing, and comparative genomic
            identification of the promoter region
  JOURNAL   Gene 382, 111-120 (2006)
   PUBMED   16919896
  REMARK    GeneRIF: Mapping of CRELD2 by FISH shows that it maps to 22q13
            rather than the GenBank reported locus of 22p13.
REFERENCE   8  (bases 1 to 1428)
  AUTHORS   Ortiz,J.A., Castillo,M., del Toro,E.D., Mulet,J., Gerber,S.,
            Valor,L.M., Sala,S., Sala,F., Gutierrez,L.M. and Criado,M.
  TITLE     The cysteine-rich with EGF-like domains 2 (CRELD2) protein
            interacts with the large cytoplasmic domain of human neuronal
            nicotinic acetylcholine receptor alpha4 and beta2 subunits
  JOURNAL   J Neurochem 95 (6), 1585-1596 (2005)
   PUBMED   16238698
  REMARK    GeneRIF: CRELD2 can act as a specific regulator of alpha4beta2
            nAChR expression
REFERENCE   9  (bases 1 to 1428)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   10 (bases 1 to 1428)
  AUTHORS   Rupp,P.A., Fouad,G.T., Egelston,C.A., Reifsteck,C.A., Olson,S.B.,
            Knosp,W.M., Glanville,R.W., Thornburg,K.L., Robinson,S.W. and
            Maslen,C.L.
  TITLE     Identification, genomic organization and mRNA expression of CRELD1,
            the founding member of a unique family of matricellular proteins
  JOURNAL   Gene 293 (1-2), 47-57 (2002)
   PUBMED   12137942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI462292.1 and AY358355.1.
            
            On Jun 2, 2019 this sequence version replaced NM_024324.4.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the central coding region, compared to variant 1, resulting
            in an isoform (b, also known as CRELD2-delta) that is shorter than
            isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358355.1, SRR1163655.113924.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328268.9/ ENSP00000332223.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                BI462292.1         24-95
            73-1428             AY358355.1         1-1356
FEATURES             Location/Qualifiers
     source          1..1428
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.33"
     gene            1..1428
                     /gene="CRELD2"
                     /note="cysteine rich with EGF like domains 2"
                     /db_xref="GeneID:79174"
                     /db_xref="HGNC:HGNC:28150"
                     /db_xref="MIM:607171"
     exon            1..265
                     /gene="CRELD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1198
                     /gene="CRELD2"
                     /EC_number="5.3.4.1"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; cysteine-rich with EGF-like domain protein 2;
                     protein disulfide isomerase CRELD2"
                     /codon_start=1
                     /product="protein disulfide isomerase CRELD2 isoform b
                     precursor"
                     /protein_id="NP_077300.3"
                     /db_xref="CCDS:CCDS14082.1"
                     /db_xref="GeneID:79174"
                     /db_xref="HGNC:HGNC:28150"
                     /db_xref="MIM:607171"
                     /translation="MRLPRRAALGLLPLLLLLPPAPEAAKKPTPCHRCRGLVDKFNQG
                     MVDTAKKNFGGGNTAWEEKTLSKYESSEIRLLEILEGLCESSDFECNQMLEAQEEHLE
                     AWWLQLKSEYPDLFEWFCVKTLKVCCSPGTYGPDCLACQGGSQRPCSGNGHCSGDGSR
                     QGDGSCRCHMGYQGPLCTDCMDGYFSSLRNETHSICTACDESCKTCSGLTNRDCGECE
                     VGWVLDEGACVDVDECAAEPPPCSAAQFCKNANGSYTCEECDSSCVGCTGEGPGNCKE
                     CISGYAREHGQCADVDECSLAEKTCVRKNENCYNTPGSYVCVCPDGFEETEDACVPPA
                     EAEATEGESPTQLPSREDL"
     exon            266..348
                     /gene="CRELD2"
                     /inference="alignment:Splign:2.1.0"
     exon            349..459
                     /gene="CRELD2"
                     /inference="alignment:Splign:2.1.0"
     exon            460..551
                     /gene="CRELD2"
                     /inference="alignment:Splign:2.1.0"
     exon            552..728
                     /gene="CRELD2"
                     /inference="alignment:Splign:2.1.0"
     exon            729..824
                     /gene="CRELD2"
                     /inference="alignment:Splign:2.1.0"
     exon            825..908
                     /gene="CRELD2"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1004
                     /gene="CRELD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1145
                     /gene="CRELD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1428
                     /gene="CRELD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1396..1401
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CRELD2"
                     /note="hexamer: AATAAA"
     polyA_site      1428
                     /gene="CRELD2"
                     /note="major polyA site"
ORIGIN      
        1 ggggcctcgc cggcgccgtc aagtagcctg ggggacaggc cggcgcggct gggagcgggt
       61 gggcggccgg gaggccggag cagcacggcc gcaggacctg gagctccggc tgcgtcttcc
      121 cgcagcgcta cccgccatgc gcctgccgcg ccgggccgcg ctggggctcc tgccgcttct
      181 gctgctgctg ccgcccgcgc cggaggccgc caagaagccg acgccctgcc accggtgccg
      241 ggggctggtg gacaagttta accaggggat ggtggacacc gcaaagaaga actttggcgg
      301 cgggaacacg gcttgggagg aaaagacgct gtccaagtac gagtccagcg agattcgcct
      361 gctggagatc ctggaggggc tgtgcgagag cagcgacttc gaatgcaatc agatgctaga
      421 ggcgcaggag gagcacctgg aggcctggtg gctgcagctg aagagcgaat atcctgactt
      481 attcgagtgg ttttgtgtga agacactgaa agtgtgctgc tctccaggaa cctacggtcc
      541 cgactgtctc gcatgccagg gcggatccca gaggccctgc agcgggaatg gccactgcag
      601 cggagatggg agcagacagg gcgacgggtc ctgccggtgc cacatggggt accagggccc
      661 gctgtgcact gactgcatgg acggctactt cagctcgctc cggaacgaga cccacagcat
      721 ctgcacagcc tgtgacgagt cctgcaagac gtgctcgggc ctgaccaaca gagactgcgg
      781 cgagtgtgaa gtgggctggg tgctggacga gggcgcctgt gtggatgtgg acgagtgtgc
      841 ggccgagccg cctccctgca gcgctgcgca gttctgtaag aacgccaacg gctcctacac
      901 gtgcgaagag tgtgactcca gctgtgtggg ctgcacaggg gaaggcccag gaaactgtaa
      961 agagtgtatc tctggctacg cgagggagca cggacagtgt gcagatgtgg acgagtgctc
     1021 actagcagaa aaaacctgtg tgaggaaaaa cgaaaactgc tacaatactc cagggagcta
     1081 cgtctgtgtg tgtcctgacg gcttcgaaga aacggaagat gcctgtgtgc cgccggcaga
     1141 ggctgaagcc acagaaggag aaagcccgac acagctgccc tcccgcgaag acctgtaatg
     1201 tgccggactt accctttaaa ttattcagaa ggatgtcccg tggaaaatgt ggccctgagg
     1261 atgccgtctc ctgcagtgga cagcggcggg gagaggctgc ctgctctcta acggttgatt
     1321 ctcatttgtc ccttaaacag ctgcatttct tggttgttct taaacagact tgtatatttt
     1381 gatacagttc tttgtaataa aattgaccat tgtaggtaat caggagga
//
