LOCUS       NM_153836               6292 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens cellular repressor of E1A stimulated genes 2 (CREG2),
            mRNA.
ACCESSION   NM_153836
VERSION     NM_153836.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6292)
  AUTHORS   Kunita,R., Otomo,A. and Ikeda,J.E.
  TITLE     Identification and characterization of novel members of the CREG
            family, putative secreted glycoproteins expressed specifically in
            brain
  JOURNAL   Genomics 80 (5), 456-460 (2002)
   PUBMED   12408961
  REMARK    GeneRIF: CREG2 are putative secreted glycoproteins and may be novel
            neuronal extracellular molecules.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB046109.1 and AC099797.6.
            
            On Nov 23, 2018 this sequence version replaced NM_153836.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The extent of this RefSeq
            transcript is supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.42519.1,
                                           SRR1803615.119343.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324768.6/ ENSP00000315203.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-957               AB046109.1         93-1049
            958-3488            AC099797.6         11591-14121         c
            3489-6292           AC099797.6         8787-11590          c
FEATURES             Location/Qualifiers
     source          1..6292
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.2"
     gene            1..6292
                     /gene="CREG2"
                     /note="cellular repressor of E1A stimulated genes 2"
                     /db_xref="GeneID:200407"
                     /db_xref="HGNC:HGNC:14272"
                     /db_xref="MIM:618540"
     exon            1..487
                     /gene="CREG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..919
                     /gene="CREG2"
                     /note="protein CREG2"
                     /codon_start=1
                     /product="protein CREG2 precursor"
                     /protein_id="NP_722578.1"
                     /db_xref="CCDS:CCDS2052.1"
                     /db_xref="GeneID:200407"
                     /db_xref="HGNC:HGNC:14272"
                     /db_xref="MIM:618540"
                     /translation="MSVRRGRRPARPGTRLSWLLCCSALLSPAAGYVIVSSVSWAVTN
                     EVDEELDSASTEEAMPALLEDSGSIWQQSFPASAHKEDAHLRPRAGAARARPPPAPPG
                     MFSYRREGGQTASAPPGPRLRAATARSLAHASVWGCLATVSTHKKIQGLPFGNCLPVS
                     DGPFNNSTGIPFFYMTAKDPVVADLMKNPMASLMLPESEGEFCRKNIVDPEDPRCVQL
                     TLTGQMIAVSPEEVEFAKQAMFSRHPGMRKWPRQYEWFFMKMRIEHIWLQKWYGGASS
                     ISREEYFKAVPRKA"
     exon            488..657
                     /gene="CREG2"
                     /inference="alignment:Splign:2.1.0"
     exon            658..771
                     /gene="CREG2"
                     /inference="alignment:Splign:2.1.0"
     exon            772..6292
                     /gene="CREG2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6270..6275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CREG2"
                     /note="hexamer: ATTAAA"
     polyA_site      6292
                     /gene="CREG2"
                     /note="major polyA site"
ORIGIN      
        1 actagcgctg ctggcggccc cggcggccgg gcgtgctgcc tgcaagatgt ccgtgcgccg
       61 cggccggcgg ccggcgcggc cggggacccg cctctcctgg ctgctgtgct gcagcgccct
      121 gctgtccccg gccgcgggct acgtgatcgt gagctccgtg tcttgggccg tcaccaacga
      181 ggtggacgag gagctggaca gcgcctccac tgaggaggct atgcccgcgc tgctagagga
      241 ttcgggcagc atctggcagc aaagcttccc cgcctctgcc cacaaggagg acgcgcacct
      301 gcggccccgg gcgggcgccg cccgggccag gccgcccccc gcgccacccg ggatgttctc
      361 ctaccggcgc gagggcggcc agacggccag tgcgcccccg ggccctagac tgcgcgccgc
      421 caccgcccgc tccctggccc atgccagcgt ctggggctgc ctggccaccg tgtccaccca
      481 caagaagatc caaggactgc catttgggaa ctgcctgccc gtcagtgatg gccccttcaa
      541 caatagcact gggattcctt tcttctacat gacagccaag gaccccgtgg tggctgatct
      601 gatgaagaac cccatggcct cgctgatgct gccagaatca gaaggggagt tctgcagaaa
      661 aaacatcgtt gatccggaag atccccgatg tgtccagtta acgctcactg gccagatgat
      721 cgcagtgtct ccagaagaag tagaatttgc caagcaagcc atgttttcaa ggcacccagg
      781 gatgaggaag tggcctcgtc aatatgaatg gttctttatg aagatgagga tagaacatat
      841 ctggcttcag aaatggtatg gaggcgcatc cagtatttca agggaggaat atttcaaagc
      901 agttcccaga aaggcctgat ggagtgagaa gaaagtcctt ggtgtttgca cttaaatgaa
      961 aaccttttca gtgatgcagc cagacagcta ttgaccactg tctctttgtt gaagggttca
     1021 tagcagccct gccatccctg cagcagaatg agagagggtg aacagggaac tctatgctag
     1081 atttgagatt aaagtggtca tttgcagatc tccaactcac acagatactt cacgtagata
     1141 gtctttattc cattgtattc aatccagact catcgattca gaaatcatat aatagctggt
     1201 ggtcaaaatg acatgttgag atcattgttg tttcattgtt taaggaaaaa aaaaaatgcc
     1261 tgtacctaca atgtgattgc tttgtattgt gagagtatct ttgttgcttg ctctgccaaa
     1321 tgcagtcttg gttctaagtt cactgtgacc acgaagcagc tgactgtgca tcacgcagtc
     1381 acaatattgt ttttagggtg agggtggagg actgtgtgtc cgtggattac tcctcctgct
     1441 ggtggattgc agatgcatta ttaggtcata ctggctagaa tgcagctttt ctcccaccat
     1501 aacatgaaaa cagtgtaaga acatagggtg ctttgtgcat agcccttctc tatgtaagca
     1561 gccatggcag tcattaaaga gaaaggagta gctttgacat taagctcccc agatccctgc
     1621 tgctcatact tctggcaagg gttcccctct ctcatgcatg aacaggggca tccaaaataa
     1681 gaagctctcc attctgtggt ggggaaagcg gagaggggag tgggtgaagc tgggaaagta
     1741 aaggcagcac gttacagaag gaagaaagga agccagtaac tgagggccca ctgcctgccc
     1801 ggccctgggc caggccctca acagaagcca tctcatttaa gccctgcaac caatgagatg
     1861 cacgtcatca ttggctctta cagacaagaa aactagactc agaggggctg agtccacatc
     1921 ccagacagct cactgcagac acaggtggag tggttcctac aagacatcca gttttaacaa
     1981 caaaagagtt attgaaatgc atgggtagaa attgaaccag gaaaatcagt aaagtgattg
     2041 taaaaaagaa ggactagctt gcctggagat gatgtttctt gcttttggaa aaaaaaaaaa
     2101 agtctctgaa atttgattct tactacagat ttaaaacttt ctacatatta tatgtaggag
     2161 ctcctagtgt ttttgagaaa ttagactgta cctgtgtaca cttctaaggt ctacatggac
     2221 ctatgtatat atatctaaga cctctgatca ttaaaaccta taaagggttg agctgtccca
     2281 agttttctgt ctttctgtaa tggctacaaa ctttctttgg taggttaggg aggttgtata
     2341 acataaaaaa cacatcacta tatgtaggaa atatacattt ttcaagtaaa taagagtgtt
     2401 attaatgatt atgaactttt gcttaacaaa ataacatacg acgagagctt gagttgtcaa
     2461 aatatatttt aattatctat tgctaaaaac atagtaagat gcagagaatt ctttatttgt
     2521 cataagccag tcctcaaaag agttcctaac agtagtgatt tctaatatat aagaataagg
     2581 tacttctgag ggaattttat attttcagag tttaaaatta ttgctactcc caatttagaa
     2641 aaatggggag aaagctggaa gaacaaatga catgctcaaa tgtattgcat aagtcaacct
     2701 cacaccttaa tactgggagc ttctctgcct cctgatcctg tcttgcagat aaggtcccct
     2761 ggctaggttt gcgtttatag tcaggttcca tttagctcat taaaggtcac tgctgcttca
     2821 aaggactttg cccagtggat gccattcata accactgatg aatgttatca gctatttatc
     2881 caaattacag gaaatgaaac ctgaaaaggt tgggtaagaa tagtgttgaa aattcacagt
     2941 tttaagtttg atggtctcca ttcaggcaag tgtgtttcag caaatctcta gaaatttaca
     3001 ttgattaaaa tgttagaggc tgttctggaa gttctagaca tggcaataag gcaagaaaaa
     3061 gagattaaat gcatacagat cgaaagaaaa aaaaagtacc cctatttaga gatgagagga
     3121 ttgcctacat agaaattcca aataatctat tttttttaaa aaaaaactct ggaactagta
     3181 tgtgagtgca acaaggtctc aggacacaag atcagcatac aaaagtcaat tgcatttctc
     3241 tatgctaacg atgaacatgt ggggaaaaaa actaaaaaca caataccatt tgcaatcact
     3301 ccaaagtgaa atacttccgt ataaacaaaa cttacccagg acctatgtag tgaaaatttt
     3361 taaatgctaa gaaaagaaat taatgaccta aacaaagaaa gagagatacc atgttcttgg
     3421 attggaagat acaaacagta aagatatcag ttctccccat ctccatctct aggtttaatg
     3481 caattcctat caaaatctca acaaggattt tgtagaccta tacaagctta ttttaaaagt
     3541 tacatggaaa ggcacaggca ttgaaatagc taaaacagtc ttgtaaaagc agaataaggt
     3601 aggagaaatc attctattta atatagagtt atgatgtagc tacagtattc aagaagtgtg
     3661 gtatttggtg gaggcataga aacacattga tggaacagaa tagggaatct agaaataggc
     3721 ccacacaaat atgctcaact gattttcttt tacaaaagta caaaactaat tcaacagagg
     3781 atagcctttt caataagtgt ggagtaagtg gacatccata ggaaaataaa atgaaccttg
     3841 gactaaactt cataccttat gcaaaaatta actcagatca tatctgtaaa aataaaatgt
     3901 aaaactataa aactatagga tatagaaaat cttttggaac tagggctaag caaagggttg
     3961 ttagacttga taccaaaagc acaattcata aaagaaaatt tgataaatta aacttcatca
     4021 gaatttaaaa catttgttct gcaaaagacc atgttaaaag gccgagaaga caggccacat
     4081 actgggagaa aatatttcca aaccacatat ccaacaaaag attagtatct agaatatata
     4141 aagaactgtc aaaactcaac agctaaaaaa ttctaattag aaaatggagc acatgaacag
     4201 acatttcact gcagaggata taaaaatggc aaataagcgc atgaaaagac atgaaaagac
     4261 agtcaacagc actagtcact aggggaactg caaactaata ctacaatgag atatcactac
     4321 atagctacca aaattgctaa aataaaaaat aatgataaca ccaaacgctg acaaggatgc
     4381 agataaaccg ggtcagtcat acactagtgg tgggaataga aaatggaaca gccactccgc
     4441 aaaaccattt gccagtttct cataaaacta aacatacaac tgccatactg accctcaatt
     4501 gctcctgggc atttatacaa gagaaatgaa aagaggttca cacaaaaact tgtgcatgaa
     4561 tgttcatatc agttttatcc ataatgttca aaaacttgga gaaatcagat ggcctttaac
     4621 gggtggctgg tgaaacagtg gatggtgcct ctatgcccgg aatactactc agcgataaaa
     4681 aagaactaat tactgacatg ggcaaccact gggatgaatt ccagagaatt gtgctgagtg
     4741 agcaaagcca atcataaaag tttgcacact gtatgattcc atttacataa cattttgaaa
     4801 tgcaaaatta taggaatgga gaatagatta ggggttgcca gggaggagtg gggagaacaa
     4861 gagagttggg cataactata aaaggatagc acaagagatc cttgtggtga tggacatatt
     4921 cagtatcttg accaaatcaa tgtgaaaatc ctggttggga tattgtactg tagtttagca
     4981 agatgtgcca ttggggaaaa ctgggtaaaa agaacacagg atctctgtat tatttcttac
     5041 aactgcatgt gaatctacag ttatctacaa ctatctcaga atctacaatt atctctgagt
     5101 aaaaagctta acataaacaa gatttagggc ttagcttaat aaagcattta tactctctct
     5161 cttattagtc cctaataaaa tgaggaactg agctataagc caaaacctag tacaaagaga
     5221 cagcatttca tttgttaacc gttaatatat ccatttgcag aagaggtgta aaattcttta
     5281 aaattttcct aaatatgttc aatttaatgt taaatacaaa ttaacaagaa ttcaacaaat
     5341 ctgctgtata gattttaagt gggtcactta ggaggagagg acatcttcga atttctgata
     5401 taaacacgtt gagtaagcta taggtgtata taagtatcca agtgtgtata taatgattct
     5461 ccactgattt tatagagaag aactatattt ccagtaatct tcccctaaat attgtgggaa
     5521 ataattctgt tttagtgaat aagctaatta aagtctatcc agaccaccat gtttttattt
     5581 acagtgacta tatatatcca tgattttgac atagagtata attctgatgt tacttatttc
     5641 aatatgcctt gtatatatta gctgtttata agagagtcgc tttttggttg aaaagtattt
     5701 ctaggctgag caaggtagct catgcctgta atccaaacac tttgggaggc caaggcagga
     5761 ggatcacttg aggtcaggag ttcaagagca gcctgggcaa catagtgaga cctcatctct
     5821 acaaaaaata tttattaaaa aaaaaaaaaa aaaagcccag catggtggtg cacacctgta
     5881 gttctagcta ctcaagaggc tgaggtggga ggattgcttt gaggccagga gtttgacctc
     5941 ctgagctgtg atcatgccac cacacttgag tgatagagtg agactttgtc tcttaaaaaa
     6001 aaaaaaaggt atttctacaa tttttccaaa aagtctgtat ttatttaaat aattgaacta
     6061 tcaaatactg ttctgaaaat aaaacctctc taggataatt tattgatgct tatttgattg
     6121 ctataacaga aagtcaatta ttgtacaatt tgaattgtaa tgatgtgatt atttgtgcca
     6181 tgtaatgcat gtaaaatgta aaatctgttt tcaaaactag atctatttaa ccaaagacta
     6241 tttcattcct gatatgattt gtgtgcttga ttaaatgaat ttatgatatt ga
//
